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Re: Defect-free care trends in the Paul Coverdell National Acute Stroke Program, program, 2008-2018.

Steven Thomas,

Am Heart J (American heart journal)
[2021, 236:110-111]

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Imaging Nanoscale Nuclear Structures with Expansion Microscopy

Emma Faulkner, Jeremy Pike, Ruth Densham, Evelyn Garlick, Steven Thomas, Robert Neely, Joanna Morris,

Commonly applied super-resolution light microscopies have provided insight into subcellular processes at the nanoscale. However, imaging depth, speed, throughput and cost remain significant challenges, reducing the numbers of three-dimensional, nanoscale processes that can be investigated and the number of laboratories able to undertake such analysis. Expansion microscopy solves many of ... Read more >>

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Simple methods for quantifying super-resolved cortical actin

Evelyn Garlick, Emma Faulkner, Stephen Briddon, Steven Thomas,

Cortical actin plays a key role in cell movement and division, but has also been implicated in the organisation of cell surface receptors such as G protein-coupled receptors. The actin mesh proximal to the inner membrane forms small fenced regions, or ‘corrals’, in which receptors can be constrained. Quantification of ... Read more >>

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Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.

Mark Gormley, James Yarmolinsky, Tom Dudding, Kimberley Burrows, Richard M Martin, Steven Thomas, Jessica Tyrrell, Paul Brennan, Miranda Pring, Stefania Boccia, Andrew F Olshan, Brenda Diergaarde, Rayjean J Hung, Geoffrey Liu, Danny Legge, Eloiza H Tajara, Patricia Severino, Martin Lacko, Andrew R Ness, George Davey Smith, Emma E Vincent, Rebecca C Richmond,

Head and neck squamous cell carcinoma (HNSCC), which includes cancers of the oral cavity and oropharynx, is a cause of substantial global morbidity and mortality. Strategies to reduce disease burden include discovery of novel therapies and repurposing of existing drugs. Statins are commonly prescribed for lowering circulating cholesterol by inhibiting ... Read more >>

PLoS Genet (PLoS genetics)
[2021, 17(4):e1009525]

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The scope and severity of white-nose syndrome on hibernating bats in North America.

Tina L Cheng, Jonathan D Reichard, Jeremy T H Coleman, Theodore J Weller, Wayne E Thogmartin, Brian E Reichert, Alyssa B Bennett, Hugh G Broders, Joshua Campbell, Katherine Etchison, Daniel J Feller, Richard Geboy, Traci Hemberger, Carl Herzog, Alan C Hicks, Sandra Houghton, Jessica Humber, Joseph A Kath, R Andrew King, Susan C Loeb, Ariane Massé, Katrina M Morris, Holly Niederriter, Gerda Nordquist, Roger W Perry, Richard J Reynolds, D Blake Sasse, Michael R Scafini, Richard C Stark, Craig W Stihler, Steven C Thomas, Gregory G Turner, Shevenell Webb, Bradford J Westrich, Winifred F Frick,

Assessing the scope and severity of threats is necessary for evaluating impacts on populations to inform conservation planning. Quantitative threat assessment often requires monitoring programs that provide reliable data over relevant spatial and temporal scales, yet such programs can be difficult to justify until there is an apparent stressor. Leveraging ... Read more >>

Conserv Biol (Conservation biology : the journal of the Society for Conservation Biology)
[2021, :]

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Configuration of vascular services: a multiple methods research programme

Jonathan Michaels, Emma Wilson, Ravi Maheswaran, Stephen Radley, Georgina Jones, Thai-Son Tong, Eva Kaltenthaler, Ahmed Aber, Andrew Booth, Helen Buckley Woods, James Chilcott, Rosie Duncan, Munira Essat, Edward Goka, Aoife Howard, Anju Keetharuth, Elizabeth Lumley, Shah Nawaz, Suzy Paisley, Simon Palfreyman, Edith Poku, Patrick Phillips, Gill Rooney, Praveen Thokala, Steven Thomas, Angela Tod, Nyantara Wickramasekera, Phil Shackley,

<h4>Background</h4>Vascular services is changing rapidly, having emerged as a new specialty with its own training and specialised techniques. This has resulted in the need for reconfiguration of services to provide adequate specialist provision and accessible and equitable services.<h4>Objectives</h4>To identify the effects of service configuration on practice, resource use and outcomes. ... Read more >>

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The experimental range extension of guppies (Poecilia reticulata) influences the metabolic activity of tropical streams.

Antoine O H C Leduc, Steven A Thomas, Ronald D Bassar, Andrés López-Sepulcre, Keeley MacNeill, Rana El-Sabaawi, David N Reznick, Alexander S Flecker, Joseph Travis,

The ecological consequences of biological range extensions reflect the interplay between the functional characteristics of the newly arrived species and their recipient ecosystems. Teasing apart the relative contribution of each component is difficult because most colonization events are studied retrospectively, i.e., after a species became established and its consequences apparent. ... Read more >>

Oecologia (Oecologia)
[2021, 195(4):1053-1069]

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Incorporating parotid gland inhomogeneity into head-and-neck treatment optimization through the use of artificial base plans.

Caleb M Sample, Jonn Wu, Steven Thomas, Haley Clark,

Despite a great improvement in target volume dose conformality made possible in recent years by modulated therapies, xerostomia remains a common and severe side effect for head-and-neck radiotherapy patients. It is known that parotid glands exhibit a spatially varying dose response; however, the relative importance of subregions throughout the entire ... Read more >>

J Appl Clin Med Phys (Journal of applied clinical medical physics)
[2021, 22(3):141-149]

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Catecholaminergic Innervation of the Lateral Nucleus of the Cerebellum Modulates Cognitive Behaviors.

Erik S Carlson, Avery C Hunker, Stefan G Sandberg, Timothy M Locke, Julianne M Geller, Abigail G Schindler, Steven A Thomas, Martin Darvas, Paul E M Phillips, Larry S Zweifel,

The cerebellum processes neural signals related to rewarding and aversive stimuli, suggesting that the cerebellum supports nonmotor functions in cognitive and emotional domains. Catecholamines are a class of neuromodulatory neurotransmitters well known for encoding such salient stimuli. Catecholaminergic modulation of classical cerebellar functions have been demonstrated. However, a role for ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2021, 41(15):3512-3530]

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Systematic review of novel technology-based interventions for ischemic stroke.

Steven Mulackal Thomas, Ellie Delanni, Brandon Christophe, Edward Sander Connolly,

<h4>Purpose</h4>To identify novel technologies pertinent to the prevention, diagnosis, treatment, and rehabilitation of ischemic stroke, and recommend the technologies that show the most promise in advancing ischemic stroke care.<h4>Method</h4>A systematic literature search on PubMed and Medscape was performed. Articles were assessed based on pre-determined criteria. Included journal articles were evaluated ... Read more >>

Neurol Sci (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2021, 42(5):1705-1717]

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CLEC-2 promotes inflammatory peritoneal macrophage emigration to draining lymph nodes during endotoxemia

Joshua Bourne, Nonantzin Beristain-Covarrubias, Malou Zuidscheroude, Joana Campos, Ying Di, Evelyn Garlick, Martina Colicchia, Lauren Terry, Steven Thomas, Alexander Brill, Jagadeesh Bayry, Steve Watson, Julie Rayes,

Macrophage recruitment during sterile inflammation and infection is essential to clear pathogens, apoptotic cells and debris. However, persistent macrophage accumulation leads to chronic inflammation. Platelets are emerging as key modulators of the inflammatory response. Here, we identify that platelet C-type-lectin-like receptor-2 (CLEC-2) is a crucial immunomodulatory receptor through the interaction ... Read more >>

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Germline Determinants of Humoral Immune Response To HPV-16 Protect Against Oropharyngeal Cancer

Aida Ferreiro-Iglesias, James McKay, Nicole Brenner, Shama Virani, Corina Lesseur, Valérie Gaborieau, Andrew Ness, Rayjean Hung, Geoffrey Liu, Brenda Diergaarde, Andrew Olshan, Hayes, Mark Weissler, Lea Schroeder, Noemi Bender, Michael Pawlita, Steven Thomas, Miranda Pring, Tom Dudding, Beatriz Kanterewicz, Robert Ferris, Sera Thomas, Yonathan Brhane, Virginia Díez-Obrero, Maja Milojevic, Karl Smith-Byrne, Daniela Mariosa, Mattias Johansson, Rolando Herrero, Stefania Boccia, Gabriella Cadoni, Martin Lacko, Ivana Holcátová, Wolfgang Ahrens, Pagona Lagiou, Areti Lagiou, Jerry Polesel, Lorenzo Simonato, Franco Merletti, Claire Healy, Bo Hansen, Mari Nygård, David Conway, Sylvia Wright, Tatiana Macfarlane, Max Robinson, Laia Alemany, Antonio Agudo, Ariana Znaor, Christopher Amos, Tim Waterboer, Paul Brennan,

Although several oropharyngeal cancer (OPC) susceptibility loci have been identified, most previous studies lacked detailed information on human papillomavirus (HPV) status. We conducted a genome-wide analysis by HPV16 serology status in 4,002 oral cancer cases (OPC and oral cavity cancer(OCC)) and 5,256 controls. Four novel susceptibility loci were detected pointing ... Read more >>

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Post-translational polymodification of β1-tubulin regulates motor protein localisation in platelet production and function.

Abdullah O Khan, Alexandre Slater, Annabel Maclachlan, Phillip L R Nicolson, Jeremy A Pike, Jasmeet S Reyat, Jack Yule, Rachel Stapley, Julie Rayes, Steven G Thomas, Neil V Morgan,

In specialised cells, the expression of specific tubulin isoforms and their subsequent post-translational modifications drive and coordinate unique morphologies and behaviours. The mechanisms by which β1-tubulin, the platelet and megakaryocyte (MK) lineage restricted tubulin isoform, drives platelet production and function remains poorly understood. We investigated the roles of two key ... Read more >>

Haematologica (Haematologica)
[2020, Online ahead of print:]

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Peripheral and proximal lung ventilation in asthma: Short-term variation and response to bronchodilator inhalation.

Helen Marshall, J Chris Kenworthy, Felix C Horn, Steven Thomas, Andrew J Swift, Salman Siddiqui, Christopher E Brightling, Jim M Wild,

<h4>Background</h4>The relative involvement of the large and small airways in asthma is not clear. Hyperpolarized gas magnetic resonance imaging (MRI) provides high-resolution 3-dimensional images of ventilation distribution that can be quantified by the ventilated volume percentage (VV%) of the lungs.<h4>Objective</h4>Our aims were to (1) quantify the baseline reproducibility of VV%, ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, 147(6):2154-2161.e6]

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Improving quality of life through the routine use of the patient concerns inventory for head and neck cancer patients: main results of a cluster preference randomised controlled trial.

Simon N Rogers, Christine Allmark, Fazilet Bekiroglu, Rhiannon Tudor Edwards, Gillon Fabbroni, Robert Flavel, Victoria Highet, Michael W S Ho, Gerald M Humphris, Terry M Jones, Owais Khattak, Jeffrey Lancaster, Christopher Loh, Derek Lowe, Cher Lowies, Dominic Macareavy, James Moor, T K Ong, A Prasai, Nicholas Roland, Cherith Semple, Llinos Haf Spencer, Sank Tandon, Steven J Thomas, Andrew Schache, Richard J Shaw, Anastasios Kanatas,

<h4>Purpose</h4>The patient concerns inventory (PCI) is a prompt list allowing head and neck cancer (HNC) patients to discuss issues that otherwise might be overlooked. This trial evaluated the effectiveness of using the PCI at routine outpatient clinics for one year after treatment on health-related QOL (HRQOL).<h4>Methods</h4>A pragmatic cluster preference randomised ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2020, :]

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Is vitamin D a modifiable risk factor for dental caries?

Serena Dodhia, Nicola West, Steven Thomas, Nicholas Timpson, Ingegerd Johansson, Pernilla Lif Holgerson, Tom Dudding, Simon Haworth,

<ns3:p> <h4>Background: </h4> Prior observational studies have reported that higher levels of vitamin D are associated with decreased caries risk in children. However, these studies are prone to bias and confounding so do not provide causal inference. Genetic variants associated with a risk factor of interest can be used as ... Read more >>

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A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer.

Mark Gormley, Tom Dudding, Eleanor Sanderson, Richard M Martin, Steven Thomas, Jessica Tyrrell, Andrew R Ness, Paul Brennan, Marcus Munafò, Miranda Pring, Stefania Boccia, Andrew F Olshan, Brenda Diergaarde, Rayjean J Hung, Geoffrey Liu, George Davey Smith, Rebecca C Richmond,

The independent effects of smoking and alcohol in head and neck cancer are not clear, given the strong association between these risk factors. Their apparent synergistic effect reported in previous observational studies may also underestimate independent effects. Here we report multivariable Mendelian randomization performed in a two-sample approach using summary ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):6071]

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Temperature dependence of metabolic rate in tropical and temperate aquatic insects: Support for the Climate Variability Hypothesis in mayflies but not stoneflies.

Alisha A Shah, H Arthur Woods, Justin C Havird, Andrea C Encalada, Alexander S Flecker, W Chris Funk, Juan M Guayasamin, Boris C Kondratieff, N LeRoy Poff, Steven A Thomas, Kelly R Zamudio, Cameron K Ghalambor,

A fundamental gap in climate change vulnerability research is an understanding of the relative thermal sensitivity of ectotherms. Aquatic insects are vital to stream ecosystem function and biodiversity but insufficiently studied with respect to their thermal physiology. With global temperatures rising at an unprecedented rate, it is imperative that we ... Read more >>

Glob Chang Biol (Global change biology)
[2021, 27(2):297-311]

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Re: Patterns of Mechanical Thrombectomy for Stroke Before and After the 2015 Pivotal Trials and US National Guideline Update.

Steven Mulackal Thomas,

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2021, 30(2):105493]

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Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study

Mark Gormley, James Yarmolinsky, Tom Dudding, Kimberley Burrows, Richard Martin, Steven Thomas, Jessica Tyrrell, Paul Brennan, Miranda Pring, Stefania Boccia, Andrew Olshan, Brenda Diergaarde, Rayjean Hung, Geoffrey Liu, Danny Legge, Eloiza Tajara, Patricia Severino, Martin Lacko, Andrew Ness, George Davey Smith, Emma Vincent, Rebecca Richmond,

<h4>Introduction</h4> Head and neck squamous cell carcinoma (HNSCC), which includes cancers of the oral cavity and oropharynx, is a cause of substantial global morbidity and mortality. Strategies to reduce disease burden include discovery of novel therapies and repurposing of existing drugs. Statins are commonly prescribed for lowering circulating cholesterol by ... Read more >>

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Loss of mDia1 and Fhod1 impacts platelet formation but not platelet function.

Malou Zuidscherwoude, Elizabeth J Haining, Victoria A Simms, Stephanie Watson, Beata Grygielska, Alex T Hardy, Andrea Bacon, Stephen P Watson, Steven G Thomas,

An organized and dynamic cytoskeleton is required for platelet formation and function. Formins are a large family of actin regulatory proteins which are also able to regulate microtubule dynamics. There are four formin family members expressed in human and mouse megakaryocytes and platelets. We have previously shown that the actin ... Read more >>

Platelets (Platelets)
[2020, :1-12]

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A semi-automated finite difference mesh creation method for use with immersed boundary software IB2d and IBAMR.

Denis Michael Senter, Dylan Ray Douglas, W Christopher Strickland, Steven G Thomas, Anne M Talkington, Laura Miller, Nicholas A Battista,

Numerous fluid-structure interaction problems in biology have been investigated using the immersed boundary method. The advantage of this method is that complex geometries, e.g., internal or external morphology, can easily be handled without the need to generate matching grids for both the fluid and the structure. Consequently, the difficulty of ... Read more >>

Bioinspir Biomim (Bioinspiration & biomimetics)
[2020, :]

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Comparison of Rapid to Standard Volumetric Modulated Arc Therapy for Palliative Radiotherapy in Lung Cancer Patients.

David Y Mak, Ian Fraser, Robynn Ferris, Kerry James, Mitchell Liu, Steven D Thomas, Michael McKenzie, Shilo Lefresne,

Patients with incurable lung cancer often present with debilitating symptoms that require urgent palliative radiotherapy. Volumetric modulated arc therapy (VMAT) provides several dosimetric advantages compared to basic non-conformal techniques, but involves complex planning resulting in a slower turn-around time for treatment. A simplified planning technique known as 'rapid VMAT' was ... Read more >>

Cureus (Cureus)
[2020, 12(8):e10055]

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Mixed methods study to develop the content validity and the conceptual framework of the electronic patient-reported outcome measure for vascular conditions.

Ahmed Aber, Patrick Phillips, Elizabeth Lumley, Stephen Radley, Steven M Thomas, Shah Nawaz, Georgina Jones, Jonathan Michaels, ,

<h4>Objective</h4>The aim of this paper is to describe the stages undertaken to generate the items and conceptual framework of a new electronic personal assessment questionnaire for vascular conditions.<h4>Design</h4>A mixed methods study: First a survey of vascular clinicians was completed to identify the most common conditions treated in vascular clinics and ... Read more >>

BMJ Open (BMJ open)
[2020, 10(8):e034154]

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Improving quality of life through the routine use of the patient concerns inventory for head and neck cancer patients: baseline results in a cluster preference randomised controlled trial.

Simon N Rogers, Christine Allmark, Fazilet Bekiroglu, Rhiannon Tudor Edwards, Gillon Fabbroni, Robert Flavel, Victoria Highet, Michael W S Ho, Gerald M Humphris, Terry M Jones, Owais Khattak, Jeffrey Lancaster, Christopher Loh, Derek Lowe, Cher Lowies, Dominic Macareavy, James Moor, T K Ong, A Prasai, Nicholas Roland, Cherith Semple, Llinos Haf Spencer, Sank Tandon, Steven J Thomas, Andrew Schache, Richard J Shaw, Anastasios Kanatas,

<h4>Purpose</h4>The main aim of this paper is to present baseline demographic and clinical characteristics and HRQOL in the two groups of the Patient Concerns Inventory (PCI) trial. The baseline PCI data will also be described.<h4>Methods</h4>This is a pragmatic cluster preference randomised control trial with 15 consultant clusters from two sites ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2020, 277(12):3435-3447]

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