Full Text Journal Articles by
Author Stuart J McDonald

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The TrkB agonist, 7,8-dihydroxyflavone, impairs fracture healing in mice.

Maddison R Johnstone, Rhys D Brady, Jarrod E Church, David Orr, Stuart J McDonald, Brian L Grills,

<h4>Objectives</h4>To study the effects of the selective TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF), on fracture healing in mice and on an osteoprogenitor cell line, Kusa4b10, <i>in vitro</i>.<h4>Methods</h4>Mice received unilateral closed mid-shaft tibial fractures and treated for two weeks with vehicle or 5 mg/kg/day DHF and euthanised at 28 days post-fracture. Calluses were ... Read more >>

J Musculoskelet Neuronal Interact (Journal of musculoskeletal & neuronal interactions)
[2021, 21(2):263-271]

Cited: 0 times

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Temporal profile and utility of serum neurofilament light in a rat model of mild traumatic brain injury.

William T O'Brien, Louise Pham, Rhys D Brady, Jesse Bain, Glenn R Yamakawa, Mujun Sun, Richelle Mychasiuk, Terence J O'Brien, Mastura Monif, Sandy R Shultz, Stuart J McDonald,

There is a widely recognized need for blood biomarkers to assist clinical decisions surrounding mild traumatic brain injury (mTBI). Serum neurofilament light (NfL), an indicator of neuroaxonal damage, is one such candidate, with early mTBI clinical investigations demonstrating significant promise. To facilitate the translation of pre-clinical mTBI findings, clinically relevant ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 341:113698]

Cited: 0 times

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Diffusion Imaging Reveals Sex Differences in the White Matter Following Sports-Related Concussion.

David K Wright, Georgia F Symons, William T O'Brien, Stuart J McDonald, Akram Zamani, Brendan Major, Zhibin Chen, Daniel Costello, Rhys D Brady, Mujun Sun, Meng Law, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz,

Sports-related concussion (SRC) is a serious health concern. However, the temporal profile of neuropathophysiological changes after SRC and how these relate to biological sex are still poorly understood. This preliminary study investigated whether diffusion-weighted magnetic resonance imaging (dMRI) was sensitive to neuropathophysiological changes following SRC; whether these changes were sex-specific; ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2021, :]

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Targeting the Cerebrovascular System: Next-Generation Biomarkers and Treatment for Mild Traumatic Brain Injury.

Tamara L Baker, Denes V Agoston, Rhys D Brady, Brendan Major, Stuart J McDonald, Richelle Mychasiuk, David K Wright, Glenn R Yamakawa, Mujun Sun, Sandy R Shultz,

The diagnosis, prognosis, and treatment of mild traumatic brain injuries (mTBIs), such as concussions, are significant unmet medical issues. The kinetic forces that occur in mTBI adversely affect the cerebral vasculature, making cerebrovascular injury (CVI) a pathophysiological hallmark of mTBI. Given the importance of a healthy cerebrovascular system in overall ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211012264]

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Pain in the Developing Brain: Early Life Factors Alter Nociception and Neurobiological Function in Adolescent Rats.

Sabrina Salberg, Glenn R Yamakawa, Yannick Griep, Jesse Bain, Jaimie K Beveridge, Mujun Sun, Stuart J McDonald, Sandy R Shultz, Rhys D Brady, David K Wright, Melanie Noel, Richelle Mychasiuk,

Although adverse early experiences prime individuals to be at increased risk for chronic pain, little research has examined the trauma-pain relationship in early life or the underlying mechanisms that drive pathology over time. Given that early experiences can potentiate the nociceptive response, this study aimed to examine the effects of ... Read more >>

Cereb Cortex Commun (Cerebral cortex communications)
[2021, 2(2):tgab014]

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Neurological heterotopic ossification: novel mechanisms, prognostic biomarkers and prophylactic therapies.

Ker Rui Wong, Richelle Mychasiuk, Terence J O'Brien, Sandy R Shultz, Stuart J McDonald, Rhys D Brady,

Neurological heterotopic ossification (NHO) is a debilitating condition where bone forms in soft tissue, such as muscle surrounding the hip and knee, following an injury to the brain or spinal cord. This abnormal formation of bone can result in nerve impingement, pain, contractures and impaired movement. Patients are often diagnosed ... Read more >>

Bone Res (Bone research)
[2020, 8(1):42]

Cited: 1 time

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Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: Novel insights using a clinically relevant rat model.

Louise Pham, David K Wright, William T O'Brien, Jesse Bain, Cheng Huang, Mujun Sun, Pablo M Casillas-Espinosa, Anup D Shah, Ralf B Schittenhelm, Christopher G Sobey, Rhys D Brady, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz, Stuart J McDonald,

A history of mild traumatic brain injury (mTBI) is linked to a number of chronic neurological conditions, however there is still much unknown about the underlying mechanisms. To provide new insights, this study used a clinically relevant model of repeated mTBI in rats to characterize the acute and chronic neuropathological ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2021, 148:105151]

Cited: 3 times

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Assessing the Long-Term Impact of Concussion upon Cognition: A 5-Year Prospective Investigation.

Stefan Piantella, Stuart J McDonald, Paul Maruff, Bradley J Wright,

OBJECTIVE:Jockeys have high rates of concussion, with 5% of jockeys receiving at least one concussion annually. The impact of acute concussion upon cognition is well understood, but less is known about the long-term effects of concussion upon cognition. Our aim was to assess the impact of concussion upon jockeys who ... Read more >>

Arch Clin Neuropsychol (Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists)
[2020, 35(5):482-490]

Cited: 1 time

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Experimental traumatic brain injury does not lead to lung infection.

Mujun Sun, Rhys D Brady, Brooke Wanrooy, Richelle Mychasiuk, Glenn R Yamakawa, Pablo M Casillas-Espinosa, Connie H Y Wong, Sandy R Shultz, Stuart J McDonald,

Traumatic brain injury (TBI) patients often experience post-traumatic infections, especially in the lung. Pulmonary infection is associated with unfavorable outcomes and increased mortality rates in TBI patients; however, our understanding of the underlying mechanisms is poor. Here we used a lateral fluid percussion injury (LFPI) model in rats to investigate ... Read more >>

J Neuroimmunol (Journal of neuroimmunology)
[2020, 343:577239]

Cited: 1 time

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Beyond the Brain: Peripheral Interactions after Traumatic Brain Injury.

Stuart J McDonald, Jessica M Sharkey, Mujun Sun, Lola M Kaukas, Sandy R Shultz, Renee J Turner, Anna V Leonard, Rhys D Brady, Frances Corrigan,

Traumatic brain injury (TBI) is a leading cause of death and disability, and there are currently no pharmacological treatments known to improve patient outcomes. Unquestionably, contributing toward a lack of effective treatments is the highly complex and heterogenous nature of TBI. In this review, we highlight the recent surge of ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, 37(5):770-781]

Cited: 15 times

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A novel rat model of heterotopic ossification after polytrauma with traumatic brain injury.

Rhys D Brady, Michael Z Zhao, Ker R Wong, Pablo M Casilla-Espinosa, Glenn R Yamakawa, Ryan C Wortman, Mujun Sun, Brian L Grills, Richelle Mychasiuk, Terence J O'Brien, Denes V Agoston, Peter V S Lee, Stuart J McDonald, Dale L Robinson, Sandy R Shultz,

Neurological heterotopic ossification (NHO) is characterized by abnormal bone growth in soft tissue and joints in response to injury to the central nervous system. The ectopic bone frequently causes pain, restricts mobility, and decreases the quality of life for those affected. NHO commonly develops in severe traumatic brain injury (TBI) ... Read more >>

Bone (Bone)
[2020, 133:115263]

Cited: 2 times

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The need to incorporate aged animals into the preclinical modeling of neurological conditions.

Mujun Sun, Stuart J McDonald, Rhys D Brady, Lyndsey Collins-Praino, Glenn R Yamakawa, Mastura Monif, Terence J O'Brien, Geoffrey C Cloud, Christopher G Sobey, Richelle Mychasiuk, David J Loane, Sandy R Shultz,

Neurological conditions such as traumatic brain injury, stroke, Parkinson's disease, epilepsy, multiple sclerosis, and Alzheimer's disease are serious clinical problems that affect millions of people worldwide. The majority of clinical trials for these common conditions have failed, and there is a critical need to understand why treatments in preclinical animal ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2020, 109:114-128]

Cited: 5 times

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Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways.

Nishanthi Mathiyalagan, Lee B Miles, Peter J Anderson, Tomasz Wilanowski, Brian L Grills, Stuart J McDonald, M Cristina Keightley, Agata Charzynska, Michal Dabrowski, Sebastian Dworkin,

: The Drosophila grainyhead (grh) and vertebrate Grainyhead-like (Grhl) transcription factors are among the most critical genes for epithelial development, maintenance and homeostasis, and are remarkably well conserved from fungi to humans. Mutations affecting grh/Grhl function lead to a myriad of developmental and adult onset epithelial disease, such as aberrant ... Read more >>

Genes (Basel) (Genes)
[2019, 10(11):]

Cited: 0 times

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Bone Health in Rats With Temporal Lobe Epilepsy in the Absence of Anti-Epileptic Drugs.

Rhys D Brady, Ker Rui Wong, Dale L Robinson, Richelle Mychasiuk, Stuart J McDonald, Ryan A D'Cunha, Glenn R Yamakawa, Mujun Sun, John D Wark, Peter Vee Sin Lee, Terence J O'Brien, Pablo M Casillas-Espinosa, Sandy R Shultz,

<b>Rationale:</b> Epilepsy patients often exhibit reduced bone mineral density and are at an increased risk of bone fracture. Whether these bone abnormalities are due to the use of anti-epileptic drugs (AED's) or the disease itself is unknown. For example, although decreased bone health in epilepsy patients is generally attributed to ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:1278]

Cited: 0 times

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Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat.

David K Wright, Rhys D Brady, Alaa Kamnaksh, Jack Trezise, Mujun Sun, Stuart J McDonald, Richelle Mychasiuk, Scott C Kolbe, Meng Law, Leigh A Johnston, Terence J O'Brien, Denes V Agoston, Sandy R Shultz,

A single mild traumatic brain injury (mTBI) typically causes only transient symptoms, but repeated mTBI (RmTBI) is associated with cumulative and chronic neurological abnormalities. Clinical management of mTBI is challenging due to the heterogeneous, subjective and transient nature of symptoms, and thus would be aided by objective biomarkers. Promising biomarkers ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):14626]

Cited: 4 times

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The genetic ablation of tau improves long-term, but not short-term, functional outcomes after experimental traumatic brain injury in mice.

Xin Lin Tan, Ping Zheng, David K Wright, Mujun Sun, Rhys D Brady, Shijie Liu, Stuart J McDonald, Richelle Mychasiuk, Sitare Cenap, Nigel C Jones, Terence J O'Brien, Sandy R Shultz,

<h4>Primary objective</h4>This study characterized the acute and chronic effects of tau reduction in traumatic brain injury (TBI).<h4>Research design</h4>A fluid percussion injury (FPI) or a sham-injury was administered to wild type (WT) or tau knockout (Tau-/-) mice. Mice were assigned to a one-week or twelve-week recovery period before behavioral testing and ... Read more >>

Brain Inj (Brain injury)
[2020, 34(1):131-139]

Cited: 2 times

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Treadmill Exercise before and during Pregnancy Improves Bone Deficits in Pregnant Growth Restricted Rats without the Exacerbated Effects of High Fat Diet.

Kristina Anevska, Dayana Mahizir, Jessica F Briffa, Andrew J Jefferies, John D Wark, Brian L Grills, Rhys D Brady, Stuart J McDonald, Mary E Wlodek, Tania Romano,

Growth restriction programs adult bone deficits and increases the risk of obesity, which may be exacerbated during pregnancy. We aimed to determine if high-fat feeding could exacerbate the bone deficits in pregnant growth restricted dams, and whether treadmill exercise would attenuate these deficits. Uteroplacental insufficiency was induced on embryonic day ... Read more >>

Nutrients (Nutrients)
[2019, 11(6):]

Cited: 0 times

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Clinical Relevance of Behavior Testing in Animal Models of Traumatic Brain Injury.

Sandy R Shultz, Stuart J McDonald, Frances Corrigan, Bridgette D Semple, Sabrina Salberg, Akram Zamani, Nigel C Jones, Richelle Mychasiuk,

Traumatic brain injury (TBI) is a leading cause of morbidity worldwide, with patients often suffering from consequences such as cognitive deficits, social abnormalities, anxiety, depression, pain, and motor dysfunction. Given that these impairments often have a significant impact on the patient's quality of life, a key aim of therapeutic intervention ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, 37(22):2381-2400]

Cited: 0 times

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Aged rats have an altered immune response and worse outcomes after traumatic brain injury.

Mujun Sun, Rhys D Brady, Pablo M Casillas-Espinosa, David K Wright, Bridgette D Semple, Hyun Ah Kim, Richelle Mychasiuk, Christopher G Sobey, Terence J O'Brien, Antony Vinh, Stuart J McDonald, Sandy R Shultz,

Initial studies suggest that increased age is associated with worse outcomes after traumatic brain injury (TBI), though the pathophysiological mechanisms responsible for this remain unclear. Immunosenescence (i.e., dysregulation of the immune system due to aging) may play a significant role in influencing TBI outcomes. This study therefore examined neurological outcomes ... Read more >>

Brain Behav Immun (Brain, behavior, and immunity)
[2019, 80:536-550]

Cited: 3 times

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The selective TrkA agonist, gambogic amide, promotes osteoblastic differentiation and improves fracture healing in mice.

Maddison R Johnstone, Rhys D Brady, Johannes A Schuijers, Jarrod E Church, David Orr, Julian M W Quinn, Stuart J McDonald, Brian L Grills,

OBJECTIVES:To study effects of the selective TrkA agonist, gambogic amide (GA), on fracture healing in mice and on an osteoprogenitor cell line in vitro. METHODS:Mice were given bilateral fibular fractures and treated for two weeks with vehicle or 1 mg/kg/day GA and euthanized at 14-, 21-, and 42-days post-fracture. Calluses ... Read more >>

J Musculoskelet Neuronal Interact (Journal of musculoskeletal & neuronal interactions)
[2019, 19(1):94-103]

Cited: 6 times

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Mild Closed-Head Injury in Conscious Rats Causes Transient Neurobehavioral and Glial Disturbances: A Novel Experimental Model of Concussion.

Louise Pham, Sandy R Shultz, Hyun Ah Kim, Rhys D Brady, Ryan C Wortman, Shannyn G Genders, Matthew W Hale, Ross D O'Shea, Elvan Djouma, Maarten van den Buuse, Jarrod E Church, Brian R Christie, Grant R Drummond, Christopher G Sobey, Stuart J McDonald,

Rodent models can provide insights into the most pertinent issues surrounding concussion. Nonetheless, the relevance of some existing models to clinical concussion can be questioned, particularly with regard to the use of surgery and anesthesia and the mechanism and severity of injury. Accordingly, we have co-developed an awake closed-head injury ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2019, 36(14):2260-2271]

Cited: 7 times

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A Concomitant Muscle Injury Does Not Worsen Traumatic Brain Injury Outcomes in Mice.

Mujun Sun, Rhys D Brady, Chris van der Poel, Danielle Apted, Bridgette D Semple, Jarrod E Church, Terence J O'Brien, Stuart J McDonald, Sandy R Shultz,

Traumatic brain injury (TBI) often involves multitrauma in which concurrent extracranial injury occurs. We previously demonstrated that a long bone fracture exacerbates neuroinflammation and functional outcomes in mice given a TBI. Whether other forms of concomitant peripheral trauma that are common in the TBI setting, such as skeletal muscle injury, ... Read more >>

Front Neurol (Frontiers in neurology)
[2018, 9:1089]

Cited: 4 times

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Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury.

Ryan C Wortman, Alicia Meconi, Katie J Neale, Rhys D Brady, Stuart J McDonald, Brian R Christie, David K Wright, Sandy R Shultz,

<h4>Objective</h4>Mild traumatic brain injury (mTBI) is a serious health concern in the adolescent population. Repeated mTBI may result in more pronounced deficits, and has been associated with long-term neurological consequences including neurodegeneration. As such, there is a critical need for the development of objective mTBI biomarkers to help guide medical ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(12):1588-1598]

Cited: 4 times

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Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury.

Xin Lin Tan, Mujun Sun, Rhys D Brady, Shijie Liu, Roxana Llanos, Steve Cheung, David K Wright, Pablo M Casillas-Espinosa, Maithili Sashindranath, Terence J O'Brien, Stuart J McDonald, Bradley J Turner, Sandy R Shultz,

Initial studies have found some evidence for transactive response DNA-binding protein 43 (TDP-43) abnormalities after traumatic brain injury (TBI), and the presence of protein inclusions consisting of TDP-43 are a pathological hallmark of amyotrophic lateral sclerosis (ALS), a condition associated with TBI. However, no study has characterized changes in TDP-43 ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2018, :]

Cited: 6 times

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The influence of immunological stressors on traumatic brain injury.

Mujun Sun, Stuart J McDonald, Rhys D Brady, Terence J O'Brien, Sandy R Shultz,

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, and typically involves a robust immune response. Although a great deal of preclinical research has been conducted to identify an effective treatment, all phase III clinical trials have been unsuccessful to date. These translational shortcomings are in ... Read more >>

Brain Behav Immun (Brain, behavior, and immunity)
[2018, 69:618-628]

Cited: 11 times

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