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Author Sravan Girada

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Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function.

Ying Lin, Jacob M Wozniak, Neil J Grimsey, Sravan Girada, Anand Patwardhan, Olivia Molinar-Inglis, Thomas H Smith, John D Lapek, David J Gonzalez, JoAnn Trejo,

Thrombin, a procoagulant protease, cleaves and activates protease-activated receptor-1 (PAR1) to promote inflammatory responses and endothelial dysfunction. In contrast, activated protein C (APC), an anticoagulant protease, activates PAR1 through a distinct cleavage site and promotes anti-inflammatory responses, prosurvival, and endothelial barrier stabilization. The distinct tethered ligands formed through cleavage of ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(9):5039-5048]

Cited: 8 times

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