Full Text Journal Articles by
Author Suma Choorapoikayil

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Current concepts in the evaluation and management of preoperative anemia.

Vanessa Neef, Suma Choorapoikayil, Florian Piekarski, Tobias Schlesinger, Patrick Meybohm, Kai Zacharowski,

<h4>Purpose of review</h4>In the past years, patient blood management (PBM) has evolved to improve patient's care and safety. Anemia is one of the most common medical diseases in the world and is an independent risk factor for morbidity and mortality. Iron deficiency is the main cause for anemia and constitutes ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):352-356]

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Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality: A Systematic Review, Meta-analysis, and Meta-regression.

Isabel Taeuber, Stephanie Weibel, Eva Herrmann, Vanessa Neef, Tobias Schlesinger, Peter Kranke, Leila Messroghli, Kai Zacharowski, Suma Choorapoikayil, Patrick Meybohm,

<h4>Importance</h4>Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns remain about the potential adverse effects, particularly vascular occlusive events, that may be associated with its use.<h4>Objective</h4>To examine the association between intravenous TXA and total thromboembolic events (TEs) and mortality in patients of all ages and of any medical disciplines.<h4>Data ... Read more >>

JAMA Surg (JAMA surgery)
[2021, :e210884]

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The association between intraoperative cell salvage and red blood cell transfusion in cardiac surgery - an observational study in a patient blood management centre.

Vanessa Neef, Linda Vo, Eva Herrmann, Chris Triphaus, Leonie Judd, Andreas Winter, Kai Zacharowski, Suma Choorapoikayil, Patrick Meybohm,

<h4>Introduction</h4>Cell salvage (CS) is an integral part of patient blood management (PBM) and aims to reduce allogeneic red blood cell (RBC) transfusion.<h4>Material and methods</h4>This observational study analysed patients scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB) between November 2015 and October 2018. Patients were divided into a CS group (patients ... Read more >>

Anaesthesiol Intensive Ther (Anaesthesiology intensive therapy)
[2021, 53(1):1-9]

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Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells.

Sasja Blokzijl-Franke, Bas Ponsioen, Stefan Schulte-Merker, Philippe Herbomel, Karima Kissa, Suma Choorapoikayil, Jeroen den Hertog,

Hematopoietic stem and progenitor cells (HSPCs) are multipotent cells giving rise to all blood lineages during life. HSPCs emerge from the ventral wall of the dorsal aorta (VDA) during a specific timespan in embryonic development through endothelial hematopoietic transition (EHT). We investigated the ontogeny of HSPCs in mutant zebrafish embryos ... Read more >>

Oncogene (Oncogene)
[2021, 40(15):2741-2755]

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Implementation of an anaemia walk-in clinic: Feasibility and preliminary data from the Orthopedic University Hospital.

Vanessa Neef, David Meisenzahl, Paul Kessler, Florian J Raimann, Florian Piekarski, Suma Choorapoikayil, Christoph Fleege, Kai D Zacharowski, Patrick Meybohm, Andrea Meurer,

<h4>Background</h4>Approximately one in three patients suffers from preoperative anaemia. Even though haemoglobin is measured before surgery, anaemia management is not implemented in every hospital.<h4>Objective</h4>Here, we demonstrate the implementation of an anaemia walk-in clinic at an Orthopedic University Hospital. To improve the diagnosis of iron deficiency (ID), we examined whether reticulocyte ... Read more >>

Transfus Med (Transfusion medicine (Oxford, England))
[2020, 30(6):467-474]

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Factors influencing the bias between blood gas analysis versus central laboratory hemoglobin testing. A secondary analysis of a randomized controlled trial.

Linda Tanner, Simone Lindau, Markus Velten, Tobias Schlesinger, Maria Wittmann, Peter Kranke, Kira Berg, Florian Piekarski, Christoph Füllenbach, Suma Choorapoikayil, Dirk Hasenclever, Kai Zacharowski, Patrick Meybohm,

<h4>Background</h4>Anemia is the most important complication during major surgery and transfusion of red blood cells is the mainstay to compensate for life threating blood loss. Therefore, accurate measurement of hemoglobin (Hb) concentration should be provided in real-time. Blood Gas Analysis (BGA) provides rapid point-of-care assessment using smaller sampling tubes compared ... Read more >>

PLoS One (PloS one)
[2020, 15(10):e0240721]

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A nationwide Turkish movement to implement Patient Blood Management.

Suma Choorapoikayil, Kai Zacharowski,

Blood Transfus (Blood transfusion = Trasfusione del sangue)
[2020, 18(4):241-243]

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Comparison of common perioperative blood loss estimation techniques: a systematic review and meta-analysis.

Lara Gerdessen, Patrick Meybohm, Suma Choorapoikayil, Eva Herrmann, Isabel Taeuber, Vanessa Neef, Florian J Raimann, Kai Zacharowski, Florian Piekarski,

Estimating intraoperative blood loss is one of the daily challenges for clinicians. Despite the knowledge of the inaccuracy of visual estimation by anaesthetists and surgeons, this is still the mainstay to estimate surgical blood loss. This review aims at highlighting the strengths and weaknesses of currently used measurement methods. A ... Read more >>

J Clin Monit Comput (Journal of clinical monitoring and computing)
[2021, 35(2):245-258]

Cited: 2 times

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Phosphatidylinositol-3 kinase activity controls survival and stemness of zebrafish hematopoietic stem/progenitor cells

Sasja Blokzijl-Franke, Bas Ponsioen, Stefan Schulte-Merker, Philippe Herbomel, Karima Kissa, Suma Choorapoikayil, Jeroen den Hertog,

Hematopoietic Stem and Progenitor Cells (HSPCs) are multipotent cells giving rise to all blood lineages during life. HSPCs emerge from the ventral wall of the dorsal aorta (VDA) during a specific timespan in embryonic development through endothelial hematopoietic transition (EHT). We investigated the ontogeny of HSPCs in mutant zebrafish embryos ... Read more >>

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Health economics of Patient Blood Management: a cost-benefit analysis based on a meta-analysis.

Patrick Meybohm, Niels Straub, Christoph Füllenbach, Leonie Judd, Adina Kleinerüschkamp, Isabel Taeuber, Kai Zacharowski, Suma Choorapoikayil,

BACKGROUND AND OBJECTIVES:Patient Blood Management (PBM) is the timely application of evidence-based medical and surgical concepts designed to improve haemoglobin concentration, optimize haemostasis and minimize blood loss in an effort to improve patient outcomes. The focus of this cost-benefit analysis is to analyse the economic benefit of widespread implementation of ... Read more >>

Vox Sang (Vox sanguinis)
[2020, 115(2):182-188]

Cited: 1 time

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Effectiveness of Preoperative Iron Supplementation in Major Surgical Patients with Iron Deficiency: A Prospective Observational Study.

Chris Triphaus, Leonie Judd, Patricia Glaser, Marie H Goehring, Elke Schmitt, Sabine Westphal, Christoph Füllenbach, Simone Lindau, Kai Zacharowski, Patrick Meybohm, Suma Choorapoikayil,

OBJECTIVE:To evaluate the effectiveness of routine intravenous iron in surgical patients with iron deficiency anemia (IDA). BACKGROUND:Anemia is the most common medical disease in the world and is an independent risk factor for morbidity and mortality. Iron deficiency (ID) is the main cause for anemia and constitutes a potentially preventable ... Read more >>

Ann Surg (Annals of surgery)
[2019, :]

Cited: 2 times

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Screening for iron deficiency in surgical patients based on noninvasive zinc protoporphyrin measurements.

Christoph Füllenbach, Philipp Stein, Patricia Glaser, Chris Triphaus, Simone Lindau, Suma Choorapoikayil, Elke Schmitt, Kai Zacharowski, Gudrun Hintereder, Georg Hennig, Christian Homann, Herbert Stepp, Gabriela H Spahn, Alexander Kaserer, Andreas Schedler, Patrick Meybohm, Donat R Spahn,

<h4>Background</h4>Approximately every third surgical patient is anemic. The most common form, iron deficiency anemia, results from persisting iron-deficient erythropoiesis (IDE). Zinc protoporphyrin (ZnPP) is a promising parameter for diagnosing IDE, hitherto requiring blood drawing and laboratory workup.<h4>Study design and methods</h4>Noninvasive ZnPP (ZnPP-NI) measurements are compared to ZnPP reference determination of ... Read more >>

Transfusion (Transfusion)
[2020, 60(1):62-72]

Cited: 1 time

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Preoperative Anaemia in Primary Hip and Knee Arthroplasty.

Patrick Meybohm, Hendrik Kohlhof, Dieter Christian Wirtz, Ingo Marzi, Christoph Füllenbach, Suma Choorapoikayil, Maria Wittmann, Ursula Marschall, Josef Thoma, Klaus Schwendner, Patrick Stark, Ansgar Raadts, Jens Friedrich, Henry Weigt, Patrick Friederich, Josef Huber, Martin Gutjahr, Elke Schmitt, Kai Zacharowski,

<h4>Introduction</h4>Approximately one in three patients has untreated preoperative anaemia, which in turn is associated with an increased need for transfusion of allogenic red blood cell concentrates (RBC) and complications in the context of a surgical intervention. Here, the prevalence of preoperative and postoperative anaemia as well as their effects on ... Read more >>

Z Orthop Unfall (Zeitschrift fur Orthopadie und Unfallchirurgie)
[2020, 158(2):194-200]

Cited: 2 times

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Multimodal Patient Blood Management Program Based on a Three-pillar Strategy: A Systematic Review and Meta-analysis.

Friederike C Althoff, Holger Neb, Eva Herrmann, Kevin M Trentino, Lee Vernich, Christoph Füllenbach, John Freedman, Jonathan H Waters, Shannon Farmer, Michael F Leahy, Kai Zacharowski, Patrick Meybohm, Suma Choorapoikayil,

<h4>Objectives</h4>To determine whether a multidisciplinary, multimodal Patient Blood Management (PBM) program for patients undergoing surgery is effective in reducing perioperative complication rate, and thereby is effective in improving clinical outcome.<h4>Background</h4>PBM is a medical concept with the focus on a comprehensive anemia management, to minimize iatrogenic (unnecessary) blood loss, and to ... Read more >>

Ann Surg (Annals of surgery)
[2019, 269(5):794-804]

Cited: 18 times

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Perioperative Anemia Management as Part of PBM in Cardiac Surgery - A Narrative Updated Review.

Patrick Meybohm, Sabine Westphal, Hanne Berg Ravn, Marco Ranucci, Seema Agarwal, Suma Choorapoikayil, Donat R Spahn, Aamer B Ahmed, Bernd Froessler, Kai Zacharowski,

Anemia is common in patients with cardiac disease. Iron deficiency is the cause of anemia in about 80% of all cases. Preoperative anemia is associated with an increased morbidity and mortality in patients undergoing cardiac surgery. The risk of receiving red blood cell transfusions, which are potentially associated with severe ... Read more >>

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2020, 34(4):1060-1073]

Cited: 0 times

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[Patient Blood Management: Preoperative Anemia and Case Reports from the Anemia Walk-In Clinic].

Sabine Westphal, Sabine Isik, Suma Choorapoikayil, Christoph Füllenbach, Kai Zacharowski, Patrick Meybohm,

Preoperative anemia is independently associated with increased morbidity and mortality and represents the strongest predictor for transfusion of red blood cells. Iron deficiency anemia is the most frequent form of anemia and could easily be treated by supplementation with iron. Patient Blood Management (PBM) focusses on prevention and management of ... Read more >>

Anasthesiol Intensivmed Notfallmed Schmerzther (Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS)
[2019, 54(3):182-193]

Cited: 1 time

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Liberal transfusion strategy to prevent mortality and anaemia-associated, ischaemic events in elderly non-cardiac surgical patients – the study design of the LIBERAL-Trial

Patrick Meybohm, Michael Bauer, Marion Ferner, Eva Wittenmeier, Karl-Heinz Gürtler, Peter Kienbaum, Marcel Gama de Abreu, Michael Sander, Timo Seyfried, Antonia Helf, Matthias Gruenewald, Suma Choorapoikayil, Markus Mueller, Erhard Seifried, Oana Brosteanu, Holger Bogatsch, Dirk Hasenclever, Rita Laufenberg-Feldmann, Markus Kredel, Simone Lindau, Christian Stoppe, Sascha Treskatsch, Roland Francis, Claudia Spies, Markus Velten, Maria Wittmann, Erdem Gueresir, Ana Kowark, Peter Kranke, Mark Coburn, Sixten Selleng, Marcel Baschin, Gregor Jenichen, Melanie Meersch, Thomas Ermert, Alexander Zarbock, Kai Zacharowski,

<h4>Background: </h4> Perioperative anaemia leads to impaired oxygen supply with a risk of vital organ ischaemia. In healthy and fit individuals, anaemia can be compensated by several mechanisms. Elderly patients, however, have less compensatory mechanisms because of multiple co-morbidities and aging-related decline of functional reserves. The purpose of the study ... Read more >>

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[Cell Salvage in Anesthesiology].

Sabine Westphal, Kai Zacharowski, Suma Choorapoikayil, Christoph Füllenbach, Patrick Meybohm,

Re-infusion of washed autologous blood cell salvage from the operative field and wound drainages is used as part of blood conservation strategy within Patient Blood Management (PBM). Cell salvage is an effective method to reduce allogeneic blood transfusion. A main advantage of cell salvage is the prevention of storage-related damage ... Read more >>

Anasthesiol Intensivmed Notfallmed Schmerzther (Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS)
[2019, 54(3):170-181]

Cited: 0 times

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Cell salvage using the continuous autotransfusion device CATSmart - an observational bicenter technical evaluation.

Simone Lindau, Madeline Kohlhaas, Michael Nosch, Suma Choorapoikayil, Kai Zacharowski, Patrick Meybohm,

<h4>Background</h4>The use of cell salvage and autologous blood transfusion has become an important method of blood conservation. So far, there are no clinical data about the performance of the continuous autotransfusion device CATSmart.<h4>Methods</h4>In total, 74 patients undergoing either cardiac or orthopedic surgery were included in this prospective, bicenter and observational ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2018, 18(1):189]

Cited: 1 time

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Liberal transfusion strategy to prevent mortality and anaemia-associated, ischaemic events in elderly non-cardiac surgical patients - the study design of the LIBERAL-Trial.

Patrick Meybohm, Simone Lindau, Sascha Treskatsch, Roland Francis, Claudia Spies, Markus Velten, Maria Wittmann, Erdem Gueresir, Christian Stoppe, Ana Kowark, Mark Coburn, Sixten Selleng, Marcel Baschin, Gregor Jenichen, Melanie Meersch, Thomas Ermert, Alexander Zarbock, Peter Kranke, Markus Kredel, Antonia Helf, Rita Laufenberg-Feldmann, Marion Ferner, Eva Wittenmeier, Karl-Heinz Gürtler, Peter Kienbaum, Marcel Gama de Abreu, Michael Sander, Michael Bauer, Timo Seyfried, Matthias Gruenewald, Suma Choorapoikayil, Markus M Mueller, Erhard Seifried, Oana Brosteanu, Holger Bogatsch, Dirk Hasenclever, Kai Zacharowski, ,

BACKGROUND:Perioperative anaemia leads to impaired oxygen supply with a risk of vital organ ischaemia. In healthy and fit individuals, anaemia can be compensated by several mechanisms. Elderly patients, however, have less compensatory mechanisms because of multiple co-morbidities and age-related decline of functional reserves. The purpose of the study is to ... Read more >>

Trials (Trials)
[2019, 20(1):101]

Cited: 1 time

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Red blood cell transfusion and its alternatives in oncologic surgery-A critical evaluation.

Dania Fischer, Holger Neb, Suma Choorapoikayil, Kai Zacharowski, Patrick Meybohm,

Although blood transfusions have been used for more than 100 years and their potential to save lives is indisputable, there is still limited data on medium- and long-term outcomes after hemotherapy. Until recently, red blood cell transfusions represented the most commonly employed treatment for cancer anemia. As transfusions have been ... Read more >>

Crit Rev Oncol Hematol (Critical reviews in oncology/hematology)
[2019, 134:1-9]

Cited: 3 times

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A model-based cost-effectiveness analysis of Patient Blood Management.

Adina Kleinerüschkamp, Patrick Meybohm, Niels Straub, Kai Zacharowski, Suma Choorapoikayil,

<h4>Background</h4>Patient blood management (PBM) is a multidisciplinary concept focused on the management of anaemia, minimisation of iatrogenic blood loss and rational use of allogeneic blood products. The aims of this study were: (i) to analyse post-operative outcome in patients with liberal vs restrictive exposure to allogeneic blood products and (ii) ... Read more >>

Blood Transfus (Blood transfusion = Trasfusione del sangue)
[2019, 17(1):16-26]

Cited: 2 times

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Patient Blood Management is Associated With a Substantial Reduction of Red Blood Cell Utilization and Safe for Patient's Outcome: A Prospective, Multicenter Cohort Study With a Noninferiority Design.

Patrick Meybohm, Eva Herrmann, Andrea U Steinbicker, Maria Wittmann, Matthias Gruenewald, Dania Fischer, Georg Baumgarten, Jochen Renner, Hugo K Van Aken, Christian F Weber, Markus M Mueller, Christof Geisen, Julia Rey, Dimitra Bon, Gudrun Hintereder, Suma Choorapoikayil, Johannes Oldenburg, Christian Brockmann, Raoul G Geissler, Erhard Seifried, Kai Zacharowski, ,

<h4>Objective</h4>To determine whether the implementation of patient blood management (PBM) is effective to decrease the use of red blood cell without impairment of patient's safety.<h4>Background</h4>The World Health Organization encouraged all member states to implement PBM programs employing multiple combined strategies to increase and preserve autologous erythrocyte volume to minimize red ... Read more >>

Ann Surg (Annals of surgery)
[2016, 264(2):203-211]

Cited: 45 times

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Washed cell salvage in surgical patients: A review and meta-analysis of prospective randomized trials under PRISMA.

Patrick Meybohm, Suma Choorapoikayil, Anke Wessels, Eva Herrmann, Kai Zacharowski, Donat R Spahn,

<h4>Background</h4>Cell salvage is commonly used as part of a blood conservation strategy. However concerns among clinicians exist about the efficacy of transfusion of washed cell salvage.<h4>Methods</h4>We performed a meta-analysis of randomized controlled trials in which patients, scheduled for all types of surgery, were randomized to washed cell salvage or to ... Read more >>

Medicine (Madr) (Medicine)
[2016, 95(31):e4490]

Cited: 17 times

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Patient Blood Management Bundles to Facilitate Implementation.

Patrick Meybohm, Toby Richards, James Isbister, Axel Hofmann, Aryeh Shander, Lawrence Tim Goodnough, Manuel Muñoz, Hans Gombotz, Christian Friedrich Weber, Suma Choorapoikayil, Donat R Spahn, Kai Zacharowski,

More than 30% of the world's population are anemic with serious economic consequences including reduced work capacity and other obstacles to national welfare and development. Red blood cell transfusion is the mainstay to correct anemia, but it is also 1 of the top 5 overused procedures. Patient blood management (PBM) ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2017, 31(1):62-71]

Cited: 39 times

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