Full Text Journal Articles by
Author Stefan Agewall

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Antithrombotic Therapy and Major Adverse Limb Events in Patients With Chronic Lower Extremity Arterial Disease: Systematic Review and Meta-analysis from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy in Collaboration with the European Society of Cardiology Working Group on Aorta & Peripheral Vascular Diseases.

Gianluigi Savarese, Martin F Reiner, Alicia Uijl, Domenico D Amario, Stefan Agewall, Dan Atar, Iris Baumgartner, Claudio Borghi, Marco De Carlo, Heinz Drexel, Juan Carlos Kaski, Keld P Kjeldsen, Nils Kucher, Lars H Lund, Alexander Niessner, Anne Grete Semb, Thomas A Schmidt, Patrick Sulzgruber, Juan Tamargo, Cristiana Vitale, Sven Wassmann, Victor Aboyans, Basil S Lewis,

INTRODUCTION:The role and selection of antithrombotic therapy to improve limb outcomes in chronic lower extremity artery disease (LEAD) is still debated. We conducted a meta-analysis to examine the efficacy and safety of anti-thrombotic and more intense antithrombotic therapy on limb outcomes and limb salvage in patients with chronic LEAD. METHODS:Study ... Read more >>

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2019, :]

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Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study.

Ingrid Hokstad, Gia Deyab, Morten Wang Fagerland, Torstein Lyberg, Gunnbjørg Hjeltnes, Øystein Førre, Stefan Agewall, Tom Eirik Mollnes, Ivana Hollan,

BACKGROUND:The complement system is involved in pathogenesis of cardiovascular disease, and might play a role in accelerated atherogenesis in spondylarthropathies (SpA). Hence, we examined complement activation in SpA, and its relationship to antirheumatic treatment, inflammatory and cardiovascular markers. METHODS:From PSARA, a prospective observational study, we examined 51 SpA patients (31 ... Read more >>

PLoS ONE (PloS one)
[2019, 14(7):e0220079]

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Lipid management in rheumatoid arthritis: a position paper by the Cardiovascular Pharmacotherapy Working Group of European Society of Cardiology.

Ivana Hollan, Nicoletta Ronda, Patrick Dessein, Stefan Agewall, George Karpouzas, Juan Tamargo, Alexander Niessner, Gianluigi Savarese, Giuseppe Rosano, Juan Carlos Kaski, Sven Wassmann, Pier Luigi Meroni,

Rheumatoid arthritis (RA) is associated with increased cardiovascular morbidity, partly due to alterations in lipoprotein quantity, quality and cell cholesterol trafficking. Although cardiovascular disease significantly contributes to mortality excess in RA, cardiovascular prevention has been largely insufficient. Because of limited evidence, optimal strategies for lipid management (LM) in RA have ... Read more >>

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2019, :]

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The age of RCT`s 3 Important Aspects of RCT`s in Cardiovascular Pharmacotherapy with examples from Lipid and Diabetes Trials.

Heinz Drexel, Giuseppe M C Rosano, Basil S Lewis, Kurt Huber, Alexander Vonbank, Jörn F Dopheide, Arthur Mader, Alexander Niessner, Gianluigi Savarese, Sven Wassmann, Stefan Agewall,

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2019, :]

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Oral anticoagulation in patients with non-valvular atrial fibrillation and a CHA2DS2-VASc score of 1: a current opinion of the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy and European Society of Cardiology Council on Stroke.

Patrick Sulzgruber, Sven Wassmann, Anne Grete Semb, Wolfram Doehner, Petr Widimsky, Thomas Gremmel, Juan Carlos Kaski, Gianluigi Savarese, Giuseppe M C Rosano, Claudio Borghi, Keld Kjeldsen, Christian Torp-Pedersen, Thomas Andersen Schmidt, Basil S Lewis, Heinz Drexel, Juan Tamargo, Dan Atar, Stefan Agewall, Alexander Niessner,

Oral anticoagulation in patients presenting with non-valvular atrial fibrillation and a CHA2DS2-VASc score of 1 (CHA2DS2-VASc of 2 in women) remains a challenging approach in clinical practice. Therapeutic decisions need to balance the individual benefit of reducing thromboembolic risk against the potential harm due to an increase in bleeding risk ... Read more >>

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2019, 5(3):171-180]

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Antiplatelet treatment in acute coronary syndrome. Still an issue.

Stefan Agewall,

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2019, 5(3):125-126]

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Medical misinformation: vet the message!

Joseph A Hill, ,

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2019, 55(1):1-3]

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Left ventricular ejection fraction and adjudicated, cause-specific hospitalizations after myocardial infarction complicated by heart failure or left ventricular dysfunction.

Trygve S Hall, Thomas G von Lueder, Faiez Zannad, Patrick Rossignol, Kevin Duarte, Tahar Chouihed, Scott D Solomon, Kenneth Dickstein, Dan Atar, Stefan Agewall, Nicolas Girerd, ,

BACKGROUND:Reduced left ventricular ejection fraction (LVEF) after acute myocardial infarction (MI) increases risk of cardiovascular (CV) hospitalizations, but evidence regarding its association with non-CV outcome is scarce. We investigated the association between LVEF and adjudicated cause-specific hospitalizations following MI complicated with low LVEF or overt heart failure (HF). METHODS:In an ... Read more >>

Am. Heart J. (American heart journal)
[2019, 215:83-90]

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All-Cause Mortality and Cardiovascular Outcomes With Non-Vitamin K Oral Anticoagulants Versus Warfarin in Patients With Heart Failure in the Food and Drug Administration Adverse Event Reporting System.

Thomas G von Lueder, Dan Atar, Stefan Agewall, Jesper K Jensen, Ingrid Hopper, Dipak Kotecha, Robert J Mentz, Moo Hyun Kim, Victor L Serebruany,

BACKGROUND:Many patients with heart failure (HF) are treated with warfarin or non-vitamin K oral anticoagulants (NOACs). Randomized outcome-driven comparisons of different anticoagulant strategies in HF are lacking. Data from international, government-mandated registries may be useful in understanding the real-life use of various anticoagulants and how they are linked to outcomes. ... Read more >>

Am J Ther (American journal of therapeutics)
[2019, :]

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Increased Inflammatory Activity in Patients 3 Months after Myocardial Infarction with Nonobstructive Coronary Arteries.

Marcus Hjort, Kai M Eggers, Lars Lindhagen, Stefan Agewall, Elin B Brolin, Olov Collste, Maria Daniel, Christina Ekenbäck, Mats Frick, Loghman Henareh, Claes Hofman-Bang, Karin Malmqvist, Jonas Spaak, Peder Sörensson, Shams Y-Hassan, Per Tornvall, Bertil Lindahl,

BACKGROUND:Around 5%-10% of patients with myocardial infarction (MI) present with nonobstructive coronary arteries (MINOCA). We aimed to assess pathophysiological mechanisms in MINOCA by extensively evaluating cardiovascular biomarkers in the stable phase after an event, comparing MINOCA patients with cardiovascular healthy controls and MI patients with obstructive coronary artery disease (MI-CAD). ... Read more >>

Clin. Chem. (Clinical chemistry)
[2019, 65(8):1023-1030]

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European Heart Journal - Cardiovascular Pharmacotherapy: now accepted for an official Impact Factor.

Stefan Agewall,

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2019, 5(2):59]

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ST-segment elevation and cardiac magnetic resonance imaging findings in myocardial infarction with non-obstructive coronary arteries.

Anais Hausvater, Sivabaskari Pasupathy, Per Tornvall, Himali Gandhi, Rosanna Tavella, John Beltrame, Stefan Agewall, Christina Ekenbäck, Elin Bacsovics Brolin, Judith S Hochman, Olov Collste, Harmony R Reynolds,

PURPOSE:Patients with myocardial infarction and non-obstructive coronary arteries (MINOCA) may present with or without ST-elevation (STE) on the electrocardiogram (ECG). Previous studies have shown that STE was associated with higher risk of early mortality and long-term major adverse coronary events, and that cardiac magnetic resonance imaging (CMR) can help to ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2019, 287:128-131]

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Ivabradine for heart failure: regulatory differences in Europe and United States.

Thomas A Marciniak, Trygve S Hall, Dan Atar, Stefan Agewall, Victor L Serebruany,

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2019, 5(2):119-121]

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Contemporary Diagnosis and Management of Patients With Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease: A Scientific Statement From the American Heart Association.

Jacqueline E Tamis-Holland, Hani Jneid, Harmony R Reynolds, Stefan Agewall, Emmanouil S Brilakis, Todd M Brown, Amir Lerman, Mary Cushman, Dharam J Kumbhani, Cynthia Arslanian-Engoren, Ann F Bolger, John F Beltrame, ,

Myocardial infarction in the absence of obstructive coronary artery disease is found in ≈5% to 6% of all patients with acute infarction who are referred for coronary angiography. There are a variety of causes that can result in this clinical condition. As such, it is important that patients are appropriately ... Read more >>

Circulation (Circulation)
[2019, 139(18):e891-e908]

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Unsolved issues in oral anticoagulation treatment in atrial fibrillation.

Stefan Agewall,

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2019, 5(2):60-61]

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Medical misinformation: vet the message!

Joseph A Hill, Stefan Agewall, Adrian Baranchuk, George W Booz, Jeffrey S Borer, Paolo G Camici, Peng-Sheng Chen, Anna F Dominiczak, Çetin Erol, Cindy L Grines, Robert Gropler, Tomasz J Guzik, Markus K Heinemann, Ami E Iskandrian, Bradley P Knight, Barry London, Thomas F Lüscher, Marco Metra, Kiran Musunuru, Brahmajee K Nallamothu, Andrea Natale, Sanjeev Saksena, Michael H Picard, Sunil V Rao, Willem J Remme, Robert S Rosenson, Nancy K Sweitzer, Adam Timmis, Christiaan Vrints,

Eur Heart J Qual Care Clin Outcomes (European heart journal. Quality of care & clinical outcomes)
[2019, 5(2):83-84]

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Medical misinformation: vet the message!

Joseph A Hill, Stefan Agewall, Adrian Baranchuk, George W Booz, Jeffrey S Borer, Paolo G Camici, Peng-Sheng Chen, Anna F Dominiczak, Çetin Erol, Cindy L Grines, Robert Gropler, Tomasz J Guzik, Markus K Heinemann, Ami E Iskandrian, Bradley P Knight, Barry London, Thomas F Lüscher, Marco Metra, Kiran Musunuru, Brahmajee K Nallamothu, Andrea Natale, Sanjeev Saksena, Michael H Picard, Sunil V Rao, Willem J Remme, Robert S Rosenson, Nancy K Sweitzer, Adam Timmis, Christiaan Vrints,

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2019, 5(2):62-63]

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Medical Misinformation.

Joseph A Hill, Stefan Agewall, Adrian Baranchuk, George W Booz, Jeffrey S Borer, Paolo G Camici, Peng-Sheng Chen, Anna F Dominiczak, Çetin Erol, Cindy L Grines, Robert Gropler, Tomasz J Guzik, Markus K Heinemann, Ami E Iskandrian, Bradley P Knight, Barry London, Thomas F Lüscher, Marco Metra, Kiran Musunuru, Brahmajee K Nallamothu, Andrea Natale, Sanjeev Saksena, Michael H Picard, Sunil V Rao, Willem J Remme, Robert S Rosenson, Nancy K Sweitzer, Adam Timmis, Christiaan Vrints,

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2019, 73(3):506-507]

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Pharmacology of new treatments for hyperkalaemia: patiromer and sodium zirconium cyclosilicate.

Giuseppe M C Rosano, Ilaria Spoletini, Stefan Agewall,

Hyperkalaemia is a life-threatening condition, resulting from decreased renal function or dysfunctional homoeostatic mechanisms, often affecting patients with cardiovascular (CV) disease. Drugs such as renin-angiotensin-aldosterone system inhibitors (RAASi) are known to improve outcomes in CV patients but can also cause drug-induced hyperkalaemia. New therapeutic options exist to enhance potassium excretion ... Read more >>

Eur Heart J Suppl (European Heart Journal Supplements : Journal of the European Society of Cardiology)
[2019, 21(Suppl A):A28-A33]

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Epidemiology and long-term outcome in outpatients with chronic heart failure in Northwestern Europe.

Hanna Fröhlich, Niklas Rosenfeld, Tobias Täger, Kevin Goode, Syed Kazmi, Torstein Hole, Hugo A Katus, Dan Atar, John G F Cleland, Stefan Agewall, Andrew L Clark, Lutz Frankenstein, Morten Grundtvig,

OBJECTIVE:To describe the epidemiology, long-term outcomes and temporal trends in mortality in ambulatory patients with chronic heart failure (HF) with reduced (HFrEF), mid-range (HFmrEF) or preserved ejection fraction (HFpEF) from three European countries. METHODS:We identified 10 312 patients from the Norwegian HF Registry and the HF registries of the universities of ... Read more >>

Heart (Heart (British Cardiac Society))
[2019, 105(16):1252-1259]

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Medical Misinformation: Vet the Message!

Joseph A Hill, , Stefan Agewall, Adrian Baranchuk, George W Booz, Jeffrey S Borer, Paolo G Camici, Peng-Sheng Chen, Anna F Dominiczak, Çetin Erol, Cindy L Grines, Robert Gropler, Tomasz J Guzik, Markus K Heinemann, Ami E Iskandrian, Bradley P Knight, Barry London, Thomas F Lüscher, Marco Metra, Kiran Musunuru, Brahmajee K Nallamothu, Andrea Natale, Sanjeev Saksena, Michael H Picard, Sunil V Rao, Willem J Remme, Robert S Rosenson, Nancy K Sweitzer, Adam Timmis, Christiaan Vrints,

Eur. Heart J. (European heart journal)
[2019, 40(5):404-405]

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Medical Misinformation.

Joseph A Hill, Stefan Agewall, Adrian Baranchuk, George W Booz, Jeffrey S Borer, Paolo G Camici, Peng-Sheng Chen, Anna F Dominiczak, Çetin Erol, Cindy L Grines, Robert Gropler, Tomasz J Guzik, Markus K Heinemann, Ami E Iskandrian, Bradley P Knight, Barry London, Thomas F Lüscher, Marco Metra, Kiran Musunuru, Brahmajee K Nallamothu, Andrea Natale, Sanjeev Saksena, Michael H Picard, Sunil V Rao, Willem J Remme, Robert S Rosenson, Nancy K Sweitzer, Adam Timmis, Christiaan Vrints,

Circ Cardiovasc Interv (Circulation. Cardiovascular interventions)
[2019, 12(2):e007796]

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Comparative effectiveness of loop diuretics on mortality in the treatment of patients with chronic heart failure - A multicenter propensity score matched analysis.

Tobias Täger, Hanna Fröhlich, Morten Grundtvig, Mirjam Seiz, Dieter Schellberg, Kevin Goode, Syed Kazmi, Torstein Hole, Hugo A Katus, Dan Atar, John G F Cleland, Stefan Agewall, Andrew L Clark, Lutz Frankenstein,

BACKGROUND:Loop diuretics are given to the majority of patients with chronic heart failure (HF). Whether the different pharmacological properties of the three guideline-recommended loop diuretics result in differential effects on survival is unknown. METHODS:6293 patients with chronic HF using either bumetanide, furosemide or torasemide were identified in three European HF ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2019, 289:83-90]

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EHJ Cardiovascular Pharmacotherapy has Impact Factor.

Stefan Agewall,

Eur. Heart J. (European heart journal)
[2019, 40(7):572]

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Medical Misinformation: Vet the Message!

Joseph A Hill, Stefan Agewall, Adrian Baranchuk, George W Booz, Jeffrey S Borer, Paolo G Camici, Peng-Sheng Chen, Anna F Dominiczak, Çetin Erol, Cindy L Grines, Robert Gropler, Tomasz J Guzik, Markus K Heinemann, Ami E Iskandrian, Bradley P Knight, Barry London, Thomas F Lüscher, Marco Metra, Kiran Musunuru, Brahmajee K Nallamothu, Andrea Natale, Sanjeev Saksena, Michael H Picard, Sunil V Rao, Willem J Remme, Robert S Rosenson, Nancy K Sweitzer, Adam Timmis, Christiaan Vrints,

J. Cardiovasc. Pharmacol. (Journal of cardiovascular pharmacology)
[2019, 73(2):61-62]

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