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Author Sumaiya Adam

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Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study.

Samantha Budhram, Valerie Vannevel, Tanita Botha, Lawrence Chauke, Shastra Bhoora, Gaynor M Balie, Natalie Odell, Hennie Lombaard, Amy Wise, Chrysanthi Georgiou, Nondumiso Ngxola, Emma Wynne, Unati Mbewu, Mfundo Mabenge, Sibusiso Phinzi, Nontsikelelo Gubu-Ntaba, Gareth Goldman, Kay Tunkyi, Sudhir Prithipal, Keshree Naidoo, Santhi Venkatachalam, Terence Moodley, Sean Mould, Mzuvele Hlabisa, Logie Govender, Charlene Maistry, John P Habineza, Priya Israel, Serantha Foolchand, Nomandla V Tsibiyane, Mala Panday, Priya Soma-Pillay, Sumaiya Adam, Felicia Molokoane, Matthew S Mojela, Elizabeth J van Rensburg, Tshililo Mashamba, Mushi Matjila, Sue Fawcus, Ayesha Osman, Mareli Venter, Gregory Petro, Ahminah Fakier, Eduard Langenegger, Catherine A Cluver, Adrie Bekker, Liesl de Waard, Chantal Stewart, Nnabuike C Ngene, Ongombe Lunda, Sylvia N Cebekhulu, Siva Moodley, Mama-Asu Koranteng-Peprah, Emmanuel M C Ati, Salome Maswime, Laura M Yates,

<h4>Objective</h4>To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities.<h4>Methods</h4>A population-based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS-CoV-2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed.<h4>Results</h4>A total ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

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Foetal magnetic resonance imaging: A necessity or adjunct? A modality comparison of in-utero ultrasound and ultrafast foetal magnetic resonance imaging.

Sunaina Ramdass, Sumaiya Adam, Zarina Lockhat, Andries Masenge, Farhana E Suleman,

<h4>Background</h4>Congenital anomalies occur in approximately 2% of newborns, resulting in severe medical, physical and social disabilities. Managing clinicians, therefore, require more confidence in their diagnosis and prognostic accuracy before appropriately counselling the parents regarding termination of pregnancy.<h4>Objective</h4>The aim of this study was to investigate the role of magnetic resonance imaging ... Read more >>

SA J Radiol (SA journal of radiology)
[2021, 25(1):2010]

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No Association Between ADIPOQ or MTHFR Polymorphisms and Gestational Diabetes Mellitus in South African Women.

Stephanie Dias, Sumaiya Adam, Paul Rheeder, Carmen Pheiffer,

<h4>Purpose</h4>Gestational diabetes mellitus (GDM) is a growing public health concern. GDM affects approximately 14% of pregnancies globally, and without effective treatment, is associated with short- and long-term complications in mother and child. Lower serum adiponectin <i>(ADIPOQ)</i> concentrations and aberrant DNA methylation have been reported during GDM. The aim of this ... Read more >>

Diabetes Metab Syndr Obes (Diabetes, metabolic syndrome and obesity : targets and therapy)
[2021, 14:791-800]

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Adiponectin DNA methylation in South African women with gestational diabetes mellitus: Effects of HIV infection.

Stephanie Dias, Sumaiya Adam, Yoonus Abrahams, Paul Rheeder, Carmen Pheiffer,

DNA methylation is increasingly recognized as a potential biomarker of metabolic disease. However, there is limited information on the impact of human immunodeficiency virus (HIV) infection on the candidacy of DNA methylation to serve as molecular biomarkers. This study investigated the effect of HIV infection on DNA methylation patterns in ... Read more >>

PLoS One (PloS one)
[2021, 16(3):e0248694]

Cited: 1 time

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Adiponectin as a Potential Biomarker for Pregnancy Disorders.

Carmen Pheiffer, Stephanie Dias, Babalwa Jack, Nompumelelo Malaza, Sumaiya Adam,

Adiponectin is an adipocyte-derived hormone that plays a critical role in energy homeostasis, mainly attributed to its insulin-sensitizing properties. Accumulating studies have reported that adiponectin concentrations are decreased during metabolic diseases, such as obesity and type 2 diabetes, with an emerging body of evidence providing support for its use as ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(3):]

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Intimate Partner Violence: A Risk Factor for Gestational Diabetes.

Carmen Pheiffer, Stephanie Dias, Sumaiya Adam,

The early detection and management of gestational diabetes mellitus (GDM) is an important public health goal. GDM, which is defined as a glucose intolerance that develops during pregnancy, affects about 14% of pregnancies globally, and without effective treatment, it is associated with adverse short- and long-term maternal and neonatal outcomes. ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(21):]

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Altered Genome-Wide DNA Methylation in Peripheral Blood of South African Women with Gestational Diabetes Mellitus.

Stephanie Dias, Sumaiya Adam, Paul Rheeder, Johan Louw, Carmen Pheiffer,

Increasing evidence implicate altered DNA methylation in the pathophysiology of gestational diabetes mellitus (GDM). This exploratory study probed the association between GDM and peripheral blood DNA methylation patterns in South African women. Genome-wide DNA methylation profiling was conducted in women with (<i>n</i> = 12) or without (<i>n</i> = 12) GDM ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(23):]

Cited: 5 times

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MicroRNA Profiling in HIV-Infected South African Women with Gestational Diabetes Mellitus.

Carmen Pheiffer, Stephanie Dias, Paul Rheeder, Sumaiya Adam,

BACKGROUND:Recently, we reported that the microRNAs (miRNAs) miR-20a-5p and-to a lesser extent-miR-222-3p hold potential as biomarkers for gestational diabetes mellitus (GDM) in human immunodeficiency virus (HIV)-negative South African women. METHODS:In this preliminary study, we measured the expression of these miRNAs in HIV-positive women (GDM 15, non-GDM 52; median 26.0 weeks; range ... Read more >>

Mol Diagn Ther (Molecular diagnosis & therapy)
[2019, 23(4):499-505]

Cited: 3 times

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Pena-Shokeir syndrome: current management strategies and palliative care.

Sumaiya Adam, Melantha Coetzee, Engela Magdalena Honey,

Pena-Shokeir syndrome (PSS) type 1, also known as fetal akinesia deformation sequence, is a rare genetic syndrome that almost always results in intrauterine or early neonatal death. It is characterized by markedly decreased fetal movements, intrauterine growth restriction, joint contractures, short umbilical cord, and features of pulmonary hypoplasia. Antenatal diagnosis ... Read more >>

Appl Clin Genet (The application of clinical genetics)
[2018, 11:111-120]

Cited: 1 time

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Global DNA methylation profiling in peripheral blood cells of South African women with gestational diabetes mellitus.

Stephanie Dias, Sumaiya Adam, Nastasja Van Wyk, Paul Rheeder, Johan Louw, Carmen Pheiffer,

<b>Background/Objective:</b> Recently, several studies have reported that DNA methylation changes in tissue are reflected in blood, sparking interest in the potential use of global DNA methylation as a biomarker for gestational diabetes mellitus (GDM). This study investigated whether global DNA methylation is associated with GDM in South African women. <b>Methods:</b> ... Read more >>

Biomarkers (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals)
[2019, 24(3):225-231]

Cited: 3 times

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Molecular Biomarkers for Gestational Diabetes Mellitus.

Stephanie Dias, Carmen Pheiffer, Yoonus Abrahams, Paul Rheeder, Sumaiya Adam,

Gestational diabetes mellitus (GDM) is a growing public health problem worldwide. The condition is associated with perinatal complications and an increased risk for future metabolic disease in both mothers and their offspring. In recent years, molecular biomarkers received considerable interest as screening tools for GDM. The purpose of this review ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(10):]

Cited: 10 times

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Decreased Expression of Circulating miR-20a-5p in South African Women with Gestational Diabetes Mellitus.

Carmen Pheiffer, Stephanie Dias, Paul Rheeder, Sumaiya Adam,

BACKGROUND AND OBJECTIVE:In recent years circulating microRNAs (miRNAs) have attracted interest as biomarkers of metabolic disease. MiRNA expression varies across population groups; thus, the aim of this study was to investigate whether serum miRNAs that have previously been shown to be associated with gestational diabetes mellitus (GDM) in other populations, ... Read more >>

Mol Diagn Ther (Molecular diagnosis & therapy)
[2018, 22(3):345-352]

Cited: 19 times

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Association between gestational diabetes and biomarkers: a role in diagnosis.

Sumaiya Adam, Carmen Pheiffer, Stephanie Dias, Paul Rheeder,

We investigated the association between markers of insulin resistance, chronic inflammation, and adipokines and GDM.In our case-cohort study in Johannesburg we included women with GDM and controls. We tested the ability of biomarkers to identify women at high risk of GDM.Of the 262 pregnant women, 83 (31.7%) had GDM. Women ... Read more >>

Biomarkers (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals)
[2018, 23(4):386-391]

Cited: 4 times

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Evaluating the utility of a point-of-care glucometer for the diagnosis of gestational diabetes.

Sumaiya Adam, Paul Rheeder,

<h4>Objective</h4>To investigate the performance of the Roche Accuchek Active glucometer in diagnosing gestational diabetes mellitus (GDM) versus the gold-standard laboratory test.<h4>Methods</h4>In a prospective cohort observational study at a primary healthcare clinic in Johannesburg, South Africa, pregnant women, excluding known diabetics, were recruited between 2013 and 2016. A 75-g 2-hour oral ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2018, 141(1):91-96]

Cited: 3 times

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Screening for gestational diabetes mellitus in a South African population: Prevalence, comparison of diagnostic criteria and the role of risk factors.

Sumaiya Adam, Paul Rheeder,

<h4>Background</h4>The prevalence of gestational diabetes mellitus (GDM) is increasing. Most major world organisations now recommend universal screening for GDM based on the International Association of Diabetes in Pregnancy Study Groups (IADPSG) criteria. Currently there is a lack of consensus on the diagnostic criteria for GDM used in South Africa (SA). ... Read more >>

S Afr Med J (South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde)
[2017, 107(6):523-527]

Cited: 31 times

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Selective Screening Strategies for Gestational Diabetes: A Prospective Cohort Observational Study.

Sumaiya Adam, Paul Rheeder,

Aim:We aimed to develop a prediction model for the diagnosis of gestational diabetes and to evaluate the performance of published prediction tools on our population. Methods:We conducted a cohort study on nondiabetic women < 26 weeks gestation at a level 1 clinic in Johannesburg, South Africa. At recruitment, participants completed a questionnaire ... Read more >>

J Diabetes Res (Journal of diabetes research)
[2017, 2017:2849346]

Cited: 3 times

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Discordant monoamniotic twins with Pena-Shokeir phenotype.

Sumaiya Adam, Hennie Lombaard, Careni Spencer,

Pena-Shokeir phenotype is a rare disorder. However, its etiology is incompletely understood. It may be familial or may be due to anoxic-ischemic etiology. Although rare, it can affect one twin in a monoamniotic pregnancy, most likely due to early cord entanglement. ... Read more >>

Clin Case Rep (Clinical case reports)
[2016, 4(10):919-921]

Cited: 1 time

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Autologous intrauterine transfusion in a case of anti-U.

Sumaiya Adam, Hennie Lombaard,

<h4>Background</h4>Minor red blood cell antibodies are becoming a more common cause of hemolytic disease of the newborn. Anti-U are a rare alloantibody found almost exclusively in people of black descent. There is limited experience to guide the management of pregnancies complicated by anti-U. Furthermore, there is often no suitable cross-matched ... Read more >>

Transfusion (Transfusion)
[2016, 56(12):3029-3032]

Cited: 2 times

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An audit of the initial resuscitation of severely ill patients presenting with septic incomplete miscarriages at a tertiary hospital in South Africa.

Hennie Lombaard, Sumaiya Adam, Jennifer Makin, Patricia Sebola,

<h4>Background</h4>Septic incomplete miscarriages remain a cause of maternal deaths in South Africa. There was an initial decline in mortality when a strict protocol based approach and the Choice of Termination of Pregnancy Act in South Africa were implemented in this country. However, a recent unpublished audit at the Pretoria Academic ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2015, 15:82]

Cited: 1 time

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