Full Text Journal Articles by
Author Stefan Beissert

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Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma.

Greta Del Mistro, Shamala Riemann, Sebastian Schindler, Stefan Beissert, Roland E Kontermann, Aurelien Ginolhac, Rashi Halder, Luana Presta, Lasse Sinkkonen, Thomas Sauter, Dagmar Kulms,

Despite remarkable advances in therapeutic interventions, malignant melanoma (MM) remains a life-threating disease. Following high initial response rates to targeted kinase-inhibition metastases quickly acquire resistance and present with enhanced tumor progression and invasion, demanding alternative treatment options. We show 2<sup>nd</sup> generation hexameric TRAIL-receptor-agonist IZI1551 (IZI) to effectively induce apoptosis in ... Read more >>

Cell Death Dis (Cell death & disease)
[2022, 13(1):54]

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Evaluation of psychological well-being and social impact of atrophic acne scarring: A multinational, mixed-methods study.

Jerry Tan, Stefan Beissert, Fran Cook-Bolden, Rajeev Chavda, Julie Harper, Adelaide Hebert, Edward Lain, Alison Layton, Marco Rocha, Jonathan Weiss, Brigitte Dréno,

<h4>Background</h4>Most people with acne are at risk of developing acne scars, but the impact of these scars on patients' quality of life is poorly researched.<h4>Objective</h4>To assess the perspective of patients with acne scars and the impact of these scars on their emotional well-being and social functioning.<h4>Methods</h4>A 60-minute interview of 30 ... Read more >>

JAAD Int (JAAD international)
[2022, 6:43-50]

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Intraoperative Anaphylaxie auf Atracurium.

Ilka Bruhn, Andrea Bauer, Stefan Beissert, Volker Neumeister, Petra Spornraft-Ragaller,

J Dtsch Dermatol Ges (Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG)
[2021, 19(12):1784-1786]

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Intraoperative anaphylaxis to atracurium.

Ilka Bruhn, Andrea Bauer, Stefan Beissert, Volker Neumeister, Petra Spornraft-Ragaller,

J Dtsch Dermatol Ges (Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG)
[2021, 19(12):1784-1785]

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Molecular mechanisms of vasculopathy and coagulopathy in COVID-19.

Suzan Al-Gburi, Stefan Beissert, Claudia Günther,

COVID-19 primarily affects the respiratory system and may lead to severe systemic complications, such as acute respiratory distress syndrome (ARDS), multiple organ failure, cytokine storm, and thromboembolic events. Depending on the immune status of the affected individual early disease control can be reached by a robust type-I-interferon (type-I-IFN) response restricting viral ... Read more >>

Biol Chem (Biological chemistry)
[2021, 402(12):1505-1518]

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The Personalised Acne Care Pathway-Recommendations to guide longitudinal management from the Personalising Acne: Consensus of Experts.

Jerry Tan, Andrew Alexis, Hilary Baldwin, Stefan Beissert, Vincenzo Bettoli, James Del Rosso, Brigitte Dréno, Linda Stein Gold, Julie Harper, Charles Lynde, Diane Thiboutot, Jonathan Weiss, Alison M Layton,

<h4>Background</h4>Acne is a chronic disease with a varying presentation that requires long-term management. Despite this, the clinical guidelines for acne offer limited guidance to facilitate personalized or longitudinal management of patients.<h4>Objectives</h4>To generate recommendations to support comprehensive, personalized, long-term patient management that address all presentations of acne and its current and ... Read more >>

JAAD Int (JAAD international)
[2021, 5:101-111]

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Dokumentation der Psoriasis in der Routineversorgung - Expertenkonsens zu einem deutschen Datensatz.

Marina Otten, Ulrich Mrowietz, Ralph Michael von Kiedrowski, Ramona Otto, Andreas Altenburg, Roland Aschoff, Stefan Beissert, Ulrike Beiteke, Bernd Bonnekoh, Matthias Hoffmann, Andreas Körber, Dirk Maaßen, Rotraut Mössner, Alexander Navarini, Holger Petering, Jutta Ramaker-Brunke, Thomas Rosenbach, Uwe Schwichtenberg, Michael Sticherling, Wiebke Sondermann, Diamant Thaci, Andreas Timmel, Athanasios Tsianakas, Thomas Werfel, Dagmar Wilsmann-Theis, Matthias Augustin,

J Dtsch Dermatol Ges (Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG)
[2021, 19(10):1463-1477]

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Documentation of psoriasis in routine care - expert consensus on a German data set.

Marina Otten, Ulrich Mrowietz, Ralph Michael von Kiedrowski, Ramona Otto, Andreas Altenburg, Roland Aschoff, Stefan Beissert, Ulrike Beiteke, Bernd Bonnekoh, Matthias Hoffmann, Andreas Körber, Dirk Maaßen, Rotraut Mössner, Alexander Navarini, Holger Petering, Jutta Ramaker-Brunke, Thomas Rosenbach, Uwe Schwichtenberg, Michael Sticherling, Wiebke Sondermann, Diamant Thaci, Andreas Timmel, Athanasios Tsianakas, Thomas Werfel, Dagmar Wilsmann-Theis, Matthias Augustin,

<h4>Background and objectives</h4>Documenting patient data in psoriasis clinical practice can improve care, but standardized and transparent documentation is rare. The current project aimed to develop a data set for the documentation of psoriasis in daily practice.<h4>Material and methods</h4>In four online Delphi rounds and one in-person meeting, 27 psoriasis experts allocated ... Read more >>

J Dtsch Dermatol Ges (Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG)
[2021, 19(10):1463-1475]

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Annular erythematous plaques as manifestation of vasculitis in pediatric Sjogren's Syndrome.

Linda M Appelt, Fabian Lander, Stefan Beissert, Claudia Günther,

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2021, :]

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Impact of Facial Atrophic Acne Scars on Quality of Life: A Multi-country Population-Based Survey.

Jerry Tan, Stefan Beissert, Fran Cook-Bolden, Rajeev Chavda, Julie Harper, Adelaide Hebert, Edward Lain, Alison Layton, Marco Rocha, Jonathan Weiss, Brigitte Dréno,

<h4>Background</h4>Acne affects more than 80% of adolescents and young adults, who most often develop acne scars. Supporting data on the effect of acne scars on patient's health-related quality of life (HRQOL) are limited.<h4>Objective</h4>The aim was to determine how the severity of acne scars impacts the HRQOL of afflicted individuals.<h4>Methods</h4>In this ... Read more >>

Am J Clin Dermatol (American journal of clinical dermatology)
[2021, :]

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Identifying gaps and providing recommendations to address shortcomings in the investigation of acne sequelae by the Personalising Acne: Consensus of Experts panel.

Alison Layton, Andrew Alexis, Hilary Baldwin, Stefan Beissert, Vincenzo Bettoli, James Del Rosso, Brigitte Dréno, Linda Stein Gold, Julie Harper, Charles Lynde, Diane Thiboutot, Jonathan Weiss, Jerry Tan,

<h4>Background</h4>The physical sequelae of acne include erythema, hyperpigmentation, and scarring, which are highly burdensome for patients. Early, effective treatment can potentially limit and prevent sequelae development, but there is a need for guidance for and evidence of prevention-oriented management to improve patient outcomes.<h4>Objective</h4>To identify unmet needs of acne sequelae and ... Read more >>

JAAD Int (JAAD international)
[2021, 5:41-48]

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Gaps and recommendations for clinical management of truncal acne from the Personalising Acne: Consensus of Experts panel.

Jerry Tan, Andrew Alexis, Hilary Baldwin, Stefan Beissert, Vincenzo Bettoli, James Del Rosso, Brigitte Dréno, Linda Stein Gold, Julie Harper, Charles Lynde, Diane Thiboutot, Jonathan Weiss, Alison M Layton,

<h4>Background</h4>Truncal acne is common and burdensome for patients; however, there is paucity of evidence and guidance for the management of truncal acne. Currently, clinical practice guidelines provide very little guidance on the assessment or management of truncal acne.<h4>Objectives</h4>To identify unmet needs in truncal acne and make recommendations to address clinical ... Read more >>

JAAD Int (JAAD international)
[2021, 5:33-40]

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Rituximab versus Mycophenolate Mofetil in Patients with Pemphigus Vulgaris.

Victoria P Werth, Pascal Joly, Daniel Mimouni, Emanual Maverakis, Frédéric Caux, Patricia Lehane, Liudmila Gearhart, Audrey Kapre, Pooneh Pordeli, Diana M Chen, ,

<h4>Background</h4>Rituximab and mycophenolate mofetil are used to treat pemphigus vulgaris, but they have not been adequately compared in clinical trials.<h4>Methods</h4>In a randomized, controlled trial, we assigned patients with moderate-to-severe pemphigus vulgaris in a 1:1 ratio to receive intravenous rituximab (1000 mg on days 1, 15, 168, and 182) or oral ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(24):2295-2305]

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Impact of facial and truncal acne on quality of life: A multi-country population-based survey.

Jerry Tan, Stefan Beissert, Fran Cook-Bolden, Rajeev Chavda, Julie Harper, Adelaide Hebert, Edward Lain, Alison Layton, Marco Rocha, Jonathan Weiss, Brigitte Dréno,

<h4>Background</h4>Acne confers an increased risk of physical, psychiatric, and psychosocial sequelae, potentially affecting multiple dimensions of health-related quality of life (HRQoL). Morbidity associated with truncal acne is poorly understood.<h4>Objective</h4>To determine how severity and location of acne lesions impact the HRQoL of those who suffer from it.<h4>Methods</h4>A total of 694 subjects ... Read more >>

JAAD Int (JAAD international)
[2021, 3:102-110]

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Systemic Therapy of Metastatic Melanoma: On the Road to Cure.

Julian Steininger, Frank Friedrich Gellrich, Alexander Schulz, Dana Westphal, Stefan Beissert, Friedegund Meier,

This decade has brought significant survival improvement in patients with metastatic melanoma with targeted therapies and immunotherapies. As our understanding of the mechanisms of action of these therapeutics evolves, even more impressive therapeutic success is being achieved through various combination strategies, including combinations of different immunotherapies as well as with ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(6):]

Cited: 8 times

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Low Threshold for Cutaneous Allergen Sensitization but No Spontaneous Dermatitis or Atopy in FLG-Deficient Mice.

Lina Muhandes, Maria Chapsa, Martin Pippel, Rayk Behrendt, Yan Ge, Andreas Dahl, Buqing Yi, Alexander Dalpke, Sylke Winkler, Michael Hiller, Sebastien Boutin, Stefan Beissert, Rolf Jessberger, Padraic G Fallon, Axel Roers,

Loss of FLG causes ichthyosis vulgaris. Reduced FLG expression compromises epidermal barrier function and is associated with atopic dermatitis, allergy, and asthma. The flaky tail mouse harbors two mutations that affect the skin barrier, Flg<sup>ft</sup>, resulting in hypomorphic FLG expression, and Tmem79<sup>ma</sup>, inactivating TMEM79. Mice defective only for TMEM79 featured ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2021, 141(11):2611-2619.e2]

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Systemic Therapy of Metastatic Melanoma: On the Road to Cure

Julian Steininger, Frank Friedrich Gellrich, Alexander Schulz, Dana Westphal, Stefan Beissert, Friedegund Meier,

<h4>Simple Summary</h4> Malignant melanoma is more dangerous than most other skin cancers due to its ability to spread early and aggressively. Until the development of new therapeutic strategies, the median survival of patients with metastatic melanoma was just a few months. Immunotherapy, the first regimen, leading to significant improvement, blocks ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(6):]

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Wiederherstellung der Sehkraft durch Osteo-Odonto-Keratoprothese nach Erblindung bei okulärem Schleimhautpemphigoid.

Anne Sophie Kochan, Konrad Hille, Beate Zahnert, Stefanie Heyne, Stefan Beissert, Claudia Günther,

J Dtsch Dermatol Ges (Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG)
[2021, 19(1):129-132]

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Type I Interferon Signature in Chilblain-Like Lesions Associated with the COVID-19 Pandemic.

Roland Aschoff, Nick Zimmermann, Stefan Beissert, Claudia Günther,

Contemporarily to the new SARS-CoV-2 mediated COVID-19 pandemic, a rise in patients with acral chilblain lesions has been described. They manifest late after mild disease or asymptomatic exposure to SARS-CoV-2. Their pathogenic evolution is currently unknown. In biopsies from three patients with acral partially ulcerating chilblain lesions that occurred associated ... Read more >>

Dermatopathology (Basel) (Dermatopathology (Basel, Switzerland))
[2020, 7(3):57-63]

Cited: 9 times

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Similar efficacy, safety, and immunogenicity of the biosimilar BI 695501 and adalimumab reference product in patients with moderate-to-severe chronic plaque psoriasis: results from the randomized Phase III VOLTAIRE-PSO study.

Alan Menter, Petr Arenberger, Sigrid Balser, Stefan Beissert, Ashley Cauthen, Niklas Czeloth, Jennifer Soung, Sasha Jazayeri, Peter Weisenseel, Girish Jayadeva,

<b>Background</b>: BI 695501 is an approved biosimilar to Humira® reference product (RP). <b>Research design and methods</b>: In this randomized Phase III trial (VOLTAIRE-PSO), patients with moderate-to-severe chronic plaque psoriasis received BI 695501 or adalimumab RP (24-week treatment). Primary efficacy endpoint: the proportion of patients with ≥75% reduction in Psoriasis Area ... Read more >>

Expert Opin Biol Ther (Expert opinion on biological therapy)
[2021, 21(1):87-96]

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Osteo-odonto-keratoprosthesis restores vision in ocular mucous membrane pemphigoid.

Anne Sophie Kochan, Konrad Hille, Beate Zahnert, Stefanie Heyne, Stefan Beissert, Claudia Günther,

J Dtsch Dermatol Ges (Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG)
[2021, 19(1):129-132]

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Filaggrin deficient mice have a lower threshold for cutaneous allergen sensitization but do not develop spontaneous skin inflammation or atopy

Lina Muhandes, Martin Pippel, Maria Chapsa, Rayk Behrendt, Yan Ge, Andreas Dahl, Buqing Yi, Alexander Dalpke, Sylke Winkler, Michael Hiller, Stefan Beissert, Rolf Jessberger, Padraic Fallon, Axel Roers,

Defects of filaggrin (FLG) compromise epidermal barrier function and represent an important known genetic risk factor for atopic dermatitis (AD), but also for systemic atopy, including allergic sensitization and asthma. The flaky tail mouse model, widely used to address mechanisms of atopy induction by barrier-defective skin, harbors two mutations that ... Read more >>

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Occupational allergy to phytase: case series of eight production workers exposed to animal feed additives.

Marvin Kuske, Katja Berndt, Petra Spornraft-Ragaller, Volker Neumeister, Monika Raulf, Ingrid Sander, Dirk Koschel, Jakob Bickhardt, Stefan Beissert, Andrea Bauer,

<h4>Background</h4>In agricultural meat production, adding enzymes such as phytase to animal feed is widespread, but there is little awareness of the allergenic potential and health risks of these fungal enzymes.<h4>Patients and methods</h4>We report on eight patients working in a plant producing phytase granulates. All patients complained about work-related rhinitis occurring ... Read more >>

J Dtsch Dermatol Ges (Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG)
[2020, 18(8):859-865]

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Systemische Immunsuppression in Zeiten von COVID‐19: Müssen wir umdenken?

Stephan Grabbe, Stefan Beissert, Alexander Enk,

J Dtsch Dermatol Ges (Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG)
[2020, 18(8):810-814]

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Systemic immunosuppression in times of COVID-19: Do we need to rethink our standards?

Stephan Grabbe, Stefan Beissert, Alexander Enk,

The current SARS-CoV-2 pandemic particularly endangers older people with pre-existing cardiopulmonary and metabolic conditions. However, it is also currently under discussion whether patients under immunosuppressive therapy also have a higher risk of suffering a severe course of the COVID-19 disease. In principle though, there is currently no data available for ... Read more >>

J Dtsch Dermatol Ges (Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG)
[2020, 18(8):810-813]

Cited: 3 times

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