Full Text Journal Articles by
Author Solomon L Woldu

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Disparities in Pre-Orchiectomy Sperm Cryopreservation Among Testicular Cancer Patients at a Public Safety Net Hospital and a Private Tertiary Care Center.

Akshat Patel, Jeffrey M Howard, Nathan Chertack, Rohit R Badia, Vitaly Margulis, Solomon L Woldu, Kevin Courtney, I Alex Bowman, Waddah Arafat, Xiaosong Meng, Tolulope Bakare, Aditya Bagrodia,

<h4>Objective</h4>To compare pre-orchiectomy sperm cryopreservation use in testicular cancer patients at a private tertiary care academic center and an affiliated public safety-net hospital.<h4>Methods</h4>This was a retrospective cohort study of patients who underwent radical orchiectomy for testicular cancer at a private tertiary-care hospital, which cared primarily for patients with private health ... Read more >>

Urology (Urology)
[2021, :]

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Re: ctDNA Guiding Adjuvant Immunotherapy in Urothelial Carcinoma.

Solomon L Woldu, Yair Lotan,

Eur Urol (European urology)
[2021, 80(4):517-518]

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Metastasis-directed radiation therapy after radical cystectomy for bladder cancer.

Andre F Miranda, Jeffrey M Howard, Mark McLaughlin, Xiaosong Meng, Timothy Clinton, Öner Şanli, Aurelie Garant, Aditya Bagrodia, Vitaly Margulis, Yair Lotan, Raquibul Hannan, Neil Desai, Solomon L Woldu,

<h4>Purpose</h4>Metastasis-directed radiation therapy (MDRT) may improve oncologic and quality of life outcomes in patients with metastatic cancer, but data on its use in metastatic bladder cancer is severely limited. We sought to review our institutional experience with MDRT in patients with metastatic bladder cancer following radical cystectomy.<h4>Materials and methods</h4>We reviewed ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Demographic Factors Associated With Non-Guideline-Based Treatment of Kidney Cancer in the United States.

Jeffrey M Howard, Karabi Nandy, Solomon L Woldu, Vitaly Margulis,

<h4>Importance</h4>Significant demographic disparities have been found to exist in the delivery of health care. Demographic factors associated with clinical decision-making in kidney cancer have not been thoroughly studied.<h4>Objective</h4>To determine whether demographic factors, including sex and race/ethnicity, are associated with receipt of non-guideline-based treatment for kidney cancer.<h4>Design, setting, and participants</h4>This retrospective ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(6):e2112813]

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Clinical outcomes of a cohort of patients with bulky, clinically node-positive bladder cancer undergoing radical cystectomy in the contemporary era.

Jeffrey M Howard, Vitaly Margulis, Solomon L Woldu,

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, 15(5):E286-E289]

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Urinary-based tumor markers enhance microhematuria risk stratification according to baseline bladder cancer prevalence.

Solomon L Woldu, Lesley Souter, Stephen A Boorjian, Daniel A Barocas, Yair Lotan,

<h4>Introduction</h4>The 2020 AUA microhematuria (MH) guideline stratifies patients into low, intermediate and high-risk for urologic malignancy based on established risk-factors for urothelial carcinoma. Notably, urine-based tumor markers (UBTMs) were not included in the risk classification. We evaluated the impact of incorporating UBTMs (cytology and multiple commercially available UBTMs) into this ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Editorial Comment.

Solomon L Woldu,

J Urol (The Journal of urology)
[2021, 205(6):1620]

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Serum Small RNA Sequencing and miR-375 Assay Do Not Identify the Presence of Pure Teratoma at Postchemotherapy Retroperitoneal Lymph Node Dissection.

John T Lafin, Alexander P Kenigsberg, Xiaosong Meng, Dreaux Abe, Anna Savelyeva, Nirmish Singla, Solomon L Woldu, Yair Lotan, Ryan J Mauck, Cheryl M Lewis, Vitaly Margulis, Daniel Wong, Liwei Jia, Payal Kapur, Lin Xu, Ryan W Speir, Gregory T Chesnut, A Lindsay Frazier, Douglas W Strand, Nicholas Coleman, Matthew J Murray, James F Amatruda, Aditya Bagrodia,

Existing tumor markers for testicular germ cell tumor (TGCT) cannot detect the presence of pure teratoma. Serum miRNAs have strong performance detecting other subtypes of TGCT. Previous reports suggest high levels of miR-375 expression in teratoma tissue. The purpose of this study was to explore the role of serum miRNA, ... Read more >>

Eur Urol Open Sci (European urology open science)
[2021, 26:83-87]

Cited: 2 times

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Neoadjuvant SABR for Renal Cell Carcinoma Inferior Vena Cava Tumor Thrombus-Safety Lead-in Results of a Phase 2 Trial.

Vitaly Margulis, Yuval Freifeld, Laurentiu M Pop, Subrata Manna, Payal Kapur, Ivan Pedrosa, Alana Christie, Osama Mohamad, Samantha Mannala, Nirmish Singla, Michael Wait, Aditya Bagrodia, Solomon L Woldu, Jeffrey Gahan, James Brugarolas, Robert Timmerman, Raquibul Hannan,

<h4>Purpose</h4>To evaluate the feasibility, safety, oncologic outcomes, and immune effect of neoadjuvant stereotactic radiation (Neo-SAbR) followed by radical nephrectomy and thrombectomy (RN-IVCT).<h4>Methods and materials</h4>These are results from the safety lead-in portion of a single-arm phase 1 and 2 trial. Patients with kidney cancer (renal cell carcinoma [RCC]) and inferior vena ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2021, 110(4):1135-1142]

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Simple Nephrectomy in a Tertiary Care Safety Net Hospital-Patient Characteristics, Causes, Cost, and Renal Function Implications.

Kyle S Ames, Fady Baky, Somer Blair, Jorge Sanchez, Whitney Franklin, Andrew Barefoot, Jessica Mears, Patricia Magness, Brett Johnson, Tolulope Bakare, Steve Hudak, Jodi Antonelli, Ryan Hutchinson, Yair Lotan, Solomon L Woldu,

<h4>Objective</h4>To evaluate factors associated with simple nephrectomy at a safety net hospital with a diverse patient population and large catchment area. Simple nephrectomy is an underreported surgery. Performance of simple nephrectomy may represent a failure of management of underlying causes.<h4>Methods</h4>We performed a retrospective review of simple nephrectomies performed at a ... Read more >>

Urology (Urology)
[2021, 149:98-102]

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Evaluation of the New American Urological Association Guidelines Risk Classification for Hematuria.

Solomon L Woldu, Casey K Ng, Ronald K Loo, Jeff M Slezak, Steven J Jacobsen, Wei Shen Tan, John D Kelly, Tony Lough, David Darling, Kim E M van Kessel, Joep J de Jong, Wim van Criekinge, Shahrokh F Shariat, Andrew Hiar, Sarah Brown, Stephen A Boorjian, Daniel A Barocas, Robert S Svatek, Yair Lotan,

<h4>Purpose</h4>Microhematuria is a prevalent condition and the American Urological Association has developed a new risk-stratified approach for the evaluation of patients with microhematuria. Our objective was to provide the first evaluation of this important guideline.<h4>Materials and methods</h4>This multinational cohort study combines contemporary patients from 5 clinical trials and 2 prospective ... Read more >>

J Urol (The Journal of urology)
[2021, 205(5):1387-1393]

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Enhanced Endoscopy with IMAGE1 S CHROMA Improves Detection of Nonmuscle Invasive Bladder Cancer During Transurethral Resection.

Jeffrey M Howard, Solomon L Woldu, Siamak Daneshmand, Yair Lotan,

<b><i>Purpose:</i></b> We assessed the ability of enhanced cystoscopy with CHROMA image enhancement (Karl Storz SE & Co. KG, Tuttlingen, Germany) to improve cancer detection during transurethral resection of bladder tumors (TURBT) in patients with known or suspected nonmuscle invasive bladder cancer (NMIBC). <b><i>Patients and Methods:</i></b> A total of 49 patients ... Read more >>

J Endourol (Journal of endourology)
[2021, 35(5):647-651]

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Impact of circulating microRNA test (miRNA-371a-3p) on appropriateness of treatment and cost outcomes in patients with Stage I non-seminomatous germ cell tumours.

Aditya Bagrodia, Anna Savelyeva, John T Lafin, Ryan W Speir, Gregory T Chesnut, Anne Lindsay Frazier, Solomon L Woldu, Vitaly Margulis, Matthew J Murray, James F Amatruda, Yair Lotan,

<h4>Objectives</h4>To determine whether utilisation of a serum microRNA (miRNA) test could improve treatment appropriateness and cost-effectiveness for patients with Stage I non-seminomatous germ cell tumours (NSGCTs).<h4>Patients and methods</h4>A decision tree model was built to investigate treatment course, clinical and cost outcomes for patients with Stage IA (T1N0M0S0) and IB (T2-4N0M0S0) ... Read more >>

BJU Int (BJU international)
[2021, 128(1):57-64]

Cited: 1 time

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Robotic Nephroureterectomy vs Laparoscopic Nephroureterectomy: Increased Utilization, Rates of Lymphadenectomy, Decreased Morbidity Robotically.

Alexander P Kenigsberg, Wesley Smith, Xiaosong Meng, Rashed Ghandour, Leonid Rapoport, Aditya Bagrodia, Yair Lotan, Solomon L Woldu, Vitaly Margulis,

<b><i>Introduction and Objective:</i></b> Robotic radical nephroureterectomy (RRNU) may offer advantages over laparoscopic radical nephroureterectomy (LRNU). The purpose of this study is to evaluate the overall survival (OS) of patients with upper tract urothelial carcinoma (UTUC) who underwent RRNU <i>vs</i> LRNU and identify factors that account for differences. <b><i>Methods:</i></b> The National ... Read more >>

J Endourol (Journal of endourology)
[2021, 35(3):312-318]

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Safety, Efficacy, and Impact on Quality of Life of Palliative Robotic Cystectomy for Advanced Prostate Cancer.

Raj R Bhanvadia, Roger K Khouri, Caleb Ashbrook, Solomon L Woldu, Vitaly Margulis, Ganesh V Raj, Aditya Bagrodia,

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, 19(2):e129-e134]

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Real-World Application of Pre-Orchiectomy miR-371a-3p Test in Testicular Germ Cell Tumor Management.

Rohit R Badia, Dreaux Abe, Daniel Wong, Nirmish Singla, Anna Savelyeva, Nathan Chertack, Solomon L Woldu, Yair Lotan, Ryan Mauck, Dan Ouyang, Xiaosong Meng, Cheryl M Lewis, Kuntal Majmudar, Liwei Jia, Payal Kapur, Lin Xu, A Lindsay Frazier, Vitaly Margulis, Douglas W Strand, Nicholas Coleman, Matthew J Murray, James F Amatruda, John T Lafin, Aditya Bagrodia,

<h4>Purpose</h4>Current serum tumor markers for testicular germ cell tumor are limited by low sensitivity. Growing evidence supports the use of circulating miR-371a-3p as a superior marker for malignant (viable) germ cell tumor management. We evaluated the real-world application of serum miR-371a-3p levels in detecting viable germ cell tumor among patients ... Read more >>

J Urol (The Journal of urology)
[2021, 205(1):137-144]

Cited: 4 times

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Overcoming sociodemographic factors in the care of patients with testicular cancer at a safety net hospital.

Nathan Chertack, Rashed A Ghandour, Nirmish Singla, Yuval Freifeld, Ryan C Hutchinson, Kevin Courtney, I Alex Bowman, Waddah Arafat, Xiaosong Meng, Joseph A Moore, Ahmet M Aydin, Arthur I Sagalowsky, Vitaly Margulis, Yair Lotan, Solomon L Woldu, Aditya Bagrodia,

<h4>Background</h4>The objective of this study was to determine whether standardized treatment of germ cell tumors (GCTs) could overcome sociodemographic factors limiting patient care.<h4>Methods</h4>The records of all patients undergoing primary treatment for GCTs at both a public safety net hospital and an academic tertiary care center in the same metropolitan area ... Read more >>

Cancer (Cancer)
[2020, 126(19):4362-4370]

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Does grossly complete transurethral resection improve response to neoadjuvant chemotherapy?

Rashed A Ghandour, Samuel Kusin, Daniel Wong, Xiaosong Meng, Nirmish Singla, Yuval Freifeld, Aditya Bagrodia, Vitaly Margulis, Arthur Sagalowsky, Yair Lotan, Solomon L Woldu,

<h4>Introduction</h4>There is controversy regarding the benefit of a grossly complete transurethral resection of bladder tumor (TURBT) for muscle-invasive bladder cancer (MIBC) in patients prior to neoadjuvant chemotherapy (NAC). Advocates for this approach suggest a higher response rate to NAC, while others suggest this can increase the surgical risk for no ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(9):736.e11-736.e18]

Cited: 1 time

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Interethnic differences in the impact of body mass index on upper tract urothelial carcinoma following radical nephroureterectomy.

Hsin-Chih Yeh, Ching-Chia Li, Tsu-Ming Chien, Chia-Yang Li, Yen-Chen Cheng, Solomon L Woldu, Haley Robyak, Chun-Nung Huang, Hung-Lung Ke, Wei-Ming Li, Hsiang-Ying Lee, Bi-Wen Yeh, Sheau-Fang Yang, Hung-Pin Tu, Arthur I Sagalowsky, Jay D Raman, Nirmish Singla, Vitaly Margulis, Yair Lotan, Jer-Tsong Hsieh, Wen-Jeng Wu,

<h4>Purpose</h4>Inconsistent prognostic implications of body mass index (BMI) in upper tract urothelial carcinoma (UTUC) have been reported across different ethnicities. In this study, we aimed to analyze the oncologic role of BMI in Asian and Caucasian patients with UTUC.<h4>Methods</h4>We retrospectively collected data from 648 Asian Taiwanese and 213 Caucasian American ... Read more >>

World J Urol (World journal of urology)
[2021, 39(2):491-500]

Cited: 1 time

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Pathologic stage as a surrogate for oncologic outcomes after receipt of neoadjuvant chemotherapy for high-grade upper tract urothelial carcinoma.

Nirmish Singla, Alana Christie, Yuval Freifeld, Rashed A Ghandour, Solomon L Woldu, Timothy N Clinton, Firas G Petros, Haley Robyak, Hsin-Chih Yeh, Dong Fang, Dmitry Enikeev, Aditya Bagrodia, Arthur I Sagalowsky, Yair Lotan, Jay D Raman, Surena F Matin, Vitaly Margulis,

<h4>Objective</h4>Whether pathologic stage at radical nephroureterectomy (RNU) can serve as an appropriate surrogate for oncologic outcomes in patients with high-grade (HG) upper tract urothelial carcinoma (UTUC) treated with neoadjuvant chemotherapy (NAC) is not defined. We sought to determine whether patients who achieve pathologically non-muscle-invasive (ypT0, ypTa, ypT1, ypTis) HG UTUC ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(12):933.e7-933.e12]

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Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma.

Hsin-Chih Yeh, Ching-Chia Li, Sheng-Chen Wen, Nirmish Singla, Solomon L Woldu, Haley Robyak, Chun-Nung Huang, Hung-Lung Ke, Wei-Ming Li, Hsiang-Ying Lee, Chia-Yang Li, Bi-Wen Yeh, Sheau-Fang Yang, Hung-Pin Tu, Shahrokh F Shariat, Arthur I Sagalowsky, Jay D Raman, Yair Lotan, Jer-Tsong Hsieh, Vitaly Margulis, Wen-Jeng Wu,

Hyponatremia has been shown to be associated with prognosis in various cancers, but its role in upper tract urothelial carcinoma (UTUC) is largely unidentified. We created an international multiregional cohort of UTUC, consisting of 524 and 213 patients from Taiwan and the U.S., to validate the significance of hyponatremia. Clinicopathologic ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(4):]

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Improved survival after cytoreductive nephrectomy for metastatic renal cell carcinoma in the contemporary immunotherapy era: An analysis of the National Cancer Database.

Nirmish Singla, Ryan C Hutchinson, Rashed A Ghandour, Yuval Freifeld, Dong Fang, Arthur I Sagalowsky, Yair Lotan, Aditya Bagrodia, Vitaly Margulis, Hans J Hammers, Solomon L Woldu,

<h4>Objectives</h4>Despite immune checkpoint inhibitor (ICI) approval for metastatic renal cell carcinoma (mRCC) in 2015, cytoreductive nephrectomy (CN) is guided by extrapolation from earlier classes of therapy. We evaluated survival outcomes, timing, and safety of combining CN with modern immunotherapy (IO) for mRCC.<h4>Methods</h4>From 96,329 renal cancer cases reported to the NCDB ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(6):604.e9-604.e17]

Cited: 4 times

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PTRF independently predicts progression and survival in multiracial upper tract urothelial carcinoma following radical nephroureterectomy.

Hsin-Chih Yeh, Vitaly Margulis, Nirmish Singla, Elizabeth Hernandez, Vandana Panwar, Solomon L Woldu, Jose A Karam, Christopher G Wood, Alon Z Weizer, Jay D Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Marco Roscigno, Christian Bolenz, Karim Bensalah, Ching-Chia Li, Hung-Lung Ke, Wei-Ming Li, Hsiang-Ying Lee, Leonid M Rapoport, Yair Lotan, Payal Kapur, Shahrokh F Shariat, Jer-Tsong Hsieh, Wen-Jeng Wu,

<h4>Objectives</h4>Polymerase I and transcript release factor (PTRF) has been implicated in cancer biology but its role in upper tract urothelial carcinoma (UTUC) is unknown. From a pilot transcriptome, we identified PTRF was significantly upregulated in high stage UTUC. Bladder cancer transcriptome from The Cancer Genome Atlas (TCGA) supported our finding ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(5):496-505]

Cited: 0 times

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Serum MicroRNA-371a-3p Levels Predict Viable Germ Cell Tumor in Chemotherapy-naïve Patients Undergoing Retroperitoneal Lymph Node Dissection.

John T Lafin, Nirmish Singla, Solomon L Woldu, Yair Lotan, Cheryl M Lewis, Kuntal Majmudar, Anna Savelyeva, Payal Kapur, Vitaly Margulis, Douglas W Strand, Matthew J Murray, James F Amatruda, Aditya Bagrodia,

Eur Urol (European urology)
[2020, 77(2):290-292]

Cited: 8 times

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Pathologic response and surgical outcomes in patients undergoing nephrectomy following receipt of immune checkpoint inhibitors for renal cell carcinoma.

Nirmish Singla, Roy Elias, Rashed A Ghandour, Yuval Freifeld, Isaac A Bowman, Leonid Rapoport, Mikhail Enikeev, Jay Lohrey, Solomon L Woldu, Jeffrey C Gahan, Aditya Bagrodia, James Brugarolas, Hans J Hammers, Vitaly Margulis,

<h4>Objective</h4>To evaluate the pathologic response, safety, and feasibility of nephrectomy following receipt of immune checkpoint inhibition (ICI) for renal cell carcinoma (RCC).<h4>Methods</h4>Patients who underwent nephrectomy for RCC after exposure to nivolumab monotherapy or combination ipilimumab/nivolumab were reviewed. Primary surgical outcomes included operative time (OT), estimated blood loss (EBL), length of ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(12):924-931]

Cited: 1 time

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