Full Text Journal Articles by
Author Sonia Salvatore

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Exogenous Nitro-Oleic Acid inhibits primary root growth by reducing the mitosis in the meristem in Arabidopsis thaliana

Luciano Di Fino, Ignacio Cerrudo, Sonia Salvatore, Francisco Schopfer, Carlos García-Mata, Ana Laxalt,

ABSTRACT Nitric oxide (NO) is a second messenger that regulates a broad range of physiological processes in plants. NO-derived molecules called reactive nitrogen species (RNS) can react with unsaturated fatty acids generating nitrated fatty acids (NO 2 -FA). NO 2 -FA work as signaling molecules in mammals where production and ... Read more >>

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Exogenous Nitro-Oleic Acid Treatment Inhibits Primary Root Growth by Reducing the Mitosis in the Meristem in Arabidopsis thaliana.

Luciano M Di Fino, Ignacio Cerrudo, Sonia R Salvatore, Francisco J Schopfer, Carlos García-Mata, Ana M Laxalt,

Nitric oxide (NO) is a second messenger that regulates a broad range of physiological processes in plants. NO-derived molecules called reactive nitrogen species (RNS) can react with unsaturated fatty acids generating nitrated fatty acids (NO2-FA). NO2-FA work as signaling molecules in mammals where production and targets have been described under ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2020, 11:1059]

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Nitro-oleic acid triggers ROS production via NADPH oxidase activation in plants: A pharmacological approach.

Andrés Arruebarrena Di Palma, Luciano M Di Fino, Sonia R Salvatore, Juan Martín D'Ambrosio, Carlos García-Mata, Francisco J Schopfer, Ana M Laxalt,

Nitrated fatty acids (NO2-FAs) are important signaling molecules in mammals. NO2-FAs are formed by the addition reaction of nitric oxide- and nitrite-derived nitrogen dioxide with unsaturated fatty acid double bonds. The study of NO2-FAs in plant systems constitutes an interesting and emerging area. The presence of NO2-FA has been reported ... Read more >>

J. Plant Physiol. (Journal of plant physiology)
[2020, 246-247:153128]

Cited: 1 time

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Evaluation of 2-thiothiazolidine-4-carboxylic Acid, a Common Metabolite of Isothiocyanates as a Potential Biomarker of Cruciferous Vegetable Intake (P06-017-19).

Dushani Palliyaguru, Sonia Salvatore, Francisco Schopfer, Xuemei Cheng, Jingyang Zhou, Stacy Wendell,

AbstractObjectivesCruciferous vegetable consumption is associated with favorable health outcomes that are attributed to bioreactivity of isothiocyanates. These compounds exert effects that contribute to prevention of disease, in large part through attenuation of inflammation and oxidative stress. However, much about isothiocyanate metabolites and their role as biomarkers of crucifer intake remain ... Read more >>

Curr Dev Nutr (Current developments in nutrition)
[2019, 3(Suppl 1):]

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Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis.

Soma Jobbagy, Dario A Vitturi, Sonia R Salvatore, Lucía Turell, Maria F Pires, Emilia Kansanen, Carlos Batthyany, Jack R Lancaster, Bruce A Freeman, Francisco J Schopfer,

Cells evolved robust homeostatic mechanisms to protect against oxidation or alkylation by electrophilic species. Glutathione (GSH) is the most abundant intracellular thiol, protects cellular components from oxidation and is maintained in a reduced state by glutathione reductase (GR). Nitro oleic acid (NO2-OA) is an electrophilic fatty acid formed under digestive ... Read more >>

Redox Biol (Redox biology)
[2019, 21:101050]

Cited: 4 times

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Evaluation of 2-Thiothiazolidine-4-Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake.

Dushani L Palliyaguru, Sonia R Salvatore, Francisco J Schopfer, Xuemei Cheng, Jingyang Zhou, Thomas W Kensler, Stacy G Wendell,

SCOPE:Cruciferous vegetable consumption is associated with favorable health outcomes. Bioactive compounds arising in these, especially isothiocyanates, exert effects that contribute to prevention of disease, in large part through the attenuation of inflammation and oxidative stress. However, much about isothiocyanate metabolites and their role as biomarkers of crucifer intake remain unknown. ... Read more >>

Mol Nutr Food Res (Molecular nutrition & food research)
[2019, 63(3):e1801029]

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Nitro-fatty acid formation and metabolism.

Gregory J Buchan, Gustavo Bonacci, Marco Fazzari, Sonia R Salvatore, Stacy Gelhaus Wendell,

Nitro-fatty acids (NO2-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a considerable amount regarding NO2-FA signaling, endogenous formation and metabolism is relatively unexplored. This ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2018, 79:38-44]

Cited: 6 times

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Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.

Anne Louise Hansen, Gregory J Buchan, Michael Rühl, Kojiro Mukai, Sonia R Salvatore, Emari Ogawa, Sidsel D Andersen, Marie B Iversen, Anne L Thielke, Camilla Gunderstofte, Mona Motwani, Charlotte T Møller, Andreas S Jakobsen, Katherine A Fitzgerald, Jessica Roos, Rongtuan Lin, Thorsten J Maier, Raphaela Goldbach-Mansky, Cathrine A Miner, Wei Qian, Jonathan J Miner, Rachel E Rigby, Jan Rehwinkel, Martin R Jakobsen, Hiroyuki Arai, Tomohiko Taguchi, Francisco J Schopfer, David Olagnier, Christian K Holm,

The adaptor molecule stimulator of IFN genes (STING) is central to production of type I IFNs in response to infection with DNA viruses and to presence of host DNA in the cytosol. Excessive release of type I IFNs through STING-dependent mechanisms has emerged as a central driver of several interferonopathies, ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(33):E7768-E7775]

Cited: 14 times

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Nitro-Oleic Acid Induced Reactive Oxygen Species Formation and Plant Defense Signaling in Tomato Cell Suspensions

Andrés Arruebarrena Di Palma, Luciano Di Fino, Sonia Salvatore, Juan Martín D’Ambrosio, Gustavo Esteban Gergoff Grozeff, Carlos García-Mata, Francisco Schopfer, Ana Laxalt,

ABSTRACT Nitrated fatty acids (NO 2 -FAs) are formed by the addition reaction of nitric oxide- and nitrite-derived nitrogen dioxide with unsaturated fatty acids. Nitrated fatty acids act as signaling molecules in mammals through the formation of covalent adducts with cellular thiols. The study of NO 2 -FAs in plant ... Read more >>

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Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.

Ashley V Menk, Nicole E Scharping, Rebecca S Moreci, Xue Zeng, Cliff Guy, Sonia Salvatore, Heekyong Bae, Jianxin Xie, Howard A Young, Stacy Gelhaus Wendell, Greg M Delgoffe,

To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process common to highly proliferative cells in which glucose is fermented into lactate rather than oxidized in mitochondria. However, the signaling events that initiate aerobic glycolysis in T cells remain unclear. We show T cell activation rapidly induces glycolysis independent of transcription, ... Read more >>

Cell Rep (Cell reports)
[2018, 22(6):1509-1521]

Cited: 38 times

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Topical electrophilic nitro-fatty acids potentiate cutaneous inflammation.

Alicia R Mathers, Cara D Carey, Meaghan E Killeen, Sonia R Salvatore, Laura K Ferris, Bruce A Freeman, Francisco J Schopfer, Louis D Falo,

Endogenous electrophilic fatty acids mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction and gene expression. Nitro-fatty acids and other electrophilic fatty acids may thus be useful for the prevention and treatment of immune-mediated diseases, including inflammatory skin disorders. In this regard, subcutaneous (SC) injections of nitro oleic acid ... Read more >>

Free Radic. Biol. Med. (Free radical biology & medicine)
[2018, 115:31-42]

Cited: 2 times

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Electrophilic nitro-fatty acids suppress allergic contact dermatitis in mice.

A R Mathers, C D Carey, M E Killeen, J A Diaz-Perez, S R Salvatore, F J Schopfer, B A Freeman, L D Falo,

BACKGROUND:Reactions between nitric oxide (NO), nitrite (NO2-), and unsaturated fatty acids give rise to electrophilic nitro-fatty acids (NO2 -FAs), such as nitro oleic acid (OA-NO2 ) and nitro linoleic acid (LNO2 ). Endogenous electrophilic fatty acids (EFAs) mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction reactions. Hence, there ... Read more >>

Allergy (Allergy)
[2017, 72(4):656-664]

Cited: 6 times

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Electrophilic nitro-fatty acids inhibit vascular inflammation by disrupting LPS-dependent TLR4 signalling in lipid rafts.

Luis Villacorta, Lin Chang, Sonia R Salvatore, Tomonaga Ichikawa, Jifeng Zhang, Danica Petrovic-Djergovic, Lingyun Jia, Harald Carlsen, Francisco J Schopfer, Bruce A Freeman, Y Eugene Chen,

Electrophilic fatty acid nitroalkene derivatives, products of unsaturated fatty acid nitration, exert long-term cardiovascular protection in experimental models of metabolic and cardiovascular diseases. The goal of this study is to examine the effects of nitro-fatty acids in the regulation of upstream signalling events in nuclear factor-κB (NF-κB) activation and determine ... Read more >>

Cardiovasc. Res. (Cardiovascular research)
[2013, 98(1):116-124]

Cited: 57 times

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