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Author Sixi Zhang

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Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.

Jinghui Zhai, Huan Gao, Shuo Wang, Sixi Zhang, Xiaoyu Qu, Yueming Zhang, Lina Tao, Jingmeng Sun, Yanqing Song, Li Fu,

The NOD-like receptor family pyrin domain-containing (NLRP3) inflammasomes is centrally implicated in cisplatin (CP)-induced kidney injury. Autophagy is critical for inhibiting production of NLRP3 protein that effectively reduces the inflammatory response. Ginsenoside Rg3 (SY), an active component extracted from ginseng, is reported to protect against CP-induced nephrotoxicity. However, the mechanisms ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2021, 35(11):e22896]

Cited: 1 time

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The evaluation of hepatoprotective effects of flavonoids from Scorzonera austriaca Wild against CCl4-induced acute liver injury in vitro and in vivo.

Enwei Wei, Sixi Zhang, Jinghui Zhai, Sitong Wu, Guangshu Wang,

<i>Scorzonera austriaca</i> Wild is a traditional herbal medicine; however, little is known with regard to the effect of flavonoids from S. <i>austriaca</i> (FSA) on liver injury induced by Carbon tetrachloride (CCl<sub>4</sub>), especially the mechanism remains unknown. Therefore, our paper was designed to investigate the hepatoprotective effect of FSA against CCl<sub>4</sub>-induced ... Read more >>

Drug Chem Toxicol (Drug and chemical toxicology)
[2020, :1-11]

Cited: 0 times

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Validation of an UHPLC-MS/MS Method for the Determination of Glaucocalyxin A, a Novel Potent Negative Akt Regulator in Rat Plasma, Lung and Brain Tissues: Application to a Pharmacokinetic Study.

Zhipeng Deng, Qian Liu, Jixiang He, Sixi Zhang, Wei Zhou,

Glaucocalyxin A, a novel potent negative Akt regulator, is a major active constituent of Rabdosia japonica. A simple, specific and sensitive ultra-high pressure liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for the quantification of glaucocalyxin A in rat plasma, lung and brain tissues after intravenous administration. ... Read more >>

J Chromatogr Sci (Journal of chromatographic science)
[2020, 58(3):234-240]

Cited: 0 times

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Calycosin ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1-NOD-like receptor protein 3 pathway.

Jinghui Zhai, Lina Tao, Sixi Zhang, Huan Gao, Yueming Zhang, Jingmeng Sun, Yanqing Song, Xiaoyu Qu,

The limitation of doxorubicin (DOX), which is widely used for the treatment of solid tumors and hematologic malignancies, is a vital problem in clinical application. The most serious of limit factors is cardiotoxicity. Calycosin (CA), an isoflavonoid that is the major active component in Radix astragali, has been reported in ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, 34(3):649-659]

Cited: 11 times

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Retrospective study of budesonide in children with eosinophilic gastroenteritis.

Shengbo Fang, Yanqing Song, Sixi Zhang, Chunyan Li,

<h4>Background</h4>The effectiveness of budesonide (BUD), a locally active steroid, on eosinophilic gastroenteritis (EGE) is not well understood. This study is to retrospectively evaluate the efficacy of BUD in children with EGE.<h4>Methods</h4>Forty-four children, diagnosed with EGE, were enrolled from 2013 to 2017 in our center. According to patients' preference, all the ... Read more >>

Pediatr Res (Pediatric research)
[2019, 86(4):505-509]

Cited: 1 time

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Salvianolic Acid B Attenuates Apoptosis of HUVEC Cells Treated with High Glucose or High Fat via Sirt1 Activation.

Jinghui Zhai, Lina Tao, Yueming Zhang, Huan Gao, Xiaoyu Qu, Yanqing Song, Sixi Zhang,

High glucose and high fat are important inducements for the development and progression of diabetic cardiopathy. Salvianolic acid B (SAB), which is the most abundant and bioactive compound in Danshen, attenuates oxidative stress-related disorders, such as cardiovascular diseases, cerebral ischemia, and diabetes. However, the effect of SAB on diabetic cardiopathy ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2019, 2019:9846325]

Cited: 4 times

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Dioscorea bulbifera L. delays the excretion of doxorubicin and aggravates doxorubicin-induced cardiotoxicity and nephrotoxicity by inhibiting the expression of P-glycoprotein in mice liver and kidney.

Xiaoyu Qu, Jinghui Zhai, Tingting Hu, Huan Gao, Lina Tao, Yueming Zhang, Yanqing Song, Sixi Zhang,

We aimed to investigate the drug-drug interaction (DDI) between doxorubicin (DOX) and <i>Dioscorea bulbifera L.</i> (DB) solution in mice, and to explore the effect of P-glycoprotein (P-gp) on this type of DDI. The toxicity of DOX in the liver, kidneys, and heart was assessed with alanine aminotransferase (ALT), aspartate aminotransferase ... Read more >>

Xenobiotica (Xenobiotica; the fate of foreign compounds in biological systems)
[2019, 49(9):1116-1125]

Cited: 1 time

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Astragaloside IV protects against cisplatin-induced liver and kidney injury via autophagy-mediated inhibition of NLRP3 in rats.

Xiaoyu Qu, Huan Gao, Lina Tao, Yueming Zhang, Jinghui Zhai, Jingmeng Sun, Yanqing Song, Sixi Zhang,

The aim of this study was to explore the role of the NOD-like receptor family, pyrin domain containing (NLRP3) inflammasome and autophagy in Astragaloside IV (AS IV)-mediated protection against cisplatin-induced liver and kidney injury in rats. Rats were intraperitoneally administered cisplatin at a dose of 15 mg/kg and orally administered ... Read more >>

J Toxicol Sci (The Journal of toxicological sciences)
[2019, 44(3):167-175]

Cited: 9 times

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Pharmacokinetics and tissue distribution of oroxin B in rats using a validated LC-MS/MS assay.

Kai Niu, Kai Niu, Huiyu Yan, Chunjie Guo, Sixi Zhang, Wei Zhu, Shiyong Teng,

A highly sensitive LC-MS/MS method was developed to measure oroxin B in rat plasma and tissue homogenates. The analyte and IS were isolated from biological matrices by a simple protein precipitation followed by centrifugation. Detection was conducted by electrospray negative-ionization mass spectrometry in selected-reaction monitoring mode. The assay was linear ... Read more >>

Biomed Chromatogr (Biomedical chromatography : BMC)
[2019, 33(3):e4417]

Cited: 0 times

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Omeprazole protects against cisplatin-induced nephrotoxicity by alleviating oxidative stress, inflammation, and transporter-mediated cisplatin accumulation in rats and HK-2 cells.

Huan Gao, Sixi Zhang, Tingting Hu, Xiaoyu Qu, Jinghui Zhai, Yueming Zhang, Lina Tao, Jianyuan Yin, Yanqing Song,

The present study assessed the therapeutic potential of omeprazole (OME), the most commonly prescribed proton pump inhibitor (PPI) used to treat gastroesophageal hyperacidity, against cisplatin (CP)-induced toxicity in human renal tubular HK-2 cells and rat kidneys. Herein, we observed that exposure of HK-2 cells to OME reversed the injury caused by CP, ... Read more >>

Chem Biol Interact (Chemico-biological interactions)
[2019, 297:130-140]

Cited: 5 times

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Salvianolic acid inhibits the effects of high glucose on vascular endothelial dysfunction by modulating the Sirt1-eNOS pathway.

Jinghui Zhai, Xiaoyu Qu, Yueming Zhang, Huan Gao, Lina Tao, Yanqing Song, Sixi Zhang,

Salvianolic acid (SA) is known for improving blood circulation, scavenging hydroxyl radicals, and preventing platelet aggregation. The research explored whether SA can protect against cardiovascular disease induced by high glucose conditions. Our results indicate that SA significantly increases cells viability and nitric oxide levels while decreasing reactive oxygen species generation. ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2019, 33(2):e22245]

Cited: 1 time

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Autophagy inhibition-enhanced assembly of the NLRP3 inflammasome is associated with cisplatin-induced acute injury to the liver and kidneys in rats.

Xiaoyu Qu, Huan Gao, Lina Tao, Yueming Zhang, Jinghui Zhai, Yanqing Song, Sixi Zhang,

The nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome has a key role in the inflammatory response. We found that cisplatin (7.5, 15 mg/kg, IV) could induce acute injury to the liver and kidneys of rats. Western blot and immunohistochemical analyses showed that expression of NLRP3, caspase-1 and ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2018, :e22208]

Cited: 6 times

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Quantitative determination of mogroside V in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.

Huiyu Yan, Lina Tao, Xiaoyu Qu, Liting Zhou, Sixi Zhang,

Mogroside V is the most abundant (approximately 0.50%) cucurbitane-type triterpene glycoside in Siraitia grosvenorii and exhibits significant antitussive, expectorant, anti-carcinogenic, and anti-inflammatory effects. A sensitive, robust and selective liquid chromatography tandem with mass spectrometry (LC-MS/MS) was developed and validated for the determination and pharmacokinetic investigation of mogroside V in rat ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(3):867-873]

Cited: 0 times

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Dysregulation of BSEP and MRP2 May Play an Important Role in Isoniazid-Induced Liver Injury via the SIRT1/FXR Pathway in Rats and HepG2 Cells.

Xiaoyu Qu, Yueming Zhang, Sixi Zhang, Jinghui Zhai, Huan Gao, Lina Tao, Yanqing Song,

To explore the role of the abnormal expression of the bile salt export pump (BSEP) and multidrug resistance protein 2 (MRP2) in isoniazid (INH)-induced liver injury, we assessed the liver injury induced by INH in rats and HepG2 cells in vitro. The regulatory pathways via Sirtuin 1 (SIRT1) and farnesoid ... Read more >>

Biol Pharm Bull (Biological & pharmaceutical bulletin)
[2018, 41(8):1211-1218]

Cited: 6 times

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Development of an LC-MS/MS method for quantification of two pairs of isomeric flavonoid glycosides and other ones in rat plasma: Application to pharmacokinetic studies.

Sixi Zhang, Yang Xie, Jing Wang, Yanmei Geng, Yu Zhou, Chengxin Sun, Guangshu Wang,

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for simultaneous determination of six flavonoid glycosides - isoorientin (1), orientin (2), 2″-O-β-d-xylopyranosyl isoorientin (3), 2″-O-β-d-xylopyranosyl isovitexin (4), 6-C-l-α-arabipyranosyl vitexin (5) and vitexin (6) - in rat plasma using isoquercitrin as the internal standard (IS). Plasma samples were prepared ... Read more >>

Biomed Chromatogr (Biomedical chromatography : BMC)
[2017, 31(10):]

Cited: 1 time

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A meta-analysis of apremilast on psoriatic arthritis long-term assessment of clinical efficacy (PALACE).

Xiaoyu Qu, Sixi Zhang, Lina Tao, Yanqing Song,

The aim of this article was to assess the efficacy and safety of apremilast in treatment of psoriatic arthritis (PsA) with meta-analysis method. We included four randomized clinical trials identified from MEDLINE, EMBASE, Cochrane Library, "ISRCTN Register" and "ClinicalTrials.gov" which compared apremilast with placebo. The meta-analysis was performed by the ... Read more >>

Expert Rev Clin Pharmacol (Expert review of clinical pharmacology)
[2016, 9(6):799-805]

Cited: 3 times

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A selective and sensitive method based on UPLC-MS/MS for quantification of momordin Ic in rat plasma: application to a pharmacokinetic study.

Huiyu Yan, Yanqing Song, Wei Zhou, Sixi Zhang,

A selective and sensitive method was developed and validated based on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). This method was applied to quantify momordin Ic in rat plasma. Chromatographic separation was performed on a Hypersil GOLD HPLC C18 column (150mm×4.6mm, 5μm) using an isocratic mobile phase of acetonitrile/water (80:20, v/v) ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2015, 115:196-200]

Cited: 1 time

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An LC-MS/MS method for determination of calceorioside B with cardiomyocyte protective activity in rat plasma and application to a pharmacokinetic study.

Fan Yang, Yanqing Song, Sixi Zhang, Wei Zhou,

A simple, sensitive and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of calceorioside B (CLB) in rat plasma. Detection was performed on a Thermo Scientific Hypersil Gold chromatography column using isocratic elution with a mobile phase of methanol-5 m m ammonium acetate-formic acid ... Read more >>

Biomed Chromatogr (Biomedical chromatography : BMC)
[2015, 29(10):1619-1622]

Cited: 0 times

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Simultaneous Determination of Seven Components from Hawthorn Leaves Flavonoids in Rat Plasma by LC-MS/MS.

Shourong Zhu, Huiyu Yan, Kai Niu, Sixi Zhang,

In this study, a simple, sensitive, and throughout liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of seven flavonoid compounds, namely, rutin, vitexin-4″-O-glucoside, vitexin-2″-O-rhamnoside, hyperoside, vitexin, shanyenoside A and quercetin in rat plasma after intravenous administration of hawthorn leaves flavonoids (HLF) using lysionotin as an internal ... Read more >>

J Chromatogr Sci (Journal of chromatographic science)
[2015, 53(6):909-914]

Cited: 5 times

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Simultaneous determination of sesquiterpene lactones isoalantolactone and alantolactone isomers in rat plasma by liquid chromatography with tandem mass spectrometry: application to a pharmacokinetic study.

Chunjie Guo, Sixi Zhang, Shiyong Teng, Kai Niu,

A selective, sensitive, and accurate LC-MS/MS method for the simultaneous determination of isoalantolactone and alantolactone in rat plasma has been developed using psoralen as the internal standard. LC-MS/MS analysis was carried out on a Triple Quadrupole mass spectrometer using positive ion ESI and the selected reaction monitoring mode. The assays ... Read more >>

J Sep Sci (Journal of separation science)
[2014, 37(8):950-956]

Cited: 4 times

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Development of an LC-MS/MS method for quantification of kadsurenone in rat plasma and its application to a pharmacokinetic study.

Nan Zhang, Rui Li, Haiyao Yu, Dan Shi, Ning Dong, Sixi Zhang, Helei Wang,

A sensitive and rapid LC-MS/MS method was developed and validated for the determination of kadsurenone in rat plasma using lysionotin as the internal standard (IS). The analytes were extracted from rat plasma with acetonitrile and separated on a SB-C18 column (50 × 2.1 mm, i.d.; 1.8 µm) at 30 °C. ... Read more >>

Biomed Chromatogr (Biomedical chromatography : BMC)
[2013, 27(12):1754-1758]

Cited: 2 times

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Nimodipine pulse sustained release mircopill preparation and preparing method thereof

HONGGANG GONG, SIXI ZHANG, CUIJUAN ZHANG, SHUHAI DENG,

The invention relates to a pulsed sustained-release pellet comprising nimodipine and a preparation method is also provided. The sustained-release pellet comprises: one of gastric-dissolved and medicines containing sustained-release pellets and enteric-coated and medicines containing sustained-release pellets, or the combination. The preparation method is that: making medicines containing pellets using nimodipine ... Read more >>

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Supercritical CO2 extraction separation purification method for silkworm chrysalis alpha-linolenic acid

SHUHAI DENG, SIXI ZHANG, JIANHUI CHANG,

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