Full Text Journal Articles by
Author Sophie Janssens

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Clarifying the translational potential of B-I09.

Juan R Del Valle, Brian C Betts, Xue-Zhong Yu, Sophie Janssens, Bart N Lambrecht, M Celeste Simon, Chih-Chi Andrew Hu,

Nat Chem Biol (Nature chemical biology)
[2020, 16(11):1152]

Cited: 0 times

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TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization.

Zan Li, Hwanhee Oh, Michelle Cung, Sofia Jenia Marquez, Jun Sun, Hamida Hammad, Sophie Janssens, Philippe Pouliot, Bart N Lambrecht, Yeon-Suk Yang, Jae-Hyuck Shim, Matthew B Greenblatt,

Current anabolic drugs to treat osteoporosis and other disorders of low bone mass all have important limitations in terms of toxicity, contraindications, or poor efficacy in certain contexts. Addressing these limitations will require a better understanding of the molecular pathways, such as the mitogen activated protein kinase (MAPK) pathways, that ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2020, 531(4):497-502]

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Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities.

Arne Martens, Dario Priem, Esther Hoste, Jessica Vetters, Sofie Rennen, Leen Catrysse, Sofie Voet, Laura Deelen, Mozes Sze, Hanna Vikkula, Karolina Slowicka, Tino Hochepied, Kalliopi Iliaki, Andy Wullaert, Sophie Janssens, Mohamed Lamkanfi, Rudi Beyaert, Marietta Armaka, Mathieu J M Bertrand, Geert van Loo,

Protein ubiquitination regulates protein stability and modulates the composition of signaling complexes. A20 is a negative regulator of inflammatory signaling, but the molecular mechanisms involved are ill understood. Here, we generated Tnfaip3 gene-targeted A20 mutant mice bearing inactivating mutations in the zinc finger 7 (ZnF7) and ZnF4 ubiquitin-binding domains, revealing ... Read more >>

Nat Immunol (Nature immunology)
[2020, 21(4):381-387]

Cited: 2 times

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Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury.

Elke Ydens, Lukas Amann, Bob Asselbergh, Charlotte L Scott, Liesbet Martens, Dorine Sichien, Omar Mossad, Thomas Blank, Sofie De Prijck, Donovan Low, Takahiro Masuda, Yvan Saeys, Vincent Timmerman, Ralf Stumm, Florent Ginhoux, Marco Prinz, Sophie Janssens, Martin Guilliams,

While CNS microglia have been extensively studied, relatively little is known about macrophages populating the peripheral nervous system. Here we performed ontogenic, transcriptomic and spatial characterization of sciatic nerve macrophages (snMacs). Using multiple fate-mapping systems, we show that snMacs do not derive from the early embryonic precursors colonizing the CNS, ... Read more >>

Nat Neurosci (Nature neuroscience)
[2020, 23(5):676-689]

Cited: 2 times

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The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF.

Jessica Vetters, Mary J van Helden, Sigrid Wahlen, Simon J Tavernier, Arne Martens, Farzaneh Fayazpour, Karl Vergote, Manon Vanheerswynghels, Kim Deswarte, Justine Van Moorleghem, Sofie De Prijck, Nozomi Takahashi, Peter Vandenabeele, Louis Boon, Geert van Loo, Eric Vivier, Bart N Lambrecht, Sophie Janssens,

The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, A20 protects cells from death in an ill-defined manner. While most studies focus on its role in the TNF-receptor complex, we here identify a novel component in the A20-mediated decision between life and death. ... Read more >>

J. Exp. Med. (The Journal of experimental medicine)
[2019, 216(9):2010-2023]

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The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice.

Nincy Debeuf, Assem Zhakupova, Regula Steiner, Sofie Van Gassen, Kim Deswarte, Farzaneh Fayazpour, Justine Van Moorleghem, Karl Vergote, Benjamin Pavie, Kelly Lemeire, Hamida Hammad, Thorsten Hornemann, Sophie Janssens, Bart N Lambrecht,

BACKGROUND:Genome-wide association studies in asthma have repeatedly identified single nucleotide polymorphisms in the ORM (yeast)-like protein isoform 3 (ORMDL3) gene across different populations. Although the ORM homologues in yeast are well-known inhibitors of sphingolipid synthesis, it is still unclear whether and how mammalian ORMDL3 regulates sphingolipid metabolism and whether altered ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2019, 144(6):1648-1659.e9]

Cited: 3 times

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Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.

Denis A Mogilenko, Joel T Haas, Laurent L'homme, Sébastien Fleury, Sandrine Quemener, Matthieu Levavasseur, Coralie Becquart, Julien Wartelle, Alexandra Bogomolova, Laurent Pineau, Olivier Molendi-Coste, Steve Lancel, Hélène Dehondt, Celine Gheeraert, Aurelie Melchior, Cédric Dewas, Artemii Nikitin, Samuel Pic, Nabil Rabhi, Jean-Sébastien Annicotte, Seiichi Oyadomari, Talia Velasco-Hernandez, Jörg Cammenga, Marc Foretz, Benoit Viollet, Milica Vukovic, Arnaud Villacreces, Kamil Kranc, Peter Carmeliet, Guillemette Marot, Alexis Boulter, Simon Tavernier, Luciana Berod, Maria P Longhi, Christophe Paget, Sophie Janssens, Delphine Staumont-Sallé, Ezra Aksoy, Bart Staels, David Dombrowicz,

Cell (Cell)
[2019, 178(1):263]

Cited: 1 time

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Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.

Denis A Mogilenko, Joel T Haas, Laurent L'homme, Sébastien Fleury, Sandrine Quemener, Matthieu Levavasseur, Coralie Becquart, Julien Wartelle, Alexandra Bogomolova, Laurent Pineau, Olivier Molendi-Coste, Steve Lancel, Hélène Dehondt, Celine Gheeraert, Aurelie Melchior, Cédric Dewas, Artemii Nikitin, Samuel Pic, Nabil Rabhi, Jean-Sébastien Annicotte, Seiichi Oyadomari, Talia Velasco-Hernandez, Jörg Cammenga, Marc Foretz, Benoit Viollet, Milica Vukovic, Arnaud Villacreces, Kamil Kranc, Peter Carmeliet, Guillemette Marot, Alexis Boulter, Simon Tavernier, Luciana Berod, Maria P Longhi, Christophe Paget, Sophie Janssens, Delphine Staumont-Sallé, Ezra Aksoy, Bart Staels, David Dombrowicz,

Innate immune responses are intricately linked with intracellular metabolism of myeloid cells. Toll-like receptor (TLR) stimulation shifts intracellular metabolism toward glycolysis, while anti-inflammatory signals depend on enhanced mitochondrial respiration. How exogenous metabolic signals affect the immune response is unknown. We demonstrate that TLR-dependent responses of dendritic cells (DCs) are exacerbated ... Read more >>

Cell (Cell)
[2019, 177(5):1201-1216.e19]

Cited: 7 times

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IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

Michael Grey, Eva Cloots, Mariska Simpson, Nicole LeDuc, Yevgeniy Serebrenik, Heidi De Luca, Delphine De Sutter, Phi Luong, Jay Thiagarajah, Adrienne Paton, James Paton, Markus Seeliger, Sven Eyckerman, Sophie Janssens, Wayne Lencer,

ABSTRACT IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated response to ER stress. IRE1β assembles with and blocks activation of the closely related and most evolutionarily ancient stress-sensor IRE1α to suppress stress-induced ... Read more >>

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Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.

Srinath Govindarajan, Djoere Gaublomme, Renée Van der Cruyssen, Eveline Verheugen, Sofie Van Gassen, Yvan Saeys, Simon Tavernier, Takao Iwawaki, Yehudi Bloch, Savvas N Savvides, Bart N Lambrecht, Sophie Janssens, Dirk Elewaut, Michael B Drennan,

Activated invariant natural killer T (iNKT) cells rapidly produce large amounts of cytokines, but how cytokine mRNAs are induced, stabilized and mobilized following iNKT activation is still unclear. Here we show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α (IRE1α), links key cellular processes required for iNKT cell effector ... Read more >>

Nat Commun (Nature communications)
[2018, 9(1):5340]

Cited: 4 times

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Sensory-Neuropathy-Causing Mutations in ATL3 Cause Aberrant ER Membrane Tethering.

Michiel Krols, Sammy Detry, Bob Asselbergh, Leonardo Almeida-Souza, Anna Kremer, Saskia Lippens, Riet De Rycke, Vicky De Winter, Franz-Josef Müller, Ingo Kurth, Harvey T McMahon, Savvas N Savvides, Vincent Timmerman, Sophie Janssens,

The endoplasmic reticulum (ER) is a complex network of sheets and tubules that is continuously remodeled. The relevance of this membrane dynamics is underscored by the fact that mutations in atlastins (ATLs), the ER fusion proteins in mammals, cause neurodegeneration. How defects in this process disrupt neuronal homeostasis is unclear. ... Read more >>

Cell Rep (Cell reports)
[2018, 23(7):2026-2038]

Cited: 6 times

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Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways.

Fabiola Osorio, Bart N Lambrecht, Sophie Janssens,

The unfolded protein response (UPR) is an adaptive response meant to restore endoplasmic reticulum homeostasis in conditions of ER stress that subvert the folding capacity of the cell. Over the past few years, it has become clear that the functions of the UPR stretch far beyond their canonical role and ... Read more >>

Curr. Opin. Immunol. (Current opinion in immunology)
[2018, 52:100-107]

Cited: 6 times

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Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model.

Sanne D'hondt, Brecht Guillemyn, Delfien Syx, Sofie Symoens, Riet De Rycke, Leen Vanhoutte, Wendy Toussaint, Bart N Lambrecht, Anne De Paepe, Douglas R Keene, Yoshihiro Ishikawa, Hans Peter Bächinger, Sophie Janssens, Mathieu J M Bertrand, Fransiska Malfait,

Type III collagen is a major fibrillar collagen consisting of three identical α1(III)-chains that is particularly present in tissues exhibiting elastic properties, such as the skin and the arterial wall. Heterozygous mutations in the COL3A1 gene result in vascular Ehlers-Danlos syndrome (vEDS), a severe, life-threatening disorder, characterized by thin, translucent ... Read more >>

Matrix Biol. (Matrix biology : journal of the International Society for Matrix Biology)
[2018, 70:72-83]

Cited: 5 times

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The Unfolded Protein Response in the Immune Cell Development: Putting the Caretaker in the Driving Seat.

Simon J Tavernier, Bart N Lambrecht, Sophie Janssens,

The endoplasmic reticulum (ER) is the primary site for the folding of proteins destined for the membranous compartment and the extracellular space. This elaborate function is coordinated by the unfolded protein response (UPR), a stress-activated cellular program that governs proteostasis. In multicellular organisms, cells have adopted specialized functions, which required ... Read more >>

Curr. Top. Microbiol. Immunol. (Current topics in microbiology and immunology)
[2018, 414:45-72]

Cited: 1 time

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Sensory neuropathy-causing mutations in ATL3 cause aberrant ER membrane tethering

Michiel Krols, Sammy Detry, Bob Asselbergh, Leonardo Almeida-Souza, Anna Kremer, Saskia Lippens, Riet de Rycke, Vicky De Winter, Franz-Josef Müller, Ingo Kurth, Harvey McMahon, Savvas Savvides, Vincent Timmerman, Sophie Janssens,

SUMMARY The ER is a complex network of sheets and tubules that is continuously being remodeled. The relevance of this membrane dynamics is underscored by the fact that mutations in Atlastins (ATL), the ER fusion proteins in mammals, cause neurodegeneration. How defects in this process disrupt neuronal homeostasis is largely ... Read more >>

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Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages.

Simon J Tavernier, Nele Vanlangenakker, Jessica Vetters, Peter Carmeliet, Sophie Janssens, Bart N Lambrecht,

The prolyl hydroxylase domain-containing enzymes (PHDs) are important metabolic sensors of the cell and its environment, which might be employed to alert cells of the immune system. These enzymes regulate the expression of the hypoxia inducible factor (HIF) isoforms and NF-κB, crucial transcription factors controlling cellular metabolism and inflammation. PHD/HIF ... Read more >>

J. Leukoc. Biol. (Journal of leukocyte biology)
[2017, 102(4):1115-1126]

Cited: 2 times

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Mitochondrial Priming by CD28.

Ramon I Klein Geltink, David O'Sullivan, Mauro Corrado, Anna Bremser, Michael D Buck, Joerg M Buescher, Elke Firat, Xuekai Zhu, Gabriele Niedermann, George Caputa, Beth Kelly, Ursula Warthorst, Anne Rensing-Ehl, Ryan L Kyle, Lana Vandersarren, Jonathan D Curtis, Annette E Patterson, Simon Lawless, Katarzyna Grzes, Jing Qiu, David E Sanin, Oliver Kretz, Tobias B Huber, Sophie Janssens, Bart N Lambrecht, Angelika S Rambold, Edward J Pearce, Erika L Pearce,

T cell receptor (TCR) signaling without CD28 can elicit primary effector T cells, but memory T cells generated during this process are anergic, failing to respond to secondary antigen exposure. We show that, upon T cell activation, CD28 transiently promotes expression of carnitine palmitoyltransferase 1a (Cpt1a), an enzyme that facilitates mitochondrial fatty acid ... Read more >>

Cell (Cell)
[2017, 171(2):385-397.e11]

Cited: 42 times

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Emerging Role of the Unfolded Protein Response in Tumor Immunosurveillance.

Hélène Vanacker, Jessica Vetters, Lyvia Moudombi, Christophe Caux, Sophie Janssens, Marie-Cécile Michallet,

Disruption of endoplasmic reticulum (ER) homeostasis results in ER stress and activation of the unfolded protein response (UPR). This response alleviates cell stress, and is activated in both tumor cells and tumor infiltrating immune cells. The UPR plays a dual function in cancer biology, acting as a barrier to tumorigenesis ... Read more >>

Trends Cancer (Trends in cancer)
[2017, 3(7):491-505]

Cited: 11 times

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HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis.

Donna Kennedy, Katarzyna Mnich, Deepu Oommen, Reka Chakravarthy, Leonardo Almeida-Souza, Michiel Krols, Svetlana Saveljeva, Karen Doyle, Sanjeev Gupta, Vincent Timmerman, Sophie Janssens, Adrienne M Gorman, Afshin Samali,

BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells overexpressing heat shock protein B1 (HSPB1 or HSP27) and that this is due to enhanced proteasomal degradation ... Read more >>

Cell Death Dis (Cell death & disease)
[2017, 8(8):e3026]

Cited: 8 times

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Epitope mapping and kinetics of CD4 T cell immunity to pneumonia virus of mice in the C57BL/6 strain.

Lana Vandersarren, Cedric Bosteels, Manon Vanheerswynghels, James J Moon, James J Moon, Andrew J Easton, Gert Van Isterdael, Sophie Janssens, Bart N Lambrecht, Mary J van Helden,

Pneumonia virus of mice (PVM) infection has been widely used as a rodent model to study the closely related human respiratory syncytial virus (hRSV). While T cells are indispensable for viral clearance, they also contribute to immunopathology. To gain more insight into mechanistic details, novel tools are needed that allow ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):3472]

Cited: 1 time

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Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.

Simon J Tavernier, Fabiola Osorio, Lana Vandersarren, Jessica Vetters, Nele Vanlangenakker, Gert Van Isterdael, Karl Vergote, Riet De Rycke, Eef Parthoens, Lianne van de Laar, Takao Iwawaki, Juan R Del Valle, Chih-Chi Andrew Hu, Bart N Lambrecht, Sophie Janssens,

The IRE1-XBP1 signalling pathway is part of a cellular programme that protects against endoplasmic reticulum (ER) stress, but also controls development and survival of immune cells. Loss of XBP1 in splenic type 1 conventional dendritic cells (cDC1s) results in functional alterations without affecting cell survival. However, in mucosal cDC1s, loss ... Read more >>

Nat Cell Biol (Nature cell biology)
[2017, 19(6):698-710]

Cited: 26 times

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Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis.

Sophie Van Welden, Martine De Vos, Ben Wielockx, Simon J Tavernier, Melissa Dullaers, Sara Neyt, Benedicte Descamps, Lindsey Devisscher, Sarah Devriese, Lien Van den Bossche, Tom Holvoet, Ann Baeyens, Carmen Correale, Silvia D'Alessio, Christian Vanhove, Filip De Vos, Bruno Verhasselt, Georg Breier, Bart N Lambrecht, Sophie Janssens, Peter Carmeliet, Silvio Danese, Dirk Elewaut, Debby Laukens, Pieter Hindryckx,

Prolyl hydroxylase domain-containing proteins (PHDs) regulate the adaptation of cells to hypoxia. Pan-hydroxylase inhibition is protective in experimental colitis, in which PHD1 plays a prominent role. However, it is currently unknown how PHD1 targeting regulates this protection and which cell type(s) are involved. Here, we demonstrated that Phd1 deletion in ... Read more >>

J. Pathol. (The Journal of pathology)
[2017, 241(4):547-558]

Cited: 9 times

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Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10.

Hamida Hammad, Matthias Vanderkerken, Philippe Pouliot, Kim Deswarte, Wendy Toussaint, Karl Vergote, Lana Vandersarren, Sophie Janssens, Ioanna Ramou, Savvas N Savvides, Jody J Haigh, Rudi Hendriks, Manfred Kopf, Katleen Craessaerts, Bart de Strooper, John F Kearney, Daniel H Conrad, Bart N Lambrecht,

Notch2 and B cell antigen receptor (BCR) signaling determine whether transitional B cells become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown how these pathways are related. We generated Taok3-/- mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects in the ... Read more >>

Nat. Immunol. (Nature immunology)
[2017, 18(3):313-320]

Cited: 14 times

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ER-Mitochondria contact sites: A new regulator of cellular calcium flux comes into play.

Michiel Krols, Geert Bultynck, Sophie Janssens,

Endoplasmic reticulum (ER)-mitochondria membrane contacts are hotspots for calcium signaling. In this issue, Raturi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512077) show that the thioredoxin TMX1 inhibits the calcium pump SERCA2b at ER-mitochondria contact sites, thereby affecting ER-mitochondrial calcium transfer and mitochondrial bioenergetics. ... Read more >>

J. Cell Biol. (The Journal of cell biology)
[2016, 214(4):367-370]

Cited: 24 times

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SCORPIUS improves trajectory inference and identifies novel modules in dendritic cell development

Robrecht Cannoodt, Wouter Saelens, Dorine Sichien, Simon Tavernier, Sophie Janssens, Martin Guilliams, Bart Lambrecht, Katleen De Preter, Yvan Saeys,

1 Summary Recent advances in RNA sequencing enable the generation of genome-wide expression data at the single-cell level, opening up new avenues for transcriptomics and systems biology. A new application of single-cell whole-transcriptomics is the unbiased ordering of cells according to their progression along a dynamic process of interest. We ... Read more >>

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