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Switching clinic-based cervical cancer screening programs to HPV self-sampling: A cost-effectiveness analysis of vaccinated and unvaccinated Norwegian women.

Kine Pedersen, Allison Portnoy, Stephen Sy, Bo T Hansen, Ameli Trope, Jane J Kim, Emily A Burger,

Several countries have implemented primary human papillomavirus (HPV) testing for cervical cancer screening. HPV testing enables home-based, self-collected sampling (self-sampling), which provides similar diagnostic accuracy as clinician-collected samples. We evaluated the impact and cost-effectiveness of switching an entire organized screening program to primary HPV self-sampling among cohorts of HPV vaccinated ... Read more >>

Int J Cancer (International journal of cancer)
[2021, :]

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Health Impact and Cost-Effectiveness of Achieving the National Salt and Sugar Reduction Initiative Voluntary Sugar Reduction Targets in the United States: A Micro-Simulation Study.

Siyi Shangguan, Dariush Mozaffarian, Stephen Sy, Yujin Lee, Junxiu Liu, Parke E Wilde, Andrea L Sharkey, Erin A Dowling, Matti Marklund, Shafika Abrahams-Gessel, Thomas A Gaziano, Renata Micha,

<b>Background:</b> High intake of added sugar is linked to weight gain and cardiometabolic risk. In 2018, the US National Salt and Sugar Reduction Initiative (NSSRI) proposed government supported voluntary national sugar reduction targets. This intervention's potential health and equity impacts, and cost-effectiveness are unclear. <b>Methods:</b> A validated microsimulation model, CVD-PREDICT, ... Read more >>

Circulation (Circulation)
[2021, :]

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Cost-effectiveness Analysis of the 2019 ASCCP Risk-Based Management Consensus Guidelines for the Management of Abnormal Cervical Cancer Screening Tests and Cancer Precursors.

Vidit N Munshi, Rebecca B Perkins, Stephen Sy, Jane J Kim,

<h4>Background</h4>Guidelines for managing abnormal cervical cancer screening tests changed from a results-based approach in 2012 to a risk-based approach in 2019. We estimated the cost-effectiveness and changes in resource utilization of the 2012 and 2019 guidelines.<h4>Methods</h4>We utilized a previously published model of cervical cancer natural history and screening to estimate ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, :]

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Cost-effectiveness of nonavalent HPV vaccine in Norway considering current empirical data and validation.

Allison Portnoy, Kine Pedersen, Lill Trogstad, Bo T Hansen, Berit Feiring, Ida Laake, Megan A Smith, Stephen Sy, Mari Nygård, Jane J Kim, Emily A Burger,

Prev Med (Preventive medicine)
[2021, 150:106688]

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Retraction: Impact and Cost-effectiveness of Human Papillomavirus Vaccination Campaigns.

Allison Portnoy, Nicole G Campos, Stephen Sy, Emily A Burger, Jamie Cohen, Catherine Regan, Jane J Kim,

Cancer Epidemiol Biomarkers Prev (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2021, 30(6):1283]

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Impact and cost-effectiveness of strategies to accelerate cervical cancer elimination: A model-based analysis.

Allison Portnoy, Kine Pedersen, Lill Trogstad, Bo T Hansen, Berit Feiring, Ida Laake, Megan A Smith, Stephen Sy, Mari Nygård, Jane J Kim, Emily A Burger,

Following the global call for action by the World Health Organization to eliminate cervical cancer (CC), we evaluated how each CC policy decision in Norway influenced the timing of CC elimination, and whether introducing nonavalent human papillomavirus (HPV) vaccine would accelerate elimination timing and be cost-effective. We used a multi-modeling ... Read more >>

Prev Med (Preventive medicine)
[2021, 144:106276]

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Cost-Effectiveness of Offering Cervical Cancer Screening with HPV Self-Sampling among African-American Women in the Mississippi Delta.

Nicole G Campos, Isabel C Scarinci, Laura Tucker, Sylvia Peral, Yufeng Li, Mary Caroline Regan, Stephen Sy, Philip E Castle, Jane J Kim,

<h4>Background</h4>African-American women in the United States have an elevated risk of cervical cancer incidence and mortality. In the Mississippi Delta, cervical cancer disparities are particularly stark.<h4>Methods</h4>We conducted a micro-costing study alongside a group randomized trial that evaluated the efficacy of a patient-centered approach ("Choice" between self-collection at home for HPV ... Read more >>

Cancer Epidemiol Biomarkers Prev (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2021, 30(6):1114-1121]

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Human papillomavirus vaccination for adults aged 30 to 45 years in the United States: A cost-effectiveness analysis.

Jane J Kim, Kate T Simms, James Killen, Megan A Smith, Emily A Burger, Stephen Sy, Catherine Regan, Karen Canfell,

<h4>Background</h4>A nonavalent human papillomavirus (HPV) vaccine has been licensed for use in women and men up to age 45 years in the United States. The cost-effectiveness of HPV vaccination for women and men aged 30 to 45 years in the context of cervical cancer screening practice was evaluated to inform ... Read more >>

PLoS Med (PLoS medicine)
[2021, 18(3):e1003534]

Cited: 2 times

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Global impact and cost-effectiveness of one-dose versus two-dose human papillomavirus vaccination schedules: a comparative modelling analysis

Kiesha Prem, Yoon Hong Choi, Élodie Bénard, Emily Burger, Liza Hadley Mmath, Jean-François Laprise, Catherine Regan, Mélanie Drolet, Stephen Sy, Kaja Abbas, Jane Kim, Marc Brisson, Mark Jit,

<h4>Summary</h4> <h4>Background</h4> To eliminate cervical cancer as a public health problem, WHO currently recommends routine vaccination of adolescent girls with two doses of the human papillomavirus (HPV) vaccine before sexual debut. However, many countries have yet to implement this because of financial or logistical barriers to delivering two doses outside ... Read more >>

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Impact of COVID-19-related care disruptions on cervical cancer screening in the United States.

Emily A Burger, Erik El Jansen, James Killen, Inge McM de Kok, Megan A Smith, Stephen Sy, Niels Dunnewind, Nicole G Campos, Jennifer S Haas, Sarah Kobrin, Aruna Kamineni, Karen Canfell, Jane J Kim,

<h4>Objectives</h4>To quantify the secondary impacts of the COVID-19 pandemic disruptions to cervical cancer screening in the United States, stratified by step in the screening process and primary test modality, on cervical cancer burden.<h4>Methods</h4>We conducted a comparative model-based analysis using three independent NCI Cancer Intervention and Surveillance Modeling Network cervical models ... Read more >>

J Med Screen (Journal of medical screening)
[2021, 28(2):213-216]

Cited: 3 times

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Cost-effectiveness of cervical cancer screening with primary HPV testing for unvaccinated women in Sweden.

Sara Fogelberg, Mark S Clements, Kine Pedersen, Stephen Sy, Pär Sparén, Jane J Kim, Emily A Burger,

<h4>Background</h4>Sweden revised their cervical cancer screening program in 2017 to include cytology-based screening for women aged 23-29 years and primary human papillomavirus (HPV) testing for women aged 30-64 years; however, alternative strategies may be preferred. To inform cervical cancer prevention policies for unvaccinated women, we evaluated the cost-effectiveness of alternative ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0239611]

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Estimating the Natural History of Cervical Carcinogenesis Using Simulation Models: A CISNET Comparative Analysis.

Emily A Burger, Inge M C M de Kok, Emily Groene, James Killen, Karen Canfell, Shalini Kulasingam, Karen M Kuntz, Suzette Matthijsse, Catherine Regan, Kate T Simms, Megan A Smith, Stephen Sy, Fernando Alarid-Escudero, Vivek Vaidyanathan, Marjolein van Ballegooijen, Jane J Kim,

<h4>Background</h4>The natural history of human papillomavirus (HPV)-induced cervical cancer (CC) is not directly observable, yet the age of HPV acquisition and duration of preclinical disease (dwell time) influences the effectiveness of alternative preventive policies. We performed a Cancer Intervention and Surveillance Modeling Network (CISNET) comparative modeling analysis to characterize the ... Read more >>

J Natl Cancer Inst (Journal of the National Cancer Institute)
[2020, 112(9):955-963]

Cited: 11 times

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Health Impact and Cost-Effectiveness of Volume, Tiered, and Absolute Sugar Content Sugar-Sweetened Beverage Tax Policies in the United States: A Microsimulation Study.

Yujin Lee, Dariush Mozaffarian, Stephen Sy, Junxiu Liu, Parke E Wilde, Matti Marklund, Shafika Abrahams-Gessel, Thomas A Gaziano, Renata Micha,

<h4>Background</h4>Sugar-sweetened beverage taxes are a rapidly growing policy tool and can be based on absolute volume, sugar content tiers, or absolute sugar content. Yet, their comparative health and economic impacts have not been quantified, in particular, tiered or sugar content taxes that provide industry incentives for sugar reduction.<h4>Methods</h4>We estimated incremental ... Read more >>

Circulation (Circulation)
[2020, 142(6):523-534]

Cited: 5 times

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Health and Economic Impacts of the National Menu Calorie Labeling Law in the United States: A Microsimulation Study.

Junxiu Liu, Dariush Mozaffarian, Stephen Sy, Yujin Lee, Parke E Wilde, Shafika Abrahams-Gessel, Tom Gaziano, Renata Micha, ,

<h4>Background</h4>Excess caloric intake is linked to weight gain, obesity, and related diseases, including type 2 diabetes mellitus and cardiovascular disease (CVD). Obesity incidence is rising, with nearly 3 in 4 US adults being overweight or obese. In 2018, the US federal government finalized the implementation of mandatory labeling of calorie ... Read more >>

Circ Cardiovasc Qual Outcomes (Circulation. Cardiovascular quality and outcomes)
[2020, 13(6):e006313]

Cited: 2 times

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The Impact of Different Screening Model Structures on Cervical Cancer Incidence and Mortality Predictions: The Maximum Clinical Incidence Reduction (MCLIR) Methodology.

Inge M C M de Kok, Emily A Burger, Steffie K Naber, Karen Canfell, James Killen, Kate Simms, Shalini Kulasingam, Emily Groene, Stephen Sy, Jane J Kim, Marjolein van Ballegooijen,

<b>Background</b>. To interpret cervical cancer screening model results, we need to understand the influence of model structure and assumptions on cancer incidence and mortality predictions. Cervical cancer cases and deaths following screening can be attributed to 1) (precancerous or cancerous) disease that occurred after screening, 2) disease that was present ... Read more >>

Med Decis Making (Medical decision making : an international journal of the Society for Medical Decision Making)
[2020, 40(4):474-482]

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Choosing the optimal HPV vaccine: The health impact and economic value of the nonavalent and bivalent HPV vaccines in 48 Gavi-eligible countries.

Emily A Burger, Allison Portnoy, Nicole G Campos, Stephen Sy, Catherine Regan, Jane J Kim,

The human papillomavirus (HPV) vaccines may provide some level of cross-protection against high-risk HPV genotypes not directly targeted by the vaccines. We evaluated the long-term health and economic impacts of routine HPV vaccination using either the nonavalent HPV vaccine or the bivalent HPV vaccine in the context of 48 Gavi-eligible ... Read more >>

Int J Cancer (International journal of cancer)
[2021, 148(4):932-940]

Cited: 3 times

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Health Impact and Cost-Effectiveness of Financing Fruit and Vegetable Subsidies with a Sugar-Sweetened Beverage Tax in the US: A Micro-Simulation Study

Matti Marklund, Yujin Lee, Junxiu Liu, Stephen Sy, Shafika Abrahams-Gessel, Parke Wilde, Dariush Mozaffarian, Thomas Gaziano, Renata Micha,

Abstract <h4>Objectives</h4> Financial incentives and disincentives are effective tools for improving food purchases and health. Healthy food subsidies have only been considered for vulnerable populations and can be costly, while sugar-sweetened beverage (SSB) taxes can be considered financially regressive and punitive. The potential joint health and economic impacts of combining ... Read more >>

Curr Dev Nutr (Current developments in nutrition)
[2020, 4(Suppl 2):1721-1721]

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Mortality impact of achieving WHO cervical cancer elimination targets: a comparative modelling analysis in 78 low-income and lower-middle-income countries.

Karen Canfell, Jane J Kim, Marc Brisson, Adam Keane, Kate T Simms, Michael Caruana, Emily A Burger, Dave Martin, Diep T N Nguyen, Élodie Bénard, Stephen Sy, Catherine Regan, Mélanie Drolet, Guillaume Gingras, Jean-Francois Laprise, Julie Torode, Megan A Smith, Elena Fidarova, Dario Trapani, Freddie Bray, Andre Ilbawi, Nathalie Broutet, Raymond Hutubessy,

<h4>Background</h4>WHO is developing a global strategy towards eliminating cervical cancer as a public health problem, which proposes an elimination threshold of four cases per 100 000 women and includes 2030 triple-intervention coverage targets for scale-up of human papillomavirus (HPV) vaccination to 90%, twice-lifetime cervical screening to 70%, and treatment of pre-invasive ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10224):591-603]

Cited: 39 times

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Projected time to elimination of cervical cancer in the USA: a comparative modelling study.

Emily A Burger, Megan A Smith, James Killen, Stephen Sy, Kate T Simms, Karen Canfell, Jane J Kim,

BACKGROUND:In May, 2018, the Director-General of WHO issued a global call to eliminate cervical cancer as a public health problem, which will involve ambitious screening and vaccination coverage targets. We aimed to assess the potential for, and timing of, cervical cancer elimination in the USA and whether this could be ... Read more >>

Lancet Public Health (The Lancet. Public health)
[2020, 5(4):e213-e222]

Cited: 7 times

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Impact of HPV vaccination and cervical screening on cervical cancer elimination: a comparative modelling analysis in 78 low-income and lower-middle-income countries.

Marc Brisson, Jane J Kim, Karen Canfell, Mélanie Drolet, Guillaume Gingras, Emily A Burger, Dave Martin, Kate T Simms, Élodie Bénard, Marie-Claude Boily, Stephen Sy, Catherine Regan, Adam Keane, Michael Caruana, Diep T N Nguyen, Megan A Smith, Jean-François Laprise, Mark Jit, Michel Alary, Freddie Bray, Elena Fidarova, Fayad Elsheikh, Paul J N Bloem, Nathalie Broutet, Raymond Hutubessy,

<h4>Background</h4>The WHO Director-General has issued a call for action to eliminate cervical cancer as a public health problem. To help inform global efforts, we modelled potential human papillomavirus (HPV) vaccination and cervical screening scenarios in low-income and lower-middle-income countries (LMICs) to examine the feasibility and timing of elimination at different ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10224):575-590]

Cited: 53 times

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Cardiometabolic disease costs associated with suboptimal diet in the United States: A cost analysis based on a microsimulation model.

Thiago Veiga Jardim, Dariush Mozaffarian, Shafika Abrahams-Gessel, Stephen Sy, Yujin Lee, Junxiu Liu, Yue Huang, Colin Rehm, Parke Wilde, Renata Micha, Thomas A Gaziano,

<h4>Background</h4>Poor diet is a leading risk factor for cardiometabolic disease (CMD) in the United States, but its economic costs are unknown. We sought to estimate the cost associated with suboptimal diet in the US.<h4>Methods and findings</h4>A validated microsimulation model (Cardiovascular Disease Policy Model for Risk, Events, Detection, Interventions, Costs, and ... Read more >>

PLoS Med (PLoS medicine)
[2019, 16(12):e1002981]

Cited: 15 times

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The cost-effectiveness of human papillomavirus self-collection among cervical cancer screening non-attenders in El Salvador.

Nicole G Campos, Karla Alfaro, Mauricio Maza, Stephen Sy, Mario Melendez, Rachel Masch, Montserrat Soler, Gabriel Conzuelo-Rodriguez, Julia C Gage, Todd A Alonzo, Philip E Castle, Juan C Felix, Miriam Cremer, Jane J Kim,

Cervical cancer screening with human papillomavirus (HPV) DNA testing has been incorporated into El Salvador's national guidelines. The feasibility of home-based HPV self-collection among women who do not attend screening at the clinic (i.e., non-attenders) has been demonstrated, but cost-effectiveness has not been evaluated. Using cost and compliance data from ... Read more >>

Prev Med (Preventive medicine)
[2020, 131:105931]

Cited: 0 times

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Impact and Cost-Effectiveness of Human Papillomavirus Vaccination Campaigns.

Allison Portnoy, Nicole G Campos, Stephen Sy, Emily A Burger, Jamie Cohen, Catherine Regan, Jane J Kim,

<h4>Background</h4>Data to inform evidence-based policy of human papillomavirus (HPV) vaccine delivery strategies in low- and middle-income countries are limited. We examined the cost-effectiveness of campaign compared with routine delivery strategies of adolescent female HPV vaccination in Uganda.<h4>Methods</h4>We used a multiple modeling approach that captured HPV transmission, cervical carcinogenesis, and population ... Read more >>

Cancer Epidemiol Biomarkers Prev (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2020, 29(1):22-30]

Cited: 2 times

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Health Impact and Cost-effectiveness of Volume, Tiered, and Sugar Content Sugar-sweetened Beverage Tax Policies in the US: A Micro-simulation Study (OR28-04-19)

Yujin Lee, Dariush Mozaffarian, Junxiu Liu, Stephen Sy, Shafika Abrahams-Gessel, Parke Wilde, Thomas Gaziano, Renata Micha,

Abstract <h4>Objectives</h4> Sugar-sweetened beverage (SSB) intake is linked to weight gain, type 2 diabetes, and cardiovascular disease (CVD). SSBs taxes are a policy tool to reduce intake, and volume-based taxes have been passed in the US. Yet, the comparative health and economic impacts of volume-based, tiered, or sugar content-based SSB ... Read more >>

Curr Dev Nutr (Current developments in nutrition)
[2019, 3(Suppl 1):]

Cited: 0 times

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Estimating the health impact of vaccination against 10 pathogens in 98 low and middle income countries from 2000 to 2030

Xiang Li, Christinah Mukandavire, Zulma Cucunubá, Kaja Abbas, Hannah Clapham, Mark Jit, Hope Johnson, Timos Papadopoulos, Emilia Vynnycky, Marc Brisson, Emily Carter, Andrew Clark, Margaret de Villiers, Kirsten Eilertson, Matthew Ferrari, Ivane Gamkrelidze, Katy Gaythorpe, Nicholas Grassly, Timothy Hallett, Michael Jackson, Kévin Jean, Andromachi Karachaliou, Petra Klepac, Justin Lessler, Xi Li, Sean Moore, Shevanthi Nayagam, Duy Manh Nguyen, Homie Razavi, Devin Razavi-Shearer, Stephen Resch, Colin Sanderson, Steven Sweet, Stephen Sy, Yvonne Tam, Hira Tanvir, Quan Minh Tran, Caroline Trotter, Shaun Truelove, Kevin van Zandvoort, Stéphane Verguet, Neff Walker, Amy Winter, Neil Ferguson, ,

<h4>Background</h4> The last two decades have seen substantial expansion of childhood vaccination programmes in low and middle income countries (LMICs). Here we quantify the health impact of these programmes by estimating the deaths and disability-adjusted life years (DALYs) averted by vaccination with ten antigens in 98 LMICs between 2000 and ... Read more >>

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