Full Text Journal Articles by
Author Stefano Mastrangelo

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Temozolomide and oral etoposide in children with recurrent malignant brain tumors.

Antonio Ruggiero, Anna Ariano, Silvia Triarico, Michele Antonio Capozza, Alberto Romano, Palma Maurizi, Stefano Mastrangelo, Giorgio Attinà,

Despite advances in the treatment of brain tumors, the prognosis of children with recurrent malignant brain tumors remains poor. Etoposide (VP-16), an inhibitor of nuclear enzyme deoxyribonucleic acid (DNA)-topoisomerase II, has shown activity in brain tumors. Its efficacy appears schedule dependent but, to date, the most effective schedule of administration ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Assessment and Management of Platinum-Related Ototoxicity in Children Treated for Cancer.

Alberto Romano, Michele Antonio Capozza, Stefano Mastrangelo, Palma Maurizi, Silvia Triarico, Rolando Rolesi, Giorgio Attinà, Anna Rita Fetoni, Antonio Ruggiero,

Platinum compounds are a group of chemotherapeutic agents included in many pediatric and adult oncologic treatment protocols. The main platinum compounds are cisplatin, carboplatin, and oxaliplatin. Their use in clinical practice has greatly improved long-term survival of pediatric patients, but they also cause some toxic effects: ototoxicity, myelosuppression, nephrotoxicity, and ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(5):]

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Multifocal infantile haemangiomatosis with hepatic involvement: two cases and treatment management.

Antonio Ruggiero, Palma Maurizi, Silvia Triarico, Michele Antonio Capozza, Stefano Mastrangelo, Giorgio Attinà,

Infantile haemangiomas (IHs) are the most common benign tumours of childhood; despite the benign histology, prognosis depends on severity of visceral involvement, with a mortality rate ranging from 50 to 90%. In this paper, we describe two infants with multifocal infantile haemangiomatosis and hepatic involvement. This condition should receive appropriate ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Gynecological cancer among adolescents and young adults (AYA).

Silvia Triarico, Michele Antonio Capozza, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi, Antonio Ruggiero,

Adolescents and young adults (AYA) patients with cancer show specific biological, sociodemographic and behavioral features, with lower survival rates than younger group. Gynecologic malignancies that occur among AYA requires a multidisciplinary management and a tailored model of care, in order to enhance the early diagnosis, the adherence to the treatment, ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2020, 8(6):397]

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Improving the Brain Delivery of Chemotherapeutic Drugs in Childhood Brain Tumors.

Silvia Triarico, Palma Maurizi, Stefano Mastrangelo, Giorgio Attinà, Michele Antonio Capozza, Antonio Ruggiero,

The central nervous system (CNS) may be considered as a sanctuary site, protected from systemic chemotherapy by the meninges, the cerebrospinal fluid (CSF) and the blood-brain barrier (BBB). Consequently, parenchymal and CSF exposure of most antineoplastic agents following intravenous (IV) administration is lower than systemic exposure. In this review, we ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(6):]

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Intranasal therapy with opioids for children and adolescents with cancer: results from clinical studies.

Silvia Triarico, Michele Antonio Capozza, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi, Antonio Ruggiero,

Opioids are essential for the treatment of pain, which is a serious symptom for children and adolescents affected by cancer. Intranasal opioids may be very useful for the treatment of breakthrough pain in children and adolescents with cancer, for their little invasiveness, ease of administration, rapid onset of action, and ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2019, 27(10):3639-3645]

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Undifferentiated Embryonal Sarcoma of the Liver (UESL) in Adolescents: An Unexpected Diagnosis.

Michele A Capozza, Antonio Ruggiero, Palma Maurizi, Stefano Mastrangelo, Giorgio Attinà, Silvia Triarico, Maria Vellone, Felice Giuliante,

Definitive diagnosis of pediatric liver masses can be challenging, because clinical manifestations are nonspecific, and ultimate diagnosis may be delayed. We describe 2 patients with liver masses that initially were misdiagnosed and treated as infectious hepatic lesions. Only after histologic examination the correct diagnosis of undifferentiated embryonal sarcoma of the ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2019, 41(2):e132-e134]

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Correction to: Multimodal treatment of pediatric patients with Askin's tumors: our experience.

Silvia Triarico, Giorgio Attinà, Palma Maurizi, Stefano Mastrangelo, Lorenzo Nanni, Vito Briganti, Elisa Meacci, Stefano Margaritora, Mario Balducci, Antonio Ruggiero,

[This corrects the article DOI: 10.1186/S12957-018-1434-2.]. ... Read more >>

World J Surg Oncol (World journal of surgical oncology)
[2018, 16:193]

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Multimodal treatment of pediatric patients with Askin's tumors: our experience.

Silvia Triarico, Giorgio Attinà, Palma Maurizi, Stefano Mastrangelo, Lorenzo Nanni, Vito Briganti, Elisa Meacci, Stefano Margaritora, Mario Balducci, Antonio Ruggiero,

BACKGROUND:We report our experience and outcomes about the management of Askin's tumors [AT], which are rare primitive neuroectodermal tumors (PNETs) that develop within the soft tissue of the thoracopulmonary region, typically in children and adolescents. METHODS:We retrospectively analyzed the charts of 9 patients affected by AT (aged 6-15 years), treated at ... Read more >>

World J Surg Oncol (World journal of surgical oncology)
[2018, 16(1):140]

Cited: 1 time

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Diagnostic Accuracy of 18F-FDG PET/CT in the Staging and Assessment of Response to Chemotherapy in Children With Ewing Sarcoma.

Antonio Ruggiero, Valerio Lanni, Alberto Librizzi, Palma Maurizi, Giorgio Attinà, Stefano Mastrangelo, Alessandro Giordano, Riccardo Riccardi,

INTRODUCTION:The purpose of this study was to evaluate the potential role of fluorine-18 fluorodeoxyglucose (18F-FDG) positron-emission tomography/computed tomography (PET-CT) in the staging and assessment of chemotherapy response in Ewing sarcoma. MATERIALS AND METHODS:For 13 patients with Ewing sarcoma, whole-body FDG PET-CT was assessed for site of primary disease, disease extent, ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2018, 40(4):277-284]

Cited: 1 time

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Feasibility and predictive performance of the Hendrich Fall Risk Model II in a rehabilitation department: a prospective study.

Isabella Campanini, Stefano Mastrangelo, Annalisa Bargellini, Agnese Bassoli, Gabriele Bosi, Francesco Lombardi, Stefano Tolomelli, Mirco Lusuardi, Andrea Merlo,

Falls are a common adverse event in both elderly inpatients and patients admitted to rehabilitation units. The Hendrich Fall Risk Model II (HIIFRM) has been already tested in all hospital wards with high fall rates, with the exception of the rehabilitation setting. This study's aim is to address the feasibility ... Read more >>

BMC Health Serv Res (BMC health services research)
[2018, 18(1):18]

Cited: 1 time

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[OssERvare Project: direct observation of use of the Safety Surgery CheckList in the operating room.]

Roberto Bentivegna, Annita Caminati, Vanni Agnoletti, Stefano Bonilauri, Stefania Buonaccorso, Giovanna Campaniello, Antonella Dovani, Giuseppina Lanciotti, Vania Maselli, Stefano Mastrangelo, Maria Teresa Montella, Teresa Palladino, Cristiano Pelati, Lorenzo Sciolino, Evita Zoni, Elisa Porcu, Anselmo Campagna, Ottavio Nicastro,

Safety Surgery CheckList (SSCL) is a support tool for operating teams, used to carry out safety checks while also encouraging compliance with the implementation of recommended quality and safety standards. In Emilia-Romagna it was deemed appropriate to check actual surgical team compliance with correct checklist application in the operating theatre, ... Read more >>

Recenti Prog Med (Recenti progressi in medicina)
[2017, 108(11):476-480]

Cited: 1 time

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[A pilot study on pain assessment among elderly with severe dementia
in residential aged care facilities of Reggio Emilia district].

Annalisa Bargellini, Stefano Mastrangelo, Monica Cervi, Michele Bagnasco, Jlenia Reghizzi, Sandra Coriani,

. A pilot study on pain assessment among elderly with severe dementia in residential aged care facilities of Reggio Emilia district.Despite the availability of pain assessment tools and best practice recommendations for the assessment and management of pain in people with severe dementia, pain in residential aged care facilities is ... Read more >>

Assist Inferm Ric (Assistenza infermieristica e ricerca : AIR)
[2017, 36(2):84-89]

Cited: 0 times

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Rechallenge to Carboplatin in Children with Low Grade Glioma and Carboplatin Hypersensitivity Reactions.

Antonio Ruggiero, Daniela Rizzo, Martina Catalano, Palma Maurizi, Stefano Mastrangelo, Giorgio Attinà, Riccardo Riccardi,

Background: Carboplatin based regimens have demonstrated activity in pediatric patients with low grade gliomas (LGG). However, carboplatin hypersensitivity reactions (CHRs) may be a major problem leading to premature cessation of an effective therapy. The objectives of this study were to describe the prevalence, characteristics and management of CHR. Methods: We ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2017, 8:179]

Cited: 0 times

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Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: case report and systematic review of literature.

Maria Scalzone, Antonio Ruggiero, Stefano Mastrangelo, Giovanna Trombatore, Vita Ridola, Palma Maurizi, Riccardo Riccardi,

Hemophagocytic lymphohistiocytosis is a potentially fatal disorder resulting from excessive activation and non-malignant proliferation of T lymphocytes and macrophages. Neoplasms, autoimmune disorders and systemic infections can cause secondary hemophagocytic syndrome. The association of hemophagocytic syndrome and visceral leishmaniasis is rarely found in childhood. We report a case of an infant ... Read more >>

J Infect Dev Ctries (Journal of infection in developing countries)
[2016, 10(1):103-108]

Cited: 2 times

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The D173G mutation in ADAMTS-13 causes a severe form of congenital thrombotic thrombocytopenic purpura. A clinical, biochemical and in silico study.

Stefano Lancellotti, Flora Peyvandi, Maria Teresa Pagliari, Andrea Cairo, Safwat Abdel-Azeim, Edrisse Chermak, Ilaria Lazzareschi, Stefano Mastrangelo, Luigi Cavallo, Romina Oliva, Raimondo De Cristofaro,

Congenital thrombotic thrombocytopenic purpura (TTP) is a rare form of thrombotic microangiopathy, inherited with autosomal recessive mode as a dysfunction or severe deficiency of ADAMTS-13 (A Disintegrin And Metalloprotease with ThromboSpondin 1 repeats Nr. 13), caused by mutations in the ADAMTS-13 gene. About 100 mutations of the ADAMTS-13 gene were ... Read more >>

Thromb. Haemost. (Thrombosis and haemostasis)
[2016, 115(1):51-62]

Cited: 1 time

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Temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: a broken promise?

Daniela Rizzo, Maria Scalzone, Antonio Ruggiero, Palma Maurizi, Giorgio Attinà, Stefano Mastrangelo, Ilaria Lazzareschi, Vita Ridola, Cesare Colosimo, Massimo Caldarelli, Mario Balducci, Riccardo Riccardi,

The purpose of this study was to assess the efficacy and toxicity of radiotherapy (RT) with concurrent temozolomide (TMZ) chemotherapy followed by adjuvant TMZ in children with diffuse intrinsic pontine glioma (DIPG).Patients younger than 18 years with newly diagnosed DIPG were enrolled. Children were treated with focal RT along with ... Read more >>

J Chemother (Journal of chemotherapy (Florence, Italy))
[2015, 27(2):106-110]

Cited: 7 times

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Neuroblastoma with symptomatic epidural compression in the infant: the AIEOP experience.

Bruno De Bernardi, Lucia Quaglietta, Riccardo Haupt, Aurora Castellano, Elisa Tirtei, Roberto Luksch, Stefano Mastrangelo, Elisabetta Viscardi, Paolo Indolfi, Monica Cellini, Angela Tamburini, Giovanni Erminio, Carlo Gandolfo, Stefania Sorrentino, Simona Vetrella, Anna Rita Gigliotti,

BACKGROUND: Symptoms of epidural compression (SEC) in children with neuroblastoma (particularly infants) may be misinterpreted, leading to delay in diagnosis. PATIENTS AND METHODS: Clinical, imaging and follow-up data of 34 infants with neuroblastoma and SEC diagnosed between 2000 and 2011 at Italian AIEOP centers were retrieved and reviewed. RESULTS: Median ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2014, 61(8):1369-1375]

Cited: 7 times

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Phase I study of temozolomide combined with oral etoposide in children with malignant glial tumors.

Antonio Ruggiero, Daniela Rizzo, Giorgio Attinà, Ilaria Lazzareschi, Palma Maurizi, Vita Ridola, Stefano Mastrangelo, Roberta Migliorati, Patrizia Bertolini, Cesare Colosimo, Riccardo Riccardi,

The treatment of children with malignant glioma remains challenging. The aim of this multicenter phase I study is to establish the recommended dose (RD) of the combination therapy with temozolomide (TMZ) and oral etoposide (VP-16) in children with relapsed or refractory malignant glioma and brainstem glioma at diagnosis. A phase ... Read more >>

J. Neurooncol. (Journal of neuro-oncology)
[2013, 113(3):513-518]

Cited: 4 times

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Treatment of pharyngeal non-Hodgkin lymphoma in a patient with Wiskott-Aldrich syndrome.

Paola Coccia, Stefano Mastrangelo, Antonio Ruggiero, Maria Scalzone, Angelo Rosolen, Palma Maurizi, Riccardo Riccardi,

Wiskott-Aldrich syndrome (WAS) is characterized by primary immunodeficiency, thrombocytopenia and eczema. Patients with WAS have an increased risk to develop tumors. Non-Hodgkin lymphoma (NHL) represents the most common malignancy occurring in WAS-affected patients, diffuse-large-B-cell lymphoma is the most frequently encountered variant. We describe a case of a patient with WAS ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2012, 59(2):318-319]

Cited: 6 times

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The role of diet on the clinical pharmacology of oral antineoplastic agents.

Antonio Ruggiero, Maria G Cefalo, Paola Coccia, Stefano Mastrangelo, Palma Maurizi, Riccardo Riccardi,

The number of oral anticancer agents has greatly increased in recent years. It is a well-known fact that food intake can induce significant variations in the bioavailability of these drugs. The aim of this review is to describe the interactions between diet and oral anticancer drugs in terms of the ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2012, 68(2):115-122]

Cited: 5 times

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Management of children with thrombocytopenia-absent radius syndrome: an institutional experience.

Paola Coccia, Antonio Ruggiero, Stefano Mastrangelo, Giorgio Attinà, Maria Scalzone, Mauro Pittiruti, Giuseppe Zampino, Palma Maurizi, Riccardo Riccardi,

AIM: Thrombocytopenia-absent radius (TAR) syndrome is characterised by bilateral absence of the radii in the presence of both thumbs and hypomegakaryocytic thrombocytopenia. We report our experience of three patients affected by TAR syndrome presenting with different clinical manifestations focusing on the management of these patients. METHODS AND RESULTS: We propose ... Read more >>

J Paediatr Child Health (Journal of paediatrics and child health)
[2012, 48(2):166-169]

Cited: 2 times

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Treatment of advanced neuroblastoma in children over 1 year of age: the critical role of ¹³¹I-metaiodobenzylguanidine combined with chemotherapy in a rapid induction regimen.

Stefano Mastrangelo, Vittoria Rufini, Antonio Ruggiero, Angela Di Giannatale, Riccardo Riccardi,

BACKGROUND: The prognosis of patients with advanced neuroblastoma (NB) remains poor. Major and early responses have an important bearing on treatment outcome. Iodine-131-metaiodobenzylguanidine (¹³¹I-MIBG) has the potential to deliver large doses of radiation specifically to NB cells. We evaluated the toxicity of, and response to, a novel induction regimen that ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2011, 56(7):1032-1040]

Cited: 13 times

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Phase I study of temozolomide combined with oral etoposide in children with recurrent or progressive medulloblastoma.

Antonio Ruggiero, Daniela Rizzo, Giorgio Attinà, Ilaria Lazzareschi, Stefano Mastrangelo, Palma Maurizi, Roberta Migliorati, Patrizia Bertolini, Maria Pastore, Cesare Colosimo, Riccardo Riccardi,

The prognosis of recurrent or progressive medulloblastoma (MB) is still poor. This study was designed to investigate the potential therapeutic benefit of combination therapy with temozolomide (TMZ) and oral etoposide (VP-16) in children with progressive or relapsed MB. Given the oral administration of both drugs the regimen was administered outpatient.A ... Read more >>

Eur. J. Cancer (European journal of cancer (Oxford, England : 1990))
[2010, 46(16):2943-2949]

Cited: 17 times

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Interactions between antiepileptic and chemotherapeutic drugs in children with brain tumors: is it time to change treatment?

Antonio Ruggiero, Daniela Rizzo, Stefano Mastrangelo, Domenica Battaglia, Giorgio Attinà, Riccardo Riccardi,

Epileptic seizures are a common clinical problem in children with brain tumors. The conventional antiepileptic drugs (AEDs) permit a good seizure control in most of these children. An emerging problem is the possible interactions between AEDs and chemotherapeutic drugs, because many of these drugs are metabolized by the cytochrome P450. ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2010, 54(2):193-198]

Cited: 8 times

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