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Author Stefania Arasi

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Preventing food allergy in infancy and childhood: systematic review of randomised controlled trials.

Debra de Silva, Susanne Halken, Chris Singh, Muraro Antonella, Elizabeth Angier, Stefania Arasi, Hasan Arshad, Kirsten Beyer, Robert Boyle, George du Toit, Philippe Eigenmann, Kate Grimshaw, Arne Hoest, Carla Jones, Ekaterina Khaleva, Gideon Lack, Hania Szajewska, Carina Venter, Valérie Verhasselt, Graham Roberts, ,

BACKGROUND:This systematic review of ways to prevent immediate-onset/IgE-mediated food allergy will inform guidelines by the European Academy of Allergy and Immunology (EAACI). METHODS:The GRADE approach was used. Eleven databases were searched from 1946 to October 2019 for randomised controlled trials (and large prospective cohort studies in the case of breastfeeding). ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Omalizumab in children and adolescents with chronic spontaneous urticaria: Case series and review of the literature.

Stefano Passanisi, Stefania Arasi, Lucia Caminiti, Giuseppe Crisafulli, Giuseppina Salzano, Giovanni B Pajno,

The recent EAACI/GA2 LEN/EDF/WAO guidelines recommend omalizumab (anti-IgE) for the management of patients aged ≥12 years with chronic urticaria unresponsive to high-doses second-generation H1 -antihistamines (antiH1 ). However, there is little published information on the success of omalizumab for such a treatment in children. We reported our experience of six patients ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2020, :e13489]

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EAACI Allergen Immunotherapy User's Guide.

Montserrat Alvaro-Lozano, Cezmi A Akdis, Mubeccel Akdis, Cherry Alviani, Elisabeth Angier, Stefania Arasi, Lisa Arzt-Gradwohl, Domingo Barber, Raphaëlle Bazire, Ozlem Cavkaytar, Pasquale Comberiati, Stephanie Dramburg, Stephen R Durham, Aarif O Eifan, Leandra Forchert, Susanne Halken, Max Kirtland, Umut C Kucuksezer, Janice A Layhadi, Paolo Maria Matricardi, Antonella Muraro, Cevdet Ozdemir, Giovanni Battista Pajno, Oliver Pfaar, Ekaterina Potapova, Carmen Riggioni, Graham Roberts, Pablo Rodríguez Del Río, Mohamed H Shamji, Gunter J Sturm, Marta Vazquez-Ortiz,

Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical efficiency relies on a well-defined immunologic mechanism promoting regulatory T cells and downplaying the immune response induced by allergens. Clinical indications have been well documented for respiratory allergy in the presence of rhinitis and/or allergic asthma, to ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, 31 Suppl 25:1-101]

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Managing childhood allergies and immunodeficiencies during respiratory virus epidemics - the 2020 COVID-19 pandemic.

Helen A Brough, Omer Kalayci, Anna Sediva, Eva Untersmayr, Daniel Munblit, Pablo Rodriquez Del Rio, Marta Vazquez-Ortiz, Stefania Arasi, Montserrat Alvaro-Lozano, Sophia Tsabouri, Elena Galli, Burcin Beken, Philippe A Eigenmann,

While the world is facing an unprecedented pandemic with COVID-19, patients with chronic diseases need special attention and if warranted adaptation of their regular treatment plan. In children, allergy and asthma are among the most prevalent non-communicable chronic diseases, and health care providers taking care of these patients need guidance. ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Pediatric use of omalizumab for allergic asthma.

Giovanni Battista Pajno, Riccardo Castagnoli, Stefania Arasi, Amelia Licari, Lucia Caminiti, Gian Luigi Marseglia,

Introduction: Severe pediatric asthma is associated with significant morbidity as well as with a high economic burden. It represents a heterogeneous disease with multiple clinical phenotypes. Currently, physicians are facing the challenge to provide a 'personalized medicine approach', which is tailored to the diverse pathomechanisms underlying clinical presentations. Three main ... Read more >>

Expert Opin Biol Ther (Expert opinion on biological therapy)
[2020, :1-9]

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Adherence to Prescribed E-Diary Recording by Patients With Seasonal Allergic Rhinitis: Observational Study.

Marco Di Fraia, Salvatore Tripodi, Stefania Arasi, Stephanie Dramburg, Sveva Castelli, Danilo Villalta, Francesca Buzzulini, Ifigenia Sfika, Valeria Villella, Ekaterina Potapova, Serena Perna, Maria Antonia Brighetti, Alessandro Travaglini, Pierluigi Verardo, Simone Pelosi, Anna Maria Zicari, Paolo Maria Matricardi,

BACKGROUND:Complete diagnosis and therapy of seasonal allergic rhinoconjunctivitis require evidence that exposure to the sensitizing pollen triggers allergic symptoms. Electronic clinical diaries, by recording disease severity scores and pollen exposure, can demonstrate this association. However, patients who spontaneously download an e-diary app show very low adherence to their recording. OBJECTIVE:The ... Read more >>

J. Med. Internet Res. (Journal of medical Internet research)
[2020, 22(3):e16642]

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Oral immunotherapy in pediatrics.

Stefania Arasi, Riccardo Castagnoli, Giovanni B Pajno,

IgE-mediated food allergy (FA) has been emerging as a public health priority, mainly in children. It represents a heavy burden for the entire society and not only for the patients and their families. There is evidence that in children with persistent FA, at least to cow's milk, hen's egg, and ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, 31 Suppl 24:51-53]

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"Whole" vs "fragmented" approach to EAACI pollen season definitions: A multicenter study in six Southern European cities.

Tara Maria Hoffmann, Aydan Acar Şahin, Xenophon Aggelidis, Stefania Arasi, Andrea Barbalace, Anne Bourgoin, Blerina Bregu, Maria Antonia Brighetti, Elsa Caeiro, Sule Caglayan Sozmen, Lucia Caminiti, Denis Charpin, Mariana Couto, Luís Delgado, Andrea Di Rienzo Businco, Claire Dimier, Maria V Dimou, João A Fonseca, Ozlem Goksel, Aykut Guvensen, Dolores Hernandez, Dah Tay Jang, Fusun Kalpaklioglu, Blerta Lame, Ruth Llusar, Michael P Makris, Michael P Makris, Angel Mazon, Eris Mesonjesi, Antonio Nieto, Ayse Öztürk, Laurie Pahus, Giovanni Battista Pajno, Ilenia Panasiti, Valentina Panetta, Nikolaos G Papadopoulos, Elisabetta Pellegrini, Simone Pelosi, Ana Margarida Pereira, Mariana Pereira, Munevver Pinar, Oliver Pfaar, Ekaterina Potapova, Alfred Priftanji, Fotis Psarros, Cansin Sackesen, Ifigenia Sfika, Javier Suarez, Michel Thibaudon, Alessandro Travaglini, Salvatore Tripodi, Valentine Verdier, Valeria Villella, Paraskevi Xepapadaki, Duygu Yazici, Paolo M Matricardi, Stephanie Dramburg,

BACKGROUND:The adequate definition of pollen seasons is essential to facilitate a correct diagnosis, treatment choice, and outcome assessment in patients with seasonal allergic rhinitis. A position paper by the European Academy of Allergy and Clinical Immunology (EAACI) proposed season definitions for Northern and Middle Europe. OBJECTIVE:To test the pollen season ... Read more >>

Allergy (Allergy)
[2019, :]

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Safety of Food Oral Immunotherapy: What We Know, and What We Need to Learn.

Sonia Vázquez-Cortés, Paloma Jaqueti, Stefania Arasi, Adrianna Machinena, Montserrat Alvaro-Lozano, Montserrat Fernández-Rivas,

Oral immunotherapy (OIT) for food allergy entails a risk of adverse reactions, including anaphylaxis. This safety concern is the major barrier for OIT to become a therapeutic option in clinical practice. The high heterogeneity in safety reporting of OIT studies prevents setting the safety profile accurately. An international consensus is ... Read more >>

Immunol Allergy Clin North Am (Immunology and allergy clinics of North America)
[2020, 40(1):111-133]

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Preventing immediate-onset food allergy in infants, children and adults: Systematic review protocol.

Debra de Silva, Susanne Halken, Chris Singh, Antonella Muraro, Elizabeth Angier, Stefania Arasi, Hasan Arshad, Kirsten Beyer, Robert Boyle, Philippe Eigenmann, Kate Grimshaw, Arne Hoest, Carla Jones, Gideon Lack, Hania Szajewska, George du Toit, Carina Venter, Valérie Verhasselt, Graham Roberts,

BACKGROUND:More than 17 million people across Europe have allergies to food and the burden of food allergies is increasing. In 2014, the European Academy of Allergy and Clinical Immunology (EAACI) published guidelines for preventing food allergy. Important research has been published since then and it is essential to ensure the ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, 31(3):243-249]

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Challenges of managing food allergy in the developing world.

Elham Hossny, Motohiro Ebisawa, Yehia El-Gamal, Stefania Arasi, Lamia Dahdah, Rasha El-Owaidy, Cesar A Galvan, Bee Wah Lee, Michael Levin, Santiago Martinez, Ruby Pawankar, Mimi L K Tang, Elizabeth H Tham, Alessandro Fiocchi,

Food allergy (FA) is currently a significant health care problem in the developing world. Widely varying study populations and methodologies, the use of surrogate markers such as self report or hospitalization rates due to anaphylaxis rather than objective methods, limits robust estimation of FA prevalence in low income settings. Also, ... Read more >>

World Allergy Organ J (The World Allergy Organization journal)
[2019, 12(11):100089]

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IgE antibody repertoire in nasal secretions of children and adults with seasonal allergic rhinitis: A molecular analysis.

Sveva Castelli, Stefania Arasi, Salvatore Tripodi, Danilo Villalta, Paola Martelli, Mariaelisabetta Conte, Valentina Panetta, Ilaria Simonelli, Alexander Rohrbach, Marco Di Fraia, Ifigenia Sfika, Valeria Villella, Andrea Di Rienzo Businco, Serena Perna, Stephanie Dramburg, Ekaterina Potapova, Paolo Maria Matricardi,

BACKGROUND:There is growing interest both in testing IgE in nasal secretions (NS) and in molecular diagnosis of seasonal allergic rhinitis (SAR). Yet, the reliability of nasal IgE detection with the newest molecular assays has never been assessed in a large cohort of pollen allergic patients. OBJECTIVE:To investigate with microarray technology ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, 31(3):273-280]

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Conflicting verdicts on peanut oral immunotherapy from the Institute for Clinical and Economic Review and US Food and Drug Administration Advisory Committee: Where do we go from here?

Thomas Eiwegger, Katherine Anagnostou, Stefania Arasi, Philippe Bégin, Moshe Ben-Shoshan, Kirsten Beyer, Katharina Blumchen, Helen Brough, Jean-Christoph Caubet, Edmond S Chan, Meng Chen, Sharon Chinthrajah, Carla M Davis, Anne Des Roches, George Du Toit, Arnon Elizur, Stephen J Galli, Geir Håland, Karin Hoffmann-Sommergruber, Harold Kim, Donald Y M Leung, Andrew Long, Antonella Muraro, Ulugbek B Nurmatov, Giovanni B Pajno, Vanitha Sampath, Jamie Saxena, Sayantani Sindher, Julia Upton, Margitta Worm, Kari C Nadeau,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, 145(4):1153-1156]

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ICER report for peanut OIT comes up short.

Thomas Eiwegger, Katherine Anagnostou, Stefania Arasi, Philippe Bégin, Moshe Ben-Shoshan, Kirsten Beyer, Katharina Blumchen, Helen Brough, Jean-Christoph Caubet, Edmond S Chan, Sharon Chinthrajah, Carla M Davis, Anne Des Roches, George Du Toit, Arnon Elizur, Stephen J Galli, Geir Håland, Karin Hoffmann-Sommergruber, Harold Kim, Donald Y M Leung, Antonella Muraro, Ulugbek B Nurmatov, Giovanni B Pajno, Sayantani Sindher, Zsolt Szepfalusi, Maria Jose Torres, Julia Upton, Margitta Worm, Kari Nadeau,

Ann. Allergy Asthma Immunol. (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2019, 123(5):430-432]

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Allergy to food additives.

Rocco Luigi Valluzzi, Vincenzo Fierro, Stefania Arasi, Maurizio Mennini, Valentina Pecora, Alessandro Fiocchi,

PURPOSE OF REVIEW:To provide an update of the studies concerning the diagnosis and management of food additives allergy. RECENT FINDINGS:Additives improve specific characteristics of food products, but they may induce allergic even life-threatening reactions. Physical examination and medical history are basic to assess specific in-vivo and in-vitro tests. The only ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2019, 19(3):256-262]

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Solid foods should be introduced into susceptible infants' diets early in life-CON.

Antonella Muraro, Stefania Arasi,

Ann. Allergy Asthma Immunol. (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2019, 122(6):586-588]

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How guideline can shape clinical practice globally: the diagnosis and rationale for action against cow's milk allergy experience.

Lamia Dahdah, Stefania Arasi, Rocco Luigi Valluzzi, Vincenzo Fierro, Alessandro Fiocchi,

PURPOSE OF REVIEW:Allergic diseases are increasing worldwide and are considered an important public health problem causing severe and even life-threatening reactions. The creation of guidelines aims to help clinicians improving the quality of diagnosis and management of such diseases. Clinical practice guidelines alone are not sufficient and there is a ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2019, 19(2):185-191]

Cited: 1 time

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Allergen immunotherapy for IgE-mediated food allergy: There is a measure in everything to a proper proportion of therapy.

Giovanni Battista Pajno, Riccardo Castagnoli, Antonella Muraro, Montserrat Alvaro-Lozano, Cezmi A Akdis, Műbeccel Akdis, Stefania Arasi,

IgE-mediated food allergy (FA) is a potentially life-threatening condition with a negative impact on quality of life and an increasing prevalence in westernized countries in the recent two decades. A strict avoidance of the triggering food(s) represents the current standard approach. However, an elimination diet may be difficult and frustrating, ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2019, 30(4):415-422]

Cited: 1 time

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The safety of oral immunotherapy for food allergy during maintenance phase: Effect of counselling on adverse reactions.

Stefania Arasi, Lucia Caminiti, Giuseppe Crisafulli, Ilenia Panasiti, Andrea Barbalace, Giovanni Passalacqua, Giovanni Battista Pajno,

World Allergy Organ J (The World Allergy Organization journal)
[2019, 12(1):100010]

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Omalizumab in children with severe allergic disease: a case series.

Giuseppe Crisafulli, Lucia Caminiti, Fernanda Chiera, Stefania Arasi, Giuseppina Salzano, Ilenia Panasiti, Andrea Barbalace, Giovanni Battista Pajno,

BACKGROUND:Currently, severe allergic asthma and food allergy in children represent an important public health problem with medical, psychosocial and economic impacts. Omalizumab is a humanized monoclonal anti-IgE antibody, approved for refractory allergic asthma and chronic urticaria. It has been widely used in clinical practice as add-on therapy in patients with ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2019, 45(1):13]

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SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children.

Carlo Caffarelli, Fabrizio Franceschini, Davide Caimmi, Francesca Mori, Lucia Diaferio, Dora Di Mauro, Carla Mastrorilli, Stefania Arasi, Simona Barni, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Pasquale Comberiati, Giuseppe Crisafulli, Lucia Liotti, Umberto Pelosi, Francesca Saretta, Gianluigi Marseglia, Marzia Duse, Francesco Paravati,

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2018, 44(1):147]

Cited: 9 times

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A new molecular multiplex IgE assay for the diagnosis of pollen allergy in Mediterranean countries: A validation study.

Marco Di Fraia, Stefania Arasi, Sveva Castelli, Stephanie Dramburg, Ekaterina Potapova, Danilo Villalta, Salvatore Tripodi, Ifigenia Sfika, Anna Maria Zicari, Valeria Villella, Serena Perna, Alessandro Travaglini, Pier Luigi Verardo, Paolo Maria Matricardi,

BACKGROUND:The identification of the primary sensitizing pollen is difficult in Southern European patients with Seasonal Allergic Rhinitis (SAR) if sensitized to various pollen sources with overlapping seasonality. A more precise diagnosis is obtained by IgE assays to allergen molecules, currently available as singleplex or microarrays. OBJECTIVES:To test the analytical performance ... Read more >>

Clin. Exp. Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2019, 49(3):341-349]

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Biomarkers in Food Allergy.

Antonella Muraro, Stefania Arasi,

PURPOSE OF REVIEW:To familiarize the reader with the concept of precision medicine in food allergy by dealing with the current biomarkers for the diagnosis, prognosis, and management of the disease. RECENT FINDINGS:Many efforts have been devoted in order to characterize reliable biomarkers able to identify specific phenotypes and endotypes in ... Read more >>

Curr Allergy Asthma Rep (Current allergy and asthma reports)
[2018, 18(11):64]

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Precision medicine in food allergy.

Stefania Arasi, Maurizio Mennini, Rocco Valluzzi, Carla Riccardi, Alessandro Fiocchi,

PURPOSE OF REVIEW:To familiarize the reader with the concept of precision medicine in food allergy through the most recent insights in the diagnosis, prognosis, and management of the disease. RECENT FINDINGS:With the advent of omics sciences, a new era is commencing. Food protein allergens characterization and quantification together with the ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2018, 18(5):438-443]

Cited: 3 times

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What's next for DRACMA?

Lamia Dahdah, Vincenzo Fierro, Maurizio Mennini, Stefania Arasi, Alessandro Fiocchi,

Expert Rev Clin Immunol (Expert review of clinical immunology)
[2018, 14(8):649-651]

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