Full Text Journal Articles by
Author Steven Lane

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A knockout combination for MPN stem cells.

Megan Bywater, Steven W Lane,

Myeloproliferative neoplasms (MPNs) are a group of blood cancers that are maintained by stem cell populations. In this issue of JEM, Dagher et al. (https://doi.org/10.1084/jem.20201268) combine arsenic and interferon α to deliver a knockout punch to MPN stem cells and provide new hope to cure patients with MPNs. ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2021, 218(2):]

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Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.

Ashok Kumar Jayavelu, Tina M Schnöder, Florian Perner, Carolin Herzog, Arno Meiler, Gurumoorthy Krishnamoorthy, Nicolas Huber, Juliane Mohr, Bärbel Edelmann-Stephan, Rebecca Austin, Sabine Brandt, Francesca Palandri, Nicolas Schröder, Berend Isermann, Frank Edlich, Amit U Sinha, Martin Ungelenk, Christian A Hübner, Robert Zeiser, Susann Rahmig, Claudia Waskow, Iain Coldham, Thomas Ernst, Andreas Hochhaus, Stefanie Jilg, Philipp J Jost, Ann Mullally, Lars Bullinger, Peter R Mertens, Steven W Lane, Matthias Mann, Florian H Heidel,

Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells<sup>1,2</sup>. The JAK gene JAK2 is frequently mutated in the ageing haematopoietic system<sup>3,4</sup> and in haematopoietic cancers<sup>5</sup>. JAK2 mutations constitutively activate downstream signalling and are drivers of myeloproliferative neoplasm (MPN). In clinical use, JAK inhibitors have mixed ... Read more >>

Nature (Nature)
[2020, 588(7836):157-163]

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Real-World Evidence of Caplacizumab Use in the Management of Acute TTP.

Tina Dutt, Rebecca J Shaw, Matthew James Stubbs, Jun Yong, Benjamin Bailiff, Tanya Cranfield, Maeve P Crowley, Michael J R Desborough, Toby Andrew Eyre, Richard Gooding, John Grainger, John P Hanley, Joanna Haughton, Joannes Hermans, Quentin A Hill, Louise Humphrey, Gillian C Lowe, Hamish Lyall, Muhammad Mohsin, Phillip Lindsay Ross Nicolson, Nicole Priddee, Alexandros Rampotas, Rachel Rayment, Susan Rhodes, Alice Taylor, Will Thomas, Oliver Tomkins, Joost J van Veen, Steven Lane, Cheng-Hock Toh, Marie Scully,

The cornerstone of life-saving therapy in immune mediated thrombotic thrombocytopenic purpura (iTTP) has been plasma exchange (PEX) combined with immunomodulatory strategies. Caplacizumab, a novel anti-von Willebrand factor nanobody, trialled in two multicentre, randomised-placebo-controlled trials leading to EU and FDA approval, has been available in the UK through a patient-access scheme. ... Read more >>

Blood (Blood)
[2020, :]

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Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory.

Megan S F Soon, Hyun Jae Lee, Jessica A Engel, Jasmin Straube, Bryce S Thomas, Clara P S Pernold, Lachlan S Clarke, Pawat Laohamonthonkul, Rohit N Haldar, Cameron G Williams, Lianne I M Lansink, Marcela L Moreira, Michael Bramhall, Lambros T Koufariotis, Scott Wood, Xi Chen, Kylie R James, Tapio Lönnberg, Steven W Lane, Gabrielle T Belz, Christian R Engwerda, David S Khoury, Miles P Davenport, Valentine Svensson, Sarah A Teichmann, Ashraful Haque,

The dynamics of CD4+ T cell memory development remain to be examined at genome scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its cessation and associates with effects on CD4+ T cells. We applied single-cell RNA sequencing and computational modelling to track memory development during Plasmodium infection and treatment. ... Read more >>

Nat Immunol (Nature immunology)
[2020, 21(12):1597-1610]

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Identifying critically ill children at high risk of acute kidney injury and renal replacement therapy.

Rachel J McGalliard, Stephen J McWilliam, Samuel Maguire, Caroline A Jones, Rebecca J Jennings, Sarah Siner, Paul Newland, Matthew Peak, Christine Chesters, Graham Jeffers, Caroline Broughton, Lynsey McColl, Steven Lane, Stephane Paulus, Nigel A Cunliffe, Paul Baines, Enitan D Carrol,

Acute kidney injury (AKI), a common complication in paediatric intensive care units (PICU), is associated with increased morbidity and mortality. In this single centre, prospective, observational cohort study, neutrophil gelatinase-associated lipocalin in urine (uNGAL) and plasma (pNGAL) and renal angina index (RAI), and combinations of these markers, were assessed for ... Read more >>

PLoS One (PloS one)
[2020, 15(10):e0240360]

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Do not get burnt by damn statistics.

Chen Li, Steven Lane, Stephen McKeever,

J Child Health Care (Journal of child health care : for professionals working with children in the hospital and community)
[2020, 24(4):449-501]

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Reply to: Anti-FXa Activity with Intermediate Dose Thromboprophylaxis in COVID-19.

Tina Dutt, David Simcox, Colin Downey, Daniella McLenaghan, Charlotte King, Manish Gautam, Steven Lane, Hassan Burhan,

Dutt T, Simcox D, Downey C, McLenaghan, D, King, C, Gautam, M, Lane, S, Burhan, H, Thromboprophylaxis in COVID-19: Anti-FXa - The Missing Factor? [published online ahead of print, 2020 Jun 8]. Am J Respir Crit Care Med. 2020;10.1164/rccm.202005-1654LE. doi:10.1164/rccm.202005-1654LE. ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, :]

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Developing a Preoperative Algorithm for the Diagnosis of Uterine Leiomyosarcoma.

Hannah Lawlor, Alexandra Ward, Alison Maclean, Steven Lane, Meera Adishesh, Sian Taylor, Shandya Bridget DeCruze, Dharani Kosala Hapangama,

Early diagnosis of the rare and life-threatening uterine leiomyosarcoma (LMS) is essential for prompt treatment, to improve survival. Preoperative distinction of LMS from benign leiomyoma remains a challenge, and thus LMS is often diagnosed post-operatively. This retrospective observational study evaluated the predictive diagnostic utility of 32 preoperative variables in 190 ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 10(10):]

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Culturally adapted family intervention for schizophrenia in Pakistan: a feasibility study.

Muhammad Omair Husain, Ameer B Khoso, Laoise Renwick, Tayyeba Kiran, Sofiya Saeed, Steven Lane, Farooq Naeem, Imran B Chaudhry, Nusrat Husain,

OBJECTIVES:To establish feasibility and acceptability of a Culturally adapted Family Intervention (CulFI) that was developed using an empirically derived conceptual framework in Pakistan. METHODS:A rater-blind, randomised trial to evaluate the feasibility and acceptability of delivering CulFI compared to treatment as usual in Karachi, Pakistan. Indicators of feasibility included evaluation of ... Read more >>

Int J Psychiatry Clin Pract (International journal of psychiatry in clinical practice)
[2020, :1-10]

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Reimagining Physician Assistant Education.

Karen Hills, Stephane VanderMeulen, Jennifer A Snyder, William Kohlhepp, Lisa Mustone Alexander, Steven Lane,

The physician assistant (PA) profession has successfully flourished for over 50 years, demand for graduates remains strong, and there is a wealth of research on the quality of care that PA graduates provide. Nevertheless, health care and education are constantly changing, and we must change with them. We must continually ... Read more >>

J Physician Assist Educ (The journal of physician assistant education : the official journal of the Physician Assistant Education Association)
[2020, 31(3):126-132]

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MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment.

Julian Grabek, Jasmin Straube, Megan Bywater, Steven W Lane,

Myeloproliferative neoplasms (MPNs) constitute a group of disorders identified by an overproduction of cells derived from myeloid lineage. The majority of MPNs have an identifiable driver mutation responsible for cytokine-independent proliferative signalling. The acquisition of coexisting mutations in chromatin modifiers, spliceosome complex components, DNA methylation modifiers, tumour suppressors and transcriptional ... Read more >>

Cells (Cells)
[2020, 9(8):]

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Murine Models of Myelofibrosis.

Sebastien Jacquelin, Frederike Kramer, Ann Mullally, Steven W Lane,

Myelofibrosis (MF) is subtype of myeloproliferative neoplasm (MPN) characterized by a relatively poor prognosis in patients. Understanding the factors that drive MF pathogenesis is crucial to identifying novel therapeutic approaches with the potential to improve patient care. Driver mutations in three main genes (janus kinase 2 (JAK2), calreticulin (CALR), and ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(9):]

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Thromboprophylaxis in COVID-19: Anti-FXa-the Missing Factor?

Tina Dutt, David Simcox, Colin Downey, Daniella McLenaghan, Charlotte King, Manish Gautam, Steven Lane, Hassan Burhan,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 202(3):455-457]

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Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia.

Therese Vu, Jasmin Straube, Amy H Porter, Megan Bywater, Axia Song, Victoria Ling, Leanne Cooper, Gabor Pali, Claudia Bruedigam, Sebastien Jacquelin, Joanne Green, Graham Magor, Andrew Perkins, Alistair M Chalk, Carl R Walkley, Florian H Heidel, Pamela Mukhopadhyay, Nicole Cloonan, Stefan Gröschel, Jan-Philipp Mallm, Stefan Fröhling, Claudia Scholl, Steven W Lane,

The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during normal blood formation. Retroviral overexpression of Cdx2 induces AML in mice, however the developmental stage at which CDX2 exerts its effect is unknown. We developed a conditionally inducible Cdx2 mouse model to determine the effects of ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):3021]

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Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria.

Christopher A Moxon, Yasir Alhamdi, Janet Storm, Julien M H Toh, Dagmara McGuinness, Joo Yeon Ko, George Murphy, Steven Lane, Terrie E Taylor, Karl B Seydel, Sam Kampondeni, Michael Potchen, James S O'Donnell, Niamh O'Regan, Guozheng Wang, Guillermo García-Cardeña, Malcolm Molyneux, Alister G Craig, Simon T Abrams, Cheng-Hock Toh,

Microvascular thrombosis and blood-brain barrier (BBB) breakdown are key components of cerebral malaria (CM) pathogenesis in African children and are implicated in fatal brain swelling. How Plasmodium falciparum infection causes this endothelial disruption and why this occurs, particularly in the brain, is not fully understood. In this study, we have ... Read more >>

Blood Adv (Blood advances)
[2020, 4(13):2851-2864]

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Body Size of Temperate Sea Spiders: No Evidence of Oxygen-Temperature Limitations.

Caitlin M Shishido, H Arthur Woods, Bret W Tobalske, Steven J Lane, Amy L Moran,

AbstractOxygen limitation has been proposed as one of the key factors that limits body size at high temperatures (the oxygen-temperature hypothesis). Geographic patterns in body size are thought to be driven in part by the effects of temperature on oxygen supply and demand, particularly when the increased oxygen demand of ... Read more >>

Biol Bull (The Biological bulletin)
[2020, 239(1):51-61]

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Orthoptic Services in the UK and Ireland During the COVID-19 Pandemic.

Fiona Rowe, Lauren Hepworth, Claire Howard, Steven Lane,

Aim:COVID-19 has widely impacted hospital services. The purpose of this study was to determine the impact of COVID-19 on Orthoptists and their clinical practice in the UK, Ireland, and Channel Islands. Methods:We conducted a prospective survey-based cross-sectional study using an online survey aiming for coverage of orthoptic departments across the ... Read more >>

Br Ir Orthopt J (The British and Irish orthoptic journal)
[2020, 16(1):29-37]

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A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.

Simon Abrams, Ben Morton, Yasir Alhamdi, Mohmad Alsabani, Zhenxing Cheng, Steven Lane, Ingeborg Welters, Guozheng Wang, Cheng-Hock Toh,

Clin Med (Lond) (Clinical medicine (London, England))
[2020, 20(Suppl 2):s114-s115]

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Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis.

Rajiv Kumar, Patrick T Bunn, Siddharth Sankar Singh, Susanna S Ng, Marcela Montes de Oca, Fabian De Labastida Rivera, Shashi Bhushan Chauhan, Neetu Singh, Rebecca J Faleiro, Chelsea L Edwards, Teija C M Frame, Meru Sheel, Rebecca J Austin, Steven W Lane, Tobias Bald, Mark J Smyth, Geoffrey R Hill, Shannon E Best, Ashraful Haque, Dillon Corvino, Nic Waddell, Lambross Koufariotis, Pamela Mukhopadhay, Madhukar Rai, Jaya Chakravarty, Om Prakash Singh, David Sacks, Susanne Nylen, Jude Uzonna, Shyam Sundar, Christian R Engwerda,

Type I interferons (IFNs) play critical roles in anti-viral and anti-tumor immunity. However, they also suppress protective immune responses in some infectious diseases. Here, we identify type I IFNs as major upstream regulators of CD4+ T cells from visceral leishmaniasis (VL) patients. Furthermore, we report that mice deficient in type I ... Read more >>

Cell Rep (Cell reports)
[2020, 30(8):2512-2525.e9]

Cited: 2 times

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Orthoptic Services in the UK and Ireland During the COVID-19 Pandemic

Fiona Rowe, Lauren Hepworth, Claire Howard, Steven Lane,

Aim: COVID-19 has widely impacted hospital services. The purpose of this study was to determine the impact of COVID-19 on Orthoptists and their clinical practice in the UK, Ireland, and Channel Islands. Methods: We conducted a prospective survey-based cross-sectional study using an online survey aiming for coverage of orthoptic departments ... Read more >>

Br Ir Orthopt J (The British and Irish orthoptic journal)
[2020, 16(1):29-37]

Cited: 0 times

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Babies in occiput posterior position are significantly more likely to require an emergency cesarean birth compared with babies in occiput transverse position in the second stage of labor: A prospective observational study.

Nicola Tempest, Steven Lane, Dharani Hapangama, ,

INTRODUCTION:Malposition complicates 2-13% of births at delivery, leading to increased obstetric interventions (cesarean section and instrumental delivery) and higher rates of adverse fetal and maternal outcomes. Limited data are available regarding the likely rates of obstetric intervention and subsequent neonatal and maternal outcomes of births with babies in persistent occiput ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2020, 99(4):537-545]

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Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations.

Rebecca J Austin, Jasmin Straube, Claudia Bruedigam, Gabor Pali, Sebastien Jacquelin, Therese Vu, Joanne Green, Julius Gräsel, Lianne Lansink, Leanne Cooper, Shin-Jye Lee, Nien-Tsu Chen, Chung-Wei Lee, Ashraful Haque, Florian H Heidel, Richard D'Andrea, Geoff R Hill, Ann Mullally, Michael D Milsom, Megan Bywater, Steven W Lane,

JAK2V617F is the most common mutation in patients with BCR-ABL negative myeloproliferative neoplasms (MPNs). The eradication of JAK2V617F hematopoietic stem cells (HSCs) is critical for achieving molecular remissions and cure. We investigate the distinct effects of two therapies, ruxolitinib (JAK1/2 inhibitor) and interferon-alpha (IFN-α), on the disease-initiating HSC population. Whereas ... Read more >>

Leukemia (Leukemia)
[2020, 34(4):1075-1089]

Cited: 2 times

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Exercise and Physical Therapy Interventions for Children with Ataxia: A Systematic Review.

Helen Hartley, Elizabeth Cassidy, Lisa Bunn, Ram Kumar, Barry Pizer, Steven Lane, Bernie Carter,

The effectiveness of exercise and physical therapy for children with ataxia is poorly understood. The aim of this systematic review was to critically evaluate the range, scope and methodological quality of studies investigating the effectiveness of exercise and physical therapy interventions for children with ataxia. The following databases were searched: ... Read more >>

Cerebellum (Cerebellum (London, England))
[2019, 18(5):951-968]

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Inflammation in del(20q): a MST opportunity?

Steven W Lane,

Blood (Blood)
[2019, 134(20):1685-1686]

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Dynamic Electronic Tracking and Escalation to reduce Critical care Transfers (DETECT): the protocol for a stepped wedge mixed method study to explore the clinical effectiveness, clinical utility and cost-effectiveness of an electronic physiological surveillance system for use in children.

Gerri Sefton, Bernie Carter, Steven Lane, Matthew Peak, Ceu Mateus, Jen Preston, Fulya Mehta, Bruce Hollingsworth, Roger Killen, Enitan D Carrol,

BACKGROUND:Active monitoring of hospitalised adults, using handheld electronic physiological surveillance systems, is associated with reduced in-patient mortality in the UK. Potential also exists to improve the recognition and response to deterioration in hospitalised children. However, the clinical effectiveness, the clinical utility, and the cost-effectiveness of this technology to reduce paediatric ... Read more >>

BMC Pediatr (BMC pediatrics)
[2019, 19(1):359]

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