Full Text Journal Articles by
Author Sonja Lorenz


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Advanced rules of relays.

Sonja Lorenz, Katrin Rittinger,

Nat Chem Biol (Nature chemical biology)
[2020, 16(11):1158-1159]

Cited: 0 times

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Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.

Anna K L Liess, Alena Kucerova, Kristian Schweimer, Dörte Schlesinger, Olexandr Dybkov, Henning Urlaub, Jörg Mansfeld, Sonja Lorenz,

At the heart of protein ubiquitination cascades, ubiquitin-conjugating enzymes (E2s) form reactive ubiquitin-thioester intermediates to enable efficient transfer of ubiquitin to cellular substrates. The precise regulation of E2s is thus crucial for cellular homeostasis, and their deregulation is frequently associated with tumorigenesis. In addition to driving substrate ubiquitination together with ... Read more >>

Sci Signal (Science signaling)
[2020, 13(654):]

Cited: 0 times

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Crystal structure of the catalytic C-lobe of the HECT-type ubiquitin ligase E6AP.

Lena K Ries, Anna K L Liess, Christian G Feiler, Donald E Spratt, Edward D Lowe, Sonja Lorenz,

The HECT-type ubiquitin ligase E6AP (UBE3A) is critically involved in several neurodevelopmental disorders and human papilloma virus-induced cervical tumorigenesis; the structural mechanisms underlying the activity of this crucial ligase, however, are incompletely understood. Here, we report a crystal structure of the C-terminal lobe ("C-lobe") of the catalytic domain of E6AP ... Read more >>

Protein Sci (Protein science : a publication of the Protein Society)
[2020, 29(6):1550-1554]

Cited: 1 time

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Enzymatic Logic of Ubiquitin Chain Assembly.

Kirandeep K Deol, Sonja Lorenz, Eric R Strieter,

Protein ubiquitination impacts virtually every biochemical pathway in eukaryotic cells. The fate of a ubiquitinated protein is largely dictated by the type of ubiquitin modification with which it is decorated, including a large variety of polymeric chains. As a result, there have been intense efforts over the last two decades ... Read more >>

(Frontiers in physiology)
[2019, 10:835]

Cited: 3 times

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Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination.

Anna K L Liess, Alena Kucerova, Kristian Schweimer, Lu Yu, Theodoros I Roumeliotis, Mathias Diebold, Olexandr Dybkov, Christoph Sotriffer, Henning Urlaub, Jyoti S Choudhary, Jörg Mansfeld, Sonja Lorenz,

Ubiquitin-conjugating enzymes (E2s) govern key aspects of ubiquitin signaling. Emerging evidence suggests that the activities of E2s are modulated by posttranslational modifications; the structural underpinnings, however, are largely unclear. Here, we unravel the structural basis and mechanistic consequences of a conserved autoubiquitination event near the catalytic center of E2s, using ... Read more >>

Structure (Structure (London, England : 1993))
[2019, 27(8):1195-1210.e7]

Cited: 2 times

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Developing Small-Molecule Inhibitors of HECT-Type Ubiquitin Ligases for Therapeutic Applications: Challenges and Opportunities.

Dan Chen, Matthias Gehringer, Sonja Lorenz,

The ubiquitin system regulates countless physiological and disease-associated processes and has emerged as an attractive entryway for therapeutic efforts. With over 600 members in the human proteome, ubiquitin ligases are the most diverse class of ubiquitylation enzymes and pivotal in encoding specificity in ubiquitin signaling. Although considerable progress has been ... Read more >>

Chembiochem (Chembiochem : a European journal of chemical biology)
[2018, 19(20):2123-2135]

Cited: 5 times

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Individualized Web-Based Exercise for the Treatment of Depression: Randomized Controlled Trial.

Nils Haller, Sonja Lorenz, Daniel Pfirrmann, Cora Koch, Klaus Lieb, Ulrich Dettweiler, Perikles Simon, Patrick Jung,

BACKGROUND:Due to the high prevalence of depressive disorders, it is mandatory to develop therapeutic strategies that provide universal access and require limited financial and human resources. Web-based therapeutic approaches fulfill these conditions. OBJECTIVE:The objective of our study was to assess the feasibility, acceptability, and efficacy of a supervised, individualized 8-week ... Read more >>

(JMIR mental health)
[2018, 5(4):e10698]

Cited: 0 times

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Structural mechanisms of HECT-type ubiquitin ligases.

Sonja Lorenz,

Ubiquitin ligases (E3 enzymes) transfer ubiquitin from ubiquitin-conjugating (E2) enzymes to target proteins. By determining the selection of target proteins, modification sites on those target proteins, and the types of ubiquitin modifications that are formed, E3 enzymes are key specificity factors in ubiquitin signaling. Here, I summarize our knowledge of ... Read more >>

Biol. Chem. (Biological chemistry)
[2018, 399(2):127-145]

Cited: 19 times

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A conformational switch regulates the ubiquitin ligase HUWE1.

Bodo Sander, Wenshan Xu, Martin Eilers, Nikita Popov, Sonja Lorenz,

The human ubiquitin ligase HUWE1 has key roles in tumorigenesis, yet it is unkown how its activity is regulated. We present the crystal structure of a C-terminal part of HUWE1, including the catalytic domain, and reveal an asymmetric auto-inhibited dimer. We show that HUWE1 dimerizes in solution and self-associates in ... Read more >>

Elife (eLife)
[2017, 6:]

Cited: 17 times

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Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.

Sonja Lorenz, Patricia Deng, Oliver Hantschel, Giulio Superti-Furga, John Kuriyan,

Constitutive activation of the non-receptor tyrosine kinase c-Abl (cellular Abelson tyrosine protein kinase 1, Abl1) in the Bcr (breakpoint cluster region)-Abl1 fusion oncoprotein is the molecular cause of chronic myeloid leukaemia (CML). Recent studies have indicated that an interaction between the SH2 (Src-homology 2) domain and the N-lobe (N-terminal lobe) ... Read more >>

Biochem J (The Biochemical journal)
[2015, 468(2):283-291]

Cited: 9 times

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Macromolecular juggling by ubiquitylation enzymes.

Sonja Lorenz, Aaron J Cantor, Michael Rape, John Kuriyan,

The posttranslational modification of target proteins with ubiquitin and ubiquitin-like proteins is accomplished by the sequential action of E1, E2, and E3 enzymes. Members of the E1 and E3 enzyme families can undergo particularly large conformational changes during their catalytic cycles, involving the remodeling of domain interfaces. This enables the ... Read more >>

BMC Biol. (BMC biology)
[2013, 11:65]

Cited: 31 times

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The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2.

Katherine E Wickliffe, Sonja Lorenz, David E Wemmer, John Kuriyan, Michael Rape,

Ubiquitin chains of different topologies trigger distinct functional consequences, including protein degradation and reorganization of complexes. The assembly of most ubiquitin chains is promoted by E2s, yet how these enzymes achieve linkage specificity is poorly understood. We have discovered that the K11-specific Ube2S orients the donor ubiquitin through an essential ... Read more >>

Cell (Cell)
[2011, 144(5):769-781]

Cited: 161 times

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Rationale and design of the randomised clinical trial comparing early medication change (EMC) strategy with treatment as usual (TAU) in patients with major depressive disorder--the EMC trial.

André Tadić, Stanislav Gorbulev, Norbert Dahmen, Christoph Hiemke, Dieter F Braus, Joachim Röschke, Dietrich van Calker, Daniel Wachtlin, Kai Kronfeld, Thorsten Gorbauch, Monika Seibert-Grafe, Klaus Lieb, ,

In major depressive disorder (MDD), the traditional belief of a delayed onset of antidepressants' effects has lead to the concept of current guidelines that treatment durations should be between 3-8 weeks before medication change in case of insufficient outcome. Post hoc analyses of clinical trials, however, have shown that improvement ... Read more >>

Trials (Trials)
[2010, 11:21]

Cited: 13 times

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Structural analysis of the interactions between paxillin LD motifs and alpha-parvin.

Sonja Lorenz, Ioannis Vakonakis, Edward D Lowe, Iain D Campbell, Martin E M Noble, Maria K Hoellerer,

The adaptor protein paxillin contains five conserved leucine-rich (LD) motifs that interact with a variety of focal adhesion proteins, such as alpha-parvin. Here, we report the first crystal structure of the C-terminal calponin homology domain (CH(C)) of alpha-parvin at 1.05 A resolution and show that it is able to bind ... Read more >>

Structure (Structure (London, England : 1993))
[2008, 16(10):1521-1531]

Cited: 18 times

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Biomimetic control of size in the polyamine-directed formation of silica nanospheres.

Manfred Sumper, Sonja Lorenz, Eike Brunner,

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2003, 42(42):5192-5195]

Cited: 39 times

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Toxicology. E.U. shifts endocrine disrupter research into overdrive.

Sonja Lorenz,

Science (Science (New York, N.Y.))
[2003, 300(5622):1069]

Cited: 5 times

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Germany. Publishers and universities wrestle over rights.

Sonja Lorenz,

Science (Science (New York, N.Y.))
[2003, 299(5615):1959]

Cited: 0 times

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Propagation of a single destabilizing mutation throughout the Escherichia coli ribonuclease HI native state.

Giulietta Spudich, Sonja Lorenz, Susan Marqusee,

A point mutation (I53A) in the core of Escherichia coli RNase H* is known to destabilize both the native conformation (DeltaG(UN)) and the kinetic intermediate (DeltaG(UI)) by 2 kcal/mole. Here, we have used native-state hydrogen deuterium exchange to ask how this destabilization is propagated throughout the molecule. Stability parameters were ... Read more >>

Protein Sci. (Protein science : a publication of the Protein Society)
[2002, 11(3):522-528]

Cited: 16 times

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