Full Text Journal Articles by
Author Siti Safiah Mokhtar

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Clinacanthus nutans attenuates atherosclerosis progression in rats with type 2 diabetes by reducing vascular oxidative stress and inflammation.

Ahmad Khusairi Azemi, Siti Safiah Mokhtar, Sharifah Emilia Tuan Sharif, Aida Hanum Ghulam Rasool,

<h4>Context</h4>Atherosclerosis predisposes individuals to adverse cardiovascular events. <i>Clinacanthus nutans</i> L. (Acanthaceae) is a traditional remedy used for diabetes and inflammatory conditions.<h4>Objectives</h4>To investigate the anti-atherosclerotic activity of a <i>C. nutans</i> leaf methanol extract (CNME) in a type 2 diabetic (T2D) rat model induced by a high-fat diet (HFD) and low-dose streptozotocin.<h4>Materials ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1432-1440]

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Current Status of Endoplasmic Reticulum Stress in Type II Diabetes.

Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Ibrahim Muazzamu Aliyu, Rabi'u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar,

The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for cellular functions. Several pathophysiological conditions and pharmacological agents are known to disrupt ER homeostasis, thereby, causing ER stress. The cells react to ER stress by initiating ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(14):]

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Vitamin D deficiency attenuates endothelial function by reducing antioxidant activity and vascular eNOS expression in the rat microcirculation.

Chee Lee Wee, Siti Safiah Mokhtar, Kirnpal Kaur Banga Singh, Aida Hanum Ghulam Rasool,

This study examined the effects of vitamin D deficiency on vascular function and tissue oxidative status in the microcirculation; and whether or not these effects can be ameliorated with calcitriol, the active vitamin D metabolite. Three groups (n = 10 each) of male Sprague Dawley rats were fed for 10 weeks with control ... Read more >>

Microvasc Res (Microvascular research)
[2021, 138:104227]

Cited: 1 time

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Review of Pharmacological Properties of Channa Striatus (Haruan) In Diabetes and Cardiovascular Complications

Ahmad Khusairi Azemi, Sagir Mustapha, Mustapha Mohammed, Aida Hanum Ghulam Rasool, Reezal Ishak, Abdull Manan Mat Jais, Siti Safiah Mokhtar,

Diabetes mellitus remains a major risk factor for developing cardiovascular diseases, resulting in increased morbidity and mortality associated with cardiovascular complications. Given the burden of diabetes-related cardiovascular complications, there is a need to identify strategies, safe and effective therapeutic agents that could effectively prevent and control diabetes. Presently, many patients ... Read more >>

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Current Status of Endoplasmic Reticulum Stress in Type II Diabetes

Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Ibrahim Muazzamu Aliyu, Rabi’u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar,

The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for cellular functions. Several pathophysiological conditions and pharmacological agents are known to disrupt ER homeostasis, thereby, causing ER stress. The cells react to ER stress by initiating ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(14):]

Cited: 0 times

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Current Status of Endoplasmic Reticulum Stress in Type II Diabetes

Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Muazzamu Aliyu, Rabi’u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar,

The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis in insulin-secreting beta-cells is essential. Several pathophysiological conditions and pharmacological agents disrupt the ER homeostasis, thereby causing ER stress. The cells react to ER stress by initiating an adaptive ... Read more >>

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Calcitriol Supplementation Ameliorates Microvascular Endothelial Dysfunction in Vitamin D-Deficient Diabetic Rats by Upregulating the Vascular eNOS Protein Expression and Reducing Oxidative Stress.

Chee Lee Wee, Siti Safiah Mokhtar, Kirnpal Kaur Banga Singh, Sahran Yahaya, Susan Wai Sum Leung, Aida Hanum Ghulam Rasool,

Diabetes mellitus contributes to macro- and microvascular complications, leading to adverse cardiovascular events. This study examined the effects of vitamin D deficiency on the vascular function and tissue oxidative status in the microcirculation of diabetic rats and to determine whether these effects can be reversed with calcitriol (active vitamin D ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2021, 2021:3109294]

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Model for type 2 diabetes exhibits changes in vascular function and structure due to vascular oxidative stress and inflammation.

Ahmad Khusairi Azemi, Siti Safiah Mokhtar, Low Jen Hou, Sharifah Emilia Tuan Sharif, Aida Hanum Ghulam Rasool,

We used a type 2 diabetes rat model produced by a high fat diet (HFD) followed by low dose streptozotocin (STZ) to study diabetic vasculopathy. Animals were evaluated for early vascular structural changes, endothelial function, inflammation, lipid profile and oxidative stress. We used 20 male Sprague-Dawley rats divided equally into ... Read more >>

Biotech Histochem (Biotechnic & histochemistry : official publication of the Biological Stain Commission)
[2021, 96(7):498-506]

Cited: 2 times

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Clinacanthus nutans Leaves Extract Reverts Endothelial Dysfunction in Type 2 Diabetes Rats by Improving Protein Expression of eNOS.

Ahmad Khusairi Azemi, Siti Safiah Mokhtar, Aida Hanum Ghulam Rasool,

Diabetes mellitus is associated with endothelial dysfunction; it causes progressive vascular damage resulting from an impaired endothelium-dependent vasorelaxation. In the diabetes state, presence of hyperglycemia and insulin resistance predisposes to endothelial dysfunction. <i>Clinacanthus nutans</i>, widely used as a traditional medicine for diabetes is reported to have hypoglycemic, hypolipidemic, antioxidant, and ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2020, 2020:7572892]

Cited: 1 time

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Vitamin D status and oxidative stress in diabetes mellitus.

Wee Chee Lee, Siti Safiah Mokhtar, Seetha Munisamy, Sahran Yahaya, Aida Hanum Ghulam Rasool,

Diabetes mellitus is an epidemic that is gaining global concern. Chronic hyperglycemia in diabetes induces the excess production of free radicals. The deleterious effects of excess free radicals are encountered by endogenous antioxidant defense system. Imbalance between free radicals production and antioxidants defense mechanisms leads to a condition known as ... Read more >>

Cell Mol Biol (Noisy-le-grand) (Cellular and molecular biology (Noisy-le-Grand, France))
[2018, 64(7):60-69]

Cited: 8 times

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Corrigendum to 'Reduced nitric oxide-mediated relaxation and endothelial nitric oxide synthase expression in the tail arteries of streptozotocin-induced diabetic rats' [Eur. J. Pharmacol. 773 (2016) 78-84].

Siti Safiah Mokhtar, Paul M Vanhoutte, Susan Wai Sum Leung, Rapeah Suppian, Mohd Imran Yusof, Aida Hanum Ghulam Rasool,

Eur J Pharmacol (European journal of pharmacology)
[2017, 812:264]

Cited: 0 times

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Role of endothelium-dependent hyperpolarisation and prostacyclin in diabetes.

Siti Safiah Mokhtar, Aida Hanum Ghulam Rasool,

The endothelium plays a crucial role in maintaining vascular homeostasis by producing several vasodilating factors, including nitric oxide (NO), prostacyclin (PGI2), and endothelium-dependent hyperpolarisation (EDH); however, the balance between endothelial relaxing and contracting factors is disrupted in disease states such as diabetes mellitus and hypertension. Most reported studies of endothelial ... Read more >>

Malays J Med Sci (The Malaysian journal of medical sciences : MJMS)
[2015, 22(2):8-17]

Cited: 4 times

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Reduced nitric oxide-mediated relaxation and endothelial nitric oxide synthase expression in the tail arteries of streptozotocin-induced diabetic rats.

Siti Safiah Mokhtar, Paul M Vanhoutte, Susan Wai Sum Leung, Rapeah Suppian, Mohd Imran Yusof, Aida Hanum Ghulam Rasool,

Diabetes is associated with endothelial dysfunction, which is characterized by impaired endothelium-dependent relaxations. The present study aimed to examine the role of nitric oxide (NO), prostacyclin and endothelium-dependent hyperpolarization (EDH), in the relaxation of ventral tail arteries of rats under diabetic conditions. Relaxations of tail arteries of control and diabetic ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2016, 773:78-84]

Cited: 11 times

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Endothelium dependent hyperpolarization-type relaxation compensates for attenuated nitric oxide-mediated responses in subcutaneous arteries of diabetic patients.

Siti Safiah Mokhtar, Paul M Vanhoutte, Susan Wai Sum Leung, Mohd Imran Yusof, Wan Azman Wan Sulaiman, Arman Zaharil Mat Saad, Rapeah Suppian, Aida Hanum Ghulam Rasool,

Diabetes impairs endothelium-dependent relaxations. The present study evaluated the contribution of different endothelium-dependent relaxing mechanisms to the regulation of vascular tone in subcutaneous blood vessels of humans with Type 2 diabetes mellitus. Subcutaneous arteries were isolated from tissues of healthy controls and diabetics. Vascular function was determined using wire myography. ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2016, 53:35-44]

Cited: 12 times

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Reduced expression of prostacyclin synthase and nitric oxide synthase in subcutaneous arteries of type 2 diabetic patients.

Siti Safiah Mokhtar, Paul M Vanhoutte, Susan W S Leung, Mohd Imran Yusof, Wan Azman Wan Sulaiman, Arman Zaharil Mat Saad, Rapeah Suppian, Aida Hanum Ghulam Rasool,

Diabetic endothelial dysfunction is characterized by impaired endothelium-dependent relaxation. In this study, we measured the expression of endothelial nitric oxide synthase (eNOS), cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), prostacyclin synthase (PGIS), and prostacyclin receptor (IP) in subcutaneous arteries of type-2 diabetic and non-diabetic patients. Subcutaneous arteries were dissected from tissues from seven ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2013, 231(3):217-222]

Cited: 10 times

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