Full Text Journal Articles by
Author Stacy Gelhaus Wendell


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Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis.

Veli Bakalov, Laura Reyes-Uribe, Rahul Deshpande, Abigail L Maloy, Steven D Shapiro, Derek C Angus, Chung-Chou H Chang, Laurence Le Moyec, Stacy Gelhaus Wendell, Ata Murat Kaynar,

Sepsis is the leading cause of death in hospitalized patients and beyond the hospital stay and these long-term sequelae are due in part to unresolved inflammation. Metabolic shift from oxidative phosphorylation to aerobic glycolysis links metabolism to inflammation and such a shift is commonly observed in sepsis under normoxic conditions. ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0241122]

Cited: 0 times

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Primary saturation of α,β-unsaturated carbonyl containing fatty acids does not abolish electrophilicity

Nathaniel Snyder, Bhupinder Singh, Gregory Buchan, James O’Brien, Alejandro Arroyo, Xiaojing Liu, Robert Sobol, Ian Blair, Clementina Mesaros, Stacy Gelhaus Wendell,

Metabolism of PUFA results in the formation of hydroxylated fatty acids that can be further oxidized by dehydrogenases, often resulting in the formation of electrophilic, α,β-unsaturated ketone containing fatty acids. As electrophiles are associated with redox signaling, we sought to investigate the metabolism of the oxo-fatty acid products in relation ... Read more >>

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G Protein-Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action.

Stacy Gelhaus Wendell, Hao Fan, Cheng Zhang,

Asthma is a heterogeneous inflammatory disease of the airways that is associated with airway hyperresponsiveness and airflow limitation. Although asthma was once simply categorized as atopic or nonatopic, emerging analyses over the last few decades have revealed a variety of asthma endotypes that are attributed to numerous pathophysiological mechanisms. The ... Read more >>

Pharmacol Rev (Pharmacological reviews)
[2020, 72(1):1-49]

Cited: 3 times

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Nitro-fatty acid formation and metabolism.

Gregory J Buchan, Gustavo Bonacci, Marco Fazzari, Sonia R Salvatore, Stacy Gelhaus Wendell,

Nitro-fatty acids (NO<sub>2</sub>-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a considerable amount regarding NO<sub>2</sub>-FA signaling, endogenous formation and metabolism is relatively unexplored. This ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2018, 79:38-44]

Cited: 6 times

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Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.

Ashley V Menk, Nicole E Scharping, Rebecca S Moreci, Xue Zeng, Cliff Guy, Sonia Salvatore, Heekyong Bae, Jianxin Xie, Howard A Young, Stacy Gelhaus Wendell, Greg M Delgoffe,

To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process common to highly proliferative cells in which glucose is fermented into lactate rather than oxidized in mitochondria. However, the signaling events that initiate aerobic glycolysis in T cells remain unclear. We show T cell activation rapidly induces glycolysis independent of transcription, ... Read more >>

Cell Rep (Cell reports)
[2018, 22(6):1509-1521]

Cited: 43 times

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Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

Kara S Hughan, Stacy Gelhaus Wendell, Meghan Delmastro-Greenwood, Nicole Helbling, Catherine Corey, Landon Bellavia, Gopal Potti, George Grimes, Bret Goodpaster, Daniel B Kim-Shapiro, Sruti Shiva, Bruce A Freeman, Mark T Gladwin,

Dietary NO<sub>3</sub><sup>-</sup> (nitrate) and NO<sub>2</sub><sup>-</sup> (nitrite) support ˙NO (nitric oxide) generation and downstream vascular signaling responses. These nitrogen oxides also generate secondary nitrosating and nitrating species that react with low molecular weight thiols, heme centers, proteins, and unsaturated fatty acids. To explore the kinetics of NO<sub>3</sub><sup>-</sup>and NO<sub>2</sub><sup>-</sup>metabolism and the impact ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2017, 70(3):634-644]

Cited: 7 times

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Fatty acids, inflammation, and asthma.

Stacy Gelhaus Wendell, Cindy Baffi, Fernando Holguin,

Fatty acids and consequently diet play an essential role in the formation of inflammatory mediators involved in the pathogenesis of asthma. Because intake variations of omega-6 (n-6) and omega-3 (n-3) fatty acids ultimately determine cell membrane incorporation, changes in diet have the potential to modify downstream production of inflammatory mediators ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2014, 133(5):1255-1264]

Cited: 55 times

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Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids.

Meghan Delmastro-Greenwood, Bruce A Freeman, Stacy Gelhaus Wendell,

Unsaturated fatty acids are metabolized to reactive products that can act as pro- or anti-inflammatory signaling mediators. Electrophilic fatty acid species, including nitro- and oxo-containing fatty acids, display salutary anti-inflammatory and metabolic actions. Electrophilicity can be conferred by both enzymatic and oxidative reactions, via the homolytic addition of nitrogen dioxide ... Read more >>

Annu Rev Physiol (Annual review of physiology)
[2014, 76:79-105]

Cited: 43 times

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