Full Text Journal Articles by
Author Soelaiman Ima Nirwana

Advertisement

Find full text journal articles






Can telomere length predict bone health? A review of current evidence.

Sok Kuan Wong, Soelaiman Ima-Nirwana, Kok-Yong Chin,

Telomeres are repetitive DNA sequences located at the end of chromosomes that serve as a protective barrier against chromosomal deterioration during cell division. Approximately 50-200 base pairs of nucleotides are lost per cell division, and new repetitive nucleotides are added by the enzyme telomerase, allowing telomere maintenance. Telomere shortening has ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):423-429]

Cited: 0 times

View full text PDF listing >>



The Role of Piper sarmentosum Aqueous Extract as a Bone Protective Agent, a Histomorphometric Study.

Siti Fadziyah Mohamad Asri, Ima Nirwana Soelaiman, Mohamad Aris Mohd Moklas, Nurul Huda Mohd Nor, Nurul Hayati Mohamad Zainal, Elvy Suhana Mohd Ramli,

Glucocorticoids are one of the causes of secondary osteoporosis. The aqueous extract of Piper sarmentosum contains flavonoids that possess antioxidant effects. In this study, we determined the effects of aqueous Piper sarmentosum leaf extract on structural, dynamic and static histomorphometric changes from osteoporotic bones of rats induced with glucocorticoids. Thirty-two ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(20):]

Cited: 0 times

View full text PDF listing >>



Advertisement

Positive association between metabolic syndrome and bone mineral density among Malaysians.

Kok-Yong Chin, Chin Yi Chan, Shaanthana Subramaniam, Norliza Muhammad, Ahmad Fairus, Pei Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Soelaiman Ima-Nirwana, Norazlina Mohamed,

Objectives: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that elevates the individual risk of cardiovascular diseases. These abnormalities are also known to alter bone remodelling. Therefore, MetS may be associated with osteoporosis. This study aims to determine the association between MetS and its components and bone mineral density ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2020, 17(16):2585-2593]

Cited: 0 times

View full text PDF listing >>



Prevalence and factors of T-score discordance between hip and spine among middle-aged and elderly Malaysians.

Chin Yi Chan, Shaanthana Subramaniam, Norazlina Mohamed, Soelaiman Ima-Nirwana, Norliza Muhammad, Ahmad Fairus, Pei Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Kok-Yong Chin,

T-score discordance between hip and spine is a common problem in the diagnosis of osteoporosis based on dual-energy X-ray absorptiometry. Not much information on the prevalence and risk factors of this problem is available in Malaysia. Our study found that factors like age, height, physical activity and menopausal status should ... Read more >>

Arch Osteoporos (Archives of osteoporosis)
[2020, 15(1):142]

Cited: 0 times

View full text PDF listing >>



Biochemical and histopathological assessment of liver in a rat model of metabolic syndrome induced by high-carbohydrate high-fat diet.

Sok Kuan Wong, Kok-Yong Chin, Fairus Ahmad, Soelaiman Ima-Nirwana,

This study aimed to evaluate the oxidative stress status, antioxidants capacity, and presence of nonalcoholic fatty liver disease (NAFLD) in an animal model of MetS induced by high-carbohydrate high-fat (HCHF) diet. Male Wistar rats were randomized into two groups, assigned for two different types of diet (standard rat pellet or ... Read more >>

J. Food Biochem. (Journal of food biochemistry)
[2020, :e13371]

Cited: 0 times

View full text PDF listing >>



Effects of astaxanthin on the protection of muscle health (Review).

Sok Kuan Wong, Soelaiman Ima-Nirwana, Kok-Yong Chin,

Sarcopenia refers to the involuntary and generalized deterioration of skeletal muscle mass and strength, which may lead to falls, frailty, physical disability, loss of independence, morbidity and mortality. The majority of molecular and cellular changes involved in the degeneration of muscle tissues are mediated by oxidative stress. Therefore, astaxanthin may ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 20(4):2941-2952]

Cited: 0 times

View full text PDF listing >>



Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats.

Kok-Yong Chin, Benjamin Ka Seng Thong, Rhivaldy Faahim Kamalulloh, Nur Vaizura Mohamad, Sok Kuan Wong, Azlan Mohd Arlamsyah, Rahma Triliana, Ima Nirwana Soelaiman,

Purpose:Prolonged use of proton pump inhibitors may cause bone loss, and limited therapeutic agents are available to prevent this skeletal side effect. The combination of annatto tocotrienol, a bone anabolic agent, with calcium presents a novel strategy to prevent bone loss caused by proton pump inhibitors. This study aims to ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2020, 14:2561-2572]

Cited: 0 times

View full text PDF listing >>



Vitamin C: A Review on its Role in the Management of Metabolic Syndrome.

Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana,

Oxidative stress and inflammation are two interlinked events that exist simultaneously in metabolic syndrome (MetS) and its related complications. These pathophysiological processes can be easily triggered by each other. This review summarizes the current evidence from animal and human studies on the effects of vitamin C in managing MetS. In ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2020, 17(11):1625-1638]

Cited: 0 times

View full text PDF listing >>



Are Oxidative Stress and Inflammation Mediators of Bone Loss due to Estrogen Deficiency? A Review of Current Evidence.

Nur-Vaizura Mohamad, Ima Nirwana Soelaiman, Kok-Yong Chin,

Osteoporosis is one of the major health issues associated with menopause-related estrogen deficiency. Various reports suggest that the hormonal changes related to menopausal transition may lead to derangement of redox homeostasis and ultimately oxidative stress. Estrogen deficiency and oxidative stress may enhance the expression of genes involved in inflammation. All ... Read more >>

Endocr Metab Immune Disord Drug Targets (Endocrine, metabolic & immune disorders drug targets)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Development of Osteoporosis Screening Algorithm for Population Aged 50 Years and above in Klang Valley, Malaysia.

Shaanthana Subramaniam, Chin-Yi Chan, Ima-Nirwana Soelaiman, Norazlina Mohamed, Norliza Muhammad, Fairus Ahmad, Pei-Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Kok-Yong Chin,

Background: The current osteoporosis screening instruments are not optimized to be used among the Malaysian population. This study aimed to develop an osteoporosis screening algorithm based on risk factors for Malaysians. Methods: Malaysians aged ≥50 years (n = 607) from Klang Valley, Malaysia were interviewed and their bone health status ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(7):]

Cited: 0 times

View full text PDF listing >>



The Performance of a Calcaneal Quantitative Ultrasound Device, CM-200, in Stratifying Osteoporosis Risk among Malaysian Population Aged 40 Years and Above.

Shaanthana Subramaniam, Chin-Yi Chan, Ima Nirwana Soelaiman, Norazlina Mohamed, Norliza Muhammad, Fairus Ahmad, Pei-Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Kok-Yong Chin,

BACKGROUND:Calcaneal quantitative ultrasound (QUS) is widely used in osteoporosis screening, but the cut-off values for risk stratification remain unclear. This study validates the performance of a calcaneal QUS device (CM-200) using dual-energy X-ray absorptiometry (DXA) as the reference and establishes a new set of cut-off values for CM-200 in identifying ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 10(4):]

Cited: 1 time

View full text PDF listing >>



Annatto-Derived Tocotrienol Promotes Mineralization of MC3T3-E1 Cells by Enhancing BMP-2 Protein Expression via Inhibiting RhoA Activation and HMG-CoA Reductase Gene Expression.

Wan Nuraini Wan Hasan, Kok-Yong Chin, Norzana Abd Ghafar, Ima Nirwana Soelaiman,

Purpose:Annatto-derived tocotrienol (AnTT) has been shown to improve bone formation in animal models of osteoporosis and promote differentiation of pre-osteoblastic cells. However, the mechanism of action of AnTT in achieving these effects is unclear. This study aims to investigate the mechanism of action of AnTT on MC3T3-E1 pre-osteoblasts via the ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2020, 14:969-976]

Cited: 0 times

View full text PDF listing >>



Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats

Kok-Yong Chin, Benjamin Ka Seng Thong, Rhivaldy Faahim Kamalulloh, Nur Vaizura Mohamad, Sok Kuan Wong, Azlan Mohd Arlamsyah, Rahma Triliana, Ima Nirwana Soelaiman,

Purpose Prolonged use of proton pump inhibitors may cause bone loss, and limited therapeutic agents are available to prevent this skeletal side effect. The combination of annatto tocotrienol, a bone anabolic agent, with calcium presents a novel strategy to prevent bone loss caused by proton pump inhibitors. This study aims ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2020, 14:2561-2572]

Cited: 0 times

View full text PDF listing >>



Determinants of Bone Health Status in a Multi-Ethnic Population in Klang Valley, Malaysia.

Chin Yi Chan, Shaanthana Subramaniam, Norazlina Mohamed, Soelaiman Ima-Nirwana, Norliza Muhammad, Ahmad Fairus, Pei Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Kok-Yong Chin,

Background and objectives: Studies on osteoporosis risk factors are limited in Malaysia, so this study assesses the factors associated with bone health assessed using dual-energy X-ray absorptiometry (DXA) among Malaysians aged ≥40 years. Subjects and Methods: Data on demography, medical history, dietary and lifestyle practices of 786 Malaysians (51.4% women) ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(2):]

Cited: 1 time

View full text PDF listing >>



The performance of osteoporosis self-assessment tool for Asians (OSTA) in identifying the risk of osteoporosis among Malaysian population aged 40 years and above.

Shaanthana Subramaniam, Chin-Yi Chan, Ima-Nirwana Soelaiman, Norazlina Mohamed, Norliza Muhammad, Fairus Ahmad, Pei-Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Kok-Yong Chin,

The concordance between osteoporosis self-assessment tool for Asians (OSTA) and dual-energy X-ray absorptiometry (DXA) was fair in the study. Modification of OSTA cutoff values improved its sensitivity to identify subjects at risk for suboptimal bone health (osteopenia/osteoporosis) and osteoporosis. PURPOSE:Osteoporosis self-assessment tool for Asians (OSTA) is a convenient screening algorithm used ... Read more >>

Arch Osteoporos (Archives of osteoporosis)
[2019, 14(1):117]

Cited: 2 times

View full text PDF listing >>



The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies.

Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana,

Kaempferol is a dietary bioflavonoid ubiquitously found in various types of plant. It possesses a wide range of medicinal properties suggesting its potential clinical utility that requires further investigation. The present review intends to highlight the efficacy of kaempferol and its molecular mechanisms of action in regulating bone metabolism. Many ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2019, 13:3497-3514]

Cited: 1 time

View full text PDF listing >>



Levels of Knowledge, Beliefs, and Practices Regarding Osteoporosis and the Associations with Bone Mineral Density among Populations More Than 40 Years Old in Malaysia.

Chin Yi Chan, Shaanthana Subramaniam, Kok-Yong Chin, Soelaiman Ima-Nirwana, Norliza Muhammad, Ahmad Fairus, Pei Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Norazlina Mohamed,

Osteoporosis is a skeletal disorder commonly found among the elderly, in which the bones become weak, brittle, and more susceptible to fracture. Adequate knowledge and positive attitude towards the disease and osteoprotective activities may prevent osteoporosis, but comprehensive studies to verify this hypothesis are limited in Malaysia. This study aims ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(21):]

Cited: 3 times

View full text PDF listing >>



Vascular Dysfunction among Malaysian Men with Increased BMI: An Indication of Synergistic Effect of Free Testosterone and Inflammation.

Amilia Aminuddin, Norizam Salamt, Ahmad Faiz Ahmad Fuad, Kok-Yong Chin, Azizah Ugusman, Ima Nirwana Soelaiman, Wan Zurinah Wan Ngah,

Background and objectives: Obesity is associated with poor vascular function and may lead to future cardiovascular disease (CVD). Obesity is also related to increased inflammation and a low testosterone level. This study was conducted to determine the relationship between inflammation, testosterone level, and vascular function among subjects with an increased ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2019, 55(9):]

Cited: 0 times

View full text PDF listing >>



The Effects of Annatto Tocotrienol Supplementation on Cartilage and Subchondral Bone in an Animal Model of Osteoarthritis Induced by Monosodium Iodoacetate.

Kok-Yong Chin, Sok Kuan Wong, Fadhlullah Zuhair Japar Sidik, Juliana Abdul Hamid, Nurul Hafizah Abas, Elvy Suhana Mohd Ramli, Sabarul Afian Mokhtar, Sakthiswary Rajalingham, Soelaiman Ima Nirwana,

Osteoarthritis is a degenerative joint disease which primarily affects the articular cartilage and subchondral bones. Since there is an underlying localized inflammatory component in the pathogenesis of osteoarthritis, compounds like tocotrienol with anti-inflammatory properties may be able to retard its progression. This study aimed to determine the effects of oral ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(16):]

Cited: 2 times

View full text PDF listing >>



Prostate Cancer and Bone Metastases: The Underlying Mechanisms.

Sok Kuan Wong, Nur-Vaizura Mohamad, Tijjani Rabiu Giaze, Kok-Yong Chin, Norazlina Mohamed, Soelaiman Ima-Nirwana,

Patients with advanced prostate cancer often develop bone metastases, leading to bone pain, skeletal fracture, and increased mortality. Bone provides a hospitable microenvironment to tumor cells. The disease manifestation is driven by the interaction between invading tumor cells, bone-forming osteoblasts, and bone-resorbing osteoclasts. The increased level of osteoclast-activating factor (parathyroid ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(10):]

Cited: 8 times

View full text PDF listing >>



Proton Pump Inhibitors and Fracture Risk: A Review of Current Evidence and Mechanisms Involved.

Benjamin Ka Seng Thong, Soelaiman Ima-Nirwana, Kok-Yong Chin,

The number of patients with gastroesophageal problems taking proton pump inhibitors (PPIs) is increasing. Several studies suggested a possible association between PPIs and fracture risk, especially hip fractures, but the relationship remains contentious. This review aimed to investigate the longitudinal studies published in the last five years on the relationship ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(9):]

Cited: 4 times

View full text PDF listing >>



Knowledge, Beliefs, Dietary, and Lifestyle Practices Related to Bone Health among Middle-Aged and Elderly Chinese in Klang Valley, Malaysia.

Chin Yi Chan, Shaanthana Subramaniam, Kok-Yong Chin, Soelaiman Ima-Nirwana, Norliza Muhammad, Ahmad Fairus, Abdul Manaf Mohd Rizal, Pei Yuen Ng, Jamil Nor Aini, Noorazah Abd Aziz, Norazlina Mohamed,

Osteoporosis is a growing health problem in Asian countries with a rapidly expanding aging population. Adequate knowledge and positive health beliefs regarding osteoporosis will encourage individuals to adopt measures to protect bone health. This study aimed to investigate the association between knowledge, beliefs, and practices regarding osteoporosis and bone health ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(10):]

Cited: 3 times

View full text PDF listing >>



The Role of Tocotrienol in Preventing Male Osteoporosis-A Review of Current Evidence.

Kok-Yong Chin, Soelaiman Ima-Nirwana,

Male osteoporosis is a significant but undetermined healthcare problem. Men suffer from a higher mortality rate post-fracture than women and they are marginalized in osteoporosis treatment. The current prophylactic agents for osteoporosis are limited. Functional food components such as tocotrienol may be an alternative option for osteoporosis prevention in men. ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(6):]

Cited: 4 times

View full text PDF listing >>



Berberine and musculoskeletal disorders: The therapeutic potential and underlying molecular mechanisms.

Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana,

BACKGROUND:Musculoskeletal disorders are a group of disorders that affect the joints, bones, and muscles, causing long-term disability. Berberine, an isoquinoline alkaloid, has been previously established to exhibit beneficial properties in preventing various diseases, including musculoskeletal disorders. PURPOSE:This review article aims to recapitulate the therapeutic potential of berberine and its mechanism ... Read more >>

Phytomedicine (Phytomedicine : international journal of phytotherapy and phytopharmacology)
[2020, 73:152892]

Cited: 6 times

View full text PDF listing >>



Comparative anti-osteoporotic properties of the leaves and roots of Marantodes pumilum var. alata in postmenopausal rat model.

Tijjani Rabiu Giaze, Ahmad Nazrun Shuid, Ima Nirwana Soelaiman, Norliza Muhammad, Jamia Azdina Jamal, Mh Busra Fauzi, Norazlina Mohamed,

Background:Marantodes pumilum var. alata (MPva), popularly known as Kacip Fatimah, is widely used to maintain female reproductive health, facilitate post-partum recovery and manage symptoms of menopause and osteoporosis in South-East Asia. This study aims to further evaluate the osteoprotective potential of MPva in view of reports of its bone-protective properties ... Read more >>

(Journal of traditional and complementary medicine)
[2019, 9(4):393-400]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0551 s