Full Text Journal Articles by
Author Stephanie J Wan

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Resistance of the murine cornea to bacterial colonization during experimental dry eye.

Stephanie J Wan, Sophia Ma, David J Evans, Suzanne M J Fleiszig,

The healthy cornea is remarkably resistant to infection, quickly clearing deliberately inoculated bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus. Contrasting with the adjacent conjunctiva and other body surfaces, it also lacks a resident viable bacterial microbiome. Corneal resistance to microbes depends on intrinsic defenses involving tear fluid and the ... Read more >>

PLoS ONE (PloS one)
[2020, 15(5):e0234013]

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Contact lens-related corneal infection: Intrinsic resistance and its compromise.

Suzanne M J Fleiszig, Abby R Kroken, Vincent Nieto, Melinda R Grosser, Stephanie J Wan, Matteo M E Metruccio, David J Evans,

Contact lenses represent a widely utilized form of vision correction with more than 140 million wearers worldwide. Although generally well-tolerated, contact lenses can cause corneal infection (microbial keratitis), with an approximate annualized incidence ranging from ~2 to ~20 cases per 10,000 wearers, and sometimes resulting in permanent vision loss. Research ... Read more >>

Prog Retin Eye Res (Progress in retinal and eye research)
[2020, 76:100804]

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DMBT1 inhibition of Pseudomonas aeruginosa twitching motility involves its N-glycosylation and cannot be conferred by the Scavenger Receptor Cysteine-Rich bacteria-binding peptide domain.

Jianfang Li, Stephanie J Wan, Matteo M E Metruccio, Sophia Ma, Kamran Nazmi, Floris J Bikker, David J Evans, Suzanne M J Fleiszig,

The scavenging capacity of glycoprotein DMBT1 helps defend mucosal epithelia against microbes. DMBT1 binding to multiple bacterial species involves its conserved Scavenger Receptor Cysteine-Rich (SRCR) domains, localized to a 16-mer consensus sequence peptide, SRCRP2. Previously, we showed that DMBT1 bound Pseudomonas aeruginosa pili, and inhibited twitching motility, a pilus-mediated movement ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):13146]

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Patterns of Care Related to Post-Operative Radiotherapy for Patients with Prostate Cancer among Canadian Radiation Oncologists and Urologists.

Bonnie Bristow, Mohammed Aldehaim, Katija Bonin, Candice Chee Ka Lam, Stephanie J Wan, Xingshan Cao, Ewa Szumacher,

The American Society for Radiation Oncology (ASTRO) and American Urological Association (AUA) developed post-prostatectomy radiotherapy (RT) guidelines to aid patient counseling on adjuvant (ART) and salvage radiotherapy (SRT). Our study compared how aware and compliant Canadian radiation oncologists and urologists are to these guidelines. Our online survey was distributed through ... Read more >>

J Cancer Educ (Journal of cancer education : the official journal of the American Association for Cancer Education)
[2018, 33(6):1195-1200]

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A novel murine model for contact lens wear reveals clandestine IL-1R dependent corneal parainflammation and susceptibility to microbial keratitis upon inoculation with Pseudomonas aeruginosa.

Matteo M E Metruccio, Stephanie J Wan, Hart Horneman, Abby R Kroken, Aaron B Sullivan, Tan N Truong, James J Mun, Connie K P Tam, Robin Frith, Laurence Welsh, Melanie D George, Carol A Morris, David J Evans, Suzanne M J Fleiszig,

PURPOSE:Contact lens wear carries a risk of complications, including corneal infection. Solving these complications has been hindered by limitations of existing animal models. Here, we report development of a new murine model of contact lens wear. METHODS:C57BL/6 mice were fitted with custom-made silicone-hydrogel contact lenses with or without prior inoculation ... Read more >>

Ocul Surf (The ocular surface)
[2019, 17(1):119-133]

Cited: 1 time

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Hair Loss and Identity-From Homer to Donne.

Stephanie J Wan, Jeff Donovan,

J Cutan Med Surg (Journal of cutaneous medicine and surgery)
[2018, 22(6):656]

Cited: 0 times

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IL-1R and MyD88 Contribute to the Absence of a Bacterial Microbiome on the Healthy Murine Cornea.

Stephanie J Wan, Aaron B Sullivan, Peyton Shieh, Matteo M E Metruccio, David J Evans, Carolyn R Bertozzi, Suzanne M J Fleiszig,

Microbial communities are important for the health of mucosal tissues. Traditional culture and gene sequencing have demonstrated bacterial populations on the conjunctiva. However, it remains unclear if the cornea, a transparent tissue critical for vision, also hosts a microbiome. Corneas of wild-type, IL-1R (-/-) and MyD88 (-/-) C57BL/6 mice were ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2018, 9:1117]

Cited: 1 time

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Fourteen-month-old infants use interpersonal synchrony as a cue to direct helpfulness.

Laura K Cirelli, Stephanie J Wan, Laurel J Trainor,

Musical behaviours such as dancing, singing and music production, which require the ability to entrain to a rhythmic beat, encourage high levels of interpersonal coordination. Such coordination has been associated with increased group cohesion and social bonding between group members. Previously, we demonstrated that this association influences even the social ... Read more >>

Philos. Trans. R. Soc. Lond., B, Biol. Sci. (Philosophical transactions of the Royal Society of London. Series B, Biological sciences)
[2014, 369(1658):20130400]

Cited: 28 times

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