Full Text Journal Articles by
Author Sundararaghavan Pattabiraman

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Vimentin protects differentiating stem cells from stress.

Sundararaghavan Pattabiraman, Gajendra Kumar Azad, Triana Amen, Shlomi Brielle, Jung Eun Park, Siu Kwan Sze, Eran Meshorer, Daniel Kaganovich,

Vimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian cells during embryogenesis, but its role in cellular fitness has long been a mystery. Vimentin is acknowledged to play a role in cell stiffness, cell motility, and cytoplasmic organization, yet it is widely considered to be ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):19525]

Cited: 1 time

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A dominant vimentin variant causes a rare syndrome with premature aging.

Benjamin Cogné, Jamal-Eddine Bouameur, Gaëlle Hayot, Xenia Latypova, Sundararaghavan Pattabiraman, Amandine Caillaud, Karim Si-Tayeb, Thomas Besnard, Sébastien Küry, Caroline Chariau, Anne Gaignerie, Laurent David, Philippe Bordure, Daniel Kaganovich, Stéphane Bézieau, Christelle Golzio, Thomas M Magin, Bertrand Isidor,

Progeroid syndromes are a group of rare genetic disorders, which mimic natural aging. Unraveling the molecular defects in such conditions could impact our understanding of age-related syndromes such as Alzheimer's or cardiovascular diseases. Here we report a de novo heterozygous missense variant in the intermediate filament vimentin (c.1160 T > C; p.(Leu387Pro)) causing ... Read more >>

Eur J Hum Genet (European journal of human genetics : EJHG)
[2020, 28(9):1218-1230]

Cited: 1 time

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Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin.

Mikołaj Ogrodnik, Hanna Salmonowicz, Rachel Brown, Joanna Turkowska, Władysław Średniawa, Sundararaghavan Pattabiraman, Triana Amen, Ayelet-chen Abraham, Noam Eichler, Roman Lyakhovetsky, Daniel Kaganovich,

Aging is associated with the accumulation of several types of damage: in particular, damage to the proteome. Recent work points to a conserved replicative rejuvenation mechanism that works by preventing the inheritance of damaged and misfolded proteins by specific cells during division. Asymmetric inheritance of misfolded and aggregated proteins has ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(22):8049-8054]

Cited: 58 times

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Imperfect asymmetry: The mechanism governing asymmetric partitioning of damaged cellular components during mitosis.

Sundararaghavan Pattabiraman, Daniel Kaganovich,

Aging is universally associated with organism-wide dysfunction and a decline in cellular fitness. From early development onwards, the efficiency of self-repair, energy production, and homeostasis all decrease. Due to the multiplicity of systems that undergo agingrelated decline, the mechanistic basis of organismal aging has been difficult to pinpoint. At the ... Read more >>

Bioarchitecture (Bioarchitecture)
[2014, 4(6):203-209]

Cited: 3 times

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