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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Professional Societies' Role in Addressing Member Burnout and Promoting Well-Being.

Seppo T Rinne, Tina Shah, Ekaterina Anderson, Sarah Delgado, Vicki Good, Nneka Sederstrom, Curtis N Sessler, Scott P Sherry, Steven Q Simpson, Karen Collishaw, Marc Moss,

<b>Rationale:</b> Critical care clinicians have high burnout rates. Previous studies have explored individual and organizational solutions to address burnout, but existing literature has not considered how professional societies can prevent burnout and promote member well-being. <b>Objectives:</b> The Critical Care Society Collaborative convened a task force to document professional society initiatives ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(9):1482-1489]

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Sepsis Among Medicare Beneficiaries: 4. Precoronavirus Disease 2019 Update January 2012-February 2020.

Charles E Frank, Timothy G Buchman, Steven Q Simpson, Kimberly L Sciarretta, George E Plopper, Kristen P Finne, Nicole Sowers, Michael Collier, Saurabh Chavan, Cheng Lin, Ibijoke Oke, Kiersten E Rhodes, Aathira Santhosh, Steve Chu, Thomas E MaCurdy, Sandeep A Patel, Gary L Disbrow, Jeffrey A Kelman,

<h4>Objectives</h4>To provide updated information on the burdens of sepsis during acute inpatient admissions for Medicare beneficiaries.<h4>Design</h4>Analysis of paid Medicare claims via the Centers for Medicare and Medicaid Services DataLink Project.<h4>Setting</h4>All U.S. acute-care hospitals, excluding federally operated hospitals (Veterans Administration and Defense Health Agency).<h4>Patients</h4>All Medicare beneficiaries, January 2012-February 2020, with an ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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Potential Implications of SARS-CoV-2 Delta Variant Surges for Rural Areas and Hospitals.

Sameer S Kadri, Steven Q Simpson,

JAMA (JAMA)
[2021, 326(11):1003-1004]

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Rationale and Design of the Awake Prone Position for Early Hypoxemia in COVID-19 Study Protocol: A Clinical Trial.

Michael A Garcia, Garrett L Rampon, Gheorghe Doros, Shijing Jia, Nikhil Jagan, Kari Gillmeyer, Andrew Berical, James Hudspeth, Michael Ieong, Katherine L Modzelewski, Elissa M Schechter-Perkins, Craig S Ross, Justin M Rucci, Steven Simpson, Allan J Walkey, Nicholas A Bosch,

The unprecedented public health burdens of coronavirus disease (COVID-19) have intensified the urgency of identifying effective, low-cost treatments that limit the need for advanced life support measures and improve clinical outcomes. However, personal protective equipment and staffing shortages, disease virulence, and infectivity have created significant barriers to traditional clinical trial ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(9):1560-1566]

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MALDI-TOF Mass Spectrometry and 16S rRNA Gene Sequence Analysis for the Identification of Foodborne Clostridium Spp.

Irshad M Sulaiman, Nancy Miranda, Steven Simpson,

<h4>Background</h4>Clostridium is a genus of Gram-positive, spore-forming, anaerobic bacteria comprising approximately 100 species. Some Clostridium spp. (C. botulinum, C. perfringens, C. tetani, and C. difficile) have been recognized to cause acute food poisoning, botulism, tetanus, and diarrheal illness in humans. Thus, rapid identification of Clostridium spp. is critical for source-tracking ... Read more >>

J AOAC Int (Journal of AOAC International)
[2021, 104(5):1381-1388]

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Application of MALDI-TOF mass spectrometry, and DNA sequencing-based SLST and MLST analysis for the identification of Cronobacter spp. isolated from environmental surveillance samples.

Irshad M Sulaiman, Kevin Tang, Katharine Segars, Nancy Miranda, Nikhat Sulaiman, Steven Simpson,

Cronobacter spp. are emerging infectious foodborne bacteria that can cause acute meningitis and necrotizing enterocolitis in neonates and immunocompromised individuals. Although, little is known about its reservoirs or transmission routes, it has been linked to powdered infant formula worldwide. Three Cronobacter spp. (C. sakazakii, C. malonaticus, and C. turicensis) have ... Read more >>

Arch Microbiol (Archives of microbiology)
[2021, 203(8):4813-4820]

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Variations in end-of-life practices in intensive care units worldwide (Ethicus-2): a prospective observational study.

Alexander Avidan, Charles L Sprung, Joerg C Schefold, Bara Ricou, Christiane S Hartog, Joseph L Nates, Ulrich Jaschinski, Suzana M Lobo, Gavin M Joynt, Olivier Lesieur, Manfred Weiss, Massimo Antonelli, Hans-Henrik Bülow, Maria G Bocci, Annette Robertsen, Matthew H Anstey, Belén Estébanez-Montiel, Alexandre Lautrette, Anastasiia Gruber, Angel Estella, Sudakshina Mullick, Roshni Sreedharan, Andrej Michalsen, Charles Feldman, Kai Tisljar, Martin Posch, Steven Ovu, Barbara Tamowicz, Alexandre Demoule, Freda DeKeyser Ganz, Hans Pargger, Alberto Noto, Philipp Metnitz, Laszlo Zubek, Veronica de la Guardia, Christopher M Danbury, Orsolya Szűcs, Alessandro Protti, Mario Filipe, Steven Q Simpson, Cameron Green, Alberto M Giannini, Ivo W Soliman, Claudio Piras, Eliana B Caser, Manuel Hache-Marliere, Spyros D Mentzelopoulos, ,

<h4>Background</h4>End-of-life practices vary among intensive care units (ICUs) worldwide. Differences can result in variable use of disproportionate or non-beneficial life-sustaining interventions across diverse world regions. This study investigated global disparities in end-of-life practices.<h4>Methods</h4>In this prospective, multinational, observational study, consecutive adult ICU patients who died or had a limitation of life-sustaining ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(10):1101-1110]

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Excipient-Induced Pulmonary Vascular Disease: An Underrecognized and Deadly Complication of Opioid Addiction.

Christine M Cook, Steven Q Simpson, Lewis Satterwhite,

Despite widespread public health concern regarding opioid misuse and overuse, there is a paucity of literature on the acute and chronic pulmonary vascular and cardiac implications of excipient lung disease. This case series describes the clinical presentation of five adult patients who experienced profound pulmonary hypertension and right heart failure ... Read more >>

Lung (Lung)
[2021, 199(4):363-368]

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Antibiotic Timing and Progression to Septic Shock Among Patients in the ED With Suspected Infection.

Roshan Bisarya, Xing Song, John Salle, Mei Liu, Anurag Patel, Steven Q Simpson,

<h4>Background</h4>Recent medical society opinions have questioned the use of early antimicrobials in patients with sepsis, but without septic shock.<h4>Research question</h4>Is time from ED presentation to administration of antibiotics associated with progression to septic shock among patients with suspected infection?<h4>Study design and methods</h4>This was a retrospective cohort study from March 2007 ... Read more >>

Chest (Chest)
[2021, :]

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Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19.

Safia Kuriakose, Kanal Singh, Alice K Pau, Eric Daar, Rajesh Gandhi, Pablo Tebas, Laura Evans, Roy M Gulick, H Clifford Lane, Henry Masur, , Judith A Aberg, Adaora A Adimora, Jason Baker, Lisa Baumann Kreuziger, Roger Bedimo, Pamela S Belperio, Stephen V Cantrill, Craig M Coopersmith, Susan L Davis, Amy L Dzierba, John J Gallagher, David V Glidden, Birgit Grund, Erica J Hardy, Carl Hinkson, Brenna L Hughes, Steven Johnson, Marla J Keller, Arthur Y Kim, Jeffrey L Lennox, Mitchell M Levy, Jonathan Z Li, Greg S Martin, Susanna Naggie, Andrew T Pavia, Nitin Seam, Steven Q Simpson, Susan Swindells, Phyllis Tien, Alpana A Waghmare, Kevin C Wilson, Jinoos Yazdany, Philip Zachariah, Danielle M Campbell, Carly Harrison, Timothy Burgess, Joseph Francis, Virginia Sheikh, Timothy M Uyeki, Robert Walker, John T Brooks, Laura Bosque Ortiz, Richard T Davey, Laurie K Doepel, Robert W Eisinger, Alison Han, Elizabeth S Higgs, Martha C Nason, Page Crew, Andrea M Lerner, Claire Lund, Christopher Worthington,

The development of the National Institutes of Health (NIH) COVID-19 Treatment Guidelines began in March 2020 in response to a request from the White House Coronavirus Task Force. Within 4 days of the request, the NIH COVID-19 Treatment Guidelines Panel was established and the first meeting took place (virtually-as did ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2021, 174(8):1151-1158]

Cited: 1 time

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Clinical factors associated with rapid treatment of sepsis.

Xing Song, Mei Liu, Lemuel R Waitman, Anurag Patel, Steven Q Simpson,

<h4>Purpose</h4>To understand what clinical presenting features of sepsis patients are historically associated with rapid treatment involving antibiotics and fluids, as appropriate.<h4>Design</h4>This was a retrospective, observational cohort study using a machine-learning model with an embedded feature selection mechanism (gradient boosting machine).<h4>Methods</h4>For adult patients (age ≥ 18 years) who were admitted through ... Read more >>

PLoS One (PloS one)
[2021, 16(5):e0250923]

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The American College of Chest Physicians' Perspective on the American Association of Bronchology and Interventional Pulmonology's Certificate of Added Qualification.

Stephanie M Levine, Steven Q Simpson, David A Schulman, Clayton T Cowl,

Chest (Chest)
[2021, 159(1):40-41]

Cited: 0 times

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Quality of the discussion of asthma on twitter.

Viren Kaul, Tamas Szakmany, Jay I Peters, David Stukus, Kathleen A Sala, Neha Dangayach, Steven Q Simpson, Christopher L Carroll,

<h4>Introduction</h4>Patients obtain a large amount of medical information online. Much of this information may not be reliable or of high quality. We investigated what influences the discussion of asthma on Twitter by evaluating the most popular tweets and the quality of the links shared.<h4>Methods</h4>We used Symplur Signals to extract data ... Read more >>

J Asthma (The Journal of asthma : official journal of the Association for the Care of Asthma)
[2020, :1-8]

Cited: 0 times

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Cross-site transportability of an explainable artificial intelligence model for acute kidney injury prediction.

Xing Song, Alan S L Yu, John A Kellum, Lemuel R Waitman, Michael E Matheny, Steven Q Simpson, Yong Hu, Mei Liu,

Artificial intelligence (AI) has demonstrated promise in predicting acute kidney injury (AKI), however, clinical adoption of these models requires interpretability and transportability. Non-interoperable data across hospitals is a major barrier to model transportability. Here, we leverage the US PCORnet platform to develop an AKI prediction model and assess its transportability ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):5668]

Cited: 3 times

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Convalescent Plasma for the Treatment of COVID-19: Perspectives of the National Institutes of Health COVID-19 Treatment Guidelines Panel.

Alice K Pau, Judith Aberg, Jason Baker, Pamela S Belperio, Craig Coopersmith, Page Crew, Birgit Grund, Roy M Gulick, Carly Harrison, Arthur Kim, H Clifford Lane, Henry Masur, Virginia Sheikh, Kanal Singh, Jinoos Yazdany, Pablo Tebas, ,

Ann Intern Med (Annals of internal medicine)
[2021, 174(1):93-95]

Cited: 14 times

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Coronavirus Disease 2019 Sepsis: A Nudge Toward Antibiotic Stewardship.

Angel O Coz Yataco, Steven Q Simpson,

Chest (Chest)
[2020, 158(5):1833-1834]

Cited: 5 times

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Impact of Small-N Studies During a Pandemic.

Dominic P Corsello, Deepa B Gotur, Christopher L Carroll, Faisal N Masud, Steven Q Simpson,

Chest (Chest)
[2020, 158(4):1338-1340]

Cited: 0 times

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Application of Ribosomal Internal Transcribed Spacer 1, Internal Transcribed Spacer 2, and Large-Subunit D1-D2 Regions as the Genetic Markers to Identify Fungi Isolated from Different Environmental Samples: A Molecular Surveillance Study of Public Health Importance.

Irshad M Sulaiman, Emily Jacobs, Steven Simpson,

<h4>Background</h4>In September 2012, a multistate fungal meningitis outbreak started across 20 states in the United States. It affected 753 individuals and caused 64 deaths who received contaminated spinal injections. In a previous study, we analyzed 26 environmental samples collected from the manufacturing premises of a compounding company to determine the ... Read more >>

J AOAC Int (Journal of AOAC International)
[2020, 103(3):843-850]

Cited: 0 times

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Antibiotic Stewardship in the Intensive Care Unit. An Official American Thoracic Society Workshop Report in Collaboration with the AACN, CHEST, CDC, and SCCM.

Richard G Wunderink, Arjun Srinivasan, Philip S Barie, Jean Chastre, Charles S Dela Cruz, Ivor S Douglas, Margaret Ecklund, Scott E Evans, Scott R Evans, Anthony T Gerlach, Lauri A Hicks, Michael Howell, Melissa L Hutchinson, Robert C Hyzy, Sandra L Kane-Gill, Erika D Lease, Mark L Metersky, Nancy Munro, Michael S Niederman, Marcos I Restrepo, Curtis N Sessler, Steven Q Simpson, Sandra M Swoboda, Christina Vazquez Guillamet, Grant W Waterer, Curtis H Weiss,

Intensive care units (ICUs) are an appropriate focus of antibiotic stewardship program efforts because a large proportion of any hospital's use of parenteral antibiotics, especially broad-spectrum, occurs in the ICU. Given the importance of antibiotic stewardship for critically ill patients and the importance of critical care practitioners as the front ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2020, 17(5):531-540]

Cited: 4 times

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Sepsis Among Medicare Beneficiaries: 2. The Trajectories of Sepsis, 2012-2018.

Timothy G Buchman, Steven Q Simpson, Kimberly L Sciarretta, Kristen P Finne, Nicole Sowers, Michael Collier, Saurabh Chavan, Ibijoke Oke, Meghan E Pennini, Aathira Santhosh, Marie Wax, Robyn Woodbury, Steve Chu, Tyler G Merkeley, Gary L Disbrow, Rick A Bright, Thomas E MaCurdy, Jeffrey A Kelman,

OBJECTIVES:To distinguish characteristics of Medicare beneficiaries who will have an acute inpatient admission for sepsis from those who have an inpatient admission without sepsis, and to describe their further trajectories during and subsequent to those inpatient admissions. DESIGN:Analysis of paid Medicare claims via the Centers for Medicare and Medicaid Services ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(3):289-301]

Cited: 5 times

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Sepsis Among Medicare Beneficiaries: 1. The Burdens of Sepsis, 2012-2018.

Timothy G Buchman, Steven Q Simpson, Kimberly L Sciarretta, Kristen P Finne, Nicole Sowers, Michael Collier, Saurabh Chavan, Ibijoke Oke, Meghan E Pennini, Aathira Santhosh, Marie Wax, Robyn Woodbury, Steve Chu, Tyler G Merkeley, Gary L Disbrow, Rick A Bright, Thomas E MaCurdy, Jeffrey A Kelman,

OBJECTIVES:To provide contemporary estimates of the burdens (costs and mortality) associated with acute inpatient Medicare beneficiary admissions for sepsis. DESIGN:Analysis of paid Medicare claims via the Centers for Medicare & Medicaid Services DataLink Project. SETTING:All U.S. acute care hospitals, excluding federally operated hospitals (Veterans Administration and Defense Health Agency). PATIENTS:All ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(3):276-288]

Cited: 21 times

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Sepsis Among Medicare Beneficiaries: 3. The Methods, Models, and Forecasts of Sepsis, 2012-2018.

Timothy G Buchman, Steven Q Simpson, Kimberly L Sciarretta, Kristen P Finne, Nicole Sowers, Michael Collier, Saurabh Chavan, Ibijoke Oke, Meghan E Pennini, Aathira Santhosh, Marie Wax, Robyn Woodbury, Steve Chu, Tyler G Merkeley, Gary L Disbrow, Rick A Bright, Thomas E MaCurdy, Jeffrey A Kelman,

OBJECTIVE:To evaluate the impact of sepsis, age, and comorbidities on death following an acute inpatient admission and to model and forecast inpatient and skilled nursing facility costs for Medicare beneficiaries during and subsequent to an acute inpatient sepsis admission. DESIGN:Analysis of paid Medicare claims via the Centers for Medicare & ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(3):302-318]

Cited: 5 times

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