Full Text Journal Articles by
Author Steven D Lovrich

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Detection of antibodies to decorin-binding protein A (DbpA) and DbpB after infection of dogs with Borrelia burgdorferi by tick challenge.

Darby G Oldenburg, Dean A Jobe, Steven D Lovrich, Rhonda L LaFleur, Douglas W White, Jennifer C Dant, Steven M Callister,

We characterized the antibody response to decorin-binding protein A (DbpA) or DbpB from immune serum samples collected from 27 dogs infected with <i>Borrelia burgdorferi</i> by <i>Ixodes scapularis</i> ticks. Immunoglobulin M (IgM) antibodies to DbpA or DbpB were rarely detected, but high levels of IgG antibodies to DbpA were detected in ... Read more >>

J Vet Diagn Invest (Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc)
[2020, 32(3):481-485]

Cited: 0 times

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Borrelia miyamotoi Infection in Patients from Upper Midwestern United States, 2014-2015.

Dean A Jobe, Steven D Lovrich, Darby G Oldenburg, Todd J Kowalski, Steven M Callister,

We confirmed Borrelia miyamotoi infection in 7 patients who had contracted an illness while near La Crosse, Wisconsin, USA, an area where Ixodes scapularis ticks are endemic. B. miyamatoi infection should now be considered among differential diagnoses for patients from the midwestern United States who have signs and symptoms suggestive ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2016, 22(8):1471-1473]

Cited: 18 times

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The Emergence of Clinically Relevant Babesiosis in Southwestern Wisconsin.

Todd J Kowalski, Dean A Jobe, Emily C Dolan, Anne Kessler, Steven D Lovrich, Steven M Callister,

<h4>Objective</h4>To determine the frequency and characteristics of babesiosis cases, and to assess the impact of the introduction of a tick-borne infection diagnostic panel on babesiosis diagnosis in the region surrounding La Crosse, Wisconsin, where babesiosis in non-travelers was previously rare.<h4>Methods</h4>In the spring of 2013, we conducted a point-in-time survey of ... Read more >>

WMJ (WMJ : official publication of the State Medical Society of Wisconsin)
[2015, 114(4):152-157]

Cited: 7 times

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Antibody responses to Borrelia burgdorferi outer surface proteins C and F in experimentally infected Beagle dogs.

Steven M Callister, Rhonda L LaFleur, Dean A Jobe, Steven D Lovrich, Terri L Wasmoen,

Antibody levels to outer surface proteins C and F (OspC and OspF, respectively) in sera collected from laboratory Beagle dogs at 1, 2, and 4 months after challenge with infected black-legged ticks (Ixodes scapularis) were determined. Each dog was confirmed by culture to harbor Borrelia burgdorferi in the skin (n ... Read more >>

J Vet Diagn Invest (Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc)
[2015, 27(4):526-530]

Cited: 3 times

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Vaccination with the ospA- and ospB-Negative Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease.

Rhonda L LaFleur, Steven M Callister, Jennifer C Dant, Terri L Wasmoen, Dean A Jobe, Steven D Lovrich,

Beagles received placebo or ospA- and ospB-negative Borrelia burgdorferi before a tick challenge. A total of 28 (41%) ticks and skin biopsy specimens from each control dog (n = 10) contained B. burgdorferi. In contrast, 12 (19%) ticks recovered from the vaccine recipients (n = 10) were infected (P = ... Read more >>

Clin Vaccine Immunol (Clinical and vaccine immunology : CVI)
[2015, 22(7):836-839]

Cited: 1 time

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Epidemiologic factors and urogenital infections associated with preterm birth in a midwestern U.S. population.

William A Agger, Danish Siddiqui, Steven D Lovrich, Steven M Callister, Andrew J Borgert, Kenneth W Merkitch, Tina C Mason, Dennis J Baumgardner, James K Burmester, Sanjay K Shukla, Joseph D Welter, Katharina S Stewart, M J Washburn, Howard H Bailey,

<h4>Objective</h4>To correlate epidemiologic factors with urogenital infections associated with preterm birth.<h4>Methods</h4>Pregnant women were sequentially included from four Wisconsin cohorts: large urban, midsize urban, small city, and rural city. Demographic, clinical, and current pregnancy data were collected. Cervical and urine specimens were analyzed by microscopy, culture, and polymerase chain reaction for ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2014, 124(5):969-977]

Cited: 15 times

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OmpR regulation of the uropathogenic Escherichia coli fimB gene in an acidic/high osmolality environment.

Ann E Rentschler, Steven D Lovrich, Robert Fitton, Jodi Enos-Berlage, William R Schwan,

Uropathogenic Escherichia coli (UPEC) causes more than 90 % of all human urinary tract infections through type 1 piliated UPEC cells binding to bladder epithelial cells. The FimB and FimE site-specific recombinases orient the fimS element containing the fimA structural gene promoter. Regulation of fimB and fimE depends on environmental pH ... Read more >>

Microbiology (Reading) (Microbiology (Reading, England))
[2013, 159(Pt 2):316-327]

Cited: 18 times

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Comparative whole-genome mapping to determine Staphylococcus aureus genome size, virulence motifs, and clonality.

Sanjay K Shukla, Madhulatha Pantrangi, Buffy Stahl, Adam M Briska, Mary E Stemper, Trevor K Wagner, Emily B Zentz, Steven M Callister, Steven D Lovrich, John K Henkhaus, Colin W Dykes,

Despite being a clonal pathogen, Staphylococcus aureus continues to acquire virulence and antibiotic-resistant genes located on mobile genetic elements such as genomic islands, prophages, pathogenicity islands, and the staphylococcal chromosomal cassette mec (SCCmec) by horizontal gene transfer from other staphylococci. The potential virulence of a S. aureus strain is often ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2012, 50(11):3526-3533]

Cited: 15 times

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Expansion of the Midwestern focus for human granulocytic anaplasmosis into the region surrounding La Crosse, Wisconsin.

Steven D Lovrich, Dean A Jobe, Todd J Kowalski, Seema M Policepatil, Steven M Callister,

Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis (HGA), shares the same enzootic life cycle as Borrelia burgdorferi, the causative agent of Lyme disease. Although La Crosse, WI, is a well-recognized Lyme disease focus with an abundance of Ixodes scapularis vector ticks and the first documentation of HGA occurred ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2011, 49(11):3855-3859]

Cited: 8 times

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One-year duration of immunity induced by vaccination with a canine Lyme disease bacterin.

Rhonda L LaFleur, Steven M Callister, Jennifer C Dant, Dean A Jobe, Steven D Lovrich, Thomas F Warner, Terri L Wasmoen, Ronald F Schell,

Laboratory-reared beagles were vaccinated with a placebo or a bacterin comprised of Borrelia burgdorferi S-1-10 and ospA-negative/ospB-negative B. burgdorferi 50772 and challenged after 1 year with B. burgdorferi-infected Ixodes scapularis ticks. For the placebo recipients, spirochetes were recovered from 9 (60%) skin biopsy specimens collected after 1 month, and the ... Read more >>

Clin Vaccine Immunol (Clinical and vaccine immunology : CVI)
[2010, 17(5):870-874]

Cited: 17 times

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Use of optical mapping to sort uropathogenic Escherichia coli strains into distinct subgroups.

William R Schwan, Adam Briska, Buffy Stahl, Trevor K Wagner, Emily Zentz, John Henkhaus, Steven D Lovrich, William A Agger, Steven M Callister, Brian DuChateau, Colin W Dykes,

Optical maps were generated for 33 uropathogenic Escherichia coli (UPEC) isolates. For individual genomes, the NcoI restriction fragments aligned into a unique chromosome map for each individual isolate, which was then compared with the in silico restriction maps of all of the sequenced E. coli and Shigella strains. All of ... Read more >>

Microbiology (Reading) (Microbiology (Reading, England))
[2010, 156(Pt 7):2124-2135]

Cited: 18 times

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Emergence of chronic myelogenous leukemia from a background of myeloproliferative disorder: JAK2V617F as a potential risk factor for BCR-ABL translocation.

Sai Ravi Kiran Pingali, Michelle A Mathiason, Steven D Lovrich, Ronald S Go,

We report the emergence of chronic myelogenous leukemia (CML) in a patient with JAK2V617F-positive polycythemia vera after 15 years of phlebotomy. The polycythemia vera clinical and molecular findings were suppressed at the time of CML diagnosis, only to re-emerge after the leukemia was successfully treated with imatinib. We explored the ... Read more >>

Clin Lymphoma Myeloma (Clinical lymphoma & myeloma)
[2009, 9(5):E25-9]

Cited: 14 times

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Bacterin that induces anti-OspA and anti-OspC borreliacidal antibodies provides a high level of protection against canine Lyme disease.

Rhonda L LaFleur, Jennifer C Dant, Terri L Wasmoen, Steven M Callister, Dean A Jobe, Steven D Lovrich, Thomas F Warner, O Abdelmagid, Ronald F Schell,

Groups of 15 laboratory-bred beagles were vaccinated and boosted with either a placebo or adjuvanted bivalent bacterin comprised of a traditional Borrelia burgdorferi strain and a unique ospA- and ospB-negative B. burgdorferi strain that expressed high levels of OspC and then challenged with B. burgdorferi-infected Ixodes scapularis ticks. The vaccinated ... Read more >>

Clin Vaccine Immunol (Clinical and vaccine immunology : CVI)
[2009, 16(2):253-259]

Cited: 31 times

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Borrelia burgdorferi in Ixodes scapularis ticks, Chicago area.

Dean A Jobe, Steven D Lovrich, Jeffrey A Nelson, Tom C Velat, Chris Anchor, Tad Koeune, Stephen A Martin,

Emerg Infect Dis (Emerging infectious diseases)
[2006, 12(6):1039-1041]

Cited: 8 times

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Significantly improved accuracy of diagnosis of early Lyme disease by peptide enzyme-linked immunosorbent assay based on the borreliacidal antibody epitope of Borrelia burgdorferi OspC.

Dean A Jobe, Steven D Lovrich, Krista E Asp, Michelle A Mathiason, Stephanie E Albrecht, Ronald F Schell, Steven M Callister,

Highly specific borreliacidal antibodies are induced by infection with Borrelia burgdorferi, and the immunodominant response during early Lyme disease is specific for an epitope within the 7 amino acids nearest the C terminus of OspC. We evaluated the ability of an enzyme-linked immunosorbent assay (ELISA) based on a synthetic peptide ... Read more >>

Clin Vaccine Immunol (Clinical and vaccine immunology : CVI)
[2008, 15(6):981-985]

Cited: 12 times

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Borreliacidal OspC antibody response of canines with Lyme disease differs significantly from that of humans with Lyme disease.

Steven D Lovrich, Rhonda L La Fleur, Dean A Jobe, Jennifer C Johnson, Krista E Asp, Ronald F Schell, Steven M Callister,

Humans reliably produce high concentrations of borreliacidal OspC antibodies specific for the seven C-terminal amino acids shortly after infection with Borrelia burgdorferi. We show that dogs also produce OspC borreliacidal antibodies but that their frequencies, intensities, and antigenicities differ significantly. The findings therefore confirm a major difference between the borreliacidal ... Read more >>

Clin Vaccine Immunol (Clinical and vaccine immunology : CVI)
[2007, 14(5):635-637]

Cited: 13 times

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Human cyclic thrombocytopenia and Anaplasma spp. infection.

Ronald S Go, Steven D Lovrich, Steven M Callister, Lori A Meyer, Wayne A Bottner, John P Farnen,

Eur J Haematol (European journal of haematology)
[2005, 74(2):182-183]

Cited: 0 times

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Borreliacidal OspC antibodies specific for a highly conserved epitope are immunodominant in human lyme disease and do not occur in mice or hamsters.

Steven D Lovrich, Dean A Jobe, Ronald F Schell, Steven M Callister,

Humans produce highly specific borreliacidal antibodies against outer surface protein C (OspC) shortly after infection with Borrelia burgdorferi sensu stricto. We previously demonstrated the epitope recognized by immunoglobulin M (IgM) and IgG OspC borreliacidal antibodies was located within the 50 amino acids nearest the carboxy (C) terminus. In this study, ... Read more >>

Clin Diagn Lab Immunol (Clinical and diagnostic laboratory immunology)
[2005, 12(6):746-751]

Cited: 21 times

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High prevalence of genital mycoplasmas among sexually active young adults with urethritis or cervicitis symptoms in La Crosse, Wisconsin.

Michael J Schlicht, Steven D Lovrich, Jeffrey S Sartin, Patricia Karpinsky, Steven M Callister, William A Agger,

Sexually active young adults in the small college town of La Crosse, Wisconsin, were evaluated for conventional sexually transmitted pathogens and tested for infections with mycoplasmas. The prevalence in 65 symptomatic men or women and 137 healthy volunteers (67 men and 70 women) was compared. Urine specimens from both cohorts ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2004, 42(10):4636-4640]

Cited: 25 times

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C-terminal region of outer surface protein C binds borreliacidal antibodies in sera from patients with Lyme disease.

Dean A Jobe, Steven D Lovrich, Ronald F Schell, Steven M Callister,

Borreliacidal antibodies specific for outer surface protein C (OspC) are induced shortly after infection with Borrelia burgdorferi. In this study, we identified the region of OspC recognized by immunoglobulin M (IgM) and IgG borreliacidal antibodies. Sera from patients with early Lyme disease were screened for borreliacidal activity specific for B. ... Read more >>

Clin Diagn Lab Immunol (Clinical and diagnostic laboratory immunology)
[2003, 10(4):573-578]

Cited: 20 times

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Reassessment of a midwestern Lyme disease focus for Borrelia burgdorferi and the human granulocytic ehrlichiosis agent.

Craig A Jackson, Steven D Lovrich, William A Agger, Steven M Callister,

Previous studies from the late 1980s defined the risk of human Lyme disease by determining the prevalence of Borrelia burgdorferi infection in Ixodes scapularis ticks and Peromyscus sp. mice captured from areas around La Crosse, Wis. High percentages of B. burgdorferi-infected I. scapularis ticks and P. leucopus mice were common ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2002, 40(6):2070-2073]

Cited: 16 times

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Ability of the borreliacidal antibody test to confirm lyme disease in clinical practice.

Steven M Callister, Dean A Jobe, William A Agger, Ronald F Schell, Todd J Kowalski, Steven D Lovrich, Jennifer A Marks,

Highly specific borreliacidal antibodies are induced by infection with Borrelia burgdorferi, and a borreliacidal antibody test (BAT) may be an accurate laboratory procedure for confirming Lyme disease in clinical practice. To investigate this, 34 Lyme disease sera and 34 sera from patients with other illnesses who had presented to a ... Read more >>

Clin Diagn Lab Immunol (Clinical and diagnostic laboratory immunology)
[2002, 9(4):908-912]

Cited: 14 times

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