Full Text Journal Articles by
Author Sok Kuan Wong

Advertisement

Find full text journal articles








Can telomere length predict bone health? A review of current evidence.

Sok Kuan Wong, Soelaiman Ima-Nirwana, Kok-Yong Chin,

Telomeres are repetitive DNA sequences located at the end of chromosomes that serve as a protective barrier against chromosomal deterioration during cell division. Approximately 50-200 base pairs of nucleotides are lost per cell division, and new repetitive nucleotides are added by the enzyme telomerase, allowing telomere maintenance. Telomere shortening has ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):423-429]

Cited: 0 times

View full text PDF listing >>



Biochemical and histopathological assessment of liver in a rat model of metabolic syndrome induced by high-carbohydrate high-fat diet.

Sok Kuan Wong, Kok-Yong Chin, Fairus Ahmad, Soelaiman Ima-Nirwana,

This study aimed to evaluate the oxidative stress status, antioxidants capacity, and presence of nonalcoholic fatty liver disease (NAFLD) in an animal model of MetS induced by high-carbohydrate high-fat (HCHF) diet. Male Wistar rats were randomized into two groups, assigned for two different types of diet (standard rat pellet or ... Read more >>

J. Food Biochem. (Journal of food biochemistry)
[2020, :e13371]

Cited: 0 times

View full text PDF listing >>



Advertisement

Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats.

Kok-Yong Chin, Benjamin Ka Seng Thong, Rhivaldy Faahim Kamalulloh, Nur Vaizura Mohamad, Sok Kuan Wong, Azlan Mohd Arlamsyah, Rahma Triliana, Ima Nirwana Soelaiman,

Purpose:Prolonged use of proton pump inhibitors may cause bone loss, and limited therapeutic agents are available to prevent this skeletal side effect. The combination of annatto tocotrienol, a bone anabolic agent, with calcium presents a novel strategy to prevent bone loss caused by proton pump inhibitors. This study aims to ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2020, 14:2561-2572]

Cited: 0 times

View full text PDF listing >>



Effects of astaxanthin on the protection of muscle health (Review).

Sok Kuan Wong, Soelaiman Ima-Nirwana, Kok-Yong Chin,

Sarcopenia refers to the involuntary and generalized deterioration of skeletal muscle mass and strength, which may lead to falls, frailty, physical disability, loss of independence, morbidity and mortality. The majority of molecular and cellular changes involved in the degeneration of muscle tissues are mediated by oxidative stress. Therefore, astaxanthin may ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 20(4):2941-2952]

Cited: 0 times

View full text PDF listing >>



Is First Trimester Maternal 25-Hydroxyvitamin D Level Related to Adverse Maternal and Neonatal Pregnancy Outcomes? A Prospective Cohort Study among Malaysian Women.

Nor Haslinda Abd Aziz, Noor Azyani Yazid, Rahana Abd Rahman, Norhashima Abd Rashid, Sok Kuan Wong, Nur Vaizura Mohamad, Pei Shan Lim, Kok-Yong Chin,

Information on the role of 25-hydroxyvitamin D (25(OH)D) in preventing adverse pregnancy/neonatal outcomes is limited in Malaysia. This study aims to determine the relationship between the level of maternal 25(OH)D in the first trimester of pregnant women and their pregnancy/neonatal outcomes. A total of 60 pregnant women in the first ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(9):]

Cited: 0 times

View full text PDF listing >>



Vitamin C: A Review on its Role in the Management of Metabolic Syndrome.

Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana,

Oxidative stress and inflammation are two interlinked events that exist simultaneously in metabolic syndrome (MetS) and its related complications. These pathophysiological processes can be easily triggered by each other. This review summarizes the current evidence from animal and human studies on the effects of vitamin C in managing MetS. In ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2020, 17(11):1625-1638]

Cited: 0 times

View full text PDF listing >>



Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats

Kok-Yong Chin, Benjamin Ka Seng Thong, Rhivaldy Faahim Kamalulloh, Nur Vaizura Mohamad, Sok Kuan Wong, Azlan Mohd Arlamsyah, Rahma Triliana, Ima Nirwana Soelaiman,

Purpose Prolonged use of proton pump inhibitors may cause bone loss, and limited therapeutic agents are available to prevent this skeletal side effect. The combination of annatto tocotrienol, a bone anabolic agent, with calcium presents a novel strategy to prevent bone loss caused by proton pump inhibitors. This study aims ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2020, 14:2561-2572]

Cited: 0 times

View full text PDF listing >>



The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies.

Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana,

Kaempferol is a dietary bioflavonoid ubiquitously found in various types of plant. It possesses a wide range of medicinal properties suggesting its potential clinical utility that requires further investigation. The present review intends to highlight the efficacy of kaempferol and its molecular mechanisms of action in regulating bone metabolism. Many ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2019, 13:3497-3514]

Cited: 1 time

View full text PDF listing >>



The Effects of Annatto Tocotrienol Supplementation on Cartilage and Subchondral Bone in an Animal Model of Osteoarthritis Induced by Monosodium Iodoacetate.

Kok-Yong Chin, Sok Kuan Wong, Fadhlullah Zuhair Japar Sidik, Juliana Abdul Hamid, Nurul Hafizah Abas, Elvy Suhana Mohd Ramli, Sabarul Afian Mokhtar, Sakthiswary Rajalingham, Soelaiman Ima Nirwana,

Osteoarthritis is a degenerative joint disease which primarily affects the articular cartilage and subchondral bones. Since there is an underlying localized inflammatory component in the pathogenesis of osteoarthritis, compounds like tocotrienol with anti-inflammatory properties may be able to retard its progression. This study aimed to determine the effects of oral ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(16):]

Cited: 2 times

View full text PDF listing >>



Prostate Cancer and Bone Metastases: The Underlying Mechanisms.

Sok Kuan Wong, Nur-Vaizura Mohamad, Tijjani Rabiu Giaze, Kok-Yong Chin, Norazlina Mohamed, Soelaiman Ima-Nirwana,

Patients with advanced prostate cancer often develop bone metastases, leading to bone pain, skeletal fracture, and increased mortality. Bone provides a hospitable microenvironment to tumor cells. The disease manifestation is driven by the interaction between invading tumor cells, bone-forming osteoblasts, and bone-resorbing osteoclasts. The increased level of osteoclast-activating factor (parathyroid ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(10):]

Cited: 8 times

View full text PDF listing >>



Berberine and musculoskeletal disorders: The therapeutic potential and underlying molecular mechanisms.

Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana,

BACKGROUND:Musculoskeletal disorders are a group of disorders that affect the joints, bones, and muscles, causing long-term disability. Berberine, an isoquinoline alkaloid, has been previously established to exhibit beneficial properties in preventing various diseases, including musculoskeletal disorders. PURPOSE:This review article aims to recapitulate the therapeutic potential of berberine and its mechanism ... Read more >>

Phytomedicine (Phytomedicine : international journal of phytotherapy and phytopharmacology)
[2020, 73:152892]

Cited: 6 times

View full text PDF listing >>



Toll-like Receptor as a Molecular Link between Metabolic Syndrome and Inflammation: A Review.

Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana,

Metabolic Syndrome (MetS) involves a cluster of five conditions, i.e. obesity, hyperglycaemia, hypertension, hypertriglyceridemia and low High-Density Lipoprotein (HDL) cholesterol. All components of MetS share an underlying chronic inflammatory aetiology, manifested by increased levels of pro-inflammatory cytokines. The pathogenic role of inflammation in the development of MetS suggested that toll-like ... Read more >>

Curr Drug Targets (Current drug targets)
[2019, 20(12):1264-1280]

Cited: 4 times

View full text PDF listing >>



The Effects of Vitamin E from Elaeis guineensis (Oil Palm) in a Rat Model of Bone Loss Due to Metabolic Syndrome.

Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Fairus Ahmad, Soelaiman Ima-Nirwana,

The beneficial effects of vitamin E in improving components of MetS or bone loss have been established. This study aimed to investigate the potential of palm vitamin E (PVE) as a single agent, targeting MetS and bone loss concurrently, using a MetS animal model. Twelve-week-old male Wistar rats were divided ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2018, 15(9):]

Cited: 5 times

View full text PDF listing >>



Exploring the potential of tocotrienol from Bixa orellana as a single agent targeting metabolic syndrome and bone loss.

Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Fairus Ahmad, Soelaiman Ima-Nirwana,

Metabolic syndrome (MetS) is associated with osteoporosis due to the underlying inflammatory and hormonal changes. Annatto tocotrienol has been shown to improve medical complications associated with MetS or bone loss in animal studies. This study aimed to investigate the effects of annatto tocotrienol as a single treatment for MetS and ... Read more >>

Bone (Bone)
[2018, 116:8-21]

Cited: 8 times

View full text PDF listing >>



The relationship between circulating testosterone and inflammatory cytokines in men.

Nur-Vaizura Mohamad, Sok Kuan Wong, Wan Nuraini Wan Hasan, James Jam Jolly, Mohd Fozi Nur-Farhana, Soelaiman Ima-Nirwana, Kok-Yong Chin,

Testosterone is the predominant gonadal androgen in men. Low testosterone levels are found to be associated with an increased in metabolic risk and systematic inflammation. Since adipose tissue is a source of inflammatory cytokines, testosterone may regulate inflammation by acting on adipose tissue. This review aimed to explore the role ... Read more >>

Aging Male (The aging male : the official journal of the International Society for the Study of the Aging Male)
[2019, 22(2):129-140]

Cited: 10 times

View full text PDF listing >>



The use of selective estrogen receptor modulators on bone health in men.

Sok Kuan Wong, Nur-Vaizura Mohamad, Putri Ayu Jayusman, Ahmad Nazrun Shuid, Soelaiman Ima-Nirwana, Kok-Yong Chin,

Selective estrogen receptor modulators (SERMs) represent a class of drugs that act as agonist or antagonist for estrogen receptor in a tissue-specific manner. The SERMs drugs are initially used for the prevention and treatment of osteoporosis in postmenopausal women. Bone health in prostate cancer patients has become a significant concern, ... Read more >>

Aging Male (The aging male : the official journal of the International Society for the Study of the Aging Male)
[2019, 22(2):89-101]

Cited: 2 times

View full text PDF listing >>



Effects of metabolic syndrome on bone mineral density, histomorphometry and remodelling markers in male rats.

Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Fairus Ahmad, Soelaiman Ima-Nirwana,

This study aimed to evaluate the effects of metabolic syndrome (MetS) induced by high-carbohydrate high-fat (HCHF) diet on bone mineral density (BMD), histomorphometry and remodelling markers in male rats. Twelve male Wistar rats aged 12 weeks old were randomized into two groups. The normal group was given standard rat chow ... Read more >>

PLoS ONE (PloS one)
[2018, 13(2):e0192416]

Cited: 10 times

View full text PDF listing >>



Vitamin D and Depression: The Evidence from an Indirect Clue to Treatment Strategy.

Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana,

Depression is a common psychiatric disorder that decreases the quality of life and increases the mortality of patients. It incurs significant healthcare costs if left untreated. Even though intervention with antidepressants can reduce depressive symptoms, side effects are often an issue and relapse is very common. Vitamin D, commonly known ... Read more >>

Curr Drug Targets (Current drug targets)
[2018, 19(8):888-897]

Cited: 2 times

View full text PDF listing >>



Osteoporosis is associated with metabolic syndrome induced by high-carbohydrate high-fat diet in a rat model.

Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Fairus Ahmad, Nor Aini Jamil, Soelaiman Ima-Nirwana,

This study aimed to investigate the bone quality in rats induced with metabolic syndrome (MetS) using high-carbohydrate high-fat (HCHF) diet. Male Wistar rats (n = 14) were randomized into two groups. The normal group was given standard rat chow. The MetS group was given HCHF diet. Diet regimen was assigned for a ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2018, 98:191-200]

Cited: 9 times

View full text PDF listing >>



The Effects of a Modified High-carbohydrate High-fat Diet on Metabolic Syndrome Parameters in Male Rats.

Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Fairus Ahmad, Soelaiman Ima-Nirwana,

Metabolic syndrome is a cluster of metabolic abnormalities including central obesity, hyperglycemia, hypertension, and dyslipidemia. A previous study has established that high-carbohydrate high-fat diet (HCHF) can induce MetS in rats. In this study, we modified components of the diet so that it resembled the diet of Southeast Asians. This study ... Read more >>

Exp. Clin. Endocrinol. Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2018, 126(4):205-212]

Cited: 7 times

View full text PDF listing >>



Vitamin E As a Potential Interventional Treatment for Metabolic Syndrome: Evidence from Animal and Human Studies.

Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Fairus Ahmad, Soelaiman Ima-Nirwana,

A constellation of medical conditions inclusive of central obesity, hyperglycemia, hypertension, and dyslipidemia is known as metabolic syndrome (MetS). The safest option in curtailing the progression of MetS is through maintaining a healthy lifestyle, which by itself, is a long-term commitment entailing much determination. A combination of pharmacological and non-pharmacological ... Read more >>

(Frontiers in pharmacology)
[2017, 8:444]

Cited: 13 times

View full text PDF listing >>



Animal models of metabolic syndrome: a review.

Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Ahmad Fairus, Soelaiman Ima-Nirwana,

Metabolic syndrome (MetS) consists of several medical conditions that collectively predict the risk for cardiovascular disease better than the sum of individual conditions. The risk of developing MetS in human depends on synergy of both genetic and environmental factors. Being a multifactorial condition with alarming rate of prevalence nowadays, establishment ... Read more >>

(Nutrition & metabolism)
[2016, 13:65]

Cited: 41 times

View full text PDF listing >>



The Relationship between Metabolic Syndrome and Osteoporosis: A Review.

Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Fairus Ahmad, Soelaiman Ima-Nirwana,

Metabolic syndrome (MetS) and osteoporosis are two major healthcare problems worldwide. Metabolic syndrome is a constellation of medical conditions consisting of central obesity, hyperglycemia, hypertension, and dyslipidemia, in which each acts on bone tissue in different ways. The growing prevalence of MetS and osteoporosis in the population along with the ... Read more >>

Nutrients (Nutrients)
[2016, 8(6):]

Cited: 19 times

View full text PDF listing >>





Advertisement

Disclaimer
0.9359 s