Full Text Journal Articles by
Author Skyler J Simpson


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Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell-Cell Biophysical Properties in Prostate Cancer.

Cynthia S Rubenstein, Jaime M C Gard, Mengdie Wang, Julie E McGrath, Nadia Ingabire, James P Hinton, Kendra D Marr, Skyler J Simpson, Raymond B Nagle, Cindy K Miranti, Noel A Warfel, Joe G N Garcia, Hina Arif-Tiwari, Anne E Cress,

Human prostate cancer confined to the gland is indolent (low-risk), but tumors outside the capsule are aggressive (high-risk). Extracapsular extension requires invasion within and through a smooth muscle-structured environment. Because integrins respond to biomechanical cues, we used a gene editing approach to determine if a specific region of laminin-binding α6β1 ... Read more >>

Cancer Res. (Cancer research)
[2019, 79(18):4703-4714]

Cited: 0 times

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Targeting the Cohesive Cluster Phenotype in Chordoma via β1 Integrin Increases Ionizing Radiation Efficacy.

William L Harryman, Jaime M C Gard, Kelvin W Pond, Skyler J Simpson, Lucas H Heppner, Daniel Hernandez-Cortes, Andrew S Little, Jennifer M Eschbacher, Anne E Cress,

Chordoma is a rare, radiation-resistant, skull-base and spinal tumor with high local recurrence containing mixed cell-adhesion phenotypes. We characterized DNA damage response (DDR) signaling (γH2AX, pKAP1, pATM) and survival response to ionizing radiation (IR) in human chordoma samples (42 resections, 23 patients) to test if blocking cell adhesion sensitizes U-CH1 ... Read more >>

Neoplasia (Neoplasia (New York, N.Y.))
[2017, 19(11):919-927]

Cited: 3 times

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