Full Text Journal Articles by
Author Stefan M Willems

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Emerging Entities and New Diagnostic Markers for Head and Neck Soft Tissue and Bone Tumors.

Alessandro Franchi, Lester D R Thompson, Juan C Hernandez-Prera, Abbas Agaimy, Michelle D Williams, Lauge H Mikkelsen, Justin A Bishop, Stefan M Willems, Henrik Hellquist, Alfio Ferlito,

Bone and soft tissue tumors of the head and neck are relatively uncommon tumors that often represent a diagnostic challenge because of the wide range of entities that must be considered in the differential diagnosis. Over the past few years, classification of bone and soft tissue tumors has evolved primarily ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):139-149]

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High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance.

Alena Skalova, Ilmo Leivo, Henrik Hellquist, Abbas Agaimy, Roderick H W Simpson, Göran Stenman, Vincent Vander Poorten, Justin A Bishop, Alessandro Franchi, Juan C Hernandez-Prera, David Slouka, Stefan M Willems, Kerry D Olsen, Alfio Ferlito,

High-grade transformation (HGT) or dedifferentiation has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, low-grade mucoepidermoid carcinoma, and hyalinizing clear cell carcinoma. High-grade (HG) transformed tumors are composed of a conventional low-grade component characterized by specific ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):107-118]

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Micro-costing diagnostics in oncology: from single-gene testing to whole genome sequencing.

Clémence Tb Pasmans, Bastiaan Bj Tops, Elisabeth Mp Steeghs, Veerle Mh Coupé, Katrien Grünberg, Eiko K de Jong, Ed Md Schuuring, Stefan M Willems, Marjolijn Jl Ligtenberg, Valesca P Retèl, Hans van Snellenberg, Ewart de Bruijn, Edwin Cuppen, Geert Wj Frederix,

<b>Purpose</b>: Predictive diagnostics play an increasingly important role in personalized medicine for cancer treatment. Whole genome sequencing (WGS) based treatment selection is expected to rapidly increase worldwide. This study aimed to calculate and compare the total cost of currently used diagnostic techniques and of WGS in treatment of non-small cell ... Read more >>

Expert Rev Pharmacoecon Outcomes Res (Expert review of pharmacoeconomics & outcomes research)
[2021, :]

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False-negative PD-L1 immunostaining in ethanol-fixed EBUS-TBNA specimens of non-small cell lung cancer patients.

Bregje M Koomen, Willem Vreuls, Mirthe de Boer, Emma J de Ruiter, Juergen Hoelters, Aryan Vink, Stefan M Willems,

<h4>Aims</h4>Programmed death-ligand 1 (PD-L1) immunostaining is used to predict which non-small cell lung cancer (NSCLC) patients respond best to treatment with PD-(L)1 inhibitors. PD-L1 immunostaining is sometimes performed on alcohol-fixed cytological specimens instead of on formalin-fixed paraffin-embedded (FFPE) biopsies or resections. We studied whether ethanol pre-fixation of clots from endo-bronchial ... Read more >>

Histopathology (Histopathology)
[2021, :]

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Feasibility study of ultrasound-guided resection of tongue cancer with immediate specimen examination to improve margin control - Comparison with conventional treatment.

Klijs J de Koning, Sjors A Koppes, Remco de Bree, Jan Willem Dankbaar, Stefan M Willems, Robert J J van Es, Rob Noorlag,

<h4>Objectives</h4>Squamous cell carcinoma of the tongue (SCCT) is preferably treated by surgery. Free resection margins (≥5 mm) provide local control and disease-free survival. However, close (1-5 mm) and positive margins (<1 mm) are frequently encountered. We present our first experience of in-vivo ultrasound (US) guided SCCT resections followed by ex-vivo US ... Read more >>

Oral Oncol (Oral oncology)
[2021, 116:105249]

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Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy.

Matt Lechner, Volker H Schartinger, Christopher D Steele, Wen Long Nei, Marc Lucas Ooft, Liesa-Marie Schreiber, Christodoulos P Pipinikas, Grace Tin-Yun Chung, Yuk Yu Chan, Feng Wu, Ka-Fai To, Chi Man Tsang, Wayne Pearce, Daniele Morelli, Martin Philpott, Liam Masterson, Reshma Nibhani, Graham Wells, Christopher G Bell, Julia Koller, Susanne Delecluse, Yim Ling Yip, Jacklyn Liu, Cillian T Forde, Martin D Forster, Amrita Jay, József Dudás, Annika Krapp, Simon Wan, Christian Uprimny, Susanne Sprung, Johannes Haybaeck, Tim R Fenton, Kerry Chester, Christina Thirlwell, Gary Royle, Teresa Marafioti, Rajeev Gupta, Sagung Rai Indrasari, Camelia Herdini, Mohd Afiq Mohd Slim, I Indrawati, Liam Sutton, Renske Fles, Bing Tan, Joe Yeong, Amit Jain, Shuting Han, Haitao Wang, Kelvin S H Loke, Wan He, Ruilian Xu, Hongtao Jin, Zhiqiang Cheng, David Howard, Peter H Hwang, Quynh-Thu Le, Joshua K Tay, Robert B West, Sai Wah Tsao, Tim Meyer, Herbert Riechelmann, Udo Oppermann, Henri-Jacques Delecluse, Stefan M Willems, Melvin L K Chua, Pierre Busson, Kwok Wai Lo, Guido Wollmann, Nischalan Pillay, Bart Vanhaesebroeck, Valerie J Lund,

Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even in high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin receptor 2 (SSTR2) expression in multiple clinical cohorts comprising 402 primary, locally recurrent and metastatic NPCs. ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):117]

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Formalin fixation for optimal concordance of programmed death-ligand 1 immunostaining between cytologic and histologic specimens from patients with non-small cell lung cancer.

Bregje M Koomen, Jose van der Starre-Gaal, Judith M Vonk, Jan H von der Thüsen, Jacqueline J C van der Meij, Kim Monkhorst, Stefan M Willems, Wim Timens, Nils A 't Hart,

<h4>Background</h4>Immunohistochemical staining of programmed death-ligand 1 (PD-L1) is used to determine which patients with non-small cell lung cancer (NSCLC) may benefit most from immunotherapy. Therapeutic management of many patients with NSCLC is based on cytology instead of histology. In this study, concordance of PD-L1 immunostaining between cytology cell blocks and ... Read more >>

Cancer Cytopathol (Cancer cytopathology)
[2021, 129(4):304-317]

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HIF-1a expression and differential effects on survival in patients with oral cavity, larynx, and oropharynx squamous cell carcinomas.

Justin E Swartz, Inge Wegner, Rob Noorlag, Pauline M W van Kempen, Robert J J van Es, Remco de Bree, Stefan M W Willems,

<h4>Background</h4>Hypoxia is a negative prognostic factor in head and neck squamous cell carcinomas. Under hypoxia, the hypoxia-inducible factor (HIF)-1a transcription factor is overexpressed. We investigated whether there were site differences in HIF-1a expression and its effect on patient outcomes per subsite.<h4>Design/method</h4>A total of 941 patients with HNSCC in the squamous ... Read more >>

Head Neck (Head & neck)
[2021, 43(3):745-756]

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Multicenter Comparison of Molecular Tumor Boards in The Netherlands: Definition, Composition, Methods, and Targeted Therapy Recommendations.

Bart Koopman, Harry J M Groen, Marjolijn J L Ligtenberg, Katrien Grünberg, Kim Monkhorst, Adrianus J de Langen, Mirjam C Boelens, Marthe S Paats, Jan H von der Thüsen, Winand N M Dinjens, Nienke Solleveld, Tom van Wezel, Hans Gelderblom, Lizza E Hendriks, Ernst-Jan M Speel, Tom E Theunissen, Leonie I Kroeze, Niven Mehra, Berber Piet, Anthonie J van der Wekken, Arja Ter Elst, Wim Timens, Stefan M Willems, Ruud W J Meijers, Wendy W J de Leng, Anne S R van Lindert, Teodora Radonic, Sayed M S Hashemi, Daniëlle A M Heideman, Ed Schuuring, Léon C van Kempen,

<h4>Background</h4>Molecular tumor boards (MTBs) provide rational, genomics-driven, patient-tailored treatment recommendations. Worldwide, MTBs differ in terms of scope, composition, methods, and recommendations. This study aimed to assess differences in methods and agreement in treatment recommendations among MTBs from tertiary cancer referral centers in The Netherlands.<h4>Materials and methods</h4>MTBs from all tertiary cancer ... Read more >>

Oncologist (The oncologist)
[2020, :]

Cited: 1 time

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Prognostic value of PSMA, c-MET and E-cadherin in salivary duct carcinoma.

Wim van Boxtel, Maike J M Uijen, Gerald W Verhaegh, Stefan M Willems, Marianne A Jonker, , Jack A Schalken, Ilse C H van Engen-van Grunsven, Carla M L van Herpen,

<h4>Objectives</h4>Salivary duct carcinoma (SDC) is a rare and aggressive subtype of salivary gland cancer. Androgen receptor (AR) (96%) and HER2 (29-46%) expression, and a high propensity for regional lymph node metastases are hallmarks of the disease. We hypothesized that c-MET, E-cadherin, PSMA tumor and PSMA neovascular expression may be prognostic ... Read more >>

Oral Oncol (Oral oncology)
[2020, 110:105018]

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Comparison of three PD-L1 immunohistochemical assays in head and neck squamous cell carcinoma (HNSCC).

Emma J de Ruiter, Frans J Mulder, Bregje M Koomen, Ernst-Jan Speel, Mari F C M van den Hout, Reinout H de Roest, Elisabeth Bloemena, Lot A Devriese, Stefan M Willems,

Expression of programmed cell death-ligand 1 (PD-L1) is being used as predictive biomarker for immunotherapy in head and neck squamous cell carcinoma (HNSCC). Several antibodies are available for PD-L1 testing and multiple staining and scoring methods are used. This study aimed to compare the performance of two PD-L1 standardized assays ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, :]

Cited: 3 times

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A novel immunohistochemical scoring system reveals associations of C-terminal MET, ectodomain shedding, and loss of E-cadherin with poor prognosis in oral squamous cell carcinoma.

Maria J De Herdt, Senada Koljenović, Berdine van der Steen, Stefan M Willems, Marjan H Wieringa, Daan Nieboer, Jose A Hardillo, Aaron M Gruver, Wei Zeng, Ling Liu, Robert J Baatenburg de Jong, Leendert H J Looijenga,

Using tissue microarrays, it was shown that membranous C-terminal MET immunoreactivity and ectodomain (ECD) shedding are associated with poor prognosis in oral cancer. Seen the potential diagnostic value, extrapolation of these results to whole-tissue sections was investigated. Because MET orchestrates epithelial-to-mesenchymal transition (EMT), the results were benchmarked to loss of ... Read more >>

Hum Pathol (Human pathology)
[2020, 104:42-53]

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Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience.

Inne J den Toom, Koos Boeve, Daphne Lobeek, Elisabeth Bloemena, Maarten L Donswijk, Bart de Keizer, W Martin C Klop, C René Leemans, Stefan M Willems, Robert P Takes, Max J H Witjes, Remco de Bree,

BACKGROUND:Sentinel lymph node biopsy (SLNB) has been introduced as a diagnostic staging modality for detection of occult metastases in patients with early stage oral cancer. Comparisons regarding accuracy to the routinely used elective neck dissection (END) are lacking in literature. METHODS:A retrospective, multicenter cohort study included 390 patients staged by ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(7):]

Cited: 1 time

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Assessment of tumour depth in early tongue cancer: Accuracy of MRI and intraoral ultrasound.

Rob Noorlag, Thomas J W Klein Nulent, Valerie E J Delwel, Frank A Pameijer, Stefan M Willems, Remco de Bree, Robert J J van Es,

<h4>Objectives</h4>Complete resection of tongue cancer is necessary to achieve local control. Unfortunately, deep resection margins are frequently inadequate. To improve deep margin control, accurate knowledge of tumour thickness is pivotal. Magnetic resonance imaging (MRI) and intraoral ultrasound (ioUS) are frequently applied for tumour staging. This study explores the accuracy of ... Read more >>

Oral Oncol (Oral oncology)
[2020, 110:104895]

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Prostate-specific membrane antigen (PSMA) expression in adenoid cystic carcinoma of the head and neck.

Thomas J W Klein Nulent, Matthijs H Valstar, Laura A Smit, Ludwig E Smeele, Nicolaas P A Zuithoff, Bart de Keizer, Remco de Bree, Robert J J van Es, Stefan M Willems,

<h4>Background</h4>Treatment options for advanced head and neck adenoid cystic carcinoma (AdCC) are limited. Prostate-Specific Membrane Antigen (PSMA), a transmembrane protein that is known for its use in diagnostics and targeted therapy in prostate cancer, is also expressed by AdCC. This study aimed to analyse PSMA expression in a large cohort ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):519]

Cited: 1 time

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Fewer cancer diagnoses during the COVID-19 epidemic in the Netherlands.

Avinash G Dinmohamed, Otto Visser, Rob H A Verhoeven, Marieke W J Louwman, Francien H van Nederveen, Stefan M Willems, Matthias A W Merkx, Valery E P P Lemmens, Iris D Nagtegaal, Sabine Siesling,

Lancet Oncol (The Lancet. Oncology)
[2020, 21(6):750-751]

Cited: 54 times

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Epithelial-to-mesenchymal transition is a prognostic marker for patient outcome in advanced stage HNSCC patients treated with chemoradiotherapy.

Martijn van der Heijden, Paul B M Essers, Caroline V M Verhagen, Stefan M Willems, Joyce Sanders, Reinout H de Roest, David M Vossen, C René Leemans, Marcel Verheij, Ruud H Brakenhoff, Michiel W M van den Brekel, Conchita Vens,

<h4>Background</h4>The prognosis of patients with HPV-negative advanced stage head and neck squamous cell carcinoma (HNSCC) remains poor. No prognostic markers other than TNM staging are routinely used in clinic. Epithelial-to-mesenchymal transition (EMT) has been shown to be a strong prognostic factor in other cancer types. The purpose of this study ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2020, 147:186-194]

Cited: 3 times

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The prognostic role of NK cells and their ligands in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis.

Sangeeta K Bisheshar, Emma J De Ruiter, Lot A Devriese, Stefan M Willems,

<b><i>Background</i></b> : Despite the improvement in therapeutic interventions, 5-year survival rates in Head and Neck Squamous Cell Carcinoma (HNSCC) are limited. HNSCC is an immunogenic cancer type for which molecular stratification markers are lacking. Tumor-infiltrating lymphocytes (TILs) have shown a favorable prognostic role in different cancer types. This study focused ... Read more >>

Oncoimmunology (Oncoimmunology)
[2020, 9(1):1747345]

Cited: 2 times

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Developing Classifications of Laryngeal Dysplasia: The Historical Basis.

Henrik Hellquist, Alfio Ferlito, Antti A Mäkitie, Lester D R Thompson, Justin A Bishop, Abbas Agaimy, Juan C Hernandez-Prera, Douglas R Gnepp, Stefan M Willems, Pieter J Slootweg, Alessandra Rinaldo,

During the last 60 years numerous significant attempts have been made to achieve a widely acceptable terminology and histological grading for laryngeal squamous intraepithelial lesions. While dysplasia was included in the pathology of the uterine cervix already in 1953, the term dysplasia was accepted in laryngeal pathology first after the Toronto ... Read more >>

Adv Ther (Advances in therapy)
[2020, 37(6):2667-2677]

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Comparability of PD-L1 immunohistochemistry assays for non-small-cell lung cancer: a systematic review.

Bregje M Koomen, Sushil K Badrising, Michel M van den Heuvel, Stefan M Willems,

Programmed cell death ligand 1 (PD-L1) immunohistochemistry is used to determine which patients with advanced non-small-cell lung cancer (NSCLC) respond best to treatment with PD-L1 inhibitors. For each inhibitor, a unique immunohistochemical assay was developed. This systematic review gives an up-to-date insight into the comparability of standardised immunohistochemical assays and ... Read more >>

Histopathology (Histopathology)
[2020, 76(6):793-802]

Cited: 6 times

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Digital pathology-aided assessment of tumor-infiltrating T lymphocytes in advanced stage, HPV-negative head and neck tumors.

Emma J de Ruiter, Reinout H de Roest, Ruud H Brakenhoff, C René Leemans, Remco de Bree, Chris H J Terhaard, Stefan M Willems,

AIM:This study aimed to evaluate the presence and prognostic value of tumor-infiltrating T cells in the tumor epithelium in advanced stage, HPV-negative head and neck squamous cell carcinoma (HNSCC) patients treated with primary chemoradiotherapy using digital pathology. METHODS:Pre-treatment biopsies from 80 oropharyngeal, 52 hypopharyngeal, and 29 laryngeal cancer patients were ... Read more >>

Cancer Immunol Immunother (Cancer immunology, immunotherapy : CII)
[2020, 69(4):581-591]

Cited: 1 time

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High CXCR4 expression in adenoid cystic carcinoma of the head and neck is associated with increased risk of locoregional recurrence.

Thomas J W Klein Nulent, Robert J J van Es, Matthijs H Valstar, Ludwig E Smeele, Laura A Smit, Raquel Klein Gunnewiek, Nicolaas P A Zuithoff, Bart de Keizer, Remco de Bree, Stefan M Willems,

AIM:Treatment options for head and neck adenoid cystic carcinoma (AdCC) are limited in advanced disease. Chemokine receptor type 4 (CXCR4) is present in various tumour types, including AdCC. Upregulation is associated with tumour recurrence and metastasis. New CXCR4-specific diagnostic and therapeutic target agents have recently been available. This study aimed ... Read more >>

J Clin Pathol (Journal of clinical pathology)
[2020, 73(8):476-482]

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Presence of Human Papillomavirus and Epstein-Barr Virus, but Absence of Merkel Cell Polyomavirus, in Head and Neck Cancer of Non-Smokers and Non-Drinkers.

Frans J Mulder, Faisal Klufah, Famke M E Janssen, Farzaneh Farshadpour, Stefan M Willems, Remco de Bree, Axel Zur Hausen, Mari F C M van den Hout, Bernd Kremer, Ernst-Jan M Speel,

<h4>Objective</h4>Determine the presence and prognostic value of human papillomavirus (HPV), Epstein-Barr virus (EBV), Merkel cell polyomavirus (MCPyV), and cell cycle proteins in head and neck squamous cell carcinoma (HNSCC) of non-smokers and non-drinkers (NSND).<h4>Methods</h4>Clinical characteristics and tumors of 119 NSND with HNSCC were retrospectively collected and analyzed on tissue microarrays. ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:560434]

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MET ectodomain shedding is associated with poor disease-free survival of patients diagnosed with oral squamous cell carcinoma.

Maria J De Herdt, Senada Koljenović, Berdine van der Steen, Stefan M Willems, Rob Noorlag, Daan Nieboer, Jose A Hardillo, Aaron M Gruver, Wei Zeng, Ling Liu, Robert J Baatenburg de Jong, Leendert H Looijenga,

Ectodomain shedding unleashes the aggressive nature of the MET oncogene product. Using specific C- and N-terminal MET antibodies (D1C2 and A2H2-3), MET protein status (i.e., no MET, decoy MET, transmembranous C-terminal MET with or without the ectodomain) was investigated in oral squamous cell carcinoma. For the cancers showing transmembranous C-terminal ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(6):1015-1032]

Cited: 0 times

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Update on Neuroendocrine Carcinomas of the Larynx.

Carolina Strosberg, Alfio Ferlito, Asterios Triantafyllou, Douglas R Gnepp, Justin A Bishop, Henrik Hellquist, Primoz Strojan, Stefan M Willems, Göran Stenman, Alessandra Rinaldo, Juan C Hernandez-Prera,

<h4>Objectives</h4>Laryngeal neuroendocrine carcinomas are heterogeneous neoplasms characterized by neuroendocrine differentiation. Their prognoses are dependent on tumor type, therefore different classifications have been developed. Moreover, other tumors have overlapping pathologic features posing a range of diagnostic possibilities.<h4>Methods</h4>A review of the literature was performed to comprehensively understand the classification and diagnosis of ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2019, 152(6):686-700]

Cited: 1 time

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