Full Text Journal Articles by
Author Steven K Huang

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High glycosyltransferase 8 domain containing two protein levels contribute to poor prognosis in urothelial carcinoma.

Tzu-Ju Chen, Ti-Chun Chan, Chien-Feng Li, Dissanayakage Dilshan Sampath Dissanayaka, Maryam Kianpour, Hong-Lin He, Steven K Huang, Wan-Shan Li, Nai-Yu Chen, Yow-Ling Shiue,

<h4>Objective</h4>To examine the expression levels of the glycosyltransferase 8 domain containing protein 2 and its clinical implications in urothelial carcinoma patients.<h4>Methods</h4>Data mining, immunohistochemistry together with H-score calculation was carried out to evaluate the glycosyltransferase 8 domain containing protein 2 levels on tissue specimens from urothelial carcinoma patients, retrospectively. Correlations between glycosyltransferase 8 domain containing protein 2 ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2021, :]

Cited: 0 times

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Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis.

Prathibha R Gajjala, Rajesh K Kasam, Divyalakshmi Soundararajan, Debora Sinner, Steven K Huang, Anil G Jegga, Satish K Madala,

Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease associated with unremitting fibroblast activation including fibroblast-to-myofibroblast transformation (FMT), migration, resistance to apoptotic clearance, and excessive deposition of extracellular matrix (ECM) proteins in the distal lung parenchyma. Aberrant activation of lung-developmental pathways is associated with severe fibrotic lung disease; however, ... Read more >>

JCI Insight (JCI insight)
[2021, :]

Cited: 0 times

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Clioquinol Attenuates Pulmonary Fibrosis through Inactivation of Fibroblasts via Iron Chelation.

Yumeng Zhu, Jing Chang, Ke Tan, Steven K Huang, Xin Liu, Xiaofan Wang, Mengshu Cao, Hongmin Zhang, Shuxin Li, Xianglin Duan, Yanzhong Chang, Yumei Fan, Pengxiu Cao,

Strict control of iron homeostasis is critical for the maintenance of normal lung function. Iron accumulates in the lungs of patients with idiopathic pulmonary fibrosis (PF), but the characteristics of iron metabolism in the pathogenesis of PF and related targeting therapeutics are not well studied. In this study, we investigated ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2021, 65(2):189-200]

Cited: 1 time

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Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix production.

Fatmah Al-Habeeb, Noof Aloufi, Hussein Traboulsi, Xingxing Liu, Parameswaran Nair, Christina Haston, Ilan Azuelos, Steven K Huang, Eric S White, Imed E Gallouzi, Sergio Di Marco, David H Eidelman, Carolyn J Baglole,

Idiopathic pulmonary fibrosis (IPF) is a disease of progressive scarring caused by excessive extracellular matrix (ECM) deposition and activation of α-SMA-expressing myofibroblasts. Human antigen R (HuR) is an RNA binding protein that promotes protein translation. Upon translocation from the nucleus to the cytoplasm, HuR functions to stabilize messenger RNA (mRNA) ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2021, 236(10):6836-6851]

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Knocking Out Smoking and Pulmonary Hypertension with a K.

Steven K Huang,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(10):1216-1218]

Cited: 0 times

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A Fresh Take on the "TCA" Cycle: TETs, Citrate, and Asthma.

Steven K Huang,

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2020, 63(1):1-3]

Cited: 0 times

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Vascular dysfunction in aged mice contributes to persistent lung fibrosis.

Nunzia Caporarello, Jeffrey A Meridew, Aja Aravamudhan, Dakota L Jones, Susan A Austin, Tho X Pham, Andrew J Haak, Kyoung Moo Choi, Qi Tan, Adil Haresi, Steven K Huang, Zvonimir S Katusic, Daniel J Tschumperlin, Giovanni Ligresti,

Idiopathic pulmonary fibrosis (IPF) is a progressive disease thought to result from impaired lung repair following injury and is strongly associated with aging. While vascular alterations have been associated with IPF previously, the contribution of lung vasculature during injury resolution and fibrosis is not well understood. To compare the role ... Read more >>

Aging Cell (Aging cell)
[2020, 19(8):e13196]

Cited: 6 times

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Transcriptional regulation of the IL-13Rα2 gene in human lung fibroblasts.

Loka R Penke, Hideyasu Ouchi, Jennifer M Speth, Njira Lugogo, Yvonne J Huang, Steven K Huang, Marc Peters-Golden,

Interleukin (IL)-13 is a type 2 cytokine with important roles in allergic diseases, asthma, and tissue fibrosis. Its receptor (R) α1 is primarily responsible for the biological actions of this cytokine, while Rα2 possesses a decoy function which can block IL-13 signaling. Although the expression of Rα2 is known to ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):1083]

Cited: 0 times

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The Role of KCNMB1 and BK Channels in Myofibroblast Differentiation and Pulmonary Fibrosis.

Anne M Scruggs, Gintautas Grabauskas, Steven K Huang,

The differentiation of fibroblasts into myofibroblasts is critical for the development of fibrotic disorders, including idiopathic pulmonary fibrosis (IPF). Previously, we demonstrated that fibroblasts from patients with IPF exhibit changes in DNA methylation across the genome that contribute to a profibrotic phenotype. One of the top differentially methylated genes identified ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2020, 62(2):191-203]

Cited: 2 times

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Amplification-driven BCL6-suppressed cytostasis is mediated by transrepression of FOXO3 and post-translational modifications of FOXO3 in urinary bladder urothelial carcinoma.

Wen-Ren Wu, Jen-Tai Lin, Cheng-Tang Pan, Ti-Chun Chan, Chen-Liang Liu, Wen-Jeng Wu, Jim Jinn-Chyuan Sheu, Bi-Wen Yeh, Steven K Huang, Jheng-Yan Jhung, Meng-Shin Hsiao, Chien-Feng Li, Yow-Ling Shiue,

Muscle-invasive urinary bladder urothelial carcinoma (UBUC) is a lethal disease for which effective prognostic markers and potential therapy targets are still lacking. Previous array comparative genomic hybridization identified that 3q27 is frequently amplified in muscle-invasive UBUCs, one candidate proto-oncogene, <i>B-cell CLL/lymphoma 6</i> (<i>BCL6</i>), mapped to this region. We therefore aimed ... Read more >>

Theranostics (Theranostics)
[2020, 10(2):707-724]

Cited: 3 times

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Therapeutic benefit of second-look transurethral resection of bladder tumors for newly diagnosed T1 bladder cancer: a single-center experience.

Wen-Hsin Tseng, Chien-Liang Liu, Steven K Huang, Alex Chien-Hwa Liao, Jinn-Rung Kuo, Shun-Hsing Hun, Chun-Hao Chen, Chia-Cheng Su, Jhih-Cheng Wang, Kau-Han Lee, Kun-Hung Shen, Chien-Feng Li,

<h4>Purpose</h4>In recent years, second-look transurethral resection of bladder tumors (TURBT) has been recommended for patients with stage T1 bladder cancer after the initial TURBT for restaging and deciding the subsequent treatment. However, we believe that second-look TURBT has therapeutic benefits, such as low incidence of recurrence and progression. Therefore, we ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2019, 51(8):1335-1342]

Cited: 1 time

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"Yap"-ing about the Antifibrotic Benefits of Prostacyclin.

Steven K Huang,

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2019, 60(5):499-500]

Cited: 1 time

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High TNFAIP6 level is associated with poor prognosis of urothelial carcinomas.

Ti-Chun Chan, Chien-Feng Li, Hung-Lung Ke, Yu-Ching Wei, Yow-Ling Shiue, Ching-Chia Li, Hsin-Chih Yeh, Hsiang-Ying Lee, Steven-K Huang, Wen-Jeng Wu, Wei-Ming Li,

<h4>Purpose</h4>Inflammatory responses affect each stage of carcinogenesis, from initiation, through invasion, to metastasis. Studies have shown that chronic inflammation induced by environmental and occupational exposures increase the risk of developing urothelial carcinoma (UC). Using a published UC transcriptome (GSE32894), we identified that among genes associated with inflammatory response (GO:0006954), TNFAIP6 ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(4):293.e11-293.e24]

Cited: 4 times

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Loss of CDKN2B Promotes Fibrosis via Increased Fibroblast Differentiation Rather Than Proliferation.

Anne M Scruggs, Hailey B Koh, Priya Tripathi, Nicholas J Leeper, Eric S White, Steven K Huang,

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease characterized by excessive scarring and fibroblast activation. We previously showed that fibroblasts from patients with IPF are hypermethylated at the CDKN2B gene locus, resulting in decreased CDKN2B expression. Here, we examine how diminished CDKN2B expression in normal and IPF fibroblasts affect ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2018, 59(2):200-214]

Cited: 5 times

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Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli.

Amos E Dodi, Iyabode O Ajayi, Christine Chang, Meghan Beard, Shanna L Ashley, Steven K Huang, Victor J Thannickal, Daniel J Tschumperlin, Thomas H Sisson, Jeffrey C Horowitz,

BACKGROUND:Fibroblast apoptosis is a critical component of normal repair and the acquisition of an apoptosis-resistant phenotype contributes to the pathogenesis of fibrotic repair. Fibroblasts from fibrotic lungs of humans and mice demonstrate resistance to apoptosis induced by Fas-ligand and prior studies have shown that susceptibility to apoptosis is enhanced when ... Read more >>

Respir Res (Respiratory research)
[2018, 19(1):91]

Cited: 10 times

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Epigenetic Regulation of Caveolin-1 Gene Expression in Lung Fibroblasts.

Yan Y Sanders, Hui Liu, Anne M Scruggs, Steven R Duncan, Steven K Huang, Victor J Thannickal,

Fibrotic disorders are associated with tissue accumulation of fibroblasts. We recently showed that caveolin (Cav)-1 gene suppression by a profibrotic cytokine, transforming growth factor (TGF)-β1, contributes to fibroblast proliferation and apoptosis resistance. Cav-1 has been shown to be constitutively suppressed in idiopathic pulmonary fibrosis (IPF), but mechanisms for this suppression ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2017, 56(1):50-61]

Cited: 16 times

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Transforming Growth Factor-β1 Increases DNA Methyltransferase 1 and 3a Expression through Distinct Post-transcriptional Mechanisms in Lung Fibroblasts.

Hailey B Koh, Anne M Scruggs, Steven K Huang,

DNA methylation is a fundamental epigenetic mark that plays a critical role in differentiation and is mediated by the actions of DNA methyltransferases (DNMTs). TGF-β1 is one of the most potent inducers of fibroblast differentiation, and although many of its actions on fibroblasts are well described, the ability of TGF-β1 ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2016, 291(37):19287-19298]

Cited: 7 times

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Protein kinase A inhibition of macrophage maturation is accompanied by an increase in DNA methylation of the colony-stimulating factor 1 receptor gene.

Zbigniew Zasłona, Anne M Scruggs, Marc Peters-Golden, Steven K Huang,

Macrophage colony-stimulating factor 1 (CSF-1) plays a critical role in the differentiation of mononuclear phagocytes from bone marrow precursors, and maturing monocytes and macrophages exhibit increased expression of the CSF-1 receptor, CSF1R. The expression of CSF1R is tightly regulated by transcription factors and epigenetic mechanisms. We previously showed that prostaglandin ... Read more >>

Immunology (Immunology)
[2016, 149(2):225-237]

Cited: 3 times

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Reversal of the Transcriptome by Prostaglandin E2 during Myofibroblast Dedifferentiation.

Scott H Wettlaufer, Jacob P Scott, Richard C McEachin, Marc Peters-Golden, Steven K Huang,

Myofibroblasts, the major effector cells in pathologic fibrosis, derive from the differentiation of fibroblasts driven by mediators such as transforming growth factor-β1 (TGF-β1) and biomechanical signals. Although the myofibroblast has traditionally been considered a terminally differentiated cell, the lipid mediator prostaglandin E2 (PGE2) has been shown to not only prevent ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2016, 54(1):114-127]

Cited: 20 times

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Epigenetic Regulation of Tolerance to Toll-Like Receptor Ligands in Alveolar Epithelial Cells.

Jacqueline Neagos, Theodore J Standiford, Michael W Newstead, Xianying Zeng, Steven K Huang, Megan N Ballinger,

To protect the host against exuberant inflammation and injury responses, cells have the ability to become hyporesponsive or "tolerized" to repeated stimulation by microbial and nonmicrobial insults. The lung airspace is constantly exposed to a variety of exogenous and endogenous Toll-like receptor (TLR) ligands, yet the ability of alveolar epithelial ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2015, 53(6):872-881]

Cited: 19 times

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Prostaglandin E₂ and polyenylphosphatidylcholine: stiff competition for the fibrotic complications of inflammatory bowel disease?

Steven K Huang, Marc Peters-Golden,

Dig Dis Sci (Digestive diseases and sciences)
[2015, 60(6):1514-1516]

Cited: 0 times

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Transforming growth factor-β induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation.

Racquel Domingo-Gonzalez, Carol A Wilke, Steven K Huang, Yasmina Laouar, Jeanette P Brown, Christine M Freeman, Jeffrey L Curtis, Gregory A Yanik, Bethany B Moore,

Hematopoietic stem cell transplantation (HSCT) is complicated by pulmonary infections that manifest posttransplantation. Despite engraftment, susceptibility to infections persists long after reconstitution. Previous work using a murine bone marrow transplant (BMT) model implicated increased cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in promoting impaired alveolar macrophage (AM) responses. However, mechanisms driving ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2015, 308(1):L86-95]

Cited: 12 times

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Lung fibroblasts from patients with idiopathic pulmonary fibrosis exhibit genome-wide differences in DNA methylation compared to fibroblasts from nonfibrotic lung.

Steven K Huang, Anne M Scruggs, Richard C McEachin, Eric S White, Marc Peters-Golden,

Excessive fibroproliferation is a central hallmark of idiopathic pulmonary fibrosis (IPF), a chronic, progressive disorder that results in impaired gas exchange and respiratory failure. Fibroblasts are the key effector cells in IPF, and aberrant expression of multiple genes contributes to their excessive fibroproliferative phenotype. DNA methylation changes are critical to ... Read more >>

PLoS One (PloS one)
[2014, 9(9):e107055]

Cited: 45 times

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Prostaglandin E2 inhibits α-smooth muscle actin transcription during myofibroblast differentiation via distinct mechanisms of modulation of serum response factor and myocardin-related transcription factor-A.

Loka R K Penke, Steven K Huang, Eric S White, Marc Peters-Golden,

Differentiation of lung fibroblasts into contractile protein-expressing myofibroblasts by transforming growth factor-β1 (TGF-β1) is a critical event in the pathogenesis of pulmonary fibrosis. Transcription of the contractile protein α-smooth muscle actin (α-SMA) is mediated by the transcription factor serum-response factor (SRF) along with its co-activator, myocardin-related transcription factor-A (MRTF-A). The ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2014, 289(24):17151-17162]

Cited: 42 times

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Outstaying their Welcome: The Persistent Myofibroblast in IPF.

Steven K Huang, Jeffrey C Horowitz,

Austin J Pulm Respir Med (Austin journal of pulmonary and respiratory medicine)
[2014, 1(1):3]

Cited: 3 times

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