Full Text Journal Articles by
Author Steven L Bealer

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Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure.

Jay Spampanato, Wendy Pouliot, Steven L Bealer, Bonnie Roach, Francis Edward Dudek,

OBJECTIVE:Exposure to organophosphates (OPs) and OP nerve agents (NAs) causes status epilepticus (SE) and irreversible brain damage. Rapid control of seizure activity is important to minimize neuronal injury and the resulting neurological and behavioral disorders; however, early treatment will not be possible after mass release of OPs or NAs. METHODS:We ... Read more >>

Epilepsia (Epilepsia)
[2019, 60(7):1387-1398]

Cited: 1 time

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Age-dependent behaviors, seizure severity and neuronal damage in response to nerve agents or the organophosphate DFP in immature and adult rats.

Erika A Scholl, Stephanie M Miller-Smith, Steven L Bealer, Mark J Lehmkuhle, Jeffrey J Ekstrand, F Edward Dudek, John H McDonough,

Exposure to nerve agents (NAs) and other organophosphates (OPs) can initiate seizures that rapidly progress to status epilepticus (SE). While the electrographic and neuropathological sequelae of SE evoked by NAs and OPs have been characterized in adult rodents, they have not been adequately investigated in immature animals. In this study ... Read more >>

Neurotoxicology (Neurotoxicology)
[2018, 66:10-21]

Cited: 5 times

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Seizures following hippocampal kindling induce QT interval prolongation and increased susceptibility to arrhythmias in rats.

Steven L Bealer, Jason G Little,

The prolonged seizures of status epilepticus produce chronic arrhythmogenic changes in cardiac function. This study was designed to determine if repeated, self-limiting seizures administered to kindled rats induce similar cardiac dysfunction. Multiple seizures administered to rats following hippocampal kindling resulted in cardiac QT interval prolongation and increased susceptibility to experimental ... Read more >>

Epilepsy Res. (Epilepsy research)
[2013, 105(1-2):216-219]

Cited: 14 times

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β adrenergic blockade prevents cardiac dysfunction following status epilepticus in rats.

Jason G Little, Steven L Bealer,

Status epilepticus (SE) can result in temporary cardiac dysfunction in patients, characterized by reduced ejection fraction, decreased ventricular contractility, and alterations in electrical activity of the heart. Although reversible, the cardiac effects of seizures are acutely life threatening, and may contribute to the delayed mortality following SE. The precise mechanisms ... Read more >>

Epilepsy Res. (Epilepsy research)
[2012, 99(3):233-239]

Cited: 8 times

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Methods for ECG evaluation of indicators of cardiac risk, and susceptibility to aconitine-induced arrhythmias in rats following status epilepticus.

Steven L Bealer, Cameron S Metcalf, Jason G Little,

Lethal cardiac arrhythmias contribute to mortality in a number of pathological conditions. Several parameters obtained from a non-invasive, easily obtained electrocardiogram (ECG) are established, well-validated prognostic indicators of cardiac risk in patients suffering from a number of cardiomyopathies. Increased heart rate, decreased heart rate variability (HRV), and increased duration and ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2011, (50):761-775]

Cited: 0 times

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Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus.

Steven L Bealer, Jason G Little, Cameron S Metcalf, Amy L Brewster, Anne E Anderson,

Prolonged seizure activity (status epilepticus; SE) can result in increased susceptibility to lethal ventricular arrhythmias for an extended period of time following seizure termination. SE is accompanied by acute, intense activation of the sympathetic nervous system (SymNS) and results in myocyte myofilament damage, arrhythmogenic alterations in cardiac electrical activity, and ... Read more >>

Epilepsy Res. (Epilepsy research)
[2010, 91(1):66-73]

Cited: 19 times

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Oxytocin release in magnocellular nuclei: neurochemical mediators and functional significance during gestation.

Steven L Bealer, William E Armstrong, William R Crowley,

When released from dendrites within the supraoptic (SON) and paraventricular (PVN) nuclei (intranuclear release) during suckling, oxytocin exerts autocrine and paracrine effects on oxytocin neurons that are necessary for the unique timing and episodic pattern of oxytocin release into the systemic circulation that is characteristic of lactation. Recent reports have ... Read more >>

Am. J. Physiol. Regul. Integr. Comp. Physiol. (American journal of physiology. Regulatory, integrative and comparative physiology)
[2010, 299(2):R452-8]

Cited: 20 times

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Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats.

Cameron S Metcalf, Steven Poelzing, Jason G Little, Steven L Bealer,

Status epilepticus (SE) is a seizure or series of seizures that persist for >30 min and often results in mortality. Death rarely occurs during or immediately following seizure activity, but usually within 30 days. Although ventricular arrhythmias have been implicated in SE-related mortality, the effects of this prolonged seizure activity ... Read more >>

Am. J. Physiol. Heart Circ. Physiol. (American journal of physiology. Heart and circulatory physiology)
[2009, 297(6):H2120-7]

Cited: 16 times

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Status epilepticus produces chronic alterations in cardiac sympathovagal balance.

Cameron S Metcalf, Przemyslaw B Radwanski, Steven L Bealer,

PURPOSE: Status epilepticus (SE) activates the autonomic nervous system, increasing sympathetic nervous system control of cardiac function during seizure activity. However, lasting effects of SE on autonomic regulation of the heart, which may contribute to mortality following seizure activity, are unknown. Therefore, autonomic control of cardiac function was assessed following ... Read more >>

Epilepsia (Epilepsia)
[2009, 50(4):747-754]

Cited: 11 times

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Oxytocin receptor binding in the hypothalamus during gestation in rats.

Steven L Bealer, David L Lipschitz, Gina Ramoz, William R Crowley,

Central oxytocin receptors (OTR) may be involved in adaptations of the brain oxytocin (OT) system during gestation, which are critical for systemic release of OT during parturition and lactation. We used quantitative autoradiography to determine changes in OTR binding in numerous brain sites during the course of gestation in the ... Read more >>

Am. J. Physiol. Regul. Integr. Comp. Physiol. (American journal of physiology. Regulatory, integrative and comparative physiology)
[2006, 291(1):R53-8]

Cited: 26 times

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Increased dietary sodium alters Fos expression in the lamina terminalis during intravenous angiotensin II infusion.

Steven L Bealer, Cameron S Metcalf, Ryan Heyborne,

These studies examined the effects of increased dietary sodium on expression of Fos, the protein product of c-fos, in forebrain structures in the rat following intravenous infusion with angiotensin II (AngII). Animals were provided with either tap water (Tap) or isotonic saline solution (Iso) as their sole drinking fluid for ... Read more >>

Exp. Neurol. (Experimental neurology)
[2007, 204(1):299-306]

Cited: 5 times

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Increased dietary sodium inhibits baroreflex-induced bradycardia during acute sodium loading.

Steven L Bealer,

The present study investigated the effects of increased dietary sodium on the modification of cardiac baroreflex responses induced by acute sodium loading. Changes in blood pressure and heart rate during intravenous phenylephrine and nitroprusside administration were compared using a four-parameter sigmoid logistic function before and after a 30-min infusion of ... Read more >>

Am. J. Physiol. Regul. Integr. Comp. Physiol. (American journal of physiology. Regulatory, integrative and comparative physiology)
[2005, 288(5):R1211-9]

Cited: 6 times

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Increased dietary sodium enhances activation of neurons in the medullary cardiovascular pathway during acute sodium loading in the rat.

Steven L Bealer, Cameron S Metcalf,

Increased sodium ingestion diminishes baroreflex-induced bradycardia in animals during acute sodium loading. These experiments studied effects of high sodium diet on activation of central nervous system sites associated with baroreflex activation and cardiovascular responses to hypernatremia during systemic sodium administration. Fos-like (Fos-Li) protein immunoreactivity was measured to estimate activation of ... Read more >>

Auton Neurosci (Autonomic neuroscience : basic & clinical)
[2005, 117(1):33-40]

Cited: 4 times

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Central neurokinin 3 receptors increase systemic oxytocin release: interaction with norepinephrine.

Steven L Bealer, Francis W Flynn,

Stimulation of central tachykinin receptors contributes to neuroendocrine functions of the hypothalamo-neurohypophyseal system. However, the specific role of each tachykinin receptor subtype has not been completely characterized. Specifically, while neurokinin 3 (NK3) receptor stimulation increases systemic vasopressin, the effects on oxytocin (OT) are not known. Therefore, the present studies investigated ... Read more >>

Exp. Neurol. (Experimental neurology)
[2003, 184(2):1027-1033]

Cited: 13 times

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Differential sensitivity of intranuclear and systemic oxytocin release to central noradrenergic receptor stimulation during mid- and late gestation in rats.

David L Lipschitz, William R Crowley, Steven L Bealer,

A number of changes occur in the oxytocin (OT) system during gestation, such as increases in hypothalamic OT mRNA, increased neural lobe and systemic OT, and morphological and electrophysiological changes in OT-containing magnocellular neurons, suggestive of altered neuronal sensitivity, which may be mediated by ovarian steroids. Because central norepinephrine (NE) ... Read more >>

Am. J. Physiol. Endocrinol. Metab. (American journal of physiology. Endocrinology and metabolism)
[2004, 287(3):E523-8]

Cited: 12 times

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Angiotensin II-induced release of oxytocin: interaction with norepinephrine and role in lactation.

Steven L Bealer, William R Crowley,

These studies examined the receptors involved in angiotensin II (Ang II) stimulated secretion of systemic oxytocin (OT) and the role of this peptide in release of OT during suckling. Plasma OT concentrations were measured following intracerebroventricular (icv) injection of vehicle, Ang II, or Ang II following pretreatment with a selective ... Read more >>

Regul. Pept. (Regulatory peptides)
[2003, 111(1-3):41-46]

Cited: 4 times

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Peripheral hyperosmolality reduces cardiac baroreflex sensitivity.

Steven L Bealer,

The effects of acute increases in peripheral osmolality on cardiac baroreflex sensitivity were tested in conscious, unrestrained rats by fitting values for arterial blood pressure and heart rate during acute pressor and depressor responses to a four-parameter, sigmoid logistic function curve. Cardiac baroreceptor reflex function curves were produced before and ... Read more >>

Auton Neurosci (Autonomic neuroscience : basic & clinical)
[2003, 104(1):25-31]

Cited: 8 times

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Increased dietary sodium alters neural control of blood pressure during intravenous ANG II infusion.

Steven L Bealer,

Increased dietary sodium enhances both excitatory and inhibitory blood pressure responses to stimulation of the central sympathetic nervous system (SNS) centers. In addition, long-term (hours to days) administration of ANG II increases blood pressure by activation of the SNS. These studies investigated the effects of increased dietary sodium on SNS ... Read more >>

Am. J. Physiol. Heart Circ. Physiol. (American journal of physiology. Heart and circulatory physiology)
[2003, 284(2):H559-65]

Cited: 4 times

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Systemic angiotensin II alters intrinsic heart rate through central mechanisms.

Steven L Bealer,

Angiotensin II (ang II)-induced increases in intrinsic heart rate (IHR), and the resulting tachycardia, may contribute to development of renal hypertension. Whether circulating ang II affects the cardiac pacemaker through peripheral mechanisms or through actions in the central nervous system (CNS) has not been directly tested. These studies determined the ... Read more >>

Brain Res. Bull. (Brain research bulletin)
[2002, 58(1):61-65]

Cited: 9 times

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