Full Text Journal Articles by
Author Smrithi Sunil


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Guidelines for obtaining an absolute blood flow index with laser speckle contrast imaging

Smrithi Sunil, Sharvari Zilpelwar, David Boas, Dmitry Postnov,

<h4>ABSTRACT</h4> Laser speckle contrast imaging (LSCI) is a technique broadly applied in research and clinical settings for full-field characterization of tissue perfusion. It is based on the analysis of speckle pattern contrast, which can be theoretically related to the decorrelation time - a quantitative measure of dynamics. A direct contrast ... Read more >>

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Stroke core revealed by tissue scattering using spatial frequency domain imaging.

Smrithi Sunil, Sefik Evren Erdener, Xiaojun Cheng, Sreekanth Kura, Jianbo Tang, John Jiang, Kavon Karrobi, Kıvılcım Kılıç, Darren Roblyer, David A Boas,

Ischemic stroke leads to a reduction or complete loss of blood supply causing injury to brain tissue, which ultimately leads to behavioral impairment. Optical techniques are widely used to study the structural and functional changes that result as a consequence of ischemic stroke both in the acute and chronic phases ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2021, 29:102539]

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Chronic Imaging of Mouse Brain: From Optical Systems to Functional Ultrasound.

Kıvılcım Kılıç, Jianbo Tang, Ş Evren Erdener, Smrithi Sunil, John T Giblin, Blaire S Lee, Dmitry D Postnov, Anderson Chen, David A Boas,

Utilization of functional ultrasound (fUS) in cerebral vascular imaging is gaining popularity among neuroscientists. In this article, we describe a chronic surgical preparation method that allows longitudinal studies and therefore is applicable to a wide range of studies, especially on aging, stroke, and neurodegenerative diseases. This method can also be ... Read more >>

Curr Protoc Neurosci (Current protocols in neuroscience)
[2020, 93(1):e98]

Cited: 2 times

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Awake chronic mouse model of targeted pial vessel occlusion via photothrombosis.

Smrithi Sunil, Sefik Evren Erdener, Blaire S Lee, Dmitry Postnov, Jianbo Tang, Sreekanth Kura, Xiaojun Cheng, Ichun Anderson Chen, David A Boas, Kıvılcım Kılıç,

Animal models of stroke are used extensively to study the mechanisms involved in the acute and chronic phases of recovery following stroke. A translatable animal model that closely mimics the mechanisms of a human stroke is essential in understanding recovery processes as well as developing therapies that improve functional outcomes. ... Read more >>

Neurophotonics (Neurophotonics)
[2020, 7(1):015005]

Cited: 7 times

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Chronic Cranial Windows for Long Term Multimodal Neurovascular Imaging in Mice.

Kıvılcım Kılıç, Michèle Desjardins, Jianbo Tang, Martin Thunemann, Smrithi Sunil, Şefik Evren Erdener, Dmitry D Postnov, David A Boas, Anna Devor,

Chronic cranial windows allow for longitudinal brain imaging experiments in awake, behaving mice. Different imaging technologies have their unique advantages and combining multiple imaging modalities offers measurements of a wide spectrum of neuronal, glial, vascular, and metabolic parameters needed for comprehensive investigation of physiological and pathophysiological mechanisms. Here, we detail ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:612678]

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Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography.

Jianbo Tang, Sefik Evren Erdener, Smrithi Sunil, David A Boas,

Optical coherence tomography angiography (OCTA) has been widely used for en face visualization of the microvasculature, but is challenged for real three-dimensional (3-D) topologic imaging due to the "tail" artifacts that appear below large vessels. Further, OCTA is generally incapable of differentiating descending arterioles from ascending venules. We introduce a ... Read more >>

J Biomed Opt (Journal of biomedical optics)
[2019, 24(3):1-8]

Cited: 6 times

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The Role of Toll-Like Receptor 2 and 4 Innate Immunity Pathways in Intracortical Microelectrode-Induced Neuroinflammation.

John K Hermann, Shushen Lin, Arielle Soffer, Chun Wong, Vishnupriya Srivastava, Jeremy Chang, Smrithi Sunil, Shruti Sudhakar, William H Tomaszewski, Grace Protasiewicz, Stephen M Selkirk, Robert H Miller, Jeffrey R Capadona,

We have recently demonstrated that partial inhibition of the cluster of differentiation 14 (CD14) innate immunity co-receptor pathway improves the long-term performance of intracortical microelectrodes better than complete inhibition. We hypothesized that partial activation of the CD14 pathway was critical to a neuroprotective response to the injury associated with initial ... Read more >>

Front Bioeng Biotechnol (Frontiers in bioengineering and biotechnology)
[2018, 6:113]

Cited: 6 times

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OptoZIF Drive: a 3D printed implant and assembly tool package for neural recording and optical stimulation in freely moving mice.

David S Freedman, Joseph B Schroeder, Gregory I Telian, Zhengyang Zhang, Smrithi Sunil, Jason T Ritt,

<h4>Objective</h4>Behavioral neuroscience studies in freely moving rodents require small, light-weight implants to facilitate neural recording and stimulation. Our goal was to develop an integrated package of 3D printed parts and assembly aids for labs to rapidly fabricate, with minimal training, an implant that combines individually positionable microelectrodes, an optical fiber, ... Read more >>

J Neural Eng (Journal of neural engineering)
[2016, 13(6):066013]

Cited: 6 times

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The roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted intracortical microelectrodes.

Madhumitha Ravikumar, Smrithi Sunil, James Black, Deborah S Barkauskas, Alex Y Haung, Robert H Miller, Stephen M Selkirk, Jeffrey R Capadona,

Resident microglia and blood-borne macrophages have both been implicated to play a dominant role in mediating the neuroinflammatory response affecting implanted intracortical microelectrodes. However, the distinction between each cell type has not been demonstrated due to a lack of discriminating cellular markers. Understanding the subtle differences of each cell population ... Read more >>

Biomaterials (Biomaterials)
[2014, 35(28):8049-8064]

Cited: 40 times

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A comparison of neuroinflammation to implanted microelectrodes in rat and mouse models.

Kelsey A Potter-Baker, Madhumitha Ravikumar, Alan A Burke, William D Meador, Kyle T Householder, Amy C Buck, Smrithi Sunil, Wade G Stewart, Jake P Anna, William H Tomaszewski, Jeffrey R Capadona,

Rat models have emerged as a common tool to study neuroinflammation to intracortical microelectrodes. While a number of studies have attempted to understand the factors resulting in neuroinflammation using rat models, a complete understanding of key mechanistic pathways remains elusive. Transgenic mouse models, however, could facilitate a deeper understanding of ... Read more >>

Biomaterials (Biomaterials)
[2014, 35(22):5637-5646]

Cited: 22 times

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The effect of resveratrol on neurodegeneration and blood brain barrier stability surrounding intracortical microelectrodes.

Kelsey A Potter, Amy C Buck, Wade K Self, Megan E Callanan, Smrithi Sunil, Jeffrey R Capadona,

The current study seeks to elucidate a biological mechanism which may mediate neuroinflammation, and decreases in both blood-brain barrier stability and neuron viability at the intracortical microelectrode-tissue interface. Here, we have focused on the role of pro-inflammatory reactive oxygen species. Specifically, adult rats implanted within intracortical microelectrodes were systemically administered ... Read more >>

Biomaterials (Biomaterials)
[2013, 34(29):7001-7015]

Cited: 61 times

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