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Oncologic Surveillance for Variant Histology Bladder Cancer after Radical Cystectomy.

Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G Schultz, Chiara Lonati, Agostino Mattei, R Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat, Marco Moschini,

<h4>Purpose</h4>Presently, major guidelines do not provide specific recommendations on oncologic surveillance for patients who harbor VH BCa at radical cystectomy. We aimed to create a personalized follow-up scheme that dynamically weighs OCM versus the risk of recurrence for VH BCa, and to compare it with a similar one for pUC.<h4>Methods</h4>Within ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001886]

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Three vs. Four Cycles of Neoadjuvant Chemotherapy for Localized Muscle Invasive Bladder Cancer Undergoing Radical Cystectomy: A Retrospective Multi-Institutional Analysis.

Matteo Ferro, Ottavio de Cobelli, Gennaro Musi, Giuseppe Lucarelli, Daniela Terracciano, Daniela Pacella, Tommaso Muto, Angelo Porreca, Gian Maria Busetto, Francesco Del Giudice, Francesco Soria, Paolo Gontero, Francesco Cantiello, Rocco Damiano, Fabio Crocerossa, Abdal Rahman Abu Farhan, Riccardo Autorino, Mihai Dorin Vartolomei, Matteo Muto, Michele Marchioni, Andrea Mari, Luca Scafuri, Andrea Minervini, Nicola Longo, Francesco Chiancone, Sisto Perdona, Pietro De Placido, Antonio Verde, Michele Catellani, Stefano Luzzago, Francesco Alessandro Mistretta, Pasquale Ditonno, Vincenzo Francesco Caputo, Michele Battaglia, Stefania Zamboni, Alessandro Antonelli, Francesco Greco, Giorgio Ivan Russo, Rodolfo Hurle, Nicolae Crisan, Matteo Manfredi, Francesco Porpiglia, Giuseppe Di Lorenzo, Felice Crocetto, Carlo Buonerba,

<h4>Background</h4>Three or four cycles of cisplatin-based chemotherapy is the standard neoadjuvant treatment prior to cystectomy in patients with muscle-invasive bladder cancer. Although NCCN guidelines recommend 4 cycles of cisplatin-gemcitabine, three cycles are also commonly administered in clinical practice. In this multicenter retrospective study, we assessed a large and homogenous cohort ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:651745]

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Single staff cystectomy in a low-volume center: Oncological outcomes and complications.

Philipp Baumeister, Davide Galioto, Marco Moschini, Chiara Lonati, Stefania Zamboni, Luca Afferi, Patrick Stucki, Hansjörg Danuser, Dirk Lehnick, Livio Mordasini, Agostino Mattei,

<h4>Introduction</h4>Radical cystectomy (RC) with bilateral pelvic lymph node dissection (PLND) is a complex surgical procedure, associated with substantial perioperative complications. Previous studies suggested reserving it to high-volume centers in order to improve oncological and perioperative outcomes. However, only limited data exist regarding low-volume centers with highly experienced surgeons. We aimed ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, :]

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Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy.

Chiara Lonati, Philipp Baumeister, Paola Irene Ornaghi, Ettore Di Trapani, Ottavio De Cobelli, Michael Rink, Robert Jeffrey Karnes, Cédric Poyet, Giuseppe Simone, Luca Afferi, Andrea Necchi, Alberto Briganti, Francesco Montorsi, Wojciech Krajewski, Alessandro Antonelli, Maria Angela Cerruto, Stefania Zamboni, Claudio Simeone, Livio Mordasini, Agostino Mattei, Marco Moschini, ,

<h4>Background</h4>Correct identification of variant histologies (VHs) of bladder cancer (BCa) at transurethral resection of the bladder (TURB) could drive the subsequent treatment.<h4>Objective</h4>To evaluate the concordance in detecting VHs between TURB and radical cystectomy (RC) specimens in BCa patients.<h4>Design, setting, and participants</h4>We retrospectively analyzed 1881 BCa patients who underwent TURB and ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Changes in body composition and lipid profile in prostate cancer patients without bone metastases given Degarelix treatment: the BLADE prospective cohort study.

Carlotta Palumbo, Alessandro Antonelli, Luca Triggiani, Alberto Dalla Volta, Filippo Maffezzoni, Stefania Zamboni, Paolo Borghetti, Luca Rinaudo, Francesca Valcamonico, Roberto Maroldi, Stefano Maria Magrini, Claudio Simeone, Alfredo Berruti, ,

<h4>Background</h4>Luteinizing hormone-releasing hormone (LHRH)-agonists in prostate cancer (PCa) patients induce sarcopenic obesity. The effect of LHRH-antagonist on body composition has never been explored. We evaluated changes in fat (FBM) and lean body mass (LBM) in PCa patients undergoing Degarelix.<h4>Methods</h4>This is a single-center prospective study, enrolling 29 non-metastatic PCa patients eligible ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

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Assessment of the oncological outcomes of three different bacillus Calmette-Guérin strains in patients with high-grade T1 non-muscle-invasive bladder cancer.

Łukasz Nowak, Wojciech Krajewski, Marco Moschini, Joanna Chorbińska, Sławomir Poletajew, Andrzej Tukiendorf, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Rossella Orlando, Ettore Di Trapani, Mario Alvarez-Maestro, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Radosław Piszczek, Evanguelos Xylinas, Romuald Zdrojowy, ,

<h4>Objective</h4>: To determine whether there are significant differences in oncological outcomes between three different bacillus Calmette-Guérin (BCG) strains used for adjuvant intravesical immunotherapy in patients with high-grade T1 (T1HG) non-muscle-invasive bladder cancer (NMIBC).<h4>Patients and methods</h4>: Data of 590 patients with a diagnosis of primary T1HG NMIBC were retrospectively reviewed. The ... Read more >>

Arab J Urol (Arab journal of urology)
[2021, 19(1):78-85]

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Immediate Shockwave Lithotripsy vs Delayed Shockwave Lithotripsy After Urgent Ureteral Stenting in Patients with Ureteral or Pyeloureteral Urolithiasis: A Matched-Pair Analysis.

Julian Cornelius, Dominique Zumbühl, Luca Afferi, Livio Mordasini, Carlo Di Bona, Stefania Zamboni, Marco Moschini, Edoardo Pozzi, Andrea Salonia, Agostino Mattei, Hansjörg Danuser, Philipp Baumeister,

<b><i>Introduction:</i></b> The most common cause of acute renal colic is a ureteral obstruction caused by ureterolithiasis. Urgent intervention is often necessary due to intractable pain. Early extracorporeal shockwave lithotripsy (SWL) as an alternative treatment option to ureteral stenting becomes forgotten in times of rising ureterorenoscopy. However, definitive guidelines are lacking, ... Read more >>

J Endourol (Journal of endourology)
[2021, 35(5):721-727]

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A thigh urinary fistula following radical prostatectomy and external beam radiation therapy for prostate cancer: a case report.

Stefania Zamboni, Chiara Lonati, Giuseppe Mirabella, Maria Furlan, Barbara Frittoli, Claudio Simeone,

Urinary fistula is a rare but severe complication which could occur after radiation therapy for prostate cancer (PCa). We describe the case of an inner thigh urinary fistula in a patient treated with radical prostatectomy and adjuvant radiation therapy for PCa. A 76-year-old man presented to the emergency room complaining ... Read more >>

Urol Case Rep (Urology case reports)
[2021, 36:101558]

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Delaying BCG immunotherapy onset after transurethral resection of non-muscle-invasive bladder cancer is associated with adverse survival outcomes.

Wojciech Krajewski, Marco Moschini, Joanna Chorbińska, Łukasz Nowak, Sławomir Poletajew, Andrzej Tukiendorf, Luca Afferi, Jeremy Yuen-Chun Teoh, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Francesco Cianflone, Andrea Mari, Ettore Di Trapani, Kees Hendricksen, Mario Alvarez-Maestro, Andrea Rodríguez-Serrano, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Guillaume Ploussard, Ekaterina Laukhtina, Karl Tully, Anna Kołodziej, Joanna Krajewska, Radosław Piszczek, Evanguelos Xylinas, Romuald Zdrojowy, ,

<h4>Purpose</h4>This study was carried out to assess whether a prolonged time between primary transurethral resection of non-muscle-invasive bladder cancer (TURB) and implementation of bacillus Calmette-Guerin (BCG) immunotherapy (time to BCG; TTBCG) is associated with adverse oncological survival in patients with T1 high-grade (HG) non-muscle-invasive bladder cancer (NMIBC).<h4>Materials and methods</h4>Data on 429 ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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Precision medicine in localized bladder cancer: Personalizing therapies to improve outcomes.

Roberto Carando, Giuseppe Mario Ludovico, Michele Zazzara, Stefania Zamboni, Luca Afferi, Claudio Simeone, Wojciech Krajewski, Marco Moschini,

In the last decades, only few improvements have been made in the comprehension of bladder cancer tumor leading to few improvements in the development of new diagnostic and therapeutic approaches.However, in the last years several step forwards in the field of precision medicine have been made. In this review we ... Read more >>

Arch Esp Urol (Archivos espanoles de urologia)
[2020, 73(10):1016-1022]

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Restaging Transurethral Resection of Bladder Tumours after BCG Immunotherapy Induction in Patients with T1 Non-Muscle-Invasive Bladder Cancer Might not Be Associated with Oncologic Benefit.

Wojciech Krajewski, Marco Moschini, Łukasz Nowak, Sławomir Poletajew, Andrzej Tukiendorf, Luca Afferi, Jeremy Teoh, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Alessandra Gozzo, Andrea Mari, Ettore Di Trapani, Kees Hendricksen, Mario Alvarez-Maestro, Andrea Rodriguez Serrano, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Guillaume Ploussard, Paweł Rajwa, Ekaterina Laukhtina, Aleksandra Zdrojowy-Wełna, Anna Kołodziej, Andrzej Paradysz, Karl Tully, Joanna Krajewska, Radosław Piszczek, Evanguelos Xylinas, Romuald Zdrojowy,

<h4>Background and purpose</h4>The European Association of Urology guidelines recommend restaging transurethral resection of bladder tumours (reTURB) 2-6 weeks after primary TURB. However, in clinical practice some patients undergo a second TURB procedure after Bacillus Calmette-Guérin immunotherapy (BCG)induction. To date, there are no studies comparing post-BCG reTURB with the classic pre-BCG ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(10):]

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Prediction of the Need for an Extended Lymphadenectomy at the Time of Radical Cystectomy in Patients with Bladder Cancer.

Marco Moschini, Luca Afferi, Giorgio Gandaglia, David D'Andrea, Stefania Zamboni, Carlo Di Bona, Livio Mordasini, Agostino Mattei, Philipp Baumeister, Alberto Martini, Giusy Burgio, Shahrokh F Shariat, Rafael Sanchez-Salas, Xavier Cathelineau, Armando Stabile, Emanuele Zaffuto, Andrea Salonia, Renzo Colombo, Andrea Necchi, Francesco Montorsi, Alberto Briganti, Andrea Gallina,

<h4>Background</h4>A prospective randomized trial (LEA AUO AB 25/02) found no survival benefit in extended compared with limited pelvic lymph node dissection (PLND) templates in bladder cancer (BCa) patients treated with radical cystectomy (RC). However, the rate of lymph node invasion (LNI) in the standard and extended templates was lower than ... Read more >>

Eur Urol Focus (European urology focus)
[2020, :]

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Is androgen deprivation therapy protective against SARS-CoV-2 infection and related complications in prostate cancer patients?

Alberto Dalla Volta, Francesca Valcamonico, Stefania Zamboni, Vittorio D Ferrari, Salvatore Grisanti, Claudio Simeone, Alfredo Berruti,

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2020, 72(6):778-779]

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Comparing oncological outcomes of laparoscopic vs open radical nephroureterectomy for the treatment of upper tract urothelial carcinoma: A propensity score-matched analysis.

Marco Moschini, Stefania Zamboni, Luca Afferi, Benjamin Pradere, Mohammad Abufaraj, Francesco Soria, David D'Andrea, Morgan Roupret, Alexandre De la Taille, Claudio Simeone, Agostino Mattei, Romain Mathieu, Karim Bensalah, Manfred Peter Wirth, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Giuseppe Simone, Michele Gallucci, Carlo Di Bona, Giancarlo Marra, Andrea Mari, Ettore Di Trapani, Mario Alvarez Maestro, Wojciech Krajewski, Shahrokh F Shariat, Evanguelos Xylinas, Philipp Baumeister,

<h4>Objectives</h4>To compare oncological outcomes of open (ORNU) and laparoscopic radical nephroureterectomy (LRNU) after controlling for preoperative patient-derived factors.<h4>Patients and methods</h4>We evaluated a multi-institutional collaborative database composed of 3984 patients diagnosed with upper tract urothelial carcinoma (UTUC) treated with RNU between 2006 and 2018. To adjust for potential selection bias, propensity ... Read more >>

Arab J Urol (Arab journal of urology)
[2020, 19(1):31-36]

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Adjuvant chemotherapy is ineffective in patients with bladder cancer and variant histology treated with radical cystectomy with curative intent.

Stefania Zamboni, Luca Afferi, Francesco Soria, Atiqullah Aziz, Mohammad Abufaraj, Cedric Poyet, Andrea Necchi, David D'Andrea, Giuseppe Simone, Mariaconsiglia Ferriero, Ettore Di Trapani, Claudio Simeone, Alessandro Antonelli, Andrea Gallina, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Giorgio Gandaglia, Agostino Mattei, Philipp Baumeister, Livio Mordasini, Kees Hendricksen, Charlotte S Voskuilen, Michael Rink, Shahrokh F Shariat, Evanguelous Xylinas, Marco Moschini,

<h4>Objectives</h4>Adjuvant chemotherapy (ACT) is recommended for non-organ-confined bladder cancer (BCa) after radical cystectomy (RC) and pelvic lymph node dissection (PLND), but there are sparse data regarding its specific efficacy in patients with histological variants. The aim of our study was to evaluate the role of ACT on survival outcomes in ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration.

Luca Afferi, Stefania Zamboni, R Jeffrey Karnes, Florian Roghmann, Paul Sargos, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Agostino Mattei, Gerald Bastian Schulz, Kees Hendricksen, Charlotte S Voskuilen, Michael Rink, Cedric Poyet, Ottavio De Cobelli, Ettore di Trapani, Claudio Simeone, Matteo Soligo, Giuseppe Simone, Gabriele Tuderti, Mario Alvarez-Maestro, Luis Martínez-Piñeiro, Atiqullah Aziz, Shahrokh F Shariat, Mohammad Abufaraj, Evanguelos Xylinas, Marco Moschini, ,

<h4>Purpose</h4>To assess the impact of perioperative chemotherapy on survival in cN+ BCa patients and analyze it according to the pN status.<h4>Methods</h4>A retrospective analysis was conducted on 639 BCa patients with cTanyN1-3M0 BCa treated with radical cystectomy (RC) and bilateral lymph node dissection (LND) with or without perioperative chemotherapy in ten tertiary referral ... Read more >>

World J Urol (World journal of urology)
[2021, 39(2):443-451]

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Trends in risk-group distribution and Pentafecta outcomes in patients treated with nerve-sparing, robot-assisted radical prostatectomy: a 10-year low-intermediate volume single-center experience.

Luca Afferi, Marco Moschini, Philipp Baumeister, Stefania Zamboni, Julian Cornelius, Gallus Ineichen, Agostino Mattei, Livio Mordasini,

<h4>Purpose</h4>To evaluate the trends in risk-group distribution and Pentafecta outcomes in patients treated with nerve-sparing (NS), robot-assisted radical prostatectomy (RARP) in a single low-intermediate volume prostate cancer (PCa) center over a 10-year period.<h4>Materials and methods</h4>We queried a prospectively maintained database for patients who underwent NS RARP between 2009 and 2018 ... Read more >>

World J Urol (World journal of urology)
[2021, 39(2):389-397]

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Multiparametric magnetic resonance imaging ultrasound-guided fusion biopsy during active surveillance: A single-centre study.

Kilian Röthlin, Stefania Zamboni, Marco Moschini, Patrick Stucki, Luca Afferi, Philipp Baumeister, Agostino Mattei,

<h4>Objective</h4>To analyse the role of multiparametric magnetic resonance imaging (mpMRI) ultrasound (US)-guided fusion biopsy (FB) in patients with low-risk prostate cancer (PCa) under active surveillance (AS).<h4>Patients and methods</h4>Our retrospective study included 47 patients under AS who consecutively underwent both FB and standard biopsy (SB), from May 2015 until November 2017. ... Read more >>

Arab J Urol (Arab journal of urology)
[2020, 18(3):142-147]

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Renal Function Impairment Below Safety Limits Correlates With Cancer-specific Mortality in Localized Renal Cell Carcinoma: Results From a Single-center Study.

Alessandro Antonelli, Carlotta Palumbo, Marco Sandri, Alessandro Veccia, Maria Furlan, Stefania Zamboni, Simone Francavilla, Tiziano Zanotelli, Alberto Cozzoli, Claudio Simeone,

BACKGROUND:A recent multi-center study showed how estimated glomerular filtration rate (eGFR) and cancer-specific mortality (CSM) are linearly and inversely related in organ-confined renal cell carcinoma (RCC) whenever the eGFR decreases below specific thresholds. We addressed our previous work limitations related to heterogeneity and missing data, and explored the relationship between ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2020, 18(4):e360-e367]

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Role of cultural analysis in patients with indwelling ureteral stent submitted to ureteroscopy for stones.

Francesca Carobbio, Stefania Zamboni, Luca Cristinelli, Damiano D'''''Aietti, Marco Lattarulo, Julian Daja, Evelyn van Hauwermeiren, Alessandra Moroni, Alessandro Antonelli, Claudio Simeone,

<h4>Background</h4>Aim of our study is to analyze the incidence of postoperative infectious complications and to assess its predictors in patients with indwelling ureteral stent treated with ureteroscopy (URS).<h4>Methods</h4>We retrospectively evaluated data of patients treated with URS from January 2017 to July 2018 at our center. We included 88 consecutive patients ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2020, 72(6):755-762]

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How to improve patient selection for neoadjuvant chemotherapy in bladder cancer patients candidate for radical cystectomy and pelvic lymph node dissection.

Stefania Zamboni, Marco Moschini, Alessandro Antonelli, Claudio Simeone, Sandra Belotti, Luca Cristinelli, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Andrea Salonia, Renzo Colombo, Livio Mordasini, Agostino Mattei, Philipp Baumeister,

<h4>Purpose</h4>To improve patient selection for neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) in bladder cancer patients (BCa).<h4>Methods</h4>Retrospective evaluation of 1057 patients with cT2-4N0M0 BCa treated with RC and pelvic lymph node dissection between 1990 and 2018 at 3 referral centers. Adverse pathologic features (APF) were defined as pT3-pT4/pN + disease at RC. ... Read more >>

World J Urol (World journal of urology)
[2020, 38(5):1229-1233]

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The Key Combined Value of Multiparametric Magnetic Resonance Imaging, and Magnetic Resonance Imaging-targeted and Concomitant Systematic Biopsies for the Prediction of Adverse Pathological Features in Prostate Cancer Patients Undergoing Radical Prostatectomy.

Giorgio Gandaglia, Guillaume Ploussard, Massimo Valerio, Agostino Mattei, Cristian Fiori, Mathieu Roumiguié, Nicola Fossati, Armando Stabile, Jean-Baptiste Beauval, Bernard Malavaud, Simone Scuderi, Francesco Barletta, Marco Moschini, Stefania Zamboni, Arnas Rakauskas, Zhe Tian, Pierre I Karakiewicz, Francesco De Cobelli, Francesco Porpiglia, Francesco Montorsi, Alberto Briganti,

<h4>Background</h4>The combined role of multiparametric magnetic resonance imaging (mp-MRI), and magnetic resonance imaging (MRI)-targeted and concomitant systematic biopsies in the identification of prostate cancer (PCa) patients at a higher risk of adverse pathology at radical prostatectomy (RP) is still unclear.<h4>Objective</h4>To develop novel models to predict extracapsular extension (ECE), seminal vesicle ... Read more >>

Eur Urol (European urology)
[2020, 77(6):733-741]

Cited: 6 times

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Therapeutic approaches for lymph node involvement in prostate, bladder and kidney cancer.

Armando Stabile, Fabio Muttin, Stefania Zamboni, Marco Moschini, Giorgio Gandaglia, Nicola Fossati, Paolo Dell'Oglio, Umberto Capitanio, Vito Cucchiara, Elio Mazzone, Carlo A Bravi, Vincenzo Mirone, Francesco Montorsi, Alberto Briganti,

<b>Introduction</b>: A considerable proportion of patients are still found with nodal involvement when considering prostate (PCa), bladder (BCa) and renal cancer (RCC). This scenario is often related to poorer oncological outcomes, but evidence supporting this correlation remain scarce or controversial. <b>Areas covered</b>: A review was conducted to provide updated evidence ... Read more >>

Expert Rev Anticancer Ther (Expert review of anticancer therapy)
[2019, 19(9):739-755]

Cited: 1 time

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Efficacy of Surgery in the Primary Tumor Site for Metastatic Urothelial Cancer: Analysis of an International, Multicenter, Multidisciplinary Database.

Marco Moschini, Evanguelos Xylinas, Stefania Zamboni, Agostino Mattei, Günter Niegisch, Evan Y Yu, Aristotelis Bamias, Neeraj Agarwal, Srikala S Sridhar, Cora N Sternberg, Ulka N Vaishampayan, Jonathan E Rosenberg, Joaquim Bellmunt, Matthew D Galsky, Francesco Montorsi, Andrea Necchi, ,

<h4>Background</h4>The effect of local treatment on survival in advanced-stage patients has gained interest in several malignancies; however, limited data exist regarding urothelial carcinoma (UC).<h4>Objective</h4>To test the impact of surgery of the primary tumor site on cancer-specific mortality (CSM) and overall mortality (OM) in patients affected by metastatic UC.<h4>Design, setting, and ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(1):94-101]

Cited: 4 times

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Adjuvant chemotherapy in bladder cancer patients with histological variants: time to change the approach?

Luca Afferi, Stefania Zamboni, Philipp Baumeister, Livio Mordasini, Agostino Mattei, Marco Moschini,

Transl Androl Urol (Translational andrology and urology)
[2019, 8(Suppl 3):S280-S282]

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