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Impact of Diabetes Mellitus in Women Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents.

Usman Baber, Giulio G Stefanini, Gennaro Giustino, Gregg W Stone, Martin B Leon, Samantha Sartori, Melissa Aquino, P Gabriel Steg, Stephan Windecker, William Wijns, Patrick W Serruys, Marco Valgimigli, Marie-Claude Morice, Edoardo Camenzind, Giora Weisz, Pieter C Smits, David E Kandzari, Clemens von Birgelen, George D Dangas, Soren Galatius, Raban V Jeger, Takeshi Kimura, Ghada W Mikhail, Dipti Itchhaporia, Laxmi Mehta, Rebecca Ortega, Hyo-Soo Kim, Adnan Kastrati, Alaide Chieffo, Roxana Mehran,

BACKGROUND:Data examining the impact of diabetes mellitus (DM) on ischemic risk after percutaneous coronary intervention in women are limited as most clinical trial participants are male. We evaluated (1) the impact of DM on ischemic outcomes in women undergoing drug-eluting stent (DES) implantation and (2) whether the outcomes of new- ... Read more >>

Circ Cardiovasc Interv (Circulation. Cardiovascular interventions)
[2019, 12(7):e007734]

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Non-Linear Relationship between Anti-Apolipoprotein A-1 IgGs and Cardiovascular Outcomes in Patients with Acute Coronary Syndromes.

Nicolas Vuilleumier, Sabrina Pagano, Christophe Combescure, Baris Gencer, Julien Virzi, Lorenz Räber, David Carballo, Sebastian Carballo, David Nanchen, Nicolas Rodondi, Stephan Windecker, Stanley L Hazen, Zeneng Wang, Xinmin S Li, Arnold von Eckardstein, Christian M Matter, Thomas F Lüscher, Roland Klingenberg, Francois Mach,

Autoantibodies against apolipoprotein A-I (anti-apoA-I IgGs) are prevalent in atherosclerosis-related conditions. It remains elusive whether they improve the prognostic accuracy of the Global Registry of Acute Coronary Events (GRACE) score 2.0 (GS) in acute coronary syndromes (ACS). In this prospective multicenter registry, 1713 ACS patients were included and followed for ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(7):]

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The hospital results and 1-year outcomes of transcatheter aortic valve-in-valve procedures and transcatheter aortic valve implantations in the native valves: the results from the Swiss-TAVI Registry.

Enrico Ferrari, Stefan Stortecky, Dik Heg, Olivier Muller, Fabian Nietlispach, David Tueller, Stefan Toggweiler, Stéphane Noble, Francesco Maisano, Marco Roffi, Raban Jeger, Jürg Grünenfelder, Christoph Huber, Stephan Windecker, Peter Wenaweser,

OBJECTIVES:The SwissTAVI Registry includes all consecutive patients undergoing transcatheter aortic valve implantation (TAVI) and valve-in-valve (VinV) procedures for a failed bioprosthesis in Switzerland. We report the real world, all-comers, 30-day and 1-year outcomes of patients undergoing VinV and standard TAVI procedures. METHODS:Prospectively collected data from the 2 groups (VinV and ... Read more >>

Eur J Cardiothorac Surg (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery)
[2019, 56(1):55-63]

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Incidence, predictors, and relevance of acute kidney injury in patients undergoing left atrial appendage closure with Amplatzer occluders: a multicentre observational study.

Alexander Sedaghat, Vivian Vij, Samuel R Streit, Jan Wilko Schrickel, Baravan Al-Kassou, Dominik Nelles, Caroline Kleinecke, Stephan Windecker, Bernhard Meier, Marco Valglimigli, Fabian Nietlispach, Georg Nickenig, Steffen Gloekler,

AIMS:Acute kidney injury (AKI) remains a frequent complication after cardiac interventions, such as left atrial appendage closure (LAAC), yet limited data are available on the incidence and clinical implication of AKI in this setting. We sought to assess incidence, predictors and relevance of AKI after LAAC. METHODS AND RESULTS:We retrospectively ... Read more >>

Clin Res Cardiol (Clinical research in cardiology : official journal of the German Cardiac Society)
[2019, :]

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Temporal trends in adoption and outcomes of transcatheter aortic valve implantation: a SwissTAVI Registry analysis.

Stefan Stortecky, Anna Franzone, Dik Heg, David Tueller, Stephane Noble, Thomas Pilgrim, Raban Jeger, Stefan Toggweiler, Enrico Ferrari, Fabian Nietlispach, Maurizio Taramasso, Francesco Maisano, Jürg Grünenfelder, Olivier Muller, Christoph Huber, Marco Roffi, Thierry Carrel, Peter Wenaweser, Stephan Windecker,

AIMS:To describe temporal trends in adoption and performance of transcatheter aortic valve implantation (TAVI) in Switzerland over a period of 5 years. METHODS AND RESULTS:Between 2011 and 2015, a total of 3493 patients were consecutively included in the SwissTAVI Registry (NCT01368250) and analysed for the purpose of this study. The primary ... Read more >>

Eur Heart J Qual Care Clin Outcomes (European heart journal. Quality of care & clinical outcomes)
[2019, 5(3):242-251]

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PASCAL: A New Addition to the Armamentarium of Transcatheter Repair Systems for Mitral Leaflet Approximation.

Fabien Praz, Stephan Windecker, Samir Kapadia,

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2019, 12(14):1379-1381]

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Validation of the updated Logistic Clinical SYNTAX score for all-cause mortality in GLOBAL LEADERS trial.

Ply Chichareon, Yoshinobu Onuma, David van Klaveren, Rodrigo Modolo, Norihiro Kogame, Kuniaki Takahashi, Chun Chin Chang, Mariusz Tomaniak, Taku Asano, Yuki Katagiri, Robert-Jan M van Geuns, Leonardo Bolognese, Carlo Tumscitz, Mathias Vrolix, Ivo Petrov, Scot Garg, Christoph Kurt Naber, Manel Sabaté, Javaid Iqbal, Joanna J Wykrzykowska, Jan J Piek, Ernest Spitzer, Peter Jüni, Christian Hamm, Philippe Gabriel Steg, Marco Valgimigli, Pascal Vranckx, Stephan Windecker, Patrick W Serruys,

To externally validate the updated logistic clinical SYNTAX score for 2-year all-cause mortality after PCI in the GLOBAL LEADERS trial. The GLOBAL LEADERS trial was an investigator-initiated, prospective randomized, multi-center, open-label trial comparing two strategies of antiplatelet therapy in 15,991 patients undergoing PCI. As a predefined analysis, we studied the ... Read more >>

EuroIntervention (EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology)
[2019, :]

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Impact of sex on comparative outcomes of bivalirudin versus unfractionated heparin in patients with acute coronary syndromes undergoing invasive management: a pre-specified analysis of the MATRIX trial.

Giuseppe Gargiulo, Bruno R da Costa, Enrico Frigoli, Cataldo Palmieri, Marco Stefano Nazzaro, Camillo Falcone, Armando Liso, Carlo Vigna, Fabio Abate, Marco Comeglio, Roberto Diletti, Gabriele Gabrielli, Emilio Di Lorenzo, Pietro Mazzarotto, Marco Zimarino, Claudio Moretti, Antonio Colombo, Carlo Penzo, Giampaolo Pasquetto, Salvatore Brugaletta, Fabio Ferrari, Gavino Casu, Vincenzo Guiducci, Antonio Dellavalle, Francesco Liistro, Ciro Mauro, Arnoud W J Van't Hof, Elmir Omerovic, Salvatore Curello, Jose Maria de la Torre Hernandez, Stefano De Servi, Flavia Belloni, Stephan Windecker, Marco Valgimigli,

AIMS:Our aim was to assess whether bivalirudin compared with unfractionated heparin (UFH) is associated with consistent outcomes in males and females with acute coronary syndrome (ACS) undergoing invasive management. METHODS AND RESULTS:In the MATRIX programme, 7,213 patients were randomised to bivalirudin or UFH. Patients in the bivalirudin group were subsequently ... Read more >>

EuroIntervention (EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology)
[2019, 15(3):e269-e278]

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Five-year clinical outcomes and intracoronary imaging findings of the COMFORTABLE AMI trial: randomized comparison of biodegradable polymer-based biolimus-eluting stents with bare-metal stents in patients with acute ST-segment elevation myocardial infarction.

Lorenz Räber, Kyohei Yamaji, Henning Kelbæk, Thomas Engstrøm, Andreas Baumbach, Marco Roffi, Clemens von Birgelen, Masanori Taniwaki, Aris Moschovitis, Serge Zaugg, Miodrag Ostojic, Giovanni Pedrazzini, Dimitrios-Alexios Karagiannis-Voules, Thomas F Lüscher, Ran Kornowski, David Tüller, Vladan Vukcevic, Dik Heg, Stephan Windecker,

AIMS:The long-term outcomes of biolimus-eluting stents (BESs) with biodegradable polymer as compared with bare-metal stent (BMS) in patients with ST-segment elevation myocardial infarction (STEMI) remain unknown. METHODS AND RESULTS:We performed a 5-year clinical follow-up of 1157 patients (BES: N = 575 and BMS: N = 582) included in the randomized COMFORTABLE AMI trial. Serial ... Read more >>

Eur. Heart J. (European heart journal)
[2019, 40(24):1909-1919]

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Time-Dependent Myocardial Necrosis in Patients With ST-Segment-Elevation Myocardial Infarction Without Angiographic Collateral Flow Visualized by Cardiac Magnetic Resonance Imaging: Results From the Multicenter STEMI-SCAR Project.

Simon Greulich, Agnes Mayr, Steffen Gloekler, Andreas Seitz, Stefan Birkmeier, Tim Schäufele, Raffi Bekeredjian, Christine S Zuern, Peter Seizer, Tobias Geisler, Karin A L Müller, Patrick Krumm, Konstantin Nikolaou, Gert Klug, Sebastian Reinstadler, Mathias Pamminger, Martin Reindl, Andreas Wahl, Tobias Traupe, Christian Seiler, Bernhard Metzler, Meinrad Gawaz, Stephan Windecker, Heiko Mahrholdt,

Background Acute complete occlusion of a coronary artery results in progressive ischemia, moving from the endocardium to the epicardium (ie, wavefront). Dependent on time to reperfusion and collateral flow, myocardial infarction ( MI ) will manifest, with transmural MI portending poor prognosis. Late gadolinium enhancement cardiac magnetic resonance imaging can ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2019, 8(12):e012429]

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Biodegradable vs. permanent polymer drug-eluting stents: the need for a new nomenclature to classify drug-eluting stent technology.

Jonas Dominik Häner, Lorenz Räber, Stephan Windecker,

Eur. Heart J. (European heart journal)
[2019, :]

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Prognostic value of total testosterone levels in patients with acute coronary syndromes.

Baris Gencer, Nicolas Vuilleumier, David Nanchen, Tinh-Hai Collet, Roland Klingenberg, Lorenz Räber, Reto Auer, David Carballo, Sebastian Carballo, Soheila Aghlmandi, Dik Heg, Stephan Windecker, Thomas F Lüscher, Christian M Matter, Nicolas Rodondi, François Mach,

BACKGROUND:Endogenous testosterone levels decrease in men with aging. Controversies persist regarding the screening and treatment of low testosterone levels in patients with acute coronary syndromes (ACS). METHODS AND RESULTS:Total serum testosterone levels were measured in 1054 men hospitalized for ACS that were part of a Swiss prospective cohort. Total testosterone ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2019, :2047487319853343]

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Utility of Multimodality Intravascular Imaging and the Local Hemodynamic Forces to Predict Atherosclerotic Disease Progression.

Christos V Bourantas, Lorenz Räber, Antonis Sakellarios, Yashusi Ueki, Thomas Zanchin, Konstantinos C Koskinas, Kyohei Yamaji, Masanori Taniwaki, Dik Heg, Maria D Radu, Michail I Papafaklis, Fanis Kalatzis, Katerina K Naka, Dimitrios I Fotiadis, Anthony Mathur, Patrick W Serruys, Lampros K Michalis, Hector M Garcia-Garcia, Alexios Karagiannis, Stephan Windecker,

OBJECTIVES:This study sought to examine the utility of multimodality intravascular imaging and of the endothelial shear stress (ESS) distribution to predict atherosclerotic evolution. BACKGROUND:There is robust evidence that intravascular ultrasound (IVUS)-derived plaque characteristics and ESS distribution can predict, with however limited accuracy, atherosclerotic evolution; nevertheless, it is yet unclear whether ... Read more >>

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2019, :]

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TAVR for the Treatment of Degenerated Aortic Bioprostheses: Aiming at a Moving Target.

Stephan Windecker, Faisal Khan, Thomas Pilgrim,

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2019, 73(21):2656-2659]

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Dyspnoea in the GLOBAL LEADERS trial - Authors' reply.

Peter Jüni, Pascal Vranckx, Marco Valgimgli, Patrick Serruys, Stephan Windecker, ,

Lancet (Lancet (London, England))
[2019, 393(10189):2393-2394]

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Diagnosis and Management of Anomalous Coronary Arteries with a Malignant Course.

Christoph Gräni, Philipp A Kaufmann, Stephan Windecker, Ronny R Buechel,

Although the prevalence of anomalous coronary artery from the opposite sinus (ACAOS) in the general population is low, more frequent use of invasive and non-invasive imaging to rule out coronary artery disease has seen an increase in absolute numbers of ACAOS. ACAOS are traditionally classified as malignant (with an interarterial ... Read more >>

Interv Cardiol (Interventional cardiology (London, England))
[2019, 14(2):83-88]

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Edge-to-Edge Mitral Valve Repair With Extended Clip Arms: Early Experience From a Multicenter Observational Study.

Fabien Praz, Daniel Braun, Matthias Unterhuber, Alessandro Spirito, Mathias Orban, Nicolas Brugger, Isabel Brinkmann, Karin Spring, Aris Moschovitis, Michael Nabauer, Stephan Blazek, Thomas Pilgrim, Holger Thiele, Philipp Lurz, Jörg Hausleiter, Stephan Windecker,

OBJECTIVES:The aim of this study was to investigate the technical success and efficacy of mitral valve edge-to-edge repair using extended clip arms. BACKGROUND:A new iteration of the MitraClip system, the MitraClip XTR, was introduced in 2018 with the aim of addressing technical limitations observed with previous versions. METHODS:Patients having received ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2019, 12(14):1356-1365]

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Interventional cardiology's golden age of contributions to evidence-based medicine.

Stephan Windecker,

EuroIntervention (EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology)
[2019, 15(1):31-34]

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Rationale and design of the Onyx ONE global randomized trial: A randomized controlled trial of high-bleeding risk patients after stent placement with 1 month of dual antiplatelet therapy.

Elvin Kedhi, Azeem Latib, Alexandre Abizaid, David Kandzari, Ajay J Kirtane, Roxana Mehran, Matthew J Price, Daniel Simon, Stephen Worthley, Azfar Zaman, Sandeep Brar, Minglei Liu, Gregg W Stone, Stephan Windecker,

BACKGROUND AND RATIONALE:Polymer-free drug-eluting stent (DES) implantation in combination with 1-month dual antiplatelet therapy (DAPT) has shown superior safety and efficacy outcomes compared with bare-metal stents among patients with high-bleeding risk (HBR) treated with 1-month DAPT. The safety and efficacy of the newer-generation durable-polymer DES Resolute Onyx compared with polymer-free ... Read more >>

Am. Heart J. (American heart journal)
[2019, 214:134-141]

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Transcatheter Aortic Valve Replacement: Role of Multimodality Imaging in Common and Complex Clinical Scenarios.

Jeroen J Bax, Victoria Delgado, Rebecca T Hahn, Jonathon Leipsic, James K Min, Paul Grayburn, Lars Sondergaard, Sung-Han Yoon, Stephan Windecker,

Transcatheter aortic valve replacement (TAVR) is an established therapy for patients with symptomatic severe aortic stenosis. Technological advances and the learning curve have resulted in better procedural results in terms of hemodynamic valve performance and intermediate-term clinical outcomes. The integration of anatomical and functional information provided by multimodality imaging has ... Read more >>

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2019, :]

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Transcatheter aortic valve-in-valve implantation in degenerative rapid deployment bioprostheses.

Uri Landes, Danny Dvir, Wolfgang Schoels, Christopher Tron, Stephan Ensminger, Matheus Simonato, Ulrich Schäfer, Matjaz Bunc, Gabriel S Aldea, Alfredo Cerillo, Stephan Windecker, Antonio Marzocchi, Martin Andreas, Nicolas Amabile, John Webb, Ran Kornowski,

AIMS:The aim of this study was to evaluate transcatheter aortic valve-in-valve (ViV) implantation performance in rapid deployment (ViVr) vs. conventional (ViVc) surgical heart valves. METHODS AND RESULTS:A multicentre registry was developed as part of the VIVID international registry. A total of 30 ViVr patients (Perceval, n=24, ATS 3f Enable™, n=5, ... Read more >>

EuroIntervention (EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology)
[2019, 15(1):37-43]

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Transcatheter aortic valve replacement in patients with concomitant mitral stenosis.

Masahiko Asami, Stephan Windecker, Fabien Praz, Jonas Lanz, Lukas Hunziker, Martina Rothenbühler, Lorenz Räber, Eva Roost, Stefan Stortecky, Thomas Pilgrim,

AIMS:Multivalvular disease is of increasing concern in elderly patients undergoing transcatheter aortic valve replacement (TAVR). The objective of the present analysis was to investigate the impact of concomitant mitral stenosis (MS) on clinical outcomes in patients undergoing TAVR for severe, symptomatic aortic stenosis (AS). METHODS AND RESULTS:Among 1339 patients undergoing ... Read more >>

Eur. Heart J. (European heart journal)
[2019, 40(17):1342-1351]

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Drug-eluting or bare-metal stents for percutaneous coronary intervention: a systematic review and individual patient data meta-analysis of randomised clinical trials.

Raffaele Piccolo, Kaare H Bonaa, Orestis Efthimiou, Olivier Varenne, Andrea Baldo, Philip Urban, Christoph Kaiser, Wouter Remkes, Lorenz Räber, Adam de Belder, Arnoud W J van 't Hof, Goran Stankovic, Pedro A Lemos, Tom Wilsgaard, Jörg Reifart, Alfredo E Rodriguez, Expedito E Ribeiro, Patrick W J C Serruys, Alex Abizaid, Manel Sabaté, Robert A Byrne, Jose M de la Torre Hernandez, William Wijns, Peter Jüni, Stephan Windecker, Marco Valgimigli, ,

BACKGROUND:New-generation drug-eluting stents (DES) have mostly been investigated in head-to-head non-inferiority trials against early-generation DES and have typically shown similar efficacy and superior safety. How the safety profile of new-generation DES compares with that of bare-metal stents (BMS) is less clear. METHODS:We did an individual patient data meta-analysis of randomised ... Read more >>

Lancet (Lancet (London, England))
[2019, 393(10190):2503-2510]

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Biodegradable-polymer stents versus durable-polymer stents - Authors' reply.

Peter Jüni, Dik Heg, Stephan Windecker, Thomas Pilgrim,

Lancet (Lancet (London, England))
[2019, 393(10184):1933]

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Mitral regurgitation in heart failure: time for a rethink.

Fabien Praz, Carmelo Grasso, Maurizio Taramasso, Andreas Baumbach, Nicolo Piazza, Corrado Tamburino, Stephan Windecker, Francesco Maisano, Bernard Prendergast,

Eur. Heart J. (European heart journal)
[2019, :]

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