Orthopade (Der Orthopade)
[2021, 50(10):828-831]
Cited: 0 times
Kiran Khawaja, Klaus W Frommer, Mona Bausch, Stefan Rehart, Ulf Müller-Ladner, Elena Neumann,
Rheumatoid arthritis (RA) is a chronic inflammatory disorder marked by synovitis, ultimately leading to cartilage and bone destruction. In RA, adiponectin levels are increased in serum and synovial fluid. Adiponectin belongs to the adipokines, a group of highly bioactive substances secreted by adipocytes and other cell types. It has been ... Read more >>
J Interferon Cytokine Res (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research)
[2021, 41(5):177-186]
Cited: 0 times
Lina van Nie, Laura Salinas-Tejedor, Nicole Dychus, Frank Fasbender, Marie-Lisa Hülser, Maurizio Cutolo, Stefan Rehart, Elena Neumann, Ulf Müller-Ladner, Silvia Capellino,
Preventing synovial fibroblast (SF) migration into the adjacent cartilage is a desirable therapeutic target in rheumatoid arthritis (RA). As previous studies demonstrated that RASF and SF from osteoarthritis (OA) patients express dopamine receptors (DR), aim of the present study was to investigate the impact of dopamine on mobility of fibroblasts ... Read more >>
Sci Rep (Scientific reports)
[2020, 10(1):11928]
Cited: 2 times
Rebecca Hasseli, Klaus W Frommer, Maria Schwarz, Marie-Lisa Hülser, Carina Schreiyäck, Mona Arnold, Magnus Diller, Ingo H Tarner, Uwe Lange, Joern Pons-Kühnemann, Markus Schönburg, Stefan Rehart, Ulf Müller-Ladner, Elena Neumann,
<b>Objective:</b> The long-distance migration of rheumatoid arthritis synovial fibroblasts (RASFs) in the severe combined immunodeficiency (SCID) mouse model of rheumatoid arthritis (RA) suggests that an interaction between RASFs and endothelial cells (EC) is critical in this process. Our objective was to assess whether immunomodulatory factors such as adipokines and antirheumatic ... Read more >>
Front Immunol (Frontiers in immunology)
[2020, 11:925]
Cited: 3 times
Klaus W Frommer, Rebecca Hasseli, Andreas Schäffler, Uwe Lange, Stefan Rehart, Jürgen Steinmeyer, Markus Rickert, Kerstin Sarter, Mario M Zaiss, Carsten Culmsee, Goutham Ganjam, Susanne Michels, Ulf Müller-Ladner, Elena Neumann,
Obesity-in which free fatty acid (FFA) levels are chronically elevated-is a known risk factor for different rheumatic diseases, and obese patients are more likely to develop osteoarthritis (OA) also in non-weight-bearing joints. These findings suggest that FFA may also play a role in inflammation-related joint damage and bone loss in ... Read more >>
Front Immunol (Frontiers in immunology)
[2019, 10:2757]
Cited: 8 times
Magnus Diller, Klaus Frommer, Berno Dankbar, Ingo Tarner, Marie-Lisa Hülser, Lali Tsiklauri, Rebecca Hasseli, Michael Sauerbier, Thomas Pap, Stefan Rehart, Ulf Müller-Ladner, Elena Neumann,
<h4>Background</h4>Activin A and follistatin exhibit immunomodulatory functions, thus affecting autoinflammatory processes as found in rheumatoid arthritis (RA). The impact of both proteins on the behavior of synovial fibroblasts (SF) in RA as well as in osteoarthritis (OA) is unknown.<h4>Methods</h4>Immunohistochemical analyses of synovial tissue for expression of activin A and follistatin ... Read more >>
Arthritis Res Ther (Arthritis research & therapy)
[2019, 21(1):144]
Cited: 0 times
Torsten Schloßhauer, Eckhard Priepke, Stefan Rehart, Shafreena Kuehn, Bernhard Jahn-Muehl, Ulrich Michael Rieger,
Tuberculosis is a central global health problem with an incidence of 10 million new cases per year and more than one million deaths per year. Contrary to this, osseous tuberculosis represents an extremely rare entity of tuberculosis. Osseous tuberculosis is challenging beginning with the correct diagnosis, adequate surgical as well ... Read more >>
Handchir Mikrochir Plast Chir (Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...)
[2019, 51(6):492-500]
Cited: 0 times
Magnus Diller, Rebecca Hasseli, Marie-Lisa Hülser, Iris Aykara, Klaus Frommer, Stefan Rehart, Ulf Müller-Ladner, Elena Neumann,
<b>Background:</b> Synovial fibroblasts (SF) play a major role in the pathogenesis of rheumatoid arthritis (RA) and develop an aggressive phenotype destroying cartilage and bone, thus termed RASF. JAK inhibitors have shown to be an efficient therapeutic option in RA treatment, but less is known about the effect of JAK inhibitors ... Read more >>
Front Immunol (Frontiers in immunology)
[2019, 10:541]
Cited: 11 times
Orthopade (Der Orthopade)
[2018, 47(11):889-890]
Cited: 0 times
Elena Neumann, Maria C Schwarz, Rebecca Hasseli, Marie-Lisa Hülser, Simon Classen, Michael Sauerbier, Stefan Rehart, Ulf Mueller-Ladner,
Tetraspanins function as membrane adaptors altering cell-cell fusion, antigen presentation, receptor-mediated signal transduction and cell motility via interaction with membrane proteins including other tetraspanins and adhesion molecules such as integrins. CD82 is expressed in several malignant cells and well described as tumour metastasis suppressor. Rheumatoid arthritis (RA) is based on ... Read more >>
Ann Rheum Dis (Annals of the rheumatic diseases)
[2018, 77(11):1619-1626]
Cited: 7 times
Christoph Biehl, Thomas Braun, Ulrich Thormann, Amir Oda, Gabor Szalay, Stefan Rehart,
<h4>Background</h4>The aim of this retrospective study is to evaluate distal resection interposition arthroplasty of the wrist as a tool to restore mobility as well as to restore stability in severely destroyed wrist joints.<h4>Methods</h4>Thirty-four wrists in 28 rheumatoid arthritis patients were included. The mean follow-up time was 9 years after surgical treatment ... Read more >>
BMC Musculoskelet Disord (BMC musculoskeletal disorders)
[2018, 19(1):286]
Cited: 3 times
Tanja Kostuj, Stefan Rehart, Ronald Matta-Hurtado, Christoph Biehl, Roland E Willburger, Klaus Schmidt, ,
<h4>Objective</h4>Most patients suffering with rheumatic diseases who undergo surgical treatment are receiving immune-modulating therapy. To determine whether these medications affect their outcomes a national registry was established in Germany by the German Society of Surgery (DGORh). Data from the first 1000 patients were used in a pilot study to identify ... Read more >>
BMJ Open (BMJ open)
[2017, 7(10):e015987]
Cited: 0 times
Stephanie Lefèvre, Maria Schwarz, Florian M P Meier, Birgit Zimmermann-Geller, Ingo H Tarner, Markus Rickert, Jürgen Steinmeyer, Michael Sauerbier, Stefan Rehart, Ulf Müller-Ladner, Elena Neumann,
In rheumatoid arthritis (RA), cartilage and bone matrix are degraded, and extracellular matrix (ECM) proteins, acting as cellular activators, are liberated. Similar to ECM proteins, matrix-bound chemokines, cytokines, and growth factors (GFs) influence functional properties of key cells in RA, especially synovial fibroblasts. The role of these molecules on attachment, ... Read more >>
J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2017, 198(12):4588-4595]
Cited: 6 times
Birgit Zimmermann-Geller, Sina Köppert, Silvia Fischer, Hector A Cabrera-Fuentes, Stephanie Lefèvre, Markus Rickert, Jürgen Steinmeyer, Stefan Rehart, Thomas Umscheid, Markus Schönburg, Ulf Müller-Ladner, Klaus T Preissner, Klaus W Frommer, Elena Neumann,
J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2017, 198(3):1376]
Cited: 0 times
Grit Krumbholz, Susann Junker, Florian M P Meier, Markus Rickert, Jürgen Steinmeyer, Stefan Rehart, Uwe Lange, Klaus W Frommer, Georg Schett, Ulf Müller-Ladner, Elena Neumann,
<h4>Objectives</h4>Adiponectin is an effector molecule in the pathophysiology of rheumatoid arthritis, e.g. by inducing cytokines and matrix degrading enzymes in synovial fibroblasts. There is growing evidence that adiponectin affects osteoblasts and osteoclasts although the contribution to the aberrant bone metabolism in rheumatoid arthritis is unclear. Therefore, the adiponectin effects on ... Read more >>
Clin Exp Rheumatol (Clinical and experimental rheumatology)
[2017, 35(3):406-414]
Cited: 13 times
Susann Junker, Klaus W Frommer, Grit Krumbholz, Lali Tsiklauri, Rüdiger Gerstberger, Stefan Rehart, Jürgen Steinmeyer, Markus Rickert, Sabine Wenisch, Georg Schett, Ulf Müller-Ladner, Elena Neumann,
<h4>Objective</h4>Osteophyte formation in osteoarthritis (OA) is mediated by increased osteoblast activity, which is -in turn- regulated by the Wnt signaling pathway. Obesity is regarded a risk factor in OA, yet little is known about the interaction between adipose tissue-derived factors, the adipokines, and bone formation, although adipokines are associated with ... Read more >>
Matrix Biol (Matrix biology : journal of the International Society for Matrix Biology)
[2017, 62:75-91]
Cited: 18 times
Birgit Zimmermann-Geller, Sina Köppert, Silvia Fischer, Hector A Cabrera-Fuentes, Stephanie Lefèvre, Markus Rickert, Markus Rickert, Jürgen Steinmeyer, Stefan Rehart, Thomas Umscheid, Markus Schönburg, Ulf Müller-Ladner, Klaus T Preissner, Klaus W Frommer, Elena Neumann,
Extracellular RNA (exRNA) has been characterized as a molecular alarm signal upon cellular stress or tissue injury and to exert biological functions as a proinflammatory, prothrombotic, and vessel permeability-regulating factor. In this study, we investigated the contribution of exRNA and its antagonist RNase1 in a chronic inflammatory joint disease, rheumatoid ... Read more >>
J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2016, 197(7):2589-2597]
Cited: 14 times
Susann Junker, Grit Krumbholz, Klaus W Frommer, Stefan Rehart, Jürgen Steinmeyer, Markus Rickert, Georg Schett, Ulf Müller-Ladner, Elena Neumann,
<h4>Objective</h4>Osteoarthritis is not only characterized by cartilage degradation but also involves subchondral bone remodeling and osteophyte formation. Osteophytes are fibrocartilage-capped bony outgrowths originating from the periosteum. The pathophysiology of osteophyte formation is not completely understood. Yet, different research approaches are under way. Therefore, a histological osteophyte classification to achieve comparable ... Read more >>
Joint Bone Spine (Joint bone spine)
[2016, 83(1):63-67]
Cited: 8 times
Hannah Störch, Birgit Zimmermann, Bastian Resch, Lars-Oliver Tykocinski, Babak Moradi, Patrick Horn, Ziya Kaya, Norbert Blank, Stefan Rehart, Marc Thomsen, Hanns-Martin Lorenz, Elena Neumann, Theresa Tretter,
<h4>Background</h4>Cross-talk between synovial fibroblasts (SF) and immune cells is suggested to play a crucial role in inflammation and chronification of rheumatoid arthritis (RA). The contribution of B cells in this process is poorly defined.<h4>Methods</h4>Here, primary B cells from healthy donors were polyclonally activated and cocultured with SF of non-synovitic origin ... Read more >>
Ann Rheum Dis (Annals of the rheumatic diseases)
[2016, 75(5):924-932]
Cited: 12 times
Orthopade (Der Orthopade)
[2014, 43(12):1112-1113]
Cited: 0 times
Silke Witulski, Thomas J Vogl, Stefan Rehart, Peter Ottl,
This study included 30 patients with diagnosed rheumatoid arthritis (RA) and 30 test subjects without RA (control group). The objective of the study was to examine both groups for the presence of temporomandibular disorders (TMD) and morphological changes of the temporomandibular joint (TMJ). All individuals were examined using a systematic ... Read more >>
Biomed Res Int (BioMed research international)
[2014, 2014:328560]
Cited: 8 times
Orthopade (Der Orthopade)
[2014, 43(6):582-583]
Cited: 1 time
Klaus W Frommer, Andreas Schäffler, Stefan Rehart, Angela Lehr, Ulf Müller-Ladner, Elena Neumann,
<h4>Objectives</h4>Due to their role in inflammatory metabolic diseases, we hypothesised that free fatty acids (FFA) are also involved in inflammatory joint diseases. To test this hypothesis, we analysed the effect of FFA on synovial fibroblasts (SF), human chondrocytes and endothelial cells. We also investigated whether the toll-like receptor 4 (TLR4), ... Read more >>
Ann Rheum Dis (Annals of the rheumatic diseases)
[2015, 74(1):303-310]
Cited: 41 times
Florian M P Meier, Klaus W Frommer, Marvin A Peters, Fabia Brentano, Stephanie Lefèvre, Dirk Schröder, Diego Kyburz, Jürgen Steinmeyer, Stefan Rehart, Steffen Gay, Ulf Müller-Ladner, Elena Neumann,
Adipokines such as adiponectin and visfatin/pre-B-cell colony-enhancing factor (PBEF) have been recently shown to contribute to synovial inflammation in rheumatoid arthritis (RA). In this study, we evaluated the pathophysiological implication of visfatin/PBEF in the molecular patterns of RA synovial tissue, focusing on RA synovial fibroblasts (RASFs), key players in RA ... Read more >>
J Biol Chem (The Journal of biological chemistry)
[2012, 287(34):28378-28385]
Cited: 31 times
Klaus W Frommer, Andreas Schäffler, Christa Büchler, Jürgen Steinmeyer, Markus Rickert, Stefan Rehart, Fabia Brentano, Steffen Gay, Ulf Müller-Ladner, Elena Neumann,
<h4>Objectives</h4>Several clinical studies have suggested the adipocytokine adiponectin is involved in the progression of rheumatoid arthritis (RA). From this point of view, adiponectin might present a new therapeutic target. However, as adiponectin also exerts beneficial effects in the human organism, a strategy that would allow its detrimental effects to be ... Read more >>
Ann Rheum Dis (Annals of the rheumatic diseases)
[2012, 71(10):1724-1732]
Cited: 40 times