Full Text Journal Articles by
Author Suellen M Walker

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Delivering transformative action in paediatric pain: a Lancet Child & Adolescent Health Commission.

Christopher Eccleston, Emma Fisher, Richard F Howard, Rebeccah Slater, Paula Forgeron, Tonya M Palermo, Kathryn A Birnie, Brian J Anderson, Christine T Chambers, Geert Crombez, Gustaf Ljungman, Isabel Jordan, Zachary Jordan, Caitriona Roberts, Neil Schechter, Christine B Sieberg, Dick Tibboel, Suellen M Walker, Dominic Wilkinson, Chantal Wood,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, :]

Cited: 0 times

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Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

James E D Thaventhiran, Hana Lango Allen, Oliver S Burren, William Rae, Daniel Greene, Emily Staples, Zinan Zhang, James H R Farmery, Ilenia Simeoni, Elizabeth Rivers, Jesmeen Maimaris, Christopher J Penkett, Jonathan Stephens, Sri V V Deevi, Alba Sanchis-Juan, Nicholas S Gleadall, Moira J Thomas, Ravishankar B Sargur, Pavels Gordins, Helen E Baxendale, Matthew Brown, Paul Tuijnenburg, Austen Worth, Steven Hanson, Rachel J Linger, Matthew S Buckland, Paula J Rayner-Matthews, Kimberly C Gilmour, Crina Samarghitean, Suranjith L Seneviratne, David M Sansom, Andy G Lynch, Karyn Megy, Eva Ellinghaus, David Ellinghaus, Silje F Jorgensen, Tom H Karlsen, Kathleen E Stirrups, Antony J Cutler, Dinakantha S Kumararatne, Anita Chandra, J David M Edgar, Archana Herwadkar, Nichola Cooper, Sofia Grigoriadou, Aarnoud P Huissoon, Sarah Goddard, Stephen Jolles, Catharina Schuetz, Felix Boschann, , Paul A Lyons, Matthew E Hurles, Sinisa Savic, Siobhan O Burns, Taco W Kuijpers, Ernest Turro, Willem H Ouwehand, Adrian J Thrasher, Kenneth G C Smith,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nature (Nature)
[2020, 584(7819):E2]

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A systematic review of outcomes reported inpediatric perioperative research: A report from the Pediatric Perioperative Outcomes Group.

Wallis T Muhly, Elsa Taylor, Cyrus Razavi, Suellen M Walker, Lei Yang, Jurgen C de Graaff, Laszlo Vutskits, Andrew Davidson, Yunxia Zuo, Carolina Pérez-Pradilla, Piedad Echeverry, Alexandra M Torborg, Ting Xu, Ellen Rawlinson, Rajeev Subramanyam, Simon Whyte, Robert Seal, Heidi M Meyer, Sandhya Yaddanapudi, Susan M Goobie, Joseph P Cravero, Aideen Keaney, M Ruth Graham, Tania Ramo, Paul A Stricker, ,

The Pediatric Perioperative Outcomes Group (PPOG) is an international collaborative of clinical investigators and clinicians within the subspecialty of pediatric anesthesiology and perioperative care which aims to use COMET (Core Outcomes Measures in Effectiveness Trials) methodology to develop core outcome setsfor infants, children and young people that are tailored to ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2020, :]

Cited: 0 times

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Whole-genome sequencing of patients with rare diseases in a national health system.

Ernest Turro, William J Astle, Karyn Megy, Stefan Gräf, Daniel Greene, Olga Shamardina, Hana Lango Allen, Alba Sanchis-Juan, Mattia Frontini, Chantal Thys, Jonathan Stephens, Rutendo Mapeta, Oliver S Burren, Kate Downes, Matthias Haimel, Salih Tuna, Sri V V Deevi, Timothy J Aitman, David L Bennett, Paul Calleja, Keren Carss, Mark J Caulfield, Patrick F Chinnery, Peter H Dixon, Daniel P Gale, Roger James, Ania Koziell, Michael A Laffan, Adam P Levine, Eamonn R Maher, Hugh S Markus, Joannella Morales, Nicholas W Morrell, Andrew D Mumford, Elizabeth Ormondroyd, Stuart Rankin, Augusto Rendon, Sylvia Richardson, Irene Roberts, Noemi B A Roy, Moin A Saleem, Kenneth G C Smith, Hannah Stark, Rhea Y Y Tan, Andreas C Themistocleous, Adrian J Thrasher, Hugh Watkins, Andrew R Webster, Martin R Wilkins, Catherine Williamson, James Whitworth, Sean Humphray, David R Bentley, , Nathalie Kingston, Neil Walker, John R Bradley, Sofie Ashford, Christopher J Penkett, Kathleen Freson, Kathleen E Stirrups, F Lucy Raymond, Willem H Ouwehand,

Most patients with rare diseases do not receive a molecular diagnosis and the aetiological variants and causative genes for more than half such disorders remain to be discovered1. Here we used whole-genome sequencing (WGS) in a national health system to streamline diagnosis and to discover unknown aetiological variants in the ... Read more >>

Nature (Nature)
[2020, 583(7814):96-102]

Cited: 2 times

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Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

James E D Thaventhiran, Hana Lango Allen, Oliver S Burren, William Rae, Daniel Greene, Emily Staples, Zinan Zhang, James H R Farmery, Ilenia Simeoni, Elizabeth Rivers, Jesmeen Maimaris, Christopher J Penkett, Jonathan Stephens, Sri V V Deevi, Alba Sanchis-Juan, Nicholas S Gleadall, Moira J Thomas, Ravishankar B Sargur, Pavels Gordins, Helen E Baxendale, Matthew Brown, Paul Tuijnenburg, Austen Worth, Steven Hanson, Rachel J Linger, Matthew S Buckland, Paula J Rayner-Matthews, Kimberly C Gilmour, Crina Samarghitean, Suranjith L Seneviratne, David M Sansom, Andy G Lynch, Karyn Megy, Eva Ellinghaus, David Ellinghaus, Silje F Jorgensen, Tom H Karlsen, Kathleen E Stirrups, Antony J Cutler, Dinakantha S Kumararatne, Anita Chandra, J David M Edgar, Archana Herwadkar, Nichola Cooper, Sofia Grigoriadou, Aarnoud P Huissoon, Sarah Goddard, Stephen Jolles, Catharina Schuetz, Felix Boschann, , Paul A Lyons, Matthew E Hurles, Sinisa Savic, Siobhan O Burns, Taco W Kuijpers, Ernest Turro, Willem H Ouwehand, Adrian J Thrasher, Kenneth G C Smith,

Primary immunodeficiency (PID) is characterized by recurrent and often life-threatening infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic challenges. Although the most severe forms of PID are identified in early childhood, most patients present in adulthood, typically with no apparent family history and a variable clinical phenotype ... Read more >>

Nature (Nature)
[2020, 583(7814):90-95]

Cited: 2 times

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Pediatric perioperative outcomes: Protocol for a systematic literature review and identification of a core outcome set for infants, children, and young people requiring anesthesia and surgery.

Cyrus Razavi, Suellen M Walker, S Ramani Moonesinghe, Paul A Stricker, ,

Clinical outcomes are measurable changes in health, function, or quality of life that are important for evaluating the quality of care and comparing the efficacy of interventions. However, clinical outcomes and related measurement tools need to be well-defined, relevant, and valid. In adults, Core Outcome Measures in Effectiveness Trials (COMET) ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2020, 30(4):392-400]

Cited: 0 times

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The feasibility and acceptability of research magnetic resonance imaging in adolescents with moderate-severe neuropathic pain.

Madeleine Verriotis, Massieh Moayedi, Clarissa Sorger, Judy Peters, Kiran Seunarine, Christopher A Clark, Suellen M Walker,

Introduction:Multimodal characterisation with questionnaires, Quantitative Sensory Testing (QST), and neuroimaging will improve understanding of neuropathic pain (NeuP) in adolescents. Magnetic resonance imaging (MRI) data in adolescents with NeuP are limited, and the perceived practical or ethical burden of scanning may represent a barrier to research. Objective:To determine the feasibility of ... Read more >>

Pain Rep (Pain reports)
[2020, 5(1):e807]

Cited: 0 times

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Long-term effects of neonatal pain.

Suellen M Walker,

Pain experienced during neonatal intensive care management can influence neurodevelopmental outcome and the somatosensory and/or emotional components of pain response in later life. Alterations in biological factors (e.g. peripheral and central somatosensory function and modulation, brain structure and connectivity) and psychosocial factors (e.g. gender, coping style, mood, parental response) that ... Read more >>

Semin Fetal Neonatal Med (Seminars in fetal & neonatal medicine)
[2019, 24(4):101005]

Cited: 1 time

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Germline selection shapes human mitochondrial DNA diversity.

Wei Wei, Salih Tuna, Michael J Keogh, Katherine R Smith, Timothy J Aitman, Phil L Beales, David L Bennett, Daniel P Gale, Maria A K Bitner-Glindzicz, Graeme C Black, Paul Brennan, Perry Elliott, Frances A Flinter, R Andres Floto, Henry Houlden, Melita Irving, Ania Koziell, Eamonn R Maher, Hugh S Markus, Nicholas W Morrell, William G Newman, Irene Roberts, John A Sayer, Kenneth G C Smith, Jenny C Taylor, Hugh Watkins, Andrew R Webster, Andrew O M Wilkie, Catherine Williamson, , , Sofie Ashford, Christopher J Penkett, Kathleen E Stirrups, Augusto Rendon, Willem H Ouwehand, John R Bradley, F Lucy Raymond, Mark Caulfield, Ernest Turro, Patrick F Chinnery,

Approximately 2.4% of the human mitochondrial DNA (mtDNA) genome exhibits common homoplasmic genetic variation. We analyzed 12,975 whole-genome sequences to show that 45.1% of individuals from 1526 mother-offspring pairs harbor a mixed population of mtDNA (heteroplasmy), but the propensity for maternal transmission differs across the mitochondrial genome. Over one generation, ... Read more >>

Science (Science (New York, N.Y.))
[2019, 364(6442):]

Cited: 17 times

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Priming of Adult Incision Response by Early-Life Injury: Neonatal Microglial Inhibition Has Persistent But Sexually Dimorphic Effects in Adult Rats.

Orla Moriarty, YuShan Tu, Ameet S Sengar, Michael W Salter, Simon Beggs, Suellen M Walker,

Neonatal hindpaw incision primes developing spinal nociceptive circuitry, resulting in enhanced hyperalgesia following reinjury in adulthood. Spinal microglia contribute to this persistent effect, and microglial inhibition at the time of adult reincision blocks the enhanced hyperalgesia. Here, we pharmacologically inhibited microglial function with systemic minocycline or intrathecal SB203580 at the ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2019, 39(16):3081-3093]

Cited: 4 times

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Pediatric Erythromelalgia and SCN9A Mutations: Systematic Review and Single-Center Case Series.

Luke Arthur, Kirsty Keen, Madeleine Verriotis, Judy Peters, Alison Kelly, Richard F Howard, Sulayman D Dib-Hajj, Stephen G Waxman, Suellen M Walker,

OBJECTIVES:To evaluate the clinical features of erythromelalgia in childhood associated with gain-of-function SCN9A mutations that increase activity of the Nav1.7 voltage-gated sodium channel, we conducted a systematic review of pediatric presentations of erythromelalgia related to SCN9A mutations, and compared pediatric clinical presentations of symptomatic erythromelalgia, with or without SCN9A mutations. ... Read more >>

J Pediatr (The Journal of pediatrics)
[2019, 206:217-224.e9]

Cited: 1 time

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Pediatric perioperative outcomes group: Defining core outcomes for pediatric anesthesia and perioperative medicine.

Paul A Stricker, Jurgen C de Graaff, Laszlo Vutskits, Wallis T Muhly, Ting Xu, Alexandra M Torborg, Yifei Jiang, Suellen M Walker, ,

Paediatr Anaesth (Paediatric anaesthesia)
[2018, 28(4):314-315]

Cited: 0 times

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Translational studies identify long-term impact of prior neonatal pain experience.

Suellen M Walker,

Pain (Pain)
[2017, 158 Suppl 1:S29-S42]

Cited: 12 times

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The big research question: who decides?

Suellen M Walker, Andrew Davidson,

Paediatr Anaesth (Paediatric anaesthesia)
[2016, 26(9):862-863]

Cited: 2 times

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Differential Suppression of Spontaneous and Noxious-evoked Somatosensory Cortical Activity by Isoflurane in the Neonatal Rat.

Pi-shan Chang, Suellen M Walker, Maria Fitzgerald,

The effect of neonatal anesthesia and pain on the developing brain is of considerable clinical importance, but few studies have evaluated noxious surgical input to the infant brain under anesthesia. Herein, the authors tested the effect of increasing isoflurane concentration on spontaneous and evoked nociceptive activity in the somatosensory cortex ... Read more >>

Anesthesiology (Anesthesiology)
[2016, 124(4):885-898]

Cited: 6 times

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Pain after surgery in children: clinical recommendations.

Suellen M Walker,

This article summarizes recent data related to the safety and efficacy of postoperative analgesia in children that influence clinical practice recommendations.Postoperative pain continues to be experienced by hospitalized children and following discharge after short stay or ambulatory surgery. Updated recommendations for post-tonsillectomy analgesia exclude codeine and suggest regular administration of ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2015, 28(5):570-576]

Cited: 9 times

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Surgical injury in the neonatal rat alters the adult pattern of descending modulation from the rostroventral medulla.

Suellen M Walker, Maria Fitzgerald, Gareth J Hathway,

Neonatal pain and injury can alter long-term sensory thresholds. Descending rostroventral medulla (RVM) pathways can inhibit or facilitate spinal nociceptive processing in adulthood. As these pathways undergo significant postnatal maturation, the authors evaluated long-term effects of neonatal surgical injury on RVM descending modulation.Plantar hind paw or forepaw incisions were performed ... Read more >>

Anesthesiology (Anesthesiology)
[2015, 122(6):1391-1400]

Cited: 28 times

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Targeting p38 Mitogen-activated Protein Kinase to Reduce the Impact of Neonatal Microglial Priming on Incision-induced Hyperalgesia in the Adult Rat.

Fred Schwaller, Simon Beggs, Suellen M Walker,

Neonatal surgical injury triggers developmentally regulated long-term changes that include enhanced hyperalgesia and spinal microglial reactivity after reinjury. To further evaluate priming of response by neonatal hindpaw incision, the authors investigated the functional role of spinal microglial p38 mitogen-activated protein kinase after reincision in adult rodents.Plantar hindpaw incision was performed ... Read more >>

Anesthesiology (Anesthesiology)
[2015, 122(6):1377-1390]

Cited: 12 times

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Persistent changes in peripheral and spinal nociceptive processing after early tissue injury.

Suellen M Walker, Simon Beggs, Mark L Baccei,

It has become clear that tissue damage during a critical period of early life can result in long-term changes in pain sensitivity, but the underlying mechanisms remain to be fully elucidated. Here we review the clinical and preclinical evidence for persistent alterations in nociceptive processing following neonatal tissue injury, which ... Read more >>

Exp Neurol (Experimental neurology)
[2016, 275 Pt 2:253-260]

Cited: 22 times

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Overview of neurodevelopment and pain research, possible treatment targets.

Suellen M Walker,

Pain is a common presenting and often persistent symptom for children with rheumatological disease. Pain is not clearly related to disease severity in children with inflammatory juvenile idiopathic arthritis, and presentations of non-inflammatory musculoskeletal pain are common but there is limited evidence to guide management. Pain assessment must extend beyond ... Read more >>

Best Pract Res Clin Rheumatol (Best practice & research. Clinical rheumatology)
[2014, 28(2):213-228]

Cited: 4 times

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Neonatal pain.

Suellen M Walker,

Effective management of procedural and postoperative pain in neonates is required to minimize acute physiological and behavioral distress and may also improve acute and long-term outcomes. Painful stimuli activate nociceptive pathways, from the periphery to the cortex, in neonates and behavioral responses form the basis for validated pain assessment tools. ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2014, 24(1):39-48]

Cited: 25 times

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Neuropathic pain in children.

Richard F Howard, Suzanne Wiener, Suellen M Walker,

Neuropathic pain (NP), due to a lesion or disease of the somatosensory nervous system, is not well documented or researched in children. NP is a clinical diagnosis that can be difficult, especially in younger children. Nevertheless, it is important to recognise NP, as pain mechanisms and consequently management and prognosis ... Read more >>

Arch. Dis. Child. (Archives of disease in childhood)
[2014, 99(1):84-89]

Cited: 27 times

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Biological and neurodevelopmental implications of neonatal pain.

Suellen M Walker,

Nociceptive pathways are functional following birth. In addition to physiological and behavioral responses, neurophysiological measures and neuroimaging evaluate nociceptive pathway function and quantify responses to noxious stimuli in preterm and term neonates. Intensive care and surgery can expose neonates to painful stimuli when the developing nervous system is sensitive to ... Read more >>

Clin Perinatol (Clinics in perinatology)
[2013, 40(3):471-491]

Cited: 36 times

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Opioid-sparing effects of perioperative paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) in children.

Ivan Wong, Celia St John-Green, Suellen M Walker,

BACKGROUND AND OBJECTIVES: Perioperative pain in children can be effectively managed with systemic opioids, but addition of paracetamol or nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce opioid requirements and potentially improve analgesia and/or reduce adverse effects. METHODS: A systematic literature search was conducted to identify trials evaluating postoperative opioid requirements in ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2013, 23(6):475-495]

Cited: 56 times

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Evaluation of spinal toxicity and long-term spinal reflex function after intrathecal levobupivaciane in the neonatal rat.

Emre Hamurtekin, Bethany L Fitzsimmons, Veronica I Shubayev, Marjorie R Grafe, Ronald Deumens, Tony L Yaksh, Suellen M Walker,

Neuraxial anesthesia is utilized in children of all ages. Local anesthetics produce dose-dependent toxicity in certain adult models, but the developing spinal cord may also be susceptible to drug-induced apoptosis. In postnatal rodents, we examined the effects of intrathecal levobupivacaine on neuropathology and long-term sensorimotor outcomes.Postnatal day 3 (P3) or ... Read more >>

Anesthesiology (Anesthesiology)
[2013, 119(1):142-155]

Cited: 12 times

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