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Coronavirus disease 2019 (COVID-19) pandemic and pregnancy.

Pradip Dashraath, Jing Lin Jeslyn Wong, Mei Xian Karen Lim, Li Min Lim, Sarah Li, Arijit Biswas, Mahesh Choolani, Citra Mattar, Lin Lin Su,

The current coronavirus disease 2019 (COVID-19) pneumonia pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading globally at an accelerated rate, with a basic reproduction number (R0) of 2-2.5, indicating that 2-3 persons will be infected from an index patient. A serious public health emergency, it ... Read more >>

Am. J. Obstet. Gynecol. (American journal of obstetrics and gynecology)
[2020, :]

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[Corrigendum] Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast‑like phenotype via the TGF‑β1/Smad3 pathway.

Bin Zhao, Hao Guan, Jia-Qi Liu, Zhao Zheng, Qin Zhou, Jian Zhang, Lin-Lin Su, Da-Hai Hu,

Following the publication of this article, the authors noticed that the published versions of Figs. 2, 7 and 8 contained incorrect western bands. In examining their raw data, the authors realized that they had used the fibroblasts of keloids [high expression of alpha‑smooth muscle actin (α‑SMA)] instead of adult dermal fibroblasts (low ... Read more >>

Int. J. Mol. Med. (International journal of molecular medicine)
[2020, 45(1):274-275]

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Erratum to "Human amniotic epithelial cells conditioned medium attenuates TGF-β1-induced human dermal fibroblasts transformation to myofibroblasts via TGF-β1/Smad3 pathway".

Bin Zhao, Jia-Qi Liu, Chen Yang, Zhao Zheng, Qin Zhou, Hao Guan, Lin-Lin Su, Da-Hai Hu,

Cytotherapy (Cytotherapy)
[2019, 21(9):1004-1005]

Cited: 0 times

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Exosomes in esophageal cancer: A review on tumorigenesis, diagnosis and therapeutic potential.

Lin-Lin Su, Xiao-Jing Chang, Huan-Di Zhou, Liu-Bing Hou, Xiao-Ying Xue,

Exosomes are nanovesicles secreted from various types of cells and can be isolated from various bodily fluids, such as blood and urine. The number and molecular contents, including proteins and RNA of exosomes, have been shown to reflect their parental cell origins, characteristics and biological behaviors. An increasing number of ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2019, 7(8):908-916]

Cited: 1 time

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Serum level of macrophage migration inhibitory factor predicts severity and prognosis in patients with ischemic stroke.

Chao-Wei Wang, Peng-Ju Ma, Yang-Yang Wang, Ming Yang, Lin-Lin Su, Shuo Wang, Yan-Xia Liu, Bin Yuan, Jian-Hua Zhao,

OBJECTIVE:To evaluate whether the macrophage migration inhibitory factor (MIF) level in serum of ischemic stroke patients was associated with their clinical severity and early outcome. METHODS:During February 2017-March 2018, consecutive patients admitted to our hospital because of first-ever ischemic stroke were identified. The prognostic value of MIF was set for ... Read more >>

Cytokine (Cytokine)
[2019, 115:8-12]

Cited: 1 time

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Aspirin resistance predicts unfavorable functional outcome in acute ischemic stroke patients.

Chao-Wei Wang, Lin-Lin Su, Qiu-Ju Hua, Ying He, Yan-Nan Fan, Ting-Ting Xi, Bin Yuan, Yan-Xia Liu, Si-Bei Ji,

OBJECTIVE:To investigate the prognostic value of aspirin reaction units (ARU) in a 3-month follow-up study in a cohort of Chinese patients with first-ever ischemic stroke. METHODS:Prospective single-center survey of acute ischemic stroke patients receiving aspirin therapy. Two hundred and seventy-five Chinese patients with first-ever ischemic stroke who previously received aspirin ... Read more >>

Brain Res. Bull. (Brain research bulletin)
[2018, 142:176-182]

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Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators.

Tuangsit Wataganara, Arundhati Gosavi, Katika Nawapun, Pradip D Vijayakumar, Nisarat Phithakwatchara, Mahesh Choolani, Lin Lin Su, Arijit Biswas, Citra N Z Mattar,

Fetoscopic laser coagulation of arterio-venous anastomoses (AVA) in a monochorionic placenta is the standard of care for twin-twin transfusion syndrome (TTTS), but is technically challenging and can lead to significant complications. Acquiring and maintaining the necessary surgical skills require consistent practice, a critical caseload, and time. Training on realistic surgical ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2018, (133):]

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Effect of gestational diabetes and hypertensive disorders of pregnancy on postpartum cardiometabolic risk.

Ling-Jun Li, Izzuddin M Aris, Lin Lin Su, Yap Seng Chong, Tien Yin Wong, Kok Hian Tan, Jie Jin Wang,

The cumulative effect of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) on postpartum cardio-metabolic diseases is equivocal. We aimed to assess the associations of GDM and HDP's individual and synergic contribution to risks of postpartum cardio-metabolic diseases (metabolic syndrome (MetS), abnormal glucose metabolism and hypertension (HTN)).Of participants ... Read more >>

Endocr Connect (Endocrine connections)
[2018, 7(3):433-442]

Cited: 1 time

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Acute downregulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1.

Yang Liu, Hao Guan, Ju-Lei Zhang, Zhao Zheng, Hong-Tao Wang, Ke Tao, Shi-Chao Han, Lin-Lin Su, Dahai Hu,

MicroRNA-199a (miR-199a) is a novel gene regulator with an important role in inflammation and lung injury. However, its role in the pathogenesis of sepsis-induced acute respiratory distress syndrome (ARDS) is currently unknown. Our study explored the role of miR-199a in sepsis-induced ARDS and its mechanism of action. First, we found ... Read more >>

Am. J. Physiol., Cell Physiol. (American journal of physiology. Cell physiology)
[2018, 314(4):C449-C455]

Cited: 4 times

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Up-regulation of FGFBP1 signaling contributes to miR-146a-induced angiogenesis in human umbilical vein endothelial cells.

Hua-Yu Zhu, Wen-Dong Bai, Jia-Qi Liu, Zhao Zheng, Hao Guan, Qin Zhou, Lin-Lin Su, Song-Tao Xie, Yun-Chuan Wang, Jun Li, Na Li, Yi-Jie Zhang, Hong-Tao Wang, Da-Hai Hu,

Recent microRNA expression profiling studies have documented an up-regulation of miR-146a in several angiogenesis models. However, the underlying molecular mechanism of miR-146a in the angiogenic activity of endothelial cells has not been clearly elucidated. The present study was aimed to evaluate whether miR-146a promotes angiogenesis in HUVECs by increasing FGFBP1 ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:25272]

Cited: 10 times

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Long-Term Fate of Human Fetal Liver Progenitor Cells Transplanted in Injured Mouse Livers.

Antony Irudayaswamy, Mark Muthiah, Lei Zhou, Hau Hung, Nur Halisah Bte Jumat, Jamil Haque, Narcissus Teoh, Geoffrey Farrell, Kimberly J Riehle, Jaymie Siqi Lin, Lin Lin Su, Jerry Ky Chan, Mahesh Choolani, Peng Cheang Wong, Aileen Wee, Seng Gee Lim, Jean Campbell, Nelson Fausto, Yock Young Dan,

Liver progenitor cells have the potential to repair and regenerate a diseased liver. The success of any translational efforts, however, hinges on thorough understanding of the fate of these cells after transplant, especially in terms of long-term safety and efficacy. Here, we report transplantation of a liver progenitor population isolated ... Read more >>

Stem Cells (Stem cells (Dayton, Ohio))
[2018, 36(1):103-113]

Cited: 2 times

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Associations of physical activity and sedentary behavior during pregnancy with gestational diabetes mellitus among Asian women in Singapore.

Natarajan Padmapriya, Jonathan Y Bernard, Shen Liang, See Ling Loy, Shirong Cai, Iris Shen Zhe, Kenneth Kwek, Keith M Godfrey, Peter D Gluckman, Seang Mei Saw, Yap-Seng Chong, Jerry Kok Yen Chan, Falk Müller-Riemenschneider, ,

Few studies have investigated physical activity (PA) and sedentary behavior (SB) in relation to fasting (FG) and 2-h postprandial plasma glucose (2hPG) levels and gestational diabetes mellitus (GDM); we investigated these associations among Asian pregnant women.As part of the Growing Up in Singapore Towards healthy Outcomes cohort study, PA and ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2017, 17(1):364]

Cited: 6 times

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Management of the extensive thoracic defects after deep sternal wound infection with the rectus abdominis myocutaneous flap: A retrospective case series.

Yue-Hua Li, Zhao Zheng, Jiaomei Yang, Lin-Lin Su, Yang Liu, Fu Han, Jia-Qi Liu, Da-Hai Hu,

Deep sternal wound infection is a severe complication after open heart surgery. According to the different severity and dimensions of the deep sternal wound infection, the treatment method is different. In this study, we aimed to describe our experience with the rectus abdominis myocutaneous flap for large sternal wound management, ... Read more >>

Medicine (Baltimore) (Medicine)
[2017, 96(16):e6391]

Cited: 0 times

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Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome.

Xinyi Lin, Ives Yubin Lim, Yonghui Wu, Ai Ling Teh, Li Chen, Izzuddin M Aris, Shu E Soh, Mya Thway Tint, Julia L MacIsaac, Alexander M Morin, Fabian Yap, Kok Hian Tan, Seang Mei Saw, Michael S Kobor, Michael J Meaney, Keith M Godfrey, Yap Seng Chong, Joanna D Holbrook, Yung Seng Lee, Peter D Gluckman, Neerja Karnani, ,

Obesity is an escalating health problem worldwide, and hence the causes underlying its development are of primary importance to public health. There is growing evidence that suboptimal intrauterine environment can perturb the metabolic programing of the growing fetus, thereby increasing the risk of developing obesity in later life. However, the ... Read more >>

BMC Med (BMC medicine)
[2017, 15(1):50]

Cited: 26 times

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Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-β1/Smad3 pathway.

Bin Zhao, Hao Guan, Jia-Qi Liu, Zhao Zheng, Qin Zhou, Jian Zhang, Lin-Lin Su, Da-Hai Hu,

Keloids, partially considered as benign tumors, are characterized by the overgrowth of fibrosis beyond the boundaries of the wound and are regulated mainly by transforming growth factor (TGF)-β1, which induces the transition of fibroblasts to myofibroblasts. Hypoxia is an important driving force in the development of lung and liver fibrosis by ... Read more >>

Int. J. Mol. Med. (International journal of molecular medicine)
[2017, 39(1):153-159]

Cited: 9 times

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Association of physical activity and sedentary behavior with depression and anxiety symptoms during pregnancy in a multiethnic cohort of Asian women.

Natarajan Padmapriya, Jonathan Y Bernard, Shen Liang, See Ling Loy, Zhe Shen, Kenneth Kwek, Keith M Godfrey, Peter D Gluckman, Yap-Seng Chong, Seang Mei Saw, Michael J Meaney, Helen Chen, Falk Müller-Riemenschneider, ,

This study aimed to investigate associations of physical activity (PA) and sedentary behavior (SB) with depression and anxiety symptoms during pregnancy among Chinese, Malay, and Indian women.Women answered PA and SB (sitting time and television time) interview questions and self-completed the Edinburgh Postnatal Depression Scale (EPDS) and State-Trait Anxiety Inventory ... Read more >>

Arch Womens Ment Health (Archives of women's mental health)
[2016, 19(6):1119-1128]

Cited: 7 times

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Rapid initiation of fetal therapy services with a system of learner-centred training under proctorship: the National University Hospital (Singapore) experience.

Arundhati Gosavi, Pradip D Vijayakumar, Bryan Sw Ng, May-Han Loh, Lay Geok Tan, Nuryanti Johana, Yi Wan Tan, Dedy Sandikin, Lin Lin Su, Tuangsit Wataganara, Arijit Biswas, Mahesh A Choolani, Citra Nz Mattar,

Management of complicated monochorionic twins and certain intrauterine structural anomalies is a pressing challenge in communities that still lack advanced fetal therapy. We describe our efforts to rapidly initiate selective feticide using radiofrequency ablation (RFA) and selective fetoscopic laser photocoagulation (SFLP) for twin-to-twin transfusion syndrome (TTTS), and present the latter ... Read more >>

Singapore Med J (Singapore medical journal)
[2017, 58(6):311-320]

Cited: 2 times

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Evaluation of preferences of women and healthcare professionals in Singapore for implementation of noninvasive prenatal testing for Down syndrome.

Angela Natalie Barrett, Henna Vishal Advani, Lyn S Chitty, Lin Lin Su, Arijit Biswas, Wei Ching Tan, Melissa Hill, Mahesh Choolani,

Invasive prenatal diagnosis (IPD) has long been used to prenatally diagnose Down syndrome (DS), but it is associated with a small risk of miscarriage. Noninvasive prenatal testing (NIPT) is a highly sensitive screening test using cell-free DNA in maternal blood for detection of DS without the risk of miscarriage, but ... Read more >>

Singapore Med J (Singapore medical journal)
[2017, 58(6):298-310]

Cited: 6 times

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Peroxisome proliferator-activated receptor-γ agonist inhibits collagen synthesis in human keloid fibroblasts by suppression of early growth response-1 expression through upregulation of miR-543 expression.

Hua-Yu Zhu, Wen-Dong Bai, Hong-Tao Wang, Song-Tao Xie, Ke Tao, Lin-Lin Su, Jia-Qi Liu, Xue-Kang Yang, Jun Li, Yun-Chuan Wang, Ting He, Jun-Tao Han, Da-Hai Hu,

A keloid is a benign skin tumor formed by an overgrowth of granulation tissue in affected patients. Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists were reported to be able to regulate extracellular matrix production in human dermal fibroblasts. This study explored the underlying molecular mechanism of PPAR-γ agonist troglitazone treatment for fibroblasts ... Read more >>

Am J Cancer Res (American journal of cancer research)
[2016, 6(6):1358-1370]

Cited: 3 times

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Human amniotic epithelial cells attenuate TGF-β1-induced human dermal fibroblast transformation to myofibroblasts via TGF-β1/Smad3 pathway.

Bin Zhao, Jia-Qi Liu, Chen Yang, Zhao Zheng, Qin Zhou, Hao Guan, Lin-Lin Su, Da-Hai Hu,

BACKGROUND AIMS:Keloids are raised dermal scars that extend beyond the boundaries of the initial injury. To date, there is no treatment to erase scars completely in humans. Growing evidence has shown that the human amniotic epithelial cells have anti-fibrotic properties and can reduce the fibrosis of lung and liver. However, ... Read more >>

Cytotherapy (Cytotherapy)
[2016, 18(8):1012-1024]

Cited: 8 times

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Improvement of the suture-occluded method in rat models of focal cerebral ischemia-reperfusion.

Ping Zhang, Zhen Huang, Hai-Qing Yan, Lin-Lin Su, Yong-Kun Gui, Hai-Xia Lv, Bin Zhu, Tong Li,

The aim of the present study was to provide a simple method of establishing a rat model for focal cerebral ischemia-reperfusion (FCIR). The suture-occluded method was used to establish FCIR in male Sprague-Dawley rats. An incision was made over the bifurcation of the common carotid artery (CCA), through which a ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2014, 7(3):657-662]

Cited: 0 times

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Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars.

Xiao-Zhi Bai, Jia-Qi Liu, Long-Long Yang, Lei Fan, Ting He, Lin-Lin Su, Ji-Hong Shi, Chao-Wu Tang, Zhao Zheng, Da-Hai Hu,

BACKGROUND AND PURPOSE:Sirtuin1 (SIRT1), the founding member of mammalian class III histone deacetylases, is reported to be a drug target involved in fibrotic diseases. However, whether it is an effective drug target in hypertrophic scar treatment is still not known. EXPERIMENTAL APPROACH:In the present study, we observed that SIRT1 localized ... Read more >>

Br. J. Pharmacol. (British journal of pharmacology)
[2016, 173(10):1589-1601]

Cited: 8 times

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A Comparison of Practices During the Confinement Period among Chinese, Malay, and Indian Mothers in Singapore.

Doris Fok, Izzuddin M Aris, Jiahui Ho, Sok Bee Lim, Mei Chien Chua, Wei Wei Pang, Seang-Mei Saw, Kenneth Kwek, Keith M Godfrey, Michael S Kramer, Yap Seng Chong, ,

BACKGROUND:Confinement (restrictions placed on diet and practices during the month right after delivery) represents a key feature of Asian populations. Few studies, however, have focused specifically on ethnic differences in confinement practices. This study assesses the confinement practices of three ethnic groups in a multi-ethnic Asian population. METHODS:Participants were part ... Read more >>

Birth (Birth (Berkeley, Calif.))
[2016, 43(3):247-254]

Cited: 1 time

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Human amniotic epithelial stem cells promote wound healing by facilitating migration and proliferation of keratinocytes via ERK, JNK and AKT signaling pathways.

Bin Zhao, Jia-Qi Liu, Zhao Zheng, Jun Zhang, Shu-Yue Wang, Shi-Chao Han, Qin Zhou, Hao Guan, Chao Li, Lin-Lin Su, Da-Hai Hu,

Wound healing is a highly orchestrated physiological process consisting in a complex interaction of cellular and biochemical events. Human amniotic epithelial stem cells (HAESCs) have been shown to be an attractive resource for wound healing because they are primitive stem cells. However, the exact effects of amnion-derived stem cells on ... Read more >>

Cell Tissue Res. (Cell and tissue research)
[2016, 365(1):85-99]

Cited: 14 times

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Relative Contribution of Risk Factors for Early-Onset Myopia in Young Asian Children.

Sharon Yu Lin Chua, M Kamran Ikram, Chuen Seng Tan, Yung Seng Lee, Yu Ni, Cai Shirong, Peter D Gluckman, Yap-Seng Chong, Fabian Yap, Tien-Yin Wong, Cheryl S Ngo, Seang-Mei Saw, ,

To investigate the associations of near work, outdoor activity, and anthropometric risk factors with early-onset myopia in Singaporean preschool children.Pregnant women who attended their first-trimester clinic at two major maternity units were recruited for the GUSTO birth cohort (n = 1236). Cycloplegic autorefraction and axial length (AL) were obtained in ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2015, 56(13):8101-8107]

Cited: 10 times

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