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Author Stephane Giraudier

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CCND2 mutations are infrequent events in BCR-ABL1 negative myeloproliferative neoplasm patients.

Bruno Cassinat, Emmanuelle Verger, Nabih Maslah, Nicolas Gauthier, William Vainchenker, Stéphane Giraudier, Jean-Jacques Kiladjian,

Haematologica (Haematologica)
[2020, :]

Cited: 0 times

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Should Transplantation Still Be Considered for Ph1-Negative Myeloproliferative Neoplasms in Transformation?

Mathilde Ruggiu, Bruno Cassinat, Jean-Jacques Kiladjian, Emmanuel Raffoux, Stéphane Giraudier, Marie Robin, Raphael Itzykson, Emmanuelle Clappier, David Michonneau, Flore Sicre de Fontbrune, Régis Peffault de Latour, Lionel Ades, Gérard Socié,

BCR-ABL-negative myeloproliferative neoplasms (MPNs) in transformation have a dismal prognosis, and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the sole curative therapeutic option. We retrospectively analyzed 53 molecularly annotated patients treated at Saint Louis Hospital, Paris, diagnosed with MPN in transformation between 2008 and 2018. The median patient age ... Read more >>

Biol. Blood Marrow Transplant. (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation)
[2020, :]

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Synergistic effects of PRIMA-1Met (APR-246) and Azacitidine in TP53-mutated myelodysplastic syndromes and acute myeloid leukemia.

Nabih Maslah, Norman Salomao, Louis Drevon, Emmanuelle Verger, Nicolas Partouche, Pierre Ly, Philippe Aubin, Nadia Naoui, Marie-Helene Schlageter, Cecile Bally, Elsa Miekoutima, Rami Rahmé, Jacqueline Lehmann-Che, Lionel Ades, Pierre Fenaux, Bruno Cassinat, Stephane Giraudier,

Myelodysplastic syndromes and acute myeloid leukemia with TP53 mutations are characterized by frequent relapses, poor or short responses, and poor survival with the currently available therapies including chemotherapy and 5-azacitidine. PRIMA-1Met (APR-246, APR) is a methylated derivative of PRIMA-1, which induces apoptosis in human tumor cells through restoration of the ... Read more >>

Haematologica (Haematologica)
[2019, :]

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Masked polycythemia vera: analysis of a single center cohort of 2480 red cell masses.

Nabih Maslah, Juliette Soret, Christine Dosquet, Laetitia Vercellino, Célia Belkhodja, Marie-Hélène Schlageter, Bruno Cassinat, Jean-Jacques Kiladjian, Christine Chomienne, Stephane Giraudier,

Haematologica (Haematologica)
[2020, 105(3):e95-e97]

Cited: 0 times

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Longer treatment duration and history of osteoarticular symptoms predispose to tyrosine kinase inhibitor withdrawal syndrome.

Marc G Berger, Bruno Pereira, Philippe Rousselot, Pascale Cony-Makhoul, Martine Gardembas, Laurence Legros, Martine Escoffre-Barbe, Franck-Emmanuel Nicolini, Sandrine Saugues, Céline Lambert, Delphine Réa, Agnès Guerci-Bresler, Stéphane Giraudier, Joëlle Guilhot, Susanne Saussele, François-Xavier Mahon, ,

The effectiveness of tyrosine kinase inhibitors (TKIs) has made it possible to consider treatment discontinuation in chronic myeloid leukaemia (CML) patients that achieve an excellent response. However, a few of the patients included in the Europe Stop Tyrosine Kinase Inhibitors (EURO-SKI) trial reported musculoskeletal pain shortly after stopping TKIs, considered ... Read more >>

Br. J. Haematol. (British journal of haematology)
[2019, 187(3):337-346]

Cited: 1 time

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How much does 2016 WHO classification of myeloproliferative neoplasms affect the clinic?

Bruno Cassinat, Stephane Giraudier, Jean-Jacques Kiladjian,

Expert Rev Hematol (Expert review of hematology)
[2019, 12(7):473-476]

Cited: 0 times

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Dramatic response of refractory sarcoidosis under ruxolitinib in a patient with associated JAK2-mutated polycythemia.

Cécile Rotenberg, Valérie Besnard, Pierre-Yves Brillet, Stéphane Giraudier, Hilario Nunes, Dominique Valeyre,

Eur. Respir. J. (The European respiratory journal)
[2018, 52(6):]

Cited: 0 times

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Positive impact of molecular analysis on prognostic scores in essential thrombocythemia: a single center prospective cohort experience.

Damien Luque Luque Paz, Olivier Mansier, Jérémie Riou, Carole Conejero, Lydia Roy, Célia Belkhodja, Valérie Ugo, Stéphane Giraudier,

Haematologica (Haematologica)
[2019, 104(4):e134-e137]

Cited: 1 time

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Ropeginterferon alpha-2b targets JAK2V617F-positive polycythemia vera cells in vitro and in vivo.

Emmanuelle Verger, Juliette Soret-Dulphy, Nabih Maslah, Lydia Roy, Jerome Rey, Zineb Ghrieb, Robert Kralovics, Heinz Gisslinger, Barbara Grohmann-Izay, Christoph Klade, Christine Chomienne, Stéphane Giraudier, Bruno Cassinat, Jean-Jacques Kiladjian,

Polycythemia vera is characterized by the acquisition of the JAK2V617F mutation. Recommended treatments include hydroxyurea and interferon-alpha. Several groups have reported a reduction in the JAK2 mutant allele burden in interferon-treated patients, but significance of this observation is questioned. We characterized the activity of ropeginterferon alpha-2b, a novel form of ... Read more >>

Blood Cancer J (Blood cancer journal)
[2018, 8(10):94]

Cited: 1 time

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Next-generation sequencing for JAK2 mutation testing: advantages and pitfalls.

Nabih Maslah, Emmanuelle Verger, Marie-Helene Schlageter, Jean-Michel Miclea, Jean-Jacques Kiladjian, Stephane Giraudier, Christine Chomienne, Bruno Cassinat,

The JAK2V617F mutation is part of the major criteria for diagnosis of myeloproliferative neoplasms (MPN). Allele-specific quantitative PCR (qPCR) is the most prevalent method used in laboratories but with the advent of next-generation sequencing (NGS) techniques, we felt necessary to evaluate this approach for JAK2 mutations testing. Among DNA samples ... Read more >>

Ann. Hematol. (Annals of hematology)
[2019, 98(1):111-118]

Cited: 1 time

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Endothelial Cells Harbouring the JAK2V617F Mutation Display Pro-Adherent and Pro-Thrombotic Features.

Anna Guadall, Elodie Lesteven, Gil Letort, Sarah Awan Toor, Marc Delord, Doriane Pognant, Mégane Brusson, Emmanuelle Verger, Nabih Maslah, Stéphane Giraudier, Jerome Larghero, Valerie Vanneaux, Christine Chomienne, Wassim El Nemer, Bruno Cassinat, Jean-Jacques Kiladjian,

Thromboembolic events are the main cause of mortality in BCR-ABL1-negative myeloproliferative neoplasms (MPNs) but their underlying mechanisms are largely unrecognized. The Janus kinase 2 (JAK2)V617F mutation is the most frequent genetic alteration leading to MPN. Usually found in haematopoietic progenitors and stem cells, this mutation has also been described in ... Read more >>

Thromb. Haemost. (Thrombosis and haemostasis)
[2018, 118(9):1586-1599]

Cited: 5 times

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Mechanisms of Thrombocytopenia During Septic Shock: A Multiplex Cluster Analysis of Endogenous Sepsis Mediators.

Alexandre Bedet, Keyvan Razazi, Florence Boissier, Mathieu Surenaud, Sophie Hue, Stéphane Giraudier, Christian Brun-Buisson, Armand Mekontso Dessap,

BACKGROUND:Thrombocytopenia is a common feature of sepsis and may involve various mechanisms often related to the inflammatory response. This study aimed at evaluating factors associated with thrombocytopenia during human septic shock. In particular, we used a multiplex analysis to assess the role of endogenous sepsis mediators. METHODS:Prospective, observational study. Thrombocytopenia ... Read more >>

Shock (Shock (Augusta, Ga.))
[2018, 49(6):641-648]

Cited: 4 times

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Non-adherence to treatment with cytoreductive and/or antithrombotic drugs is frequent and associated with an increased risk of complications in patients with polycythemia vera or essential thrombocythemia (OUEST study).

Ronan Le Calloch, Karine Lacut, Christelle Le Gall-Ianotto, Emmanuel Nowak, Morgane Abiven, Adrian Tempescul, Florence Dalbies, Jean-Richard Eveillard, Valérie Ugo, Stéphane Giraudier, Gaëlle Guillerm, Eric Lippert, Christian Berthou, Jean-Christophe Ianotto,

The purpose of this study was to identify the incidence, causes and impact of non-adherence to oral and subcutaneous chronic treatments for patients with polycythemia vera or essential thrombocythemia. Patients receiving cytoreductive drugs for polycythemia vera or essential thrombocythemia were recruited at our institution (Observatoire Brestois des Néoplasies Myéloprolifératives registry). ... Read more >>

Haematologica (Haematologica)
[2018, 103(4):607-613]

Cited: 0 times

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Adolescence/adult onset MTHFR deficiency may manifest as isolated and treatable distinct neuro-psychiatric syndromes.

Ana Gales, Marion Masingue, Stephanie Millecamps, Stephane Giraudier, Laure Grosliere, Claude Adam, Claudio Salim, Vincent Navarro, Yann Nadjar,

5,10-Methylene-tetrahydrofolate reductase (MTHFR) deficiency is a genetic disorder that can occur at any age and can be easily detected by increased homocysteinemia. In adolescence/adult onset forms, the clinical picture is often complex with association of various neurological features and thrombosis.Here we report the cases of two adult siblings who experienced ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2018, 13(1):29]

Cited: 0 times

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Clinical and biological characterization of MPN patients harboring two driver mutations, a French intergroup of myeloproliferative neoplasms (FIM) study.

Olivier Mansier, Damien Luque Paz, Jean-Christophe Ianotto, Yannick Le Bris, Aurélie Chauveau, Françoise Boyer, Carole Conejero, Olivier Fitoussi, Jérémie Riou, Didier Adiko, Mohamed Touati, Jasmine Chauzeix, Jean-François Viallard, Marie C Béné, Stéphane Giraudier, Valérie Ugo, Eric Lippert,

Am. J. Hematol. (American journal of hematology)
[2018, 93(4):E84-E86]

Cited: 2 times

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Second tyrosine kinase inhibitor discontinuation attempt in patients with chronic myeloid leukemia.

Laurence Legros, Franck E Nicolini, Gabriel Etienne, Philippe Rousselot, Delphine Rea, Stéphane Giraudier, Agnès Guerci-Bresler, Françoise Huguet, Martine Gardembas, Martine Escoffre, Jean-Christophe Ianotto, Marie-Pierre Noël, Bruno R Varet, Thomas Pagliardini, Irit Touitou, Stéphane Morisset, Francois-Xavier Mahon, ,

Several studies have demonstrated that approximately one-half of patients with chronic myeloid leukemia (CML) who receive treatment with tyrosine kinase inhibitors (TKIs) and achieve and maintain a deep molecular response (DMR) are able to successfully discontinue therapy. In patients who have a molecular relapse, a DMR is rapidly regained upon ... Read more >>

Cancer (Cancer)
[2017, 123(22):4403-4410]

Cited: 15 times

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Emergence of MPLW515 mutation in a patient with CALR deletion: Evidence of secondary acquisition of MPL mutation in the CALR clone.

Nicolas Partouche, Carole Conejero, Quentin Barathon, Julien Moroch, Michel Tulliez, Catherine Cordonnier, Stephane Giraudier,

Myeloproliferative neoplasms are characterized by transduction pathway recognized as mutually exclusive molecular abnormalities such as BCR-ABL translocation, JAK2V617F or JAK2 exon 12 mutations, MPL w515, and CALR mutations. However, in some rare cases, associations of such mutations are found in 1 patient. This can be related to 2 pathologies (at ... Read more >>

Hematol Oncol (Hematological oncology)
[2018, 36(1):336-339]

Cited: 0 times

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Pseudotyping Serotype 5 Adenovirus with the Fiber from Other Serotypes Uncovers a Key Role of the Fiber Protein in Adenovirus 5-Induced Thrombocytopenia.

Najat Raddi, Frédéric Vigant, Oriane Wagner-Ballon, Stéphane Giraudier, Jerome Custers, Silvio Hemmi, Karim Benihoud,

Adenovirus (Ad) infection in humans is associated with inflammatory responses and thrombocytopenia. Although several studies were conducted in mice models to understand molecular and cellular mechanisms of Ad-induced inflammatory responses, only few of them turned their interest toward the mechanisms of Ad-induced thrombocytopenia. Using different depletion methods, the present study ... Read more >>

Hum. Gene Ther. (Human gene therapy)
[2016, 27(2):193-201]

Cited: 1 time

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Lack of Transcription Factor p53 Exacerbates Elastase-Induced Emphysema in Mice.

Sandra Chrusciel, Maéva Zysman, Philippe Caramelle, Arnaud Tiendrebeogo, Indoumady Baskara, Sabine Le Gouvello, François Chabot, Stéphane Giraudier, Jorge Boczkowski, Laurent Boyer,

The transcription factor p53 is overexpressed in the lung of patients with emphysema, but it remains unclear if it has a deleterious or protective effect in disease progression. We investigated the role of p53 in the elastase-induced emphysema model and the molecular underlining mechanisms. Wild-type (WT) and p53(-/-) mice were ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2016, 54(2):188-199]

Cited: 2 times

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Hyperhomocysteinemia and high doses of nilotinib favor cardiovascular events in chronic phase Chronic Myelogenous Leukemia patients.

Gaëlle Fossard, Emilie Blond, Marie Balsat, Stéphane Morisset, Stéphane Giraudier, Martine Escoffre-Barbe, Hélène Labussière-Wallet, Maël Heiblig, Arthur Bert, Madeleine Etienne, Jocelyne Drai, Mohamad Sobh, Isabelle Redonnet-Vernhet, Jean-Christophe Lega, François-Xavier Mahon, Gabriel Etienne, Franck Emmanuel Nicolini,

Haematologica (Haematologica)
[2016, 101(3):e86-90]

Cited: 5 times

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Unexplained thrombocytosis: association of Baltimore polymorphism with germline MPL nonsense mutation.

Emmanuelle Verger, France Teillet, Carole Conejero, Gil Letort, Christine Chomienne, Stephane Giraudier, Bruno Cassinat,

Br. J. Haematol. (British journal of haematology)
[2016, 175(1):167-169]

Cited: 1 time

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Clinical and molecular response to interferon-α therapy in essential thrombocythemia patients with CALR mutations.

Emmanuelle Verger, Bruno Cassinat, Aurélie Chauveau, Christine Dosquet, Stephane Giraudier, Marie-Hélène Schlageter, Jean-Christophe Ianotto, Mohammed A Yassin, Nader Al-Dewik, Serge Carillo, Eric Legouffe, Valerie Ugo, Christine Chomienne, Jean-Jacques Kiladjian,

Myeloproliferative neoplasms are clonal disorders characterized by the presence of several gene mutations associated with particular hematologic parameters, clinical evolution, and prognosis. Few therapeutic options are available, among which interferon α (IFNα) presents interesting properties like the ability to induce hematologic responses (HRs) and molecular responses (MRs) in patients with ... Read more >>

Blood (Blood)
[2015, 126(24):2585-2591]

Cited: 36 times

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Utility of labile plasma iron and transferrin saturation in addition to serum ferritin as iron overload markers in different underlying anemias before and after deferasirox treatment.

John B Porter, Mohsen El-Alfy, Vip Viprakasit, Stephane Giraudier, Lee Lee Chan, Yongrong Lai, Ali El-Ali, Jackie Han, Maria D Cappellini,

Plasma markers in addition to serum ferritin (SF) may be useful for the assessment of iron overload; however, predictive utility may differ depending on underlying, transfusion-dependent, anemias.Data were collected before and after 1 year of deferasirox treatment (end of study; EOS) from the large, 1-year EPIC (Evaluation of Patients' Iron ... Read more >>

Eur. J. Haematol. (European journal of haematology)
[2016, 96(1):19-26]

Cited: 9 times

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Nilotinib and peginterferon alfa-2a for newly diagnosed chronic-phase chronic myeloid leukaemia (NiloPeg): a multicentre, non-randomised, open-label phase 2 study.

Franck E Nicolini, Gabriel Etienne, Viviane Dubruille, Lydia Roy, Françoise Huguet, Laurence Legros, Stéphane Giraudier, Valérie Coiteux, Agnès Guerci-Bresler, Pascal Lenain, Pascale Cony-Makhoul, Martine Gardembas, Eric Hermet, Philippe Rousselot, Shanti Amé, Marie-Claude Gagnieu, Christine Pivot, Sandrine Hayette, Veronique Maguer-Satta, Madeleine Etienne, Stéphanie Dulucq, Delphine Rea, François-Xavier Mahon,

Nilotinib is now recommended for patients with newly diagnosed chronic myeloid leukaemia in chronic phase and leads to important rates of molecular response 4·5 log (MR(4·5)), allowing the prospect of therapy cessation. However, most patients do not reach this criterion and nilotinib is taken for lengthy periods, resulting in chronic ... Read more >>

Lancet Haematol (The Lancet. Haematology)
[2015, 2(1):e37-46]

Cited: 11 times

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A late onset sickle cell disease reveals a mosaic segmental uniparental isodisomy of chromosome 11p15.

Isabelle Vinatier, Xavier Martin, Jean-Marc Costa, Anne Bazin, Stéphane Giraudier, Philippe Joly,

We report, in a 78-year old man constitutionally heterozygous for the sickle cell trait, a late onset sickle cell disease (SCD) caused by a mosaic segmental uniparental isodisomy of chromosome 11p15. The mosaic loss of heterozygosity (LOH) of the HBB gene was suggested in front of an unusually weak β(A) ... Read more >>

Blood Cells Mol. Dis. (Blood cells, molecules & diseases)
[2015, 54(1):53-55]

Cited: 2 times

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