Full Text Journal Articles by
Author Stephen Rothery

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The acid injury and repair (AIR) model: A novel ex-vivo tool to understand lung repair.

Sally Yunsun Kim, Róisín Mongey, Peizhu Wang, Stephen Rothery, David C A Gaboriau, Matthew Hind, Mark Griffiths, Charlotte H Dean,

Research into mechanisms underlying lung injury and subsequent repair responses is currently of paramount importance. There is a paucity of models that bridge the gap between in vitro and in vivo research. Such intermediate models are critical for researchers to decipher the mechanisms that drive repair and to test potential ... Read more >>

Biomaterials (Biomaterials)
[2021, 267:120480]

Cited: 0 times

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Mediastinal Lymphadenopathy, Class-Switched Auto-Antibodies and Myocardial Immune-Complexes During Heart Failure in Rodents and Humans.

Amalia Sintou, Catherine Mansfield, Alma Iacob, Rasheda A Chowdhury, Salomon Narodden, Stephen M Rothery, Robert Podovei, Jose L Sanchez-Alonso, Elisa Ferraro, Pamela Swiatlowska, Sian E Harding, Sanjay Prasad, Nadia Rosenthal, Julia Gorelik, Susanne Sattler,

Mediastinal lymphadenopathy and auto-antibodies are clinical phenomena during ischemic heart failure pointing to an autoimmune response against the heart. T and B cells have been convincingly demonstrated to be activated after myocardial infarction, a prerequisite for the generation of mature auto-antibodies. Yet, little is known about the immunoglobulin isotype repertoire ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2020, 8:695]

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Human pluripotent stem cell-derived cardiomyocytes as a target platform for paracrine protection by cardiac mesenchymal stromal cells.

Chrystalla Constantinou, Antonio M A Miranda, Patricia Chaves, Mohamed Bellahcene, Andrea Massaia, Kevin Cheng, Sara Samari, Stephen M Rothery, Anita M Chandler, Richard P Schwarz, Sian E Harding, Prakash Punjabi, Michael D Schneider, Michela Noseda,

Ischemic heart disease remains the foremost cause of death globally, with survivors at risk for subsequent heart failure. Paradoxically, cell therapies to offset cardiomyocyte loss after ischemic injury improve long-term cardiac function despite a lack of durable engraftment. An evolving consensus, inferred preponderantly from non-human models, is that transplanted cells ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):13016]

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Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo.

Victoria Salem, Luis Delgadillo Silva, Kinga Suba, Eleni Georgiadou, S Neda Mousavy Gharavy, Nadeem Akhtar, Aldara Martin-Alonso, David C A Gaboriau, Stephen M Rothery, Theodoros Stylianides, Gaelle Carrat, Timothy J Pullen, Sumeet Pal Singh, David J Hodson, Isabelle Leclerc, A M James Shapiro, Piero Marchetti, Linford J B Briant, Walter Distaso, Nikolay Ninov, Guy A Rutter,

Pancreatic β-cells form highly connected networks within isolated islets. Whether this behaviour pertains to the situation in vivo, after innervation and during continuous perfusion with blood, is unclear. In the present study, we used the recombinant Ca<sup>2+</sup> sensor GCaMP6 to assess glucose-regulated connectivity in living zebrafish Danio rerio, and in ... Read more >>

Nat Metab (Nature metabolism)
[2019, 1(6):615-629]

Cited: 4 times

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Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour.

Khondoker M Akram, Laura L Yates, Róisín Mongey, Stephen Rothery, David C A Gaboriau, Jeremy Sanderson, Matthew Hind, Mark Griffiths, Charlotte H Dean,

Damage to alveoli, the gas-exchanging region of the lungs, is a component of many chronic and acute lung diseases. In addition, insufficient generation of alveoli results in bronchopulmonary dysplasia, a disease of prematurity. Therefore visualising the process of alveolar development (alveologenesis) is critical for our understanding of lung homeostasis and ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):1178]

Cited: 3 times

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Persistent anti-heart autoimmunity causes cardiomyocyte damage in chronic heart failure

Amalia Sintou, Sarah el Rifai, Catherine Mansfield, Jose Sanchez Alonso, Stephen Rothery, Salomon Narodden, Keshav Sharma, Muneer Hasham, Pamela Swiatlowska, Sian Harding, Nadia Rosenthal, Julia Gorelik, Susanne Sattler, Susanne Sattler,

Although clinicians and researchers have long appreciated the detrimental effects of excessive acute inflammation after myocardial infarction (MI), less is known about the role of the adaptive immune system in MI complications including heart failure. Yet, abundant cardiac self-antigens released from necrotic cardiomyocytes in a highly inflammatory environment are likely ... Read more >>

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Porous Silicon Nanoneedles Modulate Endocytosis to Deliver Biological Payloads.

Sahana Gopal, Ciro Chiappini, Jelle Penders, Vincent Leonardo, Hyejeong Seong, Stephen Rothery, Yuri Korchev, Andrew Shevchuk, Molly M Stevens,

Owing to their ability to efficiently deliver biological cargo and sense the intracellular milieu, vertical arrays of high aspect ratio nanostructures, known as nanoneedles, are being developed as minimally invasive tools for cell manipulation. However, little is known of the mechanisms of cargo transfer across the cell membrane-nanoneedle interface. In ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2019, 31(12):e1806788]

Cited: 5 times

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Free-of-Acrylamide SDS-based Tissue Clearing (FASTClear) for three dimensional visualization of myocardial tissue.

Filippo Perbellini, Alan K L Liu, Samuel A Watson, Ifigeneia Bardi, Stephen M Rothery, Cesare M Terracciano,

Several pathologic conditions of the heart lead to cardiac structural remodelling. Given the high density and the opaque nature of the myocardium, deep three dimensional (3D) imaging is difficult to achieve and structural analysis of pathological myocardial structure is often limited to two dimensional images and of thin myocardial sections. ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):5188]

Cited: 8 times

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Reply: Search for Evidence-Based Medicine for Brugada Syndrome: The Complex Network of the Brugada Syndrome.

Koonlawee Nademanee, Hariharan Raju, Sofia De Noronha, Michael Papadakis, Laurence Robinson, Stephen Rothery, Naomasa Makita, Shinya Kowase, Nakorn Boonmee, Vorapot Vitayakritsirikul, Samrerng Ratanarapee, Sanjay Sharma, Allard C van der Wal, Michael Christiansen, Hanno L Tan, Arthur A Wilde, Akihiko Nogami, Mary N Sheppard, Gumpanart Veerakul, Elijah R Behr,

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2016, 67(13):1658-1659]

Cited: 0 times

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Sonic hedgehog multimerization: a self-organizing event driven by post-translational modifications?

Mirella V Koleva, Stephen Rothery, Martin Spitaler, Mark A A Neil, Anthony I Magee,

Sonic hedgehog (Shh) is a morphogen active during vertebrate development and tissue homeostasis in adulthood. Dysregulation of the Shh signalling pathway is known to incite carcinogenesis. Due to the highly lipophilic nature of this protein imparted by two post-translational modifications, Shh's method of transit through the aqueous extracellular milieu has ... Read more >>

Mol Membr Biol (Molecular membrane biology)
[2015, 32(3):65-74]

Cited: 3 times

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Superresolution microscopy reveals nanometer-scale reorganization of inhibitory natural killer cell receptors upon activation of NKG2D.

Sophie V Pageon, Shaun-Paul Cordoba, Dylan M Owen, Stephen M Rothery, Anna Oszmiana, Daniel M Davis,

Natural killer (NK) cell responses are regulated by a dynamic equilibrium between activating and inhibitory receptor signals at the immune synapse (or interface) with target cells. Although the organization of receptors at the immune synapse is important for appropriate integration of these signals, there is little understanding of this in ... Read more >>

Sci Signal (Science signaling)
[2013, 6(285):ra62]

Cited: 32 times

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Coexpression of connexin 45 with connexin 43 decreases gap junction size.

Katharina Grikscheit, Neil Thomas, Alexandra F Bruce, Stephen Rothery, Joachim Chan, Nicholas J Severs, Emmanuel Dupont,

In the human heart, ventricular myocytes express connexin 43 (Cx43) and traces of Cx45. In congestive heart failure, Cx43 levels decrease, Cx45 levels increase and gap junction size decreases. To determine whether alterations of connexin coexpression ratio influence gap junction size, we engineered a rat liver epithelial cell line that ... Read more >>

Cell Commun Adhes (Cell communication & adhesion)
[2008, 15(1):185-193]

Cited: 14 times

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Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1.

Alexandra F Bruce, Stephen Rothery, Emmanuel Dupont, Nicholas J Severs,

<h4>Aims</h4>Remodelling of gap junctions, involving reduction of total gap junction quantity and down-regulation of connexin43 (Cx43), contributes to the arrhythmic substrate in congestive heart failure. However, little is known of the underlying mechanisms. Recent studies from in vitro systems suggest that the connexin-interacting protein zonula occludens-1 (ZO-1) is a potential ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2008, 77(4):757-765]

Cited: 67 times

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High-resolution en-face visualization of the cardiomyocyte plasma membrane reveals distinctive distributions of spectrin and dystrophin.

Shirley A Stevenson, Michael J Cullen, Stephen Rothery, Steven R Coppen, Nicholas J Severs,

The actin-binding proteins, spectrin and dystrophin, are key components of the plasma membrane-associated cytoskeleton of the cardiac muscle cell. From confocal immunofluorescence studies, the distribution of spectrin appears to overlap with that of dystrophin, but the precise functional differentiation, molecular distributions and spatial relationship of these two cytoskeletal systems remain ... Read more >>

Eur J Cell Biol (European journal of cell biology)
[2005, 84(12):961-971]

Cited: 8 times

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Up-regulation of connexin43 correlates with increased synthetic activity and enhanced contractile differentiation in TGF-beta-treated human aortic smooth muscle cells.

Aisha Rama, Tsutomu Matsushita, Nicoletta Charolidi, Stephen Rothery, Emmanuel Dupont, Nicholas J Severs,

Up-regulation of the gap-junctional protein connexin43 (Cx43) in arterial smooth muscle cells (SMCs) features in response to injury and in atherosclerosis, in parallel with phenotypic transition to the synthetic state. TGF-beta1 is known to have a role in SMC differentiation and extracellular matrix (ECM) synthesis, key characteristics of phenotypic state. ... Read more >>

Eur J Cell Biol (European journal of cell biology)
[2006, 85(5):375-386]

Cited: 30 times

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Human atrial conduction and arrhythmogenesis correlates with conformational exposure of specific epitopes on the connexin40 carboxyl tail.

Prapa Kanagaratnam, Emmanuel Dupont, Stephen Rothery, Steven Coppen, Nicholas J Severs, Nicholas S Peters,

<h4>Background</h4>Gap junction expression is considered to influence myocardial conduction and arrhythmogenesis, but studies in patients with atrial fibrillation (AF) have reported inconsistent results. We used human atrial conduction and arrhythmogenicity to provide clinical parameters with which to correlate quantification of connexin40 (Cx40) by different techniques to address the hypothesis that ... Read more >>

J Mol Cell Cardiol (Journal of molecular and cellular cardiology)
[2006, 40(5):675-687]

Cited: 5 times

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Alterations in cardiac connexin expression in cardiomyopathies.

Nicholas J Severs, Emmanuel Dupont, Neil Thomas, Riyaz Kaba, Stephen Rothery, Revti Jain, Katherine Sharpey, Christopher H Fry,

Gap junctions, assembled from connexins, form the cell-to-cell pathways for propagation of the precisely orchestrated patterns of current flow that govern the synchronized rhythm of the healthy heart. As in most tissues and organs, multiple connexin types are co-expressed in the heart; the connexins Cx43, Cx40 and Cx45 are found ... Read more >>

Adv Cardiol (Advances in cardiology)
[2006, 42:228-242]

Cited: 40 times

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Remodelling of gap junctions and connexin expression in heart disease.

Nicholas J Severs, Emmanuel Dupont, Steven R Coppen, Deborah Halliday, Edward Inett, Daniel Baylis, Stephen Rothery,

Different combinations and relative quantities of three connexins-connexin43, connexin40 and connexin45-are expressed in different subsets of cardiomyocyte. In the healthy heart, gap junctions assembled from these different connexin combinations form the cell-to-cell pathways for the precisely orchestrated patterns of current flow that govern the normal heart rhythm. Remodelling of gap ... Read more >>

Biochim Biophys Acta (Biochimica et biophysica acta)
[2004, 1662(1-2):138-148]

Cited: 47 times

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Relative expression of immunolocalized connexins 40 and 43 correlates with human atrial conduction properties.

Prapa Kanagaratnam, Stephen Rothery, Pravina Patel, Nicholas J Severs, Nicholas S Peters,

<h4>Objectives</h4>The aim of this study was to determine the relationship between immunolocalized gap-junctional proteins and human atrial conduction.<h4>Background</h4>As a determinant of intercellular conductance, gap-junctional coupling is considered to influence myocardial conduction velocity. This study tested the hypothesis that the quantity of immunodetectable atrial gap-junctional proteins, connexin40 (Cx40) and connexin43 (Cx43), ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2002, 39(1):116-123]

Cited: 58 times

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Heat stress contributes to the enhancement of cardiac mitochondrial complex activity.

I A Sammut, J Jayakumar, N Latif, S Rothery, N J Severs, R T Smolenski, T E Bates, M H Yacoub,

Hyperthermic stress is known to protect against myocardial dysfunction after ischemia-reperfusion injury. It is unclear however, what energetic mechanisms are affected by the molecular adaptation to heat stress. We hypothesized that mild hyperthermic stress can increase mitochondrial respiratory enzyme activity, affording protection to mitochondrial energetics during prolonged cardiac preservation for ... Read more >>

Am J Pathol (The American journal of pathology)
[2001, 158(5):1821-1831]

Cited: 41 times

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Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase.

R T Palframan, P D Collins, N J Severs, S Rothery, T J Williams, S M Rankin,

Mobilization of bone marrow eosinophils is a critical early step in their trafficking to the lung during allergic inflammatory reactions. We have shown previously that the cytokine interleukin (IL)-5, generated during an allergic inflammatory reaction in the guinea pig, acts systemically to mobilize eosinophils from the bone marrow. Here, we ... Read more >>

J Exp Med (The Journal of experimental medicine)
[1998, 188(9):1621-1632]

Cited: 98 times

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