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Author Stephan F Lichtenthaler


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Chlamydia-induced curvature of the host-cell plasma membrane is required for infection.

Sebastian Hänsch, Dominik Spona, Gido Murra, Karl Köhrer, Agathe Subtil, Ana Rita Furtado, Stephan F Lichtenthaler, Bastian Dislich, Katja Mölleken, Johannes H Hegemann,

During invasion of host cells, Chlamydia pneumoniae secretes the effector protein CPn0678, which facilitates internalization of the pathogen by remodeling the target cell's plasma membrane and recruiting sorting nexin 9 (SNX9), a central multifunctional endocytic scaffold protein. We show here that the strongly amphipathic N-terminal helix of CPn0678 mediates binding ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(5):2634-2644]

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