Full Text Journal Articles by
Author Soon Yew Tang


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Sex dependent compensatory mechanisms to preserve blood pressure homeostasis in PGI2 receptor deficient mice

Soon Yew Tang, Seán Anderson, Hu Meng, Dimitra Sarantopoulou, Emanuela Ricciotti, Elizabeth Hennessy, Gregory Grant, Garret FitzGerald,

Abstract Inhibitors of microsomal prostaglandin E synthase-1 (mPges-1) are in the early phase of clinical development. Deletion of mPges-1 confers analgesia, restrains atherogenesis and fails to accelerate thrombogenesis, while suppressing prostaglandin (PG) E 2 , but increasing biosynthesis of prostacyclin (PGI 2 ). In hyperlipidemic mice, this last effect represents ... Read more >>

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Bmal1 Deletion in Myeloid Cells Attenuates Atherosclerotic Lesion Development and Restrains Abdominal Aortic Aneurysm Formation in Hyperlipidemic Mice.

Guangrui Yang, Jiayang Zhang, Tingting Jiang, James Monslow, Soon Yew Tang, Leslie Todd, Ellen Puré, Lihong Chen, Garret A FitzGerald,

OBJECTIVE:Although the molecular components of circadian rhythms oscillate in discrete cellular components of the vasculature and many aspects of vascular function display diurnal variation, the cellular connections between the molecular clock and inflammatory cardiovascular diseases remain to be elucidated. Previously we have shown that pre- versus postnatal deletion of Bmal1 ... Read more >>

Arterioscler. Thromb. Vasc. Biol. (Arteriosclerosis, thrombosis, and vascular biology)
[2020, 40(6):1523-1532]

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Comparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input.

Dimitra Sarantopoulou, Soon Yew Tang, Emanuela Ricciotti, Nicholas F Lahens, Damien Lekkas, Jonathan Schug, Xiaofeng S Guo, Georgios K Paschos, Garret A FitzGerald, Allan I Pack, Gregory R Grant,

Library preparation is a key step in sequencing. For RNA sequencing there are advantages to both strand specificity and working with minute starting material, yet until recently there was no kit available enabling both. The Illumina TruSeq stranded mRNA Sample Preparation kit (TruSeq) requires abundant starting material while the Takara Bio SMART-Seq ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):13477]

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Circadian control of lung inflammation in influenza infection

Shaon Sengupta, Soon Yew Tang, Jill Devine, Soumyashant Nayak, Shirley Zhang, Alex Valenzuela, Carolina Lopez, Gregory Grant, Garret FitzGerald,

Abstract Influenza is a leading cause of respiratory mortality and morbidity. While inflammation is necessary for fighting infection, a fine balance of anti-viral defense and host tolerance is necessary for recovery. Circadian rhythms have been known to modulate inflammation. However, the importance of diurnal variability in the timing of influenza ... Read more >>

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Cold-Induced Browning of Inguinal White Adipose Tissue Is Independent of Adipose Tissue Cyclooxygenase-2.

Georgios K Paschos, Soon Yew Tang, Katherine N Theken, Xuanwen Li, Ioannis Verginadis, Damien Lekkas, Lindsay Herman, Weili Yan, John Lawson, Garret A FitzGerald,

Previous studies using genetic mouse models have implicated COX-2 in the browning of white adipose tissues (WATs) in mice during cold exposure. However, COX-2 is important during development, and conventional knockouts (KOs) exhibit many defects, conditioned by genetic background. Similarly, the physiological relevance of transgenic overexpression of COX-2 is questionable. ... Read more >>

Cell Rep (Cell reports)
[2018, 24(4):809-814]

Cited: 6 times

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Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice.

Soon Yew Tang, James Monslow, Gregory R Grant, Leslie Todd, Sven-Christian Pawelzik, Lihong Chen, John Lawson, Ellen Puré, Garret A FitzGerald,

Inhibitors of cyclooxygenase-2 alleviate pain and reduce fever and inflammation by suppressing the biosynthesis of prostacyclin (PGI2) and prostaglandin E2. However, suppression of these prostaglandins, particularly PGI2, by cyclooxygenase-2 inhibition or deletion of its I prostanoid receptor also predisposes to accelerated atherogenesis and thrombosis in mice. By contrast, deletion of ... Read more >>

Circulation (Circulation)
[2016, 134(4):328-338]

Cited: 7 times

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Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice.

Lihong Chen, Guangrui Yang, James Monslow, Leslie Todd, David P Cormode, Jun Tang, Gregory R Grant, Jonathan H DeLong, Soon Yew Tang, John A Lawson, Ellen Pure, Garret A Fitzgerald,

Microsomal prostaglandin E synthase-1 (mPGES-1) in myeloid and vascular cells differentially regulates the response to vascular injury, reflecting distinct effects of mPGES-1-derived PGE2 in these cell types on discrete cellular components of the vasculature. The cell selective roles of mPGES-1 in atherogenesis are unknown. Mice lacking mPGES-1 conditionally in myeloid ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(18):6828-6833]

Cited: 14 times

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Cyclooxygenase-2 in endothelial and vascular smooth muscle cells restrains atherogenesis in hyperlipidemic mice.

Soon Yew Tang, James Monslow, Leslie Todd, John Lawson, Ellen Puré, Garret A FitzGerald,

Placebo-controlled trials of nonsteroidal anti-inflammatory drugs selective for inhibition of cyclooxygenase-2 (COX-2) reveal an emergent cardiovascular hazard in patients selected for low risk of heart disease. Postnatal global deletion of COX-2 accelerates atherogenesis in hyperlipidemic mice, a process delayed by selective enzyme deletion in macrophages.In the present study, selective depletion ... Read more >>

Circulation (Circulation)
[2014, 129(17):1761-1769]

Cited: 18 times

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Vascular COX-2 modulates blood pressure and thrombosis in mice.

Ying Yu, Emanuela Ricciotti, Rosario Scalia, Soon Yew Tang, Gregory Grant, Zhou Yu, Gavin Landesberg, Irene Crichton, Weichen Wu, Ellen Puré, Colin D Funk, Garret A FitzGerald,

Prostacyclin (PGI(2)) is a vasodilator and platelet inhibitor, properties consistent with cardioprotection. More than a decade ago, inhibition of cyclooxygenase-2 (COX-2) by the nonsteroidal anti-inflammatory drugs (NSAIDs) rofecoxib and celecoxib was found to reduce the amount of the major metabolite of PGI(2) (PGI-M) in the urine of healthy volunteers. This ... Read more >>

Sci Transl Med (Science translational medicine)
[2012, 4(132):132ra54]

Cited: 81 times

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Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice.

Zhou Yu, Irene Crichton, Soon Yew Tang, Yiqun Hui, Emanuela Ricciotti, Mark D Levin, John A Lawson, Ellen Puré, Garret A FitzGerald,

Suppression of cyclooxygenase 2 (COX-2)-derived prostacyclin (PGI(2)) is sufficient to explain most elements of the cardiovascular hazard from nonsteroidal antinflammatory drugs (NSAIDs). However, randomized trials are consistent with the emergence of cardiovascular risk during chronic dosing with NSAIDs. Although deletion of the PGI(2) receptor fosters atherogenesis, the importance of COX-2 ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2012, 109(17):6727-6732]

Cited: 24 times

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Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study.

Raymond C S Seet, Katherine Kasiman, Jan Gruber, Soon-Yew Tang, Meng-Cheong Wong, Hui-Meng Chang, Yiong-Huak Chan, Barry Halliwell, Christopher P Chen,

Contrasting observations have been made between serum urate and ischemic stroke outcomes in studies involving Caucasian populations. To assess the hypothesis that urate is associated with stroke outcomes, a prospective follow-up study was performed in a cohort of Asian patients with ischemic stroke. Patients diagnosed with transient ischemic attack, first ... Read more >>

Atherosclerosis (Atherosclerosis)
[2010, 209(1):215-219]

Cited: 30 times

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Medicinal plants and antioxidants: what do we learn from cell culture and Caenorhabditis elegans studies?

Soon Yew Tang, Barry Halliwell,

Traditional medicinal plants have a long history of therapeutic use. The beneficial health effects of medicinal plants rich in polyphenols are often attributed to their potent antioxidant activities, as established in vitro, since diets rich in polyphenols are epidemiologically associated with a decreased incidence of age-related diseases in humans. However, ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and Biophysical Research Communications)
[2010, 394(1):1-5]

Cited: 22 times

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Allantoin in human plasma, serum, and nasal-lining fluids as a biomarker of oxidative stress: avoiding artifacts and establishing real in vivo concentrations.

Jan Gruber, Soon Yew Tang, Andrew M Jenner, Ian Mudway, Anders Blomberg, Annelie Behndig, Katherine Kasiman, Chung-Yung J Lee, Raymond C S Seet, Wenxia Zhang, Christopher Chen, Frank J Kelly, Barry Halliwell,

Urate is the terminal product of purine metabolism in primates, including humans. Urate is also an efficient scavenger of oxidizing species and is thought to be an important antioxidant in human body fluids. Allantoin, the major oxidation product of urate, has been suggested as a candidate biomarker of oxidative stress ... Read more >>

Antioxid. Redox Signal. (Antioxidants & redox signaling)
[2009, 11(8):1767-1776]

Cited: 19 times

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Notopterygium forbesii Boiss extract and its active constituent phenethyl ferulate attenuate pro-inflammatory responses to lipopolysaccharide in RAW 264.7 macrophages. A "protective" role for oxidative stress?

Soon Yew Tang, Irwin K Cheah, Huansong Wang, Barry Halliwell,

Oxidative stress and oxidative modification of biomolecules are involved in several physiological and pathophysiological processes. We have previously reported that Notopterygium forbesii Boiss (NF), a traditional Chinese medicine, and its active constituents, including phenethyl ferulate (PF), bergaptol, and isoimperatorin, induced oxidative stress with increased levels of reactive species and heme ... Read more >>

Chem. Res. Toxicol. (Chemical research in toxicology)
[2009, 22(8):1473-1482]

Cited: 6 times

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Ageing in nematodes: do antioxidants extend lifespan in Caenorhabditis elegans?

Pamela Boon Li Pun, Jan Gruber, Soon Yew Tang, Sebastian Schaffer, Raphael Lee Sheng Ong, Sheng Fong, Li Fang Ng, Irwin Cheah, Barry Halliwell,

Antioxidants are often investigated as a promising strategy for extending lifespan. Accordingly, there is significant interest in novel antioxidant compounds derived from natural sources such as plant extracts. However, because lifespan studies are laborious and expensive to conduct, candidate compounds are frequently selected based simply on their in vitro antioxidant ... Read more >>

Biogerontology (Biogerontology)
[2010, 11(1):17-30]

Cited: 53 times

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Notopterygium forbesii boiss extract and its active constituents increase reactive species and heme oxygenase-1 in human fetal hepatocytes: mechanisms of action.

Soon Yew Tang, Huansong Wang, Wenxia Zhang, Barry Halliwell,

Notopterygium forbesii Boiss (NF) has been used as a traditional Chinese medicine for the treatment of common cold and rheumatism. However, there has been limited research on the biological properties of NF, and the mechanisms of action remain unknown. Here, we aimed to study the mechanism of NF-induced heme oxygenase-1 ... Read more >>

Chem. Res. Toxicol. (Chemical research in toxicology)
[2008, 21(12):2414-2423]

Cited: 10 times

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Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans.

Jan Gruber, Soon Yew Tang, Barry Halliwell,

Resveratrol is a naturally occurring polyphenolic compound commonly found in plant-derived products, including red wine. A large number of beneficial effects including anticarcinogenic action and protection from atherosclerotic disease have been attributed to resveratrol. Increased resveratrol intake has been suggested as an explanation for the beneficial effects of moderate red ... Read more >>

Ann. N. Y. Acad. Sci. (Annals of the New York Academy of Sciences)
[2007, 1100:530-542]

Cited: 65 times

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Deciphering the mechanism of HNE-induced apoptosis in cultured murine cortical neurons: transcriptional responses and cellular pathways.

Zhao Feng Peng, Chor Hui Vivien Koh, Qiu Tian Li, Jayapal Manikandan, Alirio J Melendez, Soon Yew Tang, Barry Halliwell, Nam Sang Cheung,

Studies have shown that the lipid peroxidation by-product, 4-hydroxynonenal (HNE), is involved in many pathological events in several neurodegenerative diseases. A number of signaling pathways mediating HNE-induced cell death in the brain have been proposed. However, the exact mechanism remains unknown. In the present study, we have examined the effects ... Read more >>

Neuropharmacology (Neuropharmacology)
[2007, 53(5):687-698]

Cited: 13 times

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The identification of antioxidants in dark soy sauce.

Huansong Wang, Andrew M Jenner, Chung-Yung J Lee, Guanghou Shui, Soon Yew Tang, Matthew Whiteman, Markus R Wenk, Barry Halliwell,

Soy sauce is a traditional fermented seasoning in Asian countries, that has high antioxidant activity in vitro and some antioxidant activity in vivo. We attempted to identify the major antioxidants present, using the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay as a guide. 3-Hydroxy-2-methyl-4H-pyran-4-one (maltol) was one of several active compounds found in ... Read more >>

Free Radic. Res. (Free radical research)
[2007, 41(4):479-488]

Cited: 19 times

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Psoralea corylifolia L. inhibits mitochondrial complex I and proteasome activities in SH-SY5Y cells.

Soon Yew Tang, Jan Gruber, Kim Ping Wong, Barry Halliwell,

The growing interest in alternative medicines, including traditional medicinal plants, has caused some health concerns due to poor awareness in the general population of the possible side effects from inappropriate practices. Psoralea corylifolia L. has been used in Chinese and Indian traditional medicine for the treatment of various inflammatory diseases ... Read more >>

Ann. N. Y. Acad. Sci. (Annals of the New York Academy of Sciences)
[2007, 1100:486-496]

Cited: 9 times

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Potential artifacts in the measurement of DNA deamination.

Kok Seong Lim, Shan Hong Huang, Andrew Jenner, Huansong Wang, Soon Yew Tang, Barry Halliwell,

Attack on DNA by some reactive nitrogen species results in deamination of adenine and guanine, leading to the formation of hypoxanthine and xanthine, respectively. Published levels of these products in cellular DNA have varied widely. Although these two deamination products are often measured by GC-MS analysis, the procedure of acid ... Read more >>

Free Radic. Biol. Med. (Free radical biology & medicine)
[2006, 40(11):1939-1948]

Cited: 12 times

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Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines.

Soon Yew Tang, Matthew Whiteman, Zhao Feng Peng, Andrew Jenner, Eu Leong Yong, Barry Halliwell,

There is considerable interest in the isolation of more potent antioxidant compounds to treat diseases involving oxidative stress. Thirty-three traditional Chinese medicine (TCM) extracts were examined for their antioxidant activity using the 2,2'-azinobis[3-ethylbenzothiazoline-6-sulfonate] (ABTS) assay. Five extracts with high activity (Cratoxylum cochinchinense, Cortex magnoliae officinalis, Psoralea corylifolia L, Curculigo orchioides ... Read more >>

Free Radic. Biol. Med. (Free radical biology & medicine)
[2004, 36(12):1575-1587]

Cited: 57 times

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Mechanism of cell death induced by an antioxidant extract of Cratoxylum cochinchinense (YCT) in Jurkat T cells: the role of reactive oxygen species and calcium.

Soon Yew Tang, Matthew Whiteman, Andrew Jenner, Zhao Feng Peng, Barry Halliwell,

YCT is a semipurified extract from Cratoxylum cochinchinense that has antioxidant properties and contains mostly mangiferin. We show here that YCT is selectively toxic to certain cell types and investigate the mechanisms of this toxicity in Jurkat T cells. By flow cytometric analyses, we show that YCT causes intense oxidative ... Read more >>

Free Radic. Biol. Med. (Free radical biology & medicine)
[2004, 36(12):1588-1611]

Cited: 8 times

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