Full Text Journal Articles by
Author Solomon Tesfaye

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Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations.

Dan Ziegler, Solomon Tesfaye, Vincenza Spallone, Irina Gurieva, Juma Al Kaabi, Boris Mankovsky, Emil Martinka, Gabriela Radulian, Khue Thy Nguyen, Alin O Stirban, Tsvetalina Tankova, Tamás Varkonyi, Roy Freeman, Péter Kempler, Andrew Jm Boulton,

Diabetic sensorimotor polyneuropathy (DSPN) affects around one third of people with diabetes and accounts for considerable morbidity, increased risk of mortality, reduced quality of life, and increased health care costs resulting particularly from neuropathic pain and foot ulcers. Painful DSPN is encountered in 13-26% of diabetes patients, while up to ... Read more >>

Diabetes Res Clin Pract (Diabetes research and clinical practice)
[2021, :109063]

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HGF, CSF-1, CD40 and 11 other inflammation-related proteins are associated with pain in diabetic neuropathy: exploration and replication serum data from the Pain in Neuropathy Study (PiNS).

Emmanuel Bäckryd, Andreas Themistocleous, Anders Larsson, Torsten Gordh, Andrew Sc Rice, Solomon Tesfaye, David L Bennett, Björn Gerdle,

<h4>Abstract</h4>One in five diabetic patients suffers from chronic pain with neuropathic characteristics, but the pathophysiological mechanisms underlying the development of neuropathic pain in diabetic distal symmetrical polyneuropathy (DSP) patients are poorly understood. Systemic low-grade inflammation has been implicated, but there is still a considerable knowledge gap concerning its scope and ... Read more >>

Pain (Pain)
[2021, :]

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Assessment of Ethical Compliance of Handling and Usage of the Human Body in Anatomical Facilities of Ethiopian Medical Schools.

Solomon Tesfaye, Niguse Hamba, Wakjira Kebede, Mitiku Bajiro, Lemessa Debela, Tihahun Alemayehu Nigatu, Asfaw Gerbi,

<h4>Background</h4>Human anatomy has historically been a cornerstone in medical education and is special in that it uses human remains kept in various anatomical facilities like a morgue, gross anatomy laboratory, or museums for instruction and research. While serving knowledge advancement facilitating clinical practice and research, human cadaver handling, and usage ... Read more >>

Pragmat Obs Res (Pragmatic and observational research)
[2021, 12:65-80]

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The Treatment of Painful Diabetic Neuropathy.

Gordon Sloan, Uazman Alam, Dinesh Selvarajah, Solomon Tesfaye,

Painful diabetic peripheral neuropathy (painful-DPN) is a highly prevalent and disabling condition, affecting up to one-third of patients with diabetes. This condition can have a profound impact, resulting in a low quality of life, disruption of employment, impaired sleep, and poor mental health with an excess of depression and anxiety. ... Read more >>

Curr Diabetes Rev (Current diabetes reviews)
[2021, :]

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Changes in Direct Medical Cost and Medications for Managing Diabetes in Beijing, China, 2016 to 2018: Electronic Insurance Data Analysis.

Lixin Guo, Jie Zheng, Qi Pan, Qun Zhang, Yan Zhou, Weihao Wang, Lina Zhang, Solomon Tesfaye, Jie Zhang,

<h4>Purpose</h4>Although the cost and complexity of managing diabetes is increasing around the world, placing greater burden on patients and their families, the cost of drug regimens prescribed to Chinese patients has not been evaluated. This study was conducted to evaluate the temporal changes in the costs and drugs used for ... Read more >>

Ann Fam Med (Annals of family medicine)
[2021, 19(4):332-341]

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Epidemiology and outcome of COVID-19 among 260 confirmed cases admitted at Guder Hospital, Western Ethiopia, 2020: a descriptive study of the first ten months

Tesfaye Solomon, Tufa Kolola, Mekdes Tsegaye,

<h4>Background: </h4> Coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection that emerged in Wuhan, China, and spread around the world. No evidence is available about the epidemiological, clinical features, and outcomes of admitted patients in the study area. This study aimed to provide insight into the ... Read more >>

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Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer; Part 3: Selective Cytotoxic Activity of 22 Plants against Human Cancer Cell Lines.

Solomon Tesfaye, Hannah Braun, Kaleab Asres, Ephrem Engidawork, Anteneh Belete, Ilias Muhammad, Christian Schulze, Nadin Schultze, Sebastian Guenther, Patrick J Bednarski,

Medicinal plants have been traditionally used to treat cancer in Ethiopia. However, very few studies have reported the in vitro anticancer activities of medicinal plants that are collected from different agro-ecological zones of Ethiopia. Hence, the main aim of this study was to screen the cytotoxic activities of 80% methanol ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(12):]

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Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy.

Gordon Sloan, Dinesh Selvarajah, Solomon Tesfaye,

Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes mellitus and is associated with increased mortality, lower-limb amputations and distressing painful neuropathic symptoms (painful DSPN). Our understanding of the pathophysiology of the disease has largely been derived from animal models, which have identified key potential mechanisms. However, effective ... Read more >>

Nat Rev Endocrinol (Nature reviews. Endocrinology)
[2021, 17(7):400-420]

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Epidemiology of Measles in West Arsi Zone, Oromia Region, Ethiopia: 2011-2015

Tesfaye Solomon, Mamo Nigatu, Birhanu Areda,

<h4>Background: </h4> Measles is a leading vaccine-preventable childhood disease, which has been designated for elimination. Despite the success of measles control, measles is still responsible for 145,700 deaths worldwide each year, with many of the outbreaks in developing countries including Ethiopia. We analyzed to characterize the epidemiology of measles and ... Read more >>

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Occupational exposure of health care workers to blood and body fluids in West Shewa Zone, Oromia, Ethiopia, 2019: A cross-sectional study

Tesfaye Solomon, Dejene Lemessa,

<h4>Background: </h4> Health care workers are at risk of occupational exposure to blood and body fluids even though very few studies were conducted in Ethiopia. Therefore, this study was aimed to investigate the magnitude of exposure to blood and body fluids among health care workers in governmental health facilities in ... Read more >>

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Exclusive breastfeeding practice and its associated factors among mothers with infants aged less than six months in Nono, Western Ethiopia: A cross-sectional study

Gerba Fufa, Tesfaye Solomon, Teka Girma,

<h4>Background: </h4> Exclusive breastfeeding is the best and cost effective intervention to prevent childhood morbidities and mortalities in developing countries. But there was no evidence in the study area regarding the practice of exclusive breastfeeding and its associated factors. Therefore, this study was aimed to assess exclusive breastfeeding practice and ... Read more >>

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Association of Cardiovascular Autonomic Neuropathy and Distal Symmetric Polyneuropathy with All-Cause Mortality: A Retrospective Cohort Study.

Orsolya E Vági, Márk M Svébis, Beatrix A Domján, Anna E Körei, Ildikó Istenes, Zsuzsanna Putz, Szilvia Mészáros, Noémi Hajdú, Magdolna Békeffy, Solomon Tesfaye, Péter Kempler, Viktor J Horváth, Adam G Tabák,

<h4>Background</h4>People with diabetic cardiovascular autonomic neuropathy (CAN) have increased cardiovascular mortality. However, the association between distal symmetric polyneuropathy (DSPN) or CAN with all-cause mortality is much less investigated. Thus, we set out to examine the effect of CAN and DSPN on all-cause mortality in a well-phenotyped cohort.<h4>Methods</h4>All diabetes cases (<i>n</i> ... Read more >>

J Diabetes Res (Journal of diabetes research)
[2021, 2021:6662159]

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Somatosensory network functional connectivity differentiates clinical pain phenotypes in diabetic neuropathy.

Kevin Teh, Iain D Wilkinson, Francesca Heiberg-Gibbons, Mohammed Awadh, Alan Kelsall, Shillo Pallai, Gordon Sloan, Solomon Tesfaye, Dinesh Selvarajah,

<h4>Aims/hypothesis</h4>The aim of this work was to investigate whether different clinical pain phenotypes of diabetic polyneuropathy (DPN) are distinguished by functional connectivity at rest.<h4>Methods</h4>This was an observational, cohort study of 43 individuals with painful DPN, divided into irritable (IR, n = 10) and non-irritable (NIR, n = 33) nociceptor phenotypes using the German Research ... Read more >>

Diabetologia (Diabetologia)
[2021, 64(6):1412-1421]

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Dynamics and risk of transmission of bovine tuberculosis in the emerging dairy regions of Ethiopia.

G A Mekonnen, A J K Conlan, S Berg, B T Ayele, A Mihret, A Olani, H Asgedom, , J L N Wood, G Ameni,

The Ethiopian government has several initiatives to expand and intensify the dairy industry; however, the risk of bovine tuberculosis (bTB) spread is a challenge. To assess the rate of expansion and risk factors for transmission of bTB within-herds, we carried out a repeated cross-sectional survey at two time points, 2016/17 ... Read more >>

Epidemiol Infect (Epidemiology and infection)
[2021, 149:e69]

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Axonal swellings are related to type 2 diabetes, but not to distal diabetic sensorimotor polyneuropathy.

Pall Karlsson, Sandra S Gylfadottir, Alexander G Kristensen, Juan D Ramirez, Pedro Cruz, Nhu Le, Pallai R Shillo, Solomon Tesfaye, Andrew S C Rice, Hatice Tankisi, Nanna B Finnerup, Jens R Nyengaard, Troels S Jensen, David L H Bennett, Andreas C Themistocleous,

<h4>Aims/hypothesis</h4>Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quantification altered in DSP. It is, however, ... Read more >>

Diabetologia (Diabetologia)
[2021, 64(4):923-931]

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Reduced Thalamic Volume and Metabolites in Type 1 Diabetes with Polyneuropathy.

Tine M Hansen, Jens B Frøkjær, Dinesh Selvarajah, Janusiya A Muthulingam, Solomon Tesfaye, Anne Juhl, Asbjørn M Drewes, Poul E Jakobsen, Jesper Karmisholt, Birgitte Brock, Christina Brock,

<h4>Objective</h4>Thalamus is essential in processing of sensory information. This study explored the associations between thalamic volume and intra-thalamic metabolites and associations to clinical and experimental characteristics of sensory function in adults with diabetic polyneuropathy.<h4>Methods</h4>48 adults with type 1 diabetes and confirmed distal symmetric peripheral neuropathy (DPSN) and 28 healthy controls ... Read more >>

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2021, :]

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Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.

Triantafyllos Didangelos, Eleni Karlafti, Evangelia Kotzakioulafi, Eleni Margariti, Parthena Giannoulaki, Georgios Batanis, Solomon Tesfaye, Kοnstantinos Kantartzis,

<h4>Aim</h4>To investigate the effect of normalizing vitamin B12 (B12) levels with oral B12 (methylcobalamin) 1000 μg/day for one year in patients with diabetic neuropathy (DN).<h4>Patients and methods</h4>In this prospective, double-blind, placebo-controlled trial, 90 patients with type 2 diabetes on metformin for at least four years and both peripheral and autonomic ... Read more >>

Nutrients (Nutrients)
[2021, 13(2):]

Cited: 3 times

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Imbalanced learning: Improving classification of diabetic neuropathy from magnetic resonance imaging.

Kevin Teh, Paul Armitage, Solomon Tesfaye, Dinesh Selvarajah, Iain D Wilkinson,

One of the fundamental challenges when dealing with medical imaging datasets is class imbalance. Class imbalance happens where an instance in the class of interest is relatively low, when compared to the rest of the data. This study aims to apply oversampling strategies in an attempt to balance the classes ... Read more >>

PLoS One (PloS one)
[2020, 15(12):e0243907]

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The Association of Fasting C-peptide with Corneal Neuropathy in Patients with Type 2 Diabetes.

Anju Zuo, Chuan Wang, Lili Li, Jingru Qu, Juan Cao, Li Chen, Solomon Tesfaye, Wenjuan Li, Xinguo Hou,

<h4>Purpose</h4>Damage to corneal nerve fibers has been demonstrated in people with type 2 diabetes mellitus (T2DM) that further progresses with increasing severity of diabetic peripheral neuropathy. However, the role of C-peptide in corneal nerve damage has not been reported in T2DM. The present study investigated the relationship of fasting C-peptide ... Read more >>

J Diabetes Res (Journal of diabetes research)
[2020, 2020:8883736]

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Anemia and Its Determinants among Male and Female Adolescents in Southern Ethiopia: A Comparative Cross-Sectional Study.

Melat Belay Zeleke, Mohammed Feyisso Shaka, Adane Tesfaye Anbesse, Solomon Hailemariam Tesfaye,

<h4>Background</h4>Adolescent anemia is a major public health problem worldwide. Adolescents (10-19 years) are at an increased risk of developing anemia due to increased iron demand during puberty, menstrual losses, limited dietary iron intake, and faulty dietary habits.<h4>Objective</h4>To assess the prevalence of anemia and associated factors among male and female adolescent ... Read more >>

Anemia (Anemia)
[2020, 2020:3906129]

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Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective.

Solomon Tesfaye, Kaleab Asres, Ermias Lulekal, Yonatan Alebachew, Eyael Tewelde, Mallika Kumarihamy, Ilias Muhammad,

This review provides an overview on the active phytochemical constituents of medicinal plants that are traditionally used to manage cancer in Ethiopia. A total of 119 articles published between 1968 and 2020 have been reviewed, using scientific search engines such as ScienceDirect, PubMed, and Google Scholar. Twenty-seven medicinal plant species ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(17):]

Cited: 1 time

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The impact of type 2 diabetes and its management on the prognosis of patients with severe COVID-19.

Zihui Xu, Zhongjing Wang, Shuo Wang, Yingchun Ye, Deng Luo, Li Wan, Ailin Yu, Lifang Sun, Solomon Tesfaye, Qingtao Meng, Ling Gao,

<h4>Background</h4>Although type 2 diabetes mellitus (T2DM) patients with coronavirus disease 2019 (COVID-19) develop a more severe condition compared to those without diabetes, the mechanisms for this are unknown. Moreover, the impact of treatment with antihyperglycemic drugs and glucocorticoids is unclear.<h4>Methods</h4>From 1584 COVID-19 patients, 364 severe/critical COVID-19 patients with clinical outcome ... Read more >>

J Diabetes (Journal of diabetes)
[2020, 12(12):909-918]

Cited: 11 times

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Authors' Reply to Eerdekens et al. "Treating Pain in Diabetic Neuropathy: Current and Developmental Drugs".

Uazman Alam, Gordon Sloan, Solomon Tesfaye,

Drugs (Drugs)
[2020, 80(11):1141-1143]

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Pulse oximeter with integrated management of childhood illness for diagnosis of severe childhood pneumonia at rural health institutions in Southern Ethiopia: results from a cluster-randomised controlled trial.

Solomon H Tesfaye, Yabibal Gebeyehu, Eskindir Loha, Kjell Arne Johansson, Bernt Lindtjørn,

<h4>Objective</h4>To assess whether pulse oximetry improves health workers' performance in diagnosing severe childhood pneumonia at health centres in Southern Ethiopia.<h4>Design</h4>Parallel cluster-randomised trial.<h4>Setting</h4>Government primary health centres.<h4>Participants</h4>Twenty-four health centres that treat at least one pneumonia case per day in Southern Ethiopia. Children aged between 2 months and 59 months who present at ... Read more >>

BMJ Open (BMJ open)
[2020, 10(6):e036814]

Cited: 1 time

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Determinants of Treatment Response in Painful Diabetic Peripheral Neuropathy: A Combined Deep Sensory Phenotyping and Multimodal Brain MRI Study.

Iain David Wilkinson, Kevin Teh, Francesa Heiberg-Gibbons, Mohammad Awadh, Alan Kelsall, Pallai Shillo, Gordon Sloan, Gordon Sloan, Solomon Tesfaye, Dinesh Selvarajah,

Painful diabetic peripheral neuropathy (DPN) is difficult to manage, as treatment response is often varied. The primary aim of this study was to examine differences in pain phenotypes between responders and nonresponders to intravenous lidocaine treatment using quantitative sensory testing. The secondary aim was to explore differences in brain structure ... Read more >>

Diabetes (Diabetes)
[2020, 69(8):1804-1814]

Cited: 2 times

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