Full Text Journal Articles by
Author Stephanie Chidester

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The Role of Extracellular Vesicles in β-Cell Function and Viability: A Scoping Review.

Stephanie Chidester, Alicia A Livinski, Anne F Fish, Paule V Joseph,

Extracellular vesicles (EVs) released by cells throughout the body have been implicated in diabetes pathogenesis. Understanding the role of EVs in regulation of β-cell function and viability may provide insights into diabetes etiology and may lead to the development of more effective screening and diagnostic tools to detect diabetes earlier ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2020, 11:375]

Cited: 0 times

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DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC.

Kunal Rai, Sharmistha Sarkar, Talmage J Broadbent, Matthew Voas, Kenneth F Grossmann, Lincoln D Nadauld, Somaye Dehghanizadeh, Fanuel T Hagos, Yumei Li, Rachel K Toth, Stephanie Chidester, Timothy M Bahr, W Evan Johnson, Brad Sklow, Randall Burt, Bradley R Cairns, David A Jones,

Although genome-wide hypomethylation is a hallmark of many cancers, roles for active DNA demethylation during tumorigenesis are unknown. Here, loss of the APC tumor suppressor gene causes upregulation of a DNA demethylase system and the concomitant hypomethylation of key intestinal cell fating genes. Notably, this hypomethylation maintained zebrafish intestinal cells ... Read more >>

Cell (Cell)
[2010, 142(6):930-942]

Cited: 49 times

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Dnmt3 and G9a cooperate for tissue-specific development in zebrafish.

Kunal Rai, Itrat F Jafri, Stephanie Chidester, Smitha R James, Adam R Karpf, Bradley R Cairns, David A Jones,

Although DNA methylation is critical for proper embryonic and tissue-specific development, how different DNA methyltransferases affect tissue-specific development and their targets remains unknown. We address this issue in zebrafish through antisense-based morpholino knockdown of Dnmt3 and Dnmt1. Our data reveal that Dnmt3 is required for proper neurogenesis, and its absence ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2010, 285(6):4110-4121]

Cited: 72 times

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A two-step model for colon adenoma initiation and progression caused by APC loss.

Reid A Phelps, Stephanie Chidester, Somaye Dehghanizadeh, Jason Phelps, Imelda T Sandoval, Kunal Rai, Talmage Broadbent, Sharmistha Sarkar, Randall W Burt, David A Jones,

Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation. Using zebrafish and human cells, we show that homozygous loss of APC causes failed intestinal cell differentiation but that this occurs in the absence of nuclear beta-catenin and increased intestinal ... Read more >>

Cell (Cell)
[2009, 137(4):623-634]

Cited: 165 times

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Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases.

Lincoln D Nadauld, Reid Phelps, Brent C Moore, Annie Eisinger, Imelda T Sandoval, Stephanie Chidester, Peter W Peterson, Elizabeth J Manos, Bradford Sklow, Randall W Burt, David A Jones,

Mutations in the human adenomatous polyposis coli (APC) gene are thought to initiate colorectal tumorigenesis. The tumor suppressor function of APC is attributed primarily to its ability to regulate the WNT pathway by targeting the destruction of beta-catenin. We report here a novel role for APC in regulating degradation of ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2006, 281(49):37828-37835]

Cited: 31 times

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The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid.

Annie L Eisinger, Lincoln D Nadauld, Dawne N Shelton, Peter W Peterson, Reid A Phelps, Stephanie Chidester, Diana M Stafforini, Stephen M Prescott, David A Jones,

Mutations in the adenomatous polyposis coli (APC) gene result in uncontrolled proliferation of intestinal epithelial cells and are associated with the earliest stages of colorectal carcinogenesis. Cyclooxygenase-2 (COX-2) is elevated in human colorectal cancers and plays an important role in colorectal tumorigenesis; however, the mechanisms by which APC mutations result ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2006, 281(29):20474-20482]

Cited: 31 times

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Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development.

Lincoln D Nadauld, Stephanie Chidester, Dawne N Shelton, Kunal Rai, Talmage Broadbent, Imelda T Sandoval, Peter W Peterson, Elizabeth J Manos, Chris M Ireland, H Joseph Yost, David A Jones,

Congenital hypertrophy/hyperplasia of the retinal pigmented epithelium is an ocular lesion found in patients harboring mutations in the adenomatous polyposis coli (APC) tumor suppressor gene. We report that Apc-deficient zebrafish display developmental abnormalities of both the lens and retina. Injection of dominant-negative Lef reduced Wnt signaling in the lens but ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2006, 103(36):13409-13414]

Cited: 25 times

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The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli.

Lincoln D Nadauld, Dawne N Shelton, Stephanie Chidester, H Joseph Yost, David A Jones,

Retinoic acid (RA) is a potent signaling molecule that plays important roles in multiple and diverse developmental processes. The contribution of retinoic acid to promoting the development and differentiation of the vertebrate intestine and the factors that regulate RA production in the gut remain poorly defined. Herein, we report that ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2005, 280(34):30490-30495]

Cited: 23 times

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Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish.

Kunal Rai, Stephanie Chidester, Chad V Zavala, Elizabeth J Manos, Smitha R James, Adam R Karpf, David A Jones, Bradley R Cairns,

The roles of DNA methyltransferase-2 (DNMT2) enzymes are controversial; whether DNMT2 functions primarily as a nuclear DNA methyltransferase or as a cytoplasmic tRNA methyltransferase, and whether DNMT2 activity impacts development, as dnmt2 mutant mice or Drosophila lack phenotypes. Here we show that morpholino knockdown of Dnmt2 protein in zebrafish embryos ... Read more >>

Genes Dev. (Genes & development)
[2007, 21(3):261-266]

Cited: 96 times

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Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development.

Kunal Rai, Lincoln D Nadauld, Stephanie Chidester, Elizabeth J Manos, Smitha R James, Adam R Karpf, Bradley R Cairns, David A Jones,

DNA methylation and histone methylation are two key epigenetic modifications that help govern heterochromatin dynamics. The roles for these chromatin-modifying activities in directing tissue-specific development remain largely unknown. To address this issue, we examined the roles of DNA methyltransferase 1 (Dnmt1) and the H3K9 histone methyltransferase Suv39h1 in zebra fish ... Read more >>

Mol. Cell. Biol. (Molecular and cellular biology)
[2006, 26(19):7077-7085]

Cited: 89 times

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Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development.

Dawne N Shelton, Imelda T Sandoval, Annie Eisinger, Stephanie Chidester, Anokha Ratnayake, Chris M Ireland, David A Jones,

Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene seem to underlie the initiation of many colorectal carcinomas. Loss of APC function results in accumulation of beta-catenin and activation of beta-catenin/TCF-dependent transcription. Recent studies have implicated APC in controlling retinoic acid biosynthesis during normal intestinal development through a WNT-independent ... Read more >>

Cancer Res. (Cancer research)
[2006, 66(15):7571-7577]

Cited: 37 times

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Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation.

Lincoln D Nadauld, Imelda T Sandoval, Stephanie Chidester, H Joseph Yost, David A Jones,

Mutations in the APC (adenomatous polyposis coli) tumor suppressor gene cause uncontrolled proliferation and impaired differentiation of intestinal epithelial cells. Recent studies indicate that human colon adenomas and carcinomas lack retinol dehydrogenases (RDHs) and that APC regulates the expression of human RDHL. These data suggest a model wherein APC controls ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2004, 279(49):51581-51589]

Cited: 38 times

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