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Comparing optimized exoskeleton assistance of the hip, knee, and ankle in single and multi-joint configurations

Patrick Franks, Gwendolyn Bryan, Russell Martin, Ricardo Reyes, Steven Collins,

Exoskeletons that assist the hip, knee, and ankle joints have begun to improve human mobility, particularly by reducing the metabolic cost of walking. However, direct comparisons of optimal assistance of these joints, or their combinations, have not yet been possible. Assisting multiple joints may be more beneficial than the sum ... Read more >>

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Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease.

Peter Hermann, Brian Appleby, Jean-Philippe Brandel, Byron Caughey, Steven Collins, Michael D Geschwind, Alison Green, Stephane Haïk, Gabor G Kovacs, Anna Ladogana, Franc Llorens, Simon Mead, Noriyuki Nishida, Suvankar Pal, Piero Parchi, Maurizio Pocchiari, Katsuya Satoh, Gianluigi Zanusso, Inga Zerr,

Sporadic Creutzfeldt-Jakob disease is a fatal neurodegenerative disease caused by misfolded prion proteins (PrP<sup>Sc</sup>). Effective therapeutics are currently not available and accurate diagnosis can be challenging. Clinical diagnostic criteria use a combination of characteristic neuropsychiatric symptoms, CSF proteins 14-3-3, MRI, and EEG. Supportive biomarkers, such as high CSF total tau, ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):235-246]

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Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease.

James M Roe, Didac Vidal-Piñeiro, Øystein Sørensen, Andreas M Brandmaier, Sandra Düzel, Hector A Gonzalez, Rogier A Kievit, Ethan Knights, Simone Kühn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Denise C Park, Sara Pudas, Melissa M Rundle, Kristine B Walhovd, Anders M Fjell, René Westerhausen, ,

Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):721]

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The effects of ground-irregularity-cancelling prosthesis control on balance over uneven surfaces.

Vincent L Chiu, Alexandra S Voloshina, Steven H Collins,

Over half of individuals with a lower-limb amputation are unable to walk on uneven terrain. Using a prosthesis emulator system, we developed an irregularity-cancelling controller intended to reduce the effect of disturbances resulting from uneven surfaces. This controller functions by changing the neutral angles of two forefoot digits in response ... Read more >>

R Soc Open Sci (Royal Society open science)
[2021, 8(1):201235]

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Shortcomings of human-in-the-loop optimization for an ankle-foot prosthesis: a case series

Cara Welker, Alexandra Voloshina, Vincent Chiu, Steven Collins,

<h4>ABSTRACT</h4> Human-in-the-loop optimization allows for individualized device control based on measured human performance. This technique has been used to produce large reductions in energy expenditure during walking with exoskeletons but has not yet been applied to prosthetic devices. In this series of case studies, we applied human-in-the-loop optimization to the ... Read more >>

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Corrigendum to "Intra-cerebral haemorrhage but not neurodegenerative disease appears over-represented in deaths of Australian cadaveric pituitary hormone recipients" [J. Clin. Neurosci. 81 (2020) 78-82].

Sultan H Alnakhli, Handan Wand, Matthew Law, Shannon Sarros, Christiane Stehmann, Matteo Senesi, Genevieve M Klug, Marion Simpson, Victoria Lewis, Colin L Masters, Steven J Collins,

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, 81:447]

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Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture.

Qian Zhang, Julia Sidorenko, Baptiste Couvy-Duchesne, Riccardo E Marioni, Margaret J Wright, Alison M Goate, Edoardo Marcora, Kuan-Lin Huang, Tenielle Porter, Simon M Laws, , Perminder S Sachdev, Karen A Mather, Nicola J Armstrong, Anbupalam Thalamuthu, Henry Brodaty, Loic Yengo, Jian Yang, Naomi R Wray, Allan F McRae, Peter M Visscher,

Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer's disease (LOAD). However, LOAD genetic architecture and prediction are unclear. Here we estimate the optimal P-threshold (P<sub>optimal</sub>) of a genetic risk score (GRS) for prediction of LOAD in three independent datasets comprising 676 cases and 35,675 ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):4799]

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Intra-cerebral haemorrhage but not neurodegenerative disease appears over-represented in deaths of Australian cadaveric pituitary hormone recipients.

Sultan H Alnakhli, Handan Wand, Matthew Law, Shannon Sarros, Christiane Stehmann, Matteo Senesi, Genevieve M Klug, Marion Simpson, Victoria Lewis, Colin L Masters, Steven J Collins,

<h4>Background and purpose</h4>Recent scientific reports and epidemiological studies have engendered mounting concerns regarding the potential human-to-human transmissibility of non-prion neurodegenerative and related diseases. This study investigated whether recipients of cadaveric pituitary hormone treatments are at increased risk of death from non-prion neurodegenerative and related diseases.<h4>Methods</h4>A retrospective national cohort study based ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, 81:78-82]

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Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study.

Emma Jones, Holger Hummerich, Emmanuelle Viré, James Uphill, Athanasios Dimitriadis, Helen Speedy, Tracy Campbell, Penny Norsworthy, Liam Quinn, Jerome Whitfield, Jacqueline Linehan, Zane Jaunmuktane, Sebastian Brandner, Parmjit Jat, Akin Nihat, Tze How Mok, Parvin Ahmed, Steven Collins, Christiane Stehmann, Shannon Sarros, Gabor G Kovacs, Michael D Geschwind, Aili Golubjatnikov, Karl Frontzek, Herbert Budka, Adriano Aguzzi, Hata Karamujić-Čomić, Sven J van der Lee, Carla A Ibrahim-Verbaas, Cornelia M van Duijn, Beata Sikorska, Ewa Golanska, Pawel P Liberski, Miguel Calero, Olga Calero, Pascual Sanchez-Juan, Antonio Salas, Federico Martinón-Torres, Elodie Bouaziz-Amar, Stéphane Haïk, Jean-Louis Laplanche, Jean-Phillipe Brandel, Phillipe Amouyel, Jean-Charles Lambert, Piero Parchi, Anna Bartoletti-Stella, Sabina Capellari, Anna Poleggi, Anna Ladogana, Maurizio Pocchiari, Serena Aneli, Giuseppe Matullo, Richard Knight, Saima Zafar, Inga Zerr, Stephanie Booth, Michael B Coulthart, Gerard H Jansen, Katie Glisic, Janis Blevins, Pierluigi Gambetti, Jiri Safar, Brian Appleby, John Collinge, Simon Mead,

<h4>Background</h4>Human prion diseases are rare and usually rapidly fatal neurodegenerative disorders, the most common being sporadic Creutzfeldt-Jakob disease (sCJD). Variants in the PRNP gene that encodes prion protein are strong risk factors for sCJD but, although the condition has similar heritability to other neurodegenerative disorders, no other genetic risk loci ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2020, 19(10):840-848]

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Self-selected step length asymmetry is not explained by energy cost minimization in individuals with chronic stroke.

Thu M Nguyen, Rachel W Jackson, Yashar Aucie, Digna de Kam, Steven H Collins, Gelsy Torres-Oviedo,

<h4>Background</h4>Asymmetric gait post-stroke is associated with decreased mobility, yet individuals with chronic stroke often self-select an asymmetric gait despite being capable of walking more symmetrically. The purpose of this study was to test whether self-selected asymmetry could be explained by energy cost minimization. We hypothesized that short-term deviations from self-selected ... Read more >>

J Neuroeng Rehabil (Journal of neuroengineering and rehabilitation)
[2020, 17(1):119]

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Long-term screening for primary mitochondrial DNA variants associated with Leber hereditary optic neuropathy: incidence, penetrance and clinical features.

Rosetta Marotta, Judy Chin, Maria Chiotis, Neil Shuey, Steven J Collins,

Leber hereditary optic neuropathy (LHON) is a neurodegenerative disorder characterised by bilateral, painless, subacute, central vision loss caused by pathogenic sequence variants in mitochondrial DNA (mtDNA). Over the course of 20 years, 734 people were systematically screened by our diagnostic laboratory for suspected LHON or for being at risk of LHON, ... Read more >>

Mitochondrion (Mitochondrion)
[2020, 54:128-132]

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Creutzfeldt-Jakob disease surveillance in Australia: update to 31 December 2019.

Christiane Stehmann, Matteo Senesi, Shannon Sarros, Amelia McGlade, Marion Simpson, Genevieve Klug, Catriona McLean, Colin L Masters, Steven Collins,

Nationwide surveillance of Creutzfeldt-Jakob disease and other human prion diseases is performed by the Australian National Creutzfeldt-Jakob Disease Registry (ANCJDR). National surveillance encompasses the period since 1 January 1970, with prospective surveillance occurring from 1 October 1993. Over this prospective surveillance period, considerable developments have occurred in pre-mortem diagnostics; in ... Read more >>

Commun Dis Intell (2018) (Communicable diseases intelligence (2018))
[2020, 44:]

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Teleoperation of an ankle-foot prosthesis with a wrist exoskeleton

Cara Welker, Vincent Chiu, Alexandra Voloshina, Steven Collins, Allison Okamura,

<h4>Objective</h4> We aimed to develop a system for people with amputation that non-invasively restores missing control and sensory information for an ankle-foot prosthesis. <h4>Methods</h4> In our approach, a wrist exoskeleton allows people with amputation to control and receive feedback from their prosthetic ankle via teleoperation. We implemented two control schemes: ... Read more >>

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Using force data to self-pace an instrumented treadmill and measure self-selected walking speed.

Seungmoon Song, Hojung Choi, Steven H Collins,

BACKGROUND:Self-selected speed is an important functional index of walking. A self-pacing controller that reliably matches walking speed without additional hardware can be useful for measuring self-selected speed in a treadmill-based laboratory. METHODS:We adapted a previously proposed self-pacing controller for force-instrumented treadmills and validated its use for measuring self-selected speeds. We ... Read more >>

J Neuroeng Rehabil (Journal of neuroengineering and rehabilitation)
[2020, 17(1):68]

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Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion disease.

Sonia M Vallabh, Eric Vallabh Minikel, Victoria J Williams, Becky C Carlyle, Alison J McManus, Chase D Wennick, Anna Bolling, Bianca A Trombetta, David Urick, Chloe K Nobuhara, Jessica Gerber, Holly Duddy, Ingolf Lachmann, Christiane Stehmann, Steven J Collins, Kaj Blennow, Henrik Zetterberg, Steven E Arnold,

<h4>Background</h4>Prion disease is neurodegenerative disease that is typically fatal within months of first symptoms. Clinical trials in this rapidly declining symptomatic patient population have proven challenging. Individuals at high lifetime risk for genetic prion disease can be identified decades before symptom onset and provide an opportunity for early therapeutic intervention. ... Read more >>

BMC Med (BMC medicine)
[2020, 18(1):140]

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PrPSc Oligomerization Appears Dynamic, Quickly Engendering Inherent M1000 Acute Synaptotoxicity.

Simote T Foliaki, Victoria Lewis, Abu M T Islam, Matteo Senesi, David I Finkelstein, Laura J Ellett, Victoria A Lawson, Paul A Adlard, Blaine R Roberts, Steven J Collins,

Prion diseases are neurodegenerative disorders pathogenically linked to cellular prion protein (PrPC) misfolding into abnormal conformers (PrPSc), with PrPSc underpinning both transmission and synaptotoxicity. Although the biophysical features of PrPSc required to induce acute synaptic dysfunction remain incompletely defined, we recently reported that acutely synaptotoxic PrPSc appeared to be oligomeric. ... Read more >>

Biophys J (Biophysical journal)
[2020, 119(1):128-141]

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Decreased cerebrospinal fluid neuronal pentraxin receptor is associated with PET-Aβ load and cerebrospinal fluid Aβ in a pilot study of Alzheimer's disease.

Bryant Lim, Christopher Fowler, Qiao-Xin Li, Christopher Rowe, Kunal Dhiman, Veer Bala Gupta, Colin L Masters, James D Doecke, Ralph N Martins, Steven Collins, Eleftherios P Diamandis,

Multifactorial pathological processes of Alzheimer's disease (AD) begin decades prior to clinical onset. Early identification of patients at risk of developing AD using biomarkers reflecting various aspects of pathogenesis is necessary for prevention and early intervention. Cortical β-amyloid (Aβ) burden assessed by positron emission tomography (PET) or cerebrospinal fluid (CSF) ... Read more >>

Neurosci Lett (Neuroscience letters)
[2020, 731:135078]

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The cellular prion protein beyond prion diseases.

Giorgia Manni, Victoria Lewis, Matteo Senesi, Giovanni Spagnolli, Francesca Fallarino, Steven J Collins, Sophie Mouillet-Richard, Emiliano Biasini,

The cellular prion protein (PrPC), a cell surface glycoprotein originally identified for its central role in prion diseases (also called transmissible spongiform encephalopathies), has recently been implicated in the pathogenesis of other neurodegenerative disorders, such as Alzheimer&rsquo;s and Parkinson&rsquo;s diseases, by acting as a toxicity-transducing receptor for different misfolded protein ... Read more >>

Swiss Med Wkly (Swiss medical weekly)
[2020, 150:w20222]

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Elecsys CSF biomarker immunoassays demonstrate concordance with amyloid-PET imaging.

James D Doecke, Larry Ward, Samantha C Burnham, Victor L Villemagne, Qiao-Xin Li, Steven Collins, Christopher J Fowler, Ekaterina Manuilova, Monika Widmann, Stephanie R Rainey-Smith, Ralph N Martins, Colin L Masters, ,

<h4>Background</h4>β-amyloid (Aβ) positron emission tomography (PET) imaging is currently the only Food and Drug Administration-approved method to support clinical diagnosis of Alzheimer's disease (AD). However, numerous research studies support the use of cerebrospinal fluid (CSF) biomarkers, as a cost-efficient, quick and equally valid method to define AD pathology.<h4>Methods</h4>Using automated Elecsys® ... Read more >>

Alzheimers Res Ther (Alzheimer's research & therapy)
[2020, 12(1):36]

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Genome-wide association study identifies risk variants for sporadic Creutzfeldt-Jakob disease in STX6 and GAL3ST1

Emma Jones, Holger Hummerich, Emmanuelle Viré, James Uphill, Athanasios Dimitriadis, Helen Speedy, Tracy Campbell, Penny Norsworthy, Liam Quinn, Jerome Whitfield, Jacqueline Linehan, Zane Jaunmuktane, Sebastian Brandner, Parmjit Jat, Akin Nihat, Tze How Mok, Parvin Ahmed, Steven Collins, Christiane Stehmann, Shannon Sarros, Gabor Kovacs, Michael Geschwind, Aili Golubjatnikov, Karl Fronztek, Herbert Budka, Adriano Aguzzi, Hata Karamujić-Čomić, Sven van der Lee, Carla Ibrahim-Verbaas, Cornelia Van Duijn, Beata Sikorska, Ewa Golanska, Pawel Liberski, Miguel Calero, Olga Calero, Pascual Sanchez Juan, Antonio Salas, Federico Martinón-Torres, Elodie Bouaziz-Amar, Stephane Haik, Jean-Louis Laplanche, Jean-Phillipe Brandel, Phillipe Amouyel, Jean-Charles Lambert, Piero Parchi, Anna Bartoletti-Stella, Sabina Capellari, Anna Poleggi, Anna Ladogana, Maurizio Pocchiari, Serena Aneli, Giuseppe Matullo, Richard Knight, Saima Zafar, Inga Zerr, Stephanie Booth, Michael Coulthart, Gerard Jansen, Katie Glisic, Janis Blevins, Pierluigi Gambetti, Jiri Safar, Brian Appleby, John Collinge, Simon Mead,

Mammalian prions are lethal pathogens composed of fibrillar assemblies of misfolded prion protein. Human prion diseases are rare and usually rapidly fatal neurodegenerative disorders, the most common being sporadic Creutzfeldt-Jakob disease (sCJD). Variants in the gene that encodes prion protein ( PRNP ) are strong risk factors for sCJD, but ... Read more >>

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Prosthesis Inversion/Eversion Stiffness Reduces Balance-Related Variability During Level Walking.

Myunghee Kim, Hannah Lyness, Tianjian Chen, Steven Collins,

Prosthesis features that enhance balance are desirable to people with below-knee amputation. Ankle inversion/eversion compliance is intended to improve balance on uneven ground, but its effects remain unclear on level ground. We posited that increasing ankle inversion/eversion stiffness during level-ground walking would reduce balance-related effort by assisting in recovery from ... Read more >>

J Biomech Eng (Journal of biomechanical engineering)
[2020, :]

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Prion disease in Indigenous Australians.

Peter K Panegyres, Christiane Stehmann, Genevieve M Klug, Colin L Masters, Steven Collins,

<h4>Background</h4>Indigenous Australians are of increased risk of developing dementia - Alzheimer's disease and mixed dementia diagnoses are the most common. Whilst prion diseases have been reported in Indigenous peoples of Papua New Guinea and the United States of America, the occurrence and phenotype of prion disease in Indigenous Australians is ... Read more >>

Intern Med J (Internal medicine journal)
[2020, :]

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Improving the energy economy of human running with powered and unpowered ankle exoskeleton assistance.

Kirby A Witte, Pieter Fiers, Alison L Sheets-Singer, Steven H Collins,

Exoskeletons that reduce energetic cost could make recreational running more enjoyable and improve running performance. Although there are many ways to assist runners, the best approaches remain unclear. In our study, we used a tethered ankle exoskeleton emulator to optimize both powered and spring-like exoskeleton characteristics while participants ran on ... Read more >>

Sci Robot (Science robotics)
[2020, 5(40):]

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Markers of A1 astrocytes stratify to molecular sub-types in sporadic Creutzfeldt-Jakob disease brain.

Cathryn L Ugalde, Victoria Lewis, Christiane Stehmann, Catriona A McLean, Victoria A Lawson, Steven J Collins, Andrew F Hill,

Astrocytes are glial cells of the central nervous system that become reactive under conditions of stress. The functional properties of reactive astrocytes depend on their stimulus that induces the upregulation of specific genes. Reactive astrocytes are a neuropathological feature of prion disorders; however, their role in the disease pathogenesis is ... Read more >>

Brain Commun (Brain communications)
[2020, 2(2):fcaa029]

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Cerebrospinal fluid neurofilament light concentration predicts brain atrophy and cognition in Alzheimer's disease.

Kunal Dhiman, Veer Bala Gupta, Victor L Villemagne, Dhamidhu Eratne, Petra L Graham, Christopher Fowler, Pierrick Bourgeat, Qiao-Xin Li, Steven Collins, Ashley I Bush, Christopher C Rowe, Colin L Masters, David Ames, Eugene Hone, Kaj Blennow, Henrik Zetterberg, Ralph N Martins,

<h4>Introduction</h4>This study assessed the utility of cerebrospinal fluid (CSF) neurofilament light (NfL) in Alzheimer's disease (AD) diagnosis, its association with amyloid and tau pathology, as well as its potential to predict brain atrophy, cognition, and amyloid accumulation.<h4>Methods</h4>CSF NfL concentration was measured in 221 participants from the Australian Imaging, Biomarkers & ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2020, 12(1):e12005]

Cited: 2 times

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