Full Text Journal Articles by
Author Sourik S Ganguly

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Androgen receptor-induced integrin α6β1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer.

Eric A Nollet, Marina Cardo-Vila, Sourik S Ganguly, Jack D Tran, Veronique V Schulz, Anne Cress, Eva Corey, Cindy K Miranti,

The androgen receptor (AR) is the major driver of prostate cancer growth and survival. However, almost all patients relapse with castration-resistant disease (CRPC) when treated with anti-androgen therapy. In CRPC, AR is often aberrantly activated independent of androgen. Targeting survival pathways downstream of AR could be a viable strategy to ... Read more >>

Oncogene (Oncogene)
[2020, 39(31):5390-5404]

Cited: 0 times

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Notch3 promotes prostate cancer-induced bone lesion development via MMP-3.

Sourik S Ganguly, Galen Hostetter, Lin Tang, Sander B Frank, Kathylynn Saboda, Rohit Mehra, Lisha Wang, Xiaohong Li, Evan T Keller, Cindy K Miranti,

Prostate cancer metastases primarily localize in the bone where they induce a unique osteoblastic response. Elevated Notch activity is associated with high-grade disease and metastasis. To address how Notch affects prostate cancer bone lesions, we manipulated Notch expression in mouse tibia xenografts and monitored tumor growth, lesion phenotype, and the ... Read more >>

Oncogene (Oncogene)
[2020, 39(1):204-218]

Cited: 3 times

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Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82.

Alexis Bergsma, Sourik S Ganguly, Mollie E Wiegand, Daniel Dick, Bart O Williams, Cindy K Miranti,

We used a myeloid-specific Cre to conditionally delete CD82 in mouse osteoclasts and their precursors. In contrast to global loss of CD82 (gKO), conditional loss of CD82 (cKO) in osteoclasts does not affect cortical bone, osteoblasts, or adipocytes. CD82 loss results in greater trabecular volume and trabecular number but reduced ... Read more >>

Bone Rep (Bone reports)
[2019, 10:100196]

Cited: 1 time

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Loss of Myeloid-Specific TGF-β Signaling Decreases CTHRC1 to Downregulate bFGF and the Development of H1993-Induced Osteolytic Bone Lesions.

Sourik S Ganguly, Paul G Daft, Jingchen Cao, Xiangqi Meng, Zhendong A Zhong, Alexandra Vander Ark, Austin Meadows, Zach Madaj, Bart Williams, Xiaohong Li,

The role of myeloid cell-specific TGF-β signaling in non-small-cell lung cancer (NSCLC)-induced osteolytic bone lesion development is unknown. We used a genetically engineered mouse model, Tgfbr2LysMCre knockout (KO), which has a loss of TGF-β signaling specifically in myeloid lineage cells, and we found that the area of H1993 cell-induced osteolytic ... Read more >>

Cancers (Basel) (Cancers)
[2018, 10(12):]

Cited: 2 times

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Global deletion of tetraspanin CD82 attenuates bone growth and enhances bone marrow adipogenesis.

Alexis Bergsma, Sourik S Ganguly, Daniel Dick, Bart O Williams, Cindy K Miranti,

CD82 is a widely expressed member of the tetraspanin family of transmembrane proteins known to control cell signaling, adhesion, and migration. Tetraspanin CD82 is induced over 9-fold during osteoclast differentiation in vitro; however, its role in bone homeostasis is unknown. A globally deleted CD82 mouse model was used to assess ... Read more >>

Bone (Bone)
[2018, 113:105-113]

Cited: 4 times

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The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis.

Sourik S Ganguly, Xiaohong Li, Cindy K Miranti,

Prostate cancer (PCa) is the second leading cause of cancer death in men worldwide. Most PCa deaths are due to osteoblastic bone metastases. What triggers PCa metastasis to the bone and what causes osteoblastic lesions remain unanswered. A major contributor to PCa metastasis is the host microenvironment. Here, we address ... Read more >>

Front Oncol (Frontiers in oncology)
[2014, 4:364]

Cited: 22 times

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c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer.

Leann S Fiore, Sourik S Ganguly, James Sledziona, Michael L Cibull, Chi Wang, Dana L Richards, Janna M Neltner, Carol Beach, Joseph R McCorkle, David M Kaetzel, Rina Plattner,

Metastasis suppressors comprise a growing class of genes whose downregulation triggers metastatic progression. In contrast to tumor suppressors, metastasis suppressors are rarely mutated or deleted, and little is known regarding the mechanisms by which their expression is downregulated. Here, we demonstrate that the metastasis suppressor, NM23-H1, is degraded by lysosomal ... Read more >>

Oncogene (Oncogene)
[2014, 33(36):4508-4520]

Cited: 20 times

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Imatinib reverses doxorubicin resistance by affecting activation of STAT3-dependent NF-κB and HSP27/p38/AKT pathways and by inhibiting ABCB1.

Jonathan T Sims, Sourik S Ganguly, Holly Bennett, J Woodrow Friend, Jessica Tepe, Rina Plattner,

Despite advances in cancer detection and prevention, a diagnosis of metastatic disease remains a death sentence due to the fact that many cancers are either resistant to chemotherapy (conventional or targeted) or develop resistance during treatment, and residual chemoresistant cells are highly metastatic. Metastatic cancer cells resist the effects of ... Read more >>

PLoS One (PloS one)
[2013, 8(1):e55509]

Cited: 48 times

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Activation of abl family kinases in solid tumors.

Sourik S Ganguly, Rina Plattner,

Although c-Abl and Arg non-receptor tyrosine kinases are well known for driving leukemia development, their role in solid tumors has not been appreciated until recently. Accumulating evidence now indicates that c-Abl and/or Arg are activated in some solid tumor cell lines via unique mechanisms that do not involve gene mutation/translocation, ... Read more >>

(Genes & cancer)
[2012, 3(5-6):414-425]

Cited: 23 times

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