Full Text Journal Articles by
Author Steven J Philips

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CueR activates transcription through a DNA distortion mechanism.

Chengli Fang, Steven J Philips, Xiaoxian Wu, Kui Chen, Jing Shi, Liqiang Shen, Juncao Xu, Yu Feng, Thomas V O'Halloran, Yu Zhang,

The MerR-family transcription factors (TFs) are a large group of bacterial proteins responding to cellular metal ions and multiple antibiotics by binding within central RNA polymerase-binding regions of a promoter. While most TFs alter transcription through protein-protein interactions, MerR TFs are capable of reshaping promoter DNA. To address the question ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

Cited: 0 times

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Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy.

Emily L Que, Francesca E Duncan, Amanda R Bayer, Steven J Philips, Eric W Roth, Reiner Bleher, Sophie C Gleber, Stefan Vogt, Teresa K Woodruff, Thomas V O'Halloran,

During fertilization or chemically-induced egg activation, the mouse egg releases billions of zinc atoms in brief bursts known as 'zinc sparks.' The zona pellucida (ZP), a glycoprotein matrix surrounding the egg, is the first structure zinc ions encounter as they diffuse away from the plasma membrane. Following fertilization, the ZP ... Read more >>

Integr Biol (Camb) (Integrative biology : quantitative biosciences from nano to macro)
[2017, 9(2):135-144]

Cited: 13 times

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TRANSCRIPTION. Allosteric transcriptional regulation via changes in the overall topology of the core promoter.

Steven J Philips, Monica Canalizo-Hernandez, Ilyas Yildirim, George C Schatz, Alfonso Mondragón, Thomas V O'Halloran,

Many transcriptional activators act at a distance from core promoter elements and work by recruiting RNA polymerase through protein-protein interactions. We show here how the prokaryotic regulatory protein CueR both represses and activates transcription by differentially modulating local DNA structure within the promoter. Structural studies reveal that the repressor state ... Read more >>

Science (Science (New York, N.Y.))
[2015, 349(6250):877-881]

Cited: 45 times

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Zinc, insulin, and the liver: a ménage à trois.

Thomas V O'Halloran, Melkam Kebede, Steven J Philips, Alan D Attie,

Insulin and Zn2+ enjoy a multivalent relationship. Zn2+ binds insulin in pancreatic β cells to form crystalline aggregates in dense core vesicles (DCVs), which are released in response to physiological signals such as increased blood glucose. This transition metal is an essential cofactor in insulin-degrading enzyme and several key Zn2+ ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2013, 123(10):4136-4139]

Cited: 14 times

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