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Author Stephen A Boorjian

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A contemporary guide to chromosomal copy number profiling in the diagnosis of renal cell carcinoma.

Sounak Gupta, William R Sukov, Chad M Vanderbilt, Wei Shen, Loren Herrera-Hernandez, Christine M Lohse, R Houston Thompson, Stephen A Boorjian, Bradley C Leibovich, Rafael E Jimenez, John C Cheville,

The routine clinical implementation of molecular methods other than fluorescence in situ hybridization in the evaluation of renal neoplasia is currently limited, as the current standard of care primarily involves a combination of morphologic and immunophenotypic analysis of such tumors. Amongst various molecular techniques, global copy number profiling using single ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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A Contemporary Analysis of Urethral Recurrence following Radical Cystectomy.

Abhinav Khanna, Andrew Zganjar, Timothy Lyon, Paras Shah, Matthew K Tollefson, R Jeffrey Karnes, Robert Tarrell, Prabin Thapa, R Houston Thompson, Igor Frank, Stephen A Boorjian,

<h4>Introduction</h4>Oncologic outcomes following UR remain incompletely described, with reports limited by small cohort sizes. We evaluated risk factors for UR as well as cancer-specific survival (CSS) and overall survival (OS) among patients with UR.<h4>Methods</h4>We reviewed our institutional RC registry to identify patients with UR. Cox proportional hazards regression was used ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001842]

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Prognostic Impact of Different Gleason Patterns on Biopsy Within Grade Group 4 Prostate Cancer.

Keiichiro Mori, Vidit Sharma, Eva M Comperat, Shun Sato, Ekaterina Laukhtina, Victor M Schuettfort, Benjamin Pradere, Reza Sari Motlagh, Hadi Mostafaei, Fahad Quhal, Mehdi Kardoust Parizi, Mohammad Abufaraj, Pierre I Karakiewicz, Shin Egawa, Derya Tilki, Stephen A Boorjian, Shahrokh F Shariat,

<h4>Background</h4>Grade group (GG) 4 prostate cancer (PC) is considered a single entity; however, there are questions regarding prognostic heterogeneity. This study assessed the prognostic differences among various Gleason scores (GSs) classified as GG 4 PC on biopsy before radical prostatectomy (RP).<h4>Methods</h4>We conducted a multicenter retrospective study, and a total of ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

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Efficacy of a Novel Penile Traction Device in Improving Penile Length and Erectile Function Post Prostatectomy: Results from a Single-Center Randomized, Controlled Trial.

Amir Toussi, Matthew Ziegelmann, David Yang, Madeleine Manka, Igor Frank, Stephen A Boorjian, Matthew Tollefson, Tobias Köhler, Landon Trost,

<h4>Purpose</h4>RestoreX is a novel penile traction therapy device, with randomized, controlled data demonstrating improvements in penile length and erectile function after 30 to 90 minutes of daily use in men with Peyronie's disease. We sought to determine if similar improvements could be achieved post prostatectomy.<h4>Materials and methods</h4>Men post prostatectomy were ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001792]

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Reply by Authors.

Amir Toussi, Matthew Ziegelmann, David Yang, Madeleine Manka, Igor Frank, Stephen A Boorjian, Matthew Tollefson, Tobias Köhler, Landon Trost,

J Urol (The Journal of urology)
[2021, :101097JU000000000000179203]

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The Impact of Upper Tract Urothelial Carcinoma Diagnostic Modality on Intravesical Recurrence after Radical Nephroureterectomy: A Single Institution Series and Updated meta-Analysis.

Vidit Sharma, Tanner S Miest, Tristan S Juvet, Amir Toussi, Vignesh Packiam, Karim Chamie, Surena F Matin, Stephen A Boorjian, R Houston Thompson, Igor Frank, Matthew K Tollefson, Aaron M Potretzke,

<h4>Introduction</h4>Diagnostic ureteroscopic biopsy for upper tract urothelial carcinoma (UTUC) has been hypothesized to increase intravesical recurrence of urothelial carcinoma after radical nephroureterectomy (RNU). Moreover, the impact of ureteroscopy without biopsy or percutaneous biopsy on intravesical recurrence remains unknown. Herein, we compared post-RNU intravesical recurrences across UTUC diagnostic modalities.<h4>Methods</h4>Patients undergoing RNU ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001834]

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The current landscape of salvage therapies for patients with bacillus Calmette-Guérin unresponsive nonmuscle invasive bladder cancer.

Vignesh T Packiam, Jordan Richards, Maximilian Schmautz, Axel Heidenreich, Stephen A Boorjian,

<h4>Purpose of review</h4>Although radical cystectomy represents the gold standard treatment for patients with high-risk nonmuscle invasive bladder cancer (NMIBC) whose disease does not respond to bacillus Calmette-Guérin (BCG), many patients are unable or unwilling to undergo surgery. The need remains for effective bladder-preserving therapies. This review aims to describe existing ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(3):178-187]

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Urinary-based tumor markers enhance microhematuria risk stratification according to baseline bladder cancer prevalence.

Solomon L Woldu, Lesley Souter, Stephen A Boorjian, Daniel A Barocas, Yair Lotan,

<h4>Introduction</h4>The 2020 AUA microhematuria (MH) guideline stratifies patients into low, intermediate and high-risk for urologic malignancy based on established risk-factors for urothelial carcinoma. Notably, urine-based tumor markers (UBTMs) were not included in the risk classification. We evaluated the impact of incorporating UBTMs (cytology and multiple commercially available UBTMs) into this ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Assessment of isochromosome 12p and 12p abnormalities in germ cell tumors using fluorescence in situ hybridization, single-nucleotide polymorphism arrays, and next-generation sequencing/mate-pair sequencing.

C Eric Freitag, William R Sukov, Alan H Bryce, Jamie V Berg, Chad M Vanderbilt, Wei Shen, James B Smadbeck, Patricia T Greipp, Rhett P Ketterling, Robert B Jenkins, Loren Herrera-Hernandez, Brian A Costello, R Houston Thompson, Stephen A Boorjian, Bradley C Leibovich, Rafael E Jimenez, Stephen J Murphy, George Vasmatzis, John C Cheville, Sounak Gupta,

The identification of isochromosome 12p [i(12p)] and 12p gains have significant clinical utility in the diagnosis of germ cell tumors (GCTs). We have summarized the results of fluorescence in situ hybridization (FISH) assays to identify i(12p), performed in a Clinical Laboratory Improvement Amendments (CLIA)-validated setting for 536 specimens. In addition, ... Read more >>

Hum Pathol (Human pathology)
[2021, 112:20-34]

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When Less Is More: The Comparative Effectiveness of Partial Versus Radical Nephrectomy.

Boris Gershman, Stephen A Boorjian,

Eur Urol (European urology)
[2021, 79(6):781-782]

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Collaborative Review: Factors Influencing Treatment Decisions for Patients with a Localized Solid Renal Mass.

Thenappan Chandrasekar, Stephen A Boorjian, Umberto Capitanio, Boris Gershman, Maria Carmen Mir, Alexander Kutikov,

<h4>Context</h4>With the addition of active surveillance and thermal ablation (TA) to the urologist's established repertoire of partial (PN) and radical nephrectomy (RN) as first-line management options for localized renal cell carcinoma (RCC), appropriate treatment decision-making has become increasingly nuanced.<h4>Objective</h4>To critically review the treatment options for localized, nonrecurrent RCC; to highlight ... Read more >>

Eur Urol (European urology)
[2021, :]

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Incidence and predictors of occult preoperative deep vein thrombosis at radical cystectomy for urothelial carcinoma.

Tanner S Miest, Vidit Sharma, R Jeffrey Karnes, Stephen A Boorjian, R Houston Thompson, Igor Frank, Matthew K Tollefson,

<h4>Introduction</h4>Patients undergoing radical cystectomy are at high perioperative risk for deep vein thrombosis due to age, malignancy, recent transurethral resection, and neoadjuvant chemotherapy. We, therefore, evaluated the incidence and predictors of occult preoperative deep vein thrombosis prior to radical cystectomy for urothelial carcinoma.<h4>Methods</h4>We prospectively screened 52 asymptomatic patients with urothelial ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, :]

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Renal Neoplasia in Tuberous Sclerosis: A Study of 41 Patients.

Sounak Gupta, Rafael E Jimenez, Loren Herrera-Hernandez, Christine M Lohse, R Houston Thompson, Stephen A Boorjian, Bradley C Leibovich, John C Cheville,

<h4>Objective</h4>To study the clinical features and identify unique renal neoplasia subtypes and their prognostic implications in individuals with tuberous sclerosis complex (TSC).<h4>Patients and methods</h4>The Mayo Clinic nephrectomy registry included 37 patients with TSC diagnosed between 1970 and 2018. Four additional patients were identified from the pathology consultation and autopsy files. ... Read more >>

Mayo Clin Proc (Mayo Clinic proceedings)
[2021, 96(6):1470-1489]

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The association of salvage intravesical therapy following BCG with pathologic outcomes and survival after radical cystectomy for patients with high-grade non-muscle invasive bladder cancer: A multi-institution analysis.

Vignesh T Packiam, Craig V Labbate, Stephen A Boorjian, Robert Tarrell, John C Cheville, Svetlana Avulova, Vidit Sharma, Matvey Tsivian, Brittany Adamic, Mohammad Mahmoud, Ryan P Werntz, Norm D Smith, R Jeffrey Karnes, Matthew K Tollefson, Gary D Steinberg, Igor Frank,

<h4>Introduction</h4>While numerous current clinical trials are testing novel salvage therapies (ST) for patients with recurrent nonmuscle invasive bladder cancer (NMIBC) after bacillus Calmette-Guérin (BCG), the natural history of this disease state has been poorly defined to date. Herein, we evaluated oncologic outcomes in patients previously treated with BCG and ST ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

Cited: 1 time

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Differential prognostic impact of different Gleason patterns in grade group 4 in radical prostatectomy specimens.

Keiichiro Mori, Vidit Sharma, Eva M Comperat, Shun Sato, Ekaterina Laukhtina, Victor M Schuettfort, Benjamin Pradere, Mehdi Kardoust Parizi, Pierre I Karakiewicz, Shin Egawa, Derya Tilki, Stephen A Boorjian, Shahrokh F Shariat,

<h4>Introduction</h4>There are questions regarding whether grade group (GG) 4 prostate cancer (PC) is heterogeneous in terms of prognosis. We assessed prognostic differences in PC patients within GG 4 treated with radical prostatectomy (RP).<h4>Material and methods</h4>Biochemical recurrence (BCR)-free, cancer-specific, and overall survival were analyzed in 787 PC patients with GG 4 based ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2021, 47(5):1172-1178]

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Creation of a primary tumor tissue expression biomarker-augmented prognostic model for patients with metastatic renal cell carcinoma.

Elizabeth N Bearrick, Vignesh Packiam, Bimal Bhindi, Christine M Lohse, John C Cheville, Ross J Mason, Matthew Tollefson, Susan Harrington, Haidong Dong, Alexander S Parker, Stephen A Boorjian, R Houston Thompson, Bradley C Leibovich,

<h4>Background</h4>Clinical and pathological factors alone have limited prognostic ability in patients with metastatic clear cell renal cell carcinoma (ccRCC). Bim, a downstream pro-apoptotic molecule in the PD-1 signaling pathway, has recently been associated with survival in other malignancies. We sought to determine if tissue biomarkers including Bim, added to a ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(2):135.e1-135.e8]

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Evaluation of the New American Urological Association Guidelines Risk Classification for Hematuria.

Solomon L Woldu, Casey K Ng, Ronald K Loo, Jeff M Slezak, Steven J Jacobsen, Wei Shen Tan, John D Kelly, Tony Lough, David Darling, Kim E M van Kessel, Joep J de Jong, Wim van Criekinge, Shahrokh F Shariat, Andrew Hiar, Sarah Brown, Stephen A Boorjian, Daniel A Barocas, Robert S Svatek, Yair Lotan,

<h4>Purpose</h4>Microhematuria is a prevalent condition and the American Urological Association has developed a new risk-stratified approach for the evaluation of patients with microhematuria. Our objective was to provide the first evaluation of this important guideline.<h4>Materials and methods</h4>This multinational cohort study combines contemporary patients from 5 clinical trials and 2 prospective ... Read more >>

J Urol (The Journal of urology)
[2021, 205(5):1387-1393]

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The evolving role of lymphadenectomy for bladder cancer: why, when, and how.

Vignesh T Packiam, Matvey Tsivian, Stephen A Boorjian,

Radical cystectomy (RC) represents a standard treatment for non-metastatic muscle-invasive and select high-risk non-muscle invasive bladder cancer. Lymphadenectomy performed at time of RC identifies nodal metastases in up to 25% of patients despite normal imaging. There has been an increasing utilization of pelvic lymph node dissection (PLND) with RC since ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(6):3082-3093]

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Cost-Effectiveness Analysis of Pembrolizumab for Bacillus Calmette-Guérin-Unresponsive Carcinoma In Situ of the Bladder.

Kevin M Wymer, Vidit Sharma, Christopher S Saigal, Karim Chamie, Mark S Litwin, Vignesh T Packiam, Matthew Mossanen, Lance C Pagliaro, Bijan J Borah, Stephen A Boorjian,

<h4>Purpose</h4>Patients with bacillus Calmette-Guérin-unresponsive carcinoma in situ are treated with radical cystectomy or salvage intravesical chemotherapy. Recently, pembrolizumab was approved for bacillus Calmette-Guérin-unresponsive carcinoma in situ.<h4>Materials and methods</h4>We used a decision-analytic Markov model to compare pembrolizumab, salvage intravesical chemotherapy (with gemcitabine-docetaxel induction+monthly maintenance) and radical cystectomy for patients with bacillus ... Read more >>

J Urol (The Journal of urology)
[2021, 205(5):1326-1335]

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Prospective validation of microseminoprotein-β added to the 4Kscore in predicting high-grade prostate cancer in an international multicentre cohort.

Peter E Lonergan, Emily A Vertosick, Melissa Assel, Daniel D Sjoberg, Alexander Haese, Markus Graefen, Stephen A Boorjian, George G Klee, Matthew R Cooperberg, Kim Pettersson, Erica Routila, Andrew J Vickers, Hans Lilja,

<h4>Objectives</h4>To prospectively evaluate the performance of a pre-specified statistical model based on four kallikrein markers in blood (total prostate-specific antigen [PSA], free PSA, intact PSA, and human kallikrein-related peptidase 2), commercially available as the 4Kscore, in predicting Gleason Grade Group (GG) ≥2 prostate cancer at biopsy in an international multicentre ... Read more >>

BJU Int (BJU international)
[2020, :]

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Association of intraoperative hypothermia with oncologic outcomes following radical cystectomy.

Timothy D Lyon, Igor Frank, Matthew K Tollefson, Robert F Tarrell, Paras H Shah, Robert H Thompson, Robert J Karnes, Stephen A Boorjian,

<h4>Introduction</h4>Intraoperative hypothermia (IOH) has been suggested to adversely impact outcomes following surgery. The objective of this study was to evaluate the association between IOH and survival following radical cystectomy (RC).<h4>Methods</h4>Patients who underwent RC for bladder cancer from 2003 to 2018 were identified in our cystectomy registry. Intraoperative temperatures were extracted ... Read more >>

Urol Oncol (Urologic oncology)
[2020, :]

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Grading Chromophobe Renal Cell Carcinoma: Evidence for a Four-tiered Classification Incorporating Coagulative Tumor Necrosis.

Svetlana Avulova, John C Cheville, Christine M Lohse, Sounak Gupta, Theodora A Potretzke, Matvey Tsivian, R Houston Thompson, Stephen A Boorjian, Bradley C Leibovich, Aaron M Potretzke,

<h4>Background</h4>Although grading systems have been proposed for chromophobe renal cell carcinoma (ChRCC), including a three-tiered system by Paner et al (Paner GP, Amin MB, Alvarado-Cabrero I, et al. A novel tumor grading scheme for chromophobe renal cell carcinoma: prognostic utility and comparison with Fuhrman nuclear grade. Am J Surg Pathol ... Read more >>

Eur Urol (European urology)
[2021, 79(2):225-231]

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Renal neoplasia with papillary architecture involving the pelvicalyceal system.

Sounak Gupta, John C Cheville, Belinda K Galeano, William R Sukov, Loren Herrera-Hernandez, Katelyn A Reed, Christine M Lohse, R Houston Thompson, Stephen A Boorjian, Bradley C Leibovich, Rafael E Jimenez,

Pelvicalyceal system (PS) involvement by renal cell carcinoma (RCC) is staged as pT3a disease (American Joint Committee on Cancer [AJCC], 8th edition). As papillary RCC (PRCC) has been infrequently represented in studies looking at the prognostic impact of PS involvement, we reviewed our institutional cohort of 8225 cases for PS ... Read more >>

Hum Pathol (Human pathology)
[2021, 107:46-57]

Cited: 3 times

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Development of a technique for evaluating the presence of malignant cells in prostatic fluid during robotic prostatectomy.

Timothy D Lyon, Michael R Henry, Paras H Shah, Stephen A Boorjian, Matthew K Tollefson, Igor Frank,

<h4>Introduction</h4>To develop a technique to collect fluid expressed during robot-assisted radical prostatectomy (RARP) to assess whether malignant cells may have been inadvertently introduced into the surgical field.<h4>Methods</h4>Men with clinically localized grade group 2 to 5 prostate adenocarcinoma undergoing RARP were identified. Following bladder neck division, fluid expressed via prostatic urethra ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(3):192.e1-192.e6]

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Does Ureteral Stent Drainage Prior to Cystectomy Increase the Risk of Subsequent Upper Tract Urothelial Carcinoma and Ureteral Complications?

Tanner S Miest, Vidit Sharma, Luca Boeri, Matthew K Tollefson, R Houston Thompson, Stephen A Boorjian, Igor Frank, R Jeffrey Karnes,

<h4>Objective</h4>To guide management of preoperative hydronephrosis prior to radical cystectomy (RC), we compared post-RC risks of upper tract urothelial carcinoma (UTUC) and ureteroenteric anastomotic complications between ureteral stent and percutaneous nephrostomy tube drainage.<h4>Methods</h4>Patients who underwent RC for urothelial carcinoma without a prior diagnosis of UTUC at our institution between 2000 ... Read more >>

Urology (Urology)
[2020, :]

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