Full Text Journal Articles by
Author Sophie Launay


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Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation.

Bela Papp, Sophie Launay, Pascal Gélébart, Atousa Arbabian, Agnes Enyedi, Jean-Philippe Brouland, Edgardo D Carosella, Homa Adle-Biassette,

Endoplasmic reticulum (ER) calcium homeostasis plays an essential role in cellular calcium signaling, intra-ER protein chaperoning and maturation, as well as in the interaction of the ER with other organelles. Calcium is accumulated in the ER by sarco/endoplasmic reticulum calcium ATPases (SERCA enzymes) that generate by active, ATP-dependent transport, a ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(9):]

Cited: 0 times

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Validation of Novaprep(®) HQ+ liquid-based cytology medium for high-risk human papillomavirus detection by hc2.

David Guenat, Sophie Launay, Didier Riethmuller, Christiane Mougin, Jean-Luc Prétet,

Preanalytical conditions determine the reliability and validity of bioassays. Therefore, the analytic performances of biological tests need to be determined when preanalytical steps differ from those recommended by the manufacturer. The objective of the study was to assess the analytic performance of the hc2 test for the detection of high-risk ... Read more >>

Infect. Agents Cancer (Infectious agents and cancer)
[2016, 11:41]

Cited: 1 time

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Efferocytosis of apoptotic human papillomavirus-positive cervical cancer cells by human primary fibroblasts.

François Hermetet, Elise Jacquin, Sophie Launay, Emilie Gaiffe, Mélanie Couturier, Fabienne Hirchaud, Patrick Sandoz, Jean-Luc Prétet, Christiane Mougin,

Efficient clearance of apoptotic cells, named efferocytosis, is a fundamental physiological process for tissue development and homeostasis. The contribution of non-professional phagocytes like fibroblasts to efferocytosis has been established, although the underlying mechanisms are not well understood. We recently demonstrated that horizontal DNA transfer can occur through the uptake of ... Read more >>

Biol. Cell (Biology of the cell)
[2016, 108(7):189-204]

Cited: 11 times

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Apoptotic HPV positive cancer cells exhibit transforming properties.

Emilie Gaiffe, Jean-Luc Prétet, Sophie Launay, Elise Jacquin, Maëlle Saunier, Geneviève Hetzel, Pierre Oudet, Christiane Mougin,

Previous studies have shown that DNA can be transferred from dying engineered cells to neighboring cells through the phagocytosis of apoptotic bodies, which leads to cellular transformation. Here, we provide evidence of an uptake of apoptotic-derived cervical cancer cells by human mesenchymal cells. Interestingly, HeLa (HPV 18+) or Ca Ski ... Read more >>

PLoS ONE (PloS one)
[2012, 7(5):e36766]

Cited: 16 times

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A step further toward glyphosate-induced epidermal cell death: involvement of mitochondrial and oxidative mechanisms.

Celine Heu, Celine Elie-Caille, Virginie Mougey, Sophie Launay, Laurence Nicod,

A deregulation of programmed cell death mechanisms in human epidermis leads to skin pathologies. We previously showed that glyphosate, an extensively used herbicide, provoked cytotoxic effects on cultured human keratinocytes, affecting their antioxidant capacities and impairing morphological and functional cell characteristics. The aim of the present study, carried out on ... Read more >>

Environ. Toxicol. Pharmacol. (Environmental toxicology and pharmacology)
[2012, 34(2):144-153]

Cited: 5 times

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Sodium butyrate with UCN-01 has marked antitumour activity against cervical cancer cells.

Anne-Zélie Decrion-Barthod, Matthieu Bosset, Marie-Laure Plissonnier, Antonio Marchini, Magalie Nicolier, Sophie Launay, Jean-Luc Prétet, Jean Rommelaere, Christiane Mougin,

AIM: The effect of combining sodium butyrate (NaB), a histone deacetylase inhibitor, and 7-hydroxy-staurosporine (UCN-01) on cytotoxicity in human cervical carcinoma cells was evaluated. MATERIALS AND METHODS: HeLa and CaSki cells were treated using NaB alone or in combination with staurosporine (STS) or its analog UCN-01. Cytotoxicity was determined by ... Read more >>

Anticancer Res. (Anticancer research)
[2010, 30(10):4049-4061]

Cited: 4 times

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Spatiotemporal activation of caspase-dependent and -independent pathways in staurosporine-induced apoptosis of p53wt and p53mt human cervical carcinoma cells.

Magali Nicolier, Anne-Zélie Decrion-Barthod, Sophie Launay, Jean-Luc Prétet, Christiane Mougin,

Caspase-dependent and -independent death mechanisms are involved in apoptosis in a variety of human carcinoma cells treated with antineoplastic compounds. Our laboratory has reported that p53 is a key contributor of mitochondrial apoptosis in cervical carcinoma cells after staurosporine exposure. However, higher mitochondrial membrane potential dissipation and greater DNA fragmentation ... Read more >>

Biol. Cell (Biology of the cell)
[2009, 101(8):455-467]

Cited: 20 times

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Vital functions for lethal caspases.

Sophie Launay, Olivier Hermine, Michaëla Fontenay, Guido Kroemer, Eric Solary, Carmen Garrido,

Caspases are a family of cysteine proteases expressed as inactive zymogens in virtually all animal cells. These enzymes play a central role in most cell death pathways leading to apoptosis but growing evidences implicate caspases also in nonapoptotic functions. Several of these enzymes, activated in molecular platforms referred to as ... Read more >>

Oncogene (Oncogene)
[2005, 24(33):5137-5148]

Cited: 116 times

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Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation.

Séverine Cathelin, Cédric Rébé, Lamya Haddaoui, Nicolas Simioni, Frédérique Verdier, Michaëla Fontenay, Sophie Launay, Patrick Mayeux, Eric Solary,

We have shown previously that caspases were specifically involved in the differentiation of peripheral blood monocytes into macrophages while not required for monocyte differentiation into dendritic cells. To identify caspase targets in monocytes undergoing macrophagic differentiation, we used the human monocytic leukemic cell line U937, whose macrophagic differentiation induced by ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2006, 281(26):17779-17788]

Cited: 35 times

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Translocation of the inhibitor of apoptosis protein c-IAP1 from the nucleus to the Golgi in hematopoietic cells undergoing differentiation: a nuclear export signal-mediated event.

Stéphanie Plenchette, Séverine Cathelin, Cédric Rébé, Sophie Launay, Sylvain Ladoire, Olivier Sordet, Tibor Ponnelle, Najet Debili, Thi-Hai Phan, Rose-Ann Padua, Laurence Dubrez-Daloz, Eric Solary,

The caspase inhibitor and RING finger-containing protein cellular inhibitor of apoptosis protein 1 (c-IAP1) has been shown to be involved in both apoptosis inhibition and signaling by members of the tumor necrosis factor (TNF) receptor family. The protein is regulated transcriptionally (eg, is a target for nuclear factor-kappaB [NF-kappaB]) and ... Read more >>

Blood (Blood)
[2004, 104(7):2035-2043]

Cited: 35 times

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Expression of WASP and Scar1/WAVE1 actin-associated proteins is differentially modulated during differentiation of HL-60 cells.

Sophie Launay, Geoffrey Brown, Laura M Machesky,

The Wiskott-Aldrich Syndrome (WAS) is a disease associated with mutations in the WAS gene and characterised by developmental defects in haematopoietic cells such as myeloid cells. The Wiskott-Aldrich Syndrome protein (WASP)-family includes Scar1 and WASP, which are key regulators of actin reorganization in motile cells. To understand the roles of ... Read more >>

Cell Motil. Cytoskeleton (Cell motility and the cytoskeleton)
[2003, 54(4):274-285]

Cited: 15 times

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Bcl-2 proteins: targets and tools for chemosensitisation of tumor cells.

Ali Bettaieb, Laurence Dubrez-Daloz, Sophie Launay, Stéphanie Plenchette, Cédric Rébé, Séverine Cathelin, Eric Solary,

Proteins of the Bcl-2 family share one or several Bcl-2 homology (BH) regions and behave as pro- or anti-apoptotic proteins. Prosurvival members such as Bcl-2 and Bcl-X(L) are supposed to preserve mitochondrial outer membrane integrity, thus preventing the release of soluble apoptogenic molecules. Pro-apoptotic members include BH3-only proteins that act ... Read more >>

Curr Med Chem Anticancer Agents (Current medicinal chemistry. Anti-cancer agents)
[2003, 3(4):307-318]

Cited: 19 times

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Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in scratch wound models.

Juana Magdalena, Thomas H Millard, Sandrine Etienne-Manneville, Sophie Launay, Helen K Warwick, Laura M Machesky,

Cell motility and cell polarity are essential for morphogenesis, immune system function, and tissue repair. Many animal cells move by crawling, and one main driving force for movement is derived from the coordinated assembly and disassembly of actin filaments. As tissue culture cells migrate to close a scratch wound, this ... Read more >>

Mol. Biol. Cell (Molecular biology of the cell)
[2003, 14(2):670-684]

Cited: 37 times

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Enhancement of ATRA-induced cell differentiation by inhibition of calcium accumulation into the endoplasmic reticulum: cross-talk between RAR alpha and calcium-dependent signaling.

Sophie Launay, Maurizio Giannì, Luisa Diomede, Laura M Machesky, Jocelyne Enouf, Béla Papp,

Sarco-endoplasmic reticulum calcium ATPase (SERCA) enzymes control calcium-induced cellular activation by accumulating calcium from the cytosol into the endoplasmic reticulum (ER). To better understand the role of SERCA proteins and cellular calcium homeostasis in all-trans retinoic acid (ATRA)-induced differentiation, we investigated the effect of pharmacologic inhibition of SERCA-dependent calcium uptake ... Read more >>

Blood (Blood)
[2003, 101(8):3220-3228]

Cited: 30 times

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Understanding actin turnover - no longer a mere speckle on the horizon.

Sophie Launay,

Trends Cell Biol. (Trends in cell biology)
[2002, 12(5):212]

Cited: 0 times

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Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5.

Thomas H Millard, Barbara Behrendt, Sophie Launay, Klaus Fütterer, Laura M Machesky,

The Arp2/3 complex is an actin filament nucleator that activates regulated actin assembly in response to extracellular signals. The mammalian complex is composed of seven subunits, the smallest of which is known as ARPC5 or p16-Arc. We have identified a human cDNA sequence with homology to ARPC5 and here provide ... Read more >>

Cell Motil. Cytoskeleton (Cell motility and the cytoskeleton)
[2003, 54(1):81-90]

Cited: 22 times

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