Full Text Journal Articles by
Author Stephanie Tzetzo

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Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer.

Erik S Knudsen, Vishnu Kumarasamy, Sejin Chung, Amanda Ruiz, Paris Vail, Stephanie Tzetzo, Jin Wu, Ram Nambiar, Jared Sivinski, Shailender S Chauhan, Mukund Seshadri, Scott I Abrams, Jianmin Wang, Agnieszka K Witkiewicz,

OBJECTIVE:This study exploits the intersection between molecular-targeted therapies and immune-checkpoint inhibition to define new means to treat pancreatic cancer. DESIGN:Patient-derived cell lines and xenograft models were used to define the response to CDK4/6 and MEK inhibition in the tumour compartment. Impacts relative to immunotherapy were performed using subcutaneous and orthotopic ... Read more >>

Gut (Gut)
[2020, :]

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Inhibition of LSD1 in MDS progenitors restores differentiation of CD141Hi conventional dendritic cells.

Pragya Srivastava, Stephanie L Tzetzo, Eduardo Cortes Gomez, Kevin H Eng, Sheila N Jani Sait, Joseph B Kuechle, Prashant K Singh, Kitty De Jong, Kyle R Wiatrowski, Jennifer Peresie, Ava Dimitroff, Miranda L Lynch, Jianmin Wang, Scott I Abrams, Elizabeth A Griffiths, Michael J Nemeth,

The use of immunotherapy to treat patients with myelodysplastic syndromes (MDS) shows promise but is limited by our incomplete understanding of the immunologic milieu. In solid tumors, CD141Hi conventional dendritic cells (CD141Hi cDCs) are necessary for antitumor immunosurveillance and the response to immunotherapy. Here, we found that CD141Hi cDCs are ... Read more >>

Leukemia (Leukemia)
[2020, 34(9):2460-2472]

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Targeting dual signaling pathways in concert with immune checkpoints for the treatment of pancreatic cancer

Erik Knudsen, Vishnu Kumarasamy, Sejin Chung, Paris Vail, Stephanie Tzetzo, Amanda Ruiz, Mukund Seshadri, Scott Abrams, Jianmin Wang, Agnieszka Witkiewicz,

ABSTRACT Pancreatic cancer harbors a poor prognosis due to the lack of effective systemic therapies. Here we interrogated means to target key effector pathways down-stream from KRAS. We found that combination treatment with MEK and CDK4/6 inhibitors was effective across a broad range of PDX models in delaying tumor progression. ... Read more >>

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Myeloid-driven mechanisms as barriers to antitumor CD8+ T cell activity.

Sean H Colligan, Stephanie L Tzetzo, Scott I Abrams,

The adaptive immune system is essential for host defense against pathogenic challenges, and a major constituent is the CD8+ cytotoxic T cell. Ordinarily, CD8+ T cells are endowed with a unique ability to specifically recognize and destroy their targets. However, in cases where disease emerges, especially in cancer, the efficacy ... Read more >>

Mol Immunol (Molecular immunology)
[2020, 118:165-173]

Cited: 1 time

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BK Virus in Kidney Transplant: Current Concepts, Recent Advances, and Future Directions.

Rajeev Sharma, Stephanie Tzetzo, Sunil Patel, Mareena Zachariah, Sonakshi Sharma, Thomas Melendy,

BK virus nephropathy is a challenging clinical problem in kidney transplant recipients with wide range of surveillance and management practices, based on individual experience. BK virus reactivation in kidney transplant recipients can result in BK virus nephropathy and graft loss. The most effective strategy for early diagnosis and treatment of ... Read more >>

Exp Clin Transplant (Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation)
[2016, 14(4):377-384]

Cited: 4 times

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