Full Text Journal Articles by
Author Siobhan McMahon

Advertisement

Find full text journal articles






Lectin Histochemistry for Tissues and Cells, and Dual Lectin and Antibody Co-localization.

Siobhán S McMahon, Michelle Kilcoyne,

In this chapter we describe in detail methods for lectin staining of (1) tissues, and (2) cells to identify and map endogenous glycosylation. We also describe (3) dual antibody and lectin staining of tissues to associate glycosylation with particular proteins or cells in tissues. ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2370:281-299]

Cited: 0 times

View full text PDF listing >>



The Effect of Neural Stem Cell Treatment on Astrocyte Phenotypes morphology and Galectin Expression in Following Rat Spinal Cord Injury

Michelle Kilcoyne, Dearbhaile Dooley, Azim Patar, Niall Bergin, Laura Duane, Kerry Thompson, Timothy Allsopp, Frank Barry, Siobhan McMahon,

Traumatic spinal cord injury (SCI) results in complex neurological dysfunction. Astrocytes react in response to SCI by undergoing proliferation and migrating to the injury site, resulting in astrogliosis. Neural stem cells (NSCs) have been proposed as a promising therapeutic strategy to promote neurogenesis following transplantation post SCI. In this study ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Identifying associations between dental arch relationship scores, relative deprivation and other cleft audit outcomes. Part 1.

Zak Christopher Sullivan, Simon Van Eeden, Siobhan McMahon, Zoe Edwards, Norah Flannigan, Madhavi Seshu, Susana Dominguez-Gonzalez,

<h4>Objectives</h4>To assess whether dental arch relationship scores are associated with speech, audiological and psychology outcomes in patients with complete unilateral cleft lip and palate (UCLP) and bilateral cleft lip and palate (BCLP).<h4>Setting and sample population</h4>One hundred 5-year-old children with non-syndromic complete UCLP and forty-two 5-year-olds with non-syndromic complete BCLP from ... Read more >>

Orthod Craniofac Res (Orthodontics & craniofacial research)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Understanding Women's Cardiovascular Health Using MyStrengths+MyHealth: A Patient-Generated Data Visualization Study of Strengths, Challenges, and Needs Differences.

Robin R Austin, Michelle A Mathiason, Ruth A Lindquist, Siobhan K McMahon, David S Pieczkiewicz, Karen A Monsen,

<h4>Purpose</h4>The purpose of this data visualization study was to identify patterns in patient-generated health data (PGHD) of women with and without Circulation signs or symptoms. Specific aims were to (a) visualize and interpret relationships among strengths, challenges, and needs of women with and without Circulation signs or symptoms; (b) generate ... Read more >>

J Nurs Scholarsh (Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing)
[2021, 53(5):634-642]

Cited: 0 times

View full text PDF listing >>



Barriers to implementation of STRIDE, a national study to prevent fall-related injuries.

Jennifer M Reckrey, Priscilla Gazarian, David B Reuben, Nancy K Latham, Siobhan K McMahon, Albert L Siu, Fred C Ko,

<h4>Background/objectives</h4>Evaluations of complex models of care for older adults may benefit from simultaneous assessment of intervention implementation. The STRIDE (Strategies To Reduce Injuries and Develop confidence in Elders) pragmatic trial evaluated the effectiveness of a multifactorial intervention to reduce serious fall injuries in older adults. We conducted multi-level stakeholder interviews ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2021, 69(5):1334-1342]

Cited: 1 time

View full text PDF listing >>



A robust platform for high-throughput screening of therapeutic strategies for acute and chronic spinal cord injury.

Vaibhav Patil, Enda O'Connell, Leo R Quinlan, Howard Fearnhead, Siobhan McMahon, Abhay Pandit,

Astrocytes and microglia are critical regulators of inflammatory cascade after spinal cord injury (SCI). Existing glial <i>in vitro</i> studies do not replicate inflammatory phases associated with SCI. Here, we report an <i>in vitro</i> model of mixed glial culture where inflammation is induced by the administration of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β, ... Read more >>

iScience (iScience)
[2021, 24(3):102182]

Cited: 0 times

View full text PDF listing >>



Community-based intervention effects on older adults' physical activity and falls: Protocol and rationale for a randomized optimization trial (Ready Steady3.0).

Siobhan K McMahon, Beth A Lewis, Weihua Guan, Jean F Wyman, Alexander J Rothman,

The Ready Steady 3.0 trial is designed to test the main and interactive effects of two behavior change intervention components, within an 8-week physical activity intervention, on older adults' physical activity (PA). Each component is comprised of behavior change strategies that emphasize two different evidence-based ways to motivate older adults ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2021, 101:106238]

Cited: 0 times

View full text PDF listing >>



Effect of a Multifactorial Fall Injury Prevention Intervention on Patient Well-Being: The STRIDE Study.

Thomas M Gill, Shalender Bhasin, David B Reuben, Nancy K Latham, Katy Araujo, David A Ganz, Chad Boult, Albert W Wu, Jay Magaziner, Neil Alexander, Robert B Wallace, Michael E Miller, Thomas G Travison, Susan L Greenspan, Jerry H Gurwitz, Jeremy Rich, Elena Volpi, Stephen C Waring, Todd M Manini, Lillian C Min, Jeanne Teresi, Patricia C Dykes, Siobhan McMahon, Joanne M McGloin, Eleni A Skokos, Peter Charpentier, Shehzad Basaria, Pamela W Duncan, Thomas W Storer, Priscilla Gazarian, Heather G Allore, James Dziura, Denise Esserman, Martha B Carnie, Catherine Hanson, Fred Ko, Neil M Resnick, Jocelyn Wiggins, Charles Lu, Can Meng, Lori Goehring, Maureen Fagan, Rosaly Correa-de-Araujo, Carri Casteel, Peter Peduzzi, Erich J Greene,

<h4>Background/objectives</h4>In the Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) study, a multifactorial intervention was associated with a nonsignificant 8% reduction in time to first serious fall injury but a significant 10% reduction in time to first self-reported fall injury relative to enhanced usual care. The effect of ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2021, 69(1):173-179]

Cited: 0 times

View full text PDF listing >>



A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries.

Shalender Bhasin, Thomas M Gill, David B Reuben, Nancy K Latham, David A Ganz, Erich J Greene, James Dziura, Shehzad Basaria, Jerry H Gurwitz, Patricia C Dykes, Siobhan McMahon, Thomas W Storer, Priscilla Gazarian, Michael E Miller, Thomas G Travison, Denise Esserman, Martha B Carnie, Lori Goehring, Maureen Fagan, Susan L Greenspan, Neil Alexander, Jocelyn Wiggins, Fred Ko, Albert L Siu, Elena Volpi, Albert W Wu, Jeremy Rich, Stephen C Waring, Robert B Wallace, Carri Casteel, Neil M Resnick, Jay Magaziner, Peter Charpentier, Charles Lu, Katy Araujo, Haseena Rajeevan, Can Meng, Heather Allore, Brooke F Brawley, Rich Eder, Joanne M McGloin, Eleni A Skokos, Pamela W Duncan, Dorothy Baker, Chad Boult, Rosaly Correa-de-Araujo, Peter Peduzzi, ,

<h4>Background</h4>Injuries from falls are major contributors to complications and death in older adults. Despite evidence from efficacy trials that many falls can be prevented, rates of falls resulting in injury have not declined.<h4>Methods</h4>We conducted a pragmatic, cluster-randomized trial to evaluate the effectiveness of a multifactorial intervention that included risk assessment ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(2):129-140]

Cited: 10 times

View full text PDF listing >>



Ex Vivo Rat Transected Spinal Cord Slices as a Model to Assess Lentiviral Vector Delivery of Neurotrophin-3 and Short Hairpin RNA against NG2.

Azim Patar, Peter Dockery, Siobhan McMahon, Linda Howard,

The failure of the spinal cord to regenerate can be attributed both to a lack of trophic support for regenerating axons and to upregulation of inhibitory factors such as chondroitin sulphate proteoglycans including NG2 following injury. Lentiviral vector-mediated gene therapy is a possible strategy for treating spinal cord injury (SCI). ... Read more >>

Biology (Basel) (Biology)
[2020, 9(3):]

Cited: 1 time

View full text PDF listing >>



Aging Adults' Preferences for Wellness Program Activities and Delivery Characteristics: A Cross-Sectional Survey.

Kristine M C Talley, Corjena Cheung, Michelle A Mathiason, Erica Schorr, Siobhan McMahon, Jean F Wyman,

Background:Lifestyle wellness programs help prevent and manage chronic diseases, yet few are designed for aging adults. Purpose:Identify characteristics associated with aging adults' preferences for wellness program activities and delivery characteristics. Subjects/methods:Cross-sectional, self-administered survey of a convenience sample of 386 adults aged ≥55 years. Logistic regression models identified characteristics influencing preferences. ... Read more >>

Top Geriatr Rehabil (Topics in geriatric rehabilitation)
[2019, 35(4):289-299]

Cited: 0 times

View full text PDF listing >>



Examining Potential Psychosocial Mediators in a Physical Activity Intervention for Older Adults.

Siobhan K McMahon, Beth Lewis, J Michael Oakes, Jean F Wyman, Weihua Guan, Alexander J Rothman,

The purpose of this study was to examine psychosocial constructs targeted as potential mediators in a prior physical activity (PA) intervention study. This secondary analysis used data from 102 older adults randomized to one of four conditions-within a 2 (Interpersonal Strategies: yes, no) x 2 (Intrapersonal Strategies: yes, no) factorial ... Read more >>

West J Nurs Res (Western journal of nursing research)
[2020, 42(8):581-592]

Cited: 1 time

View full text PDF listing >>



Older Adults' Utilization of Community Resources Targeting Fall Prevention and Physical Activity.

Siobhan K McMahon, Young Shin Park, Beth Lewis, Weihua Guan, J Michael Oakes, Jean F Wyman, Alexander J Rothman,

BACKGROUND AND OBJECTIVES:Despite the availability of community resources, fall and inactivity rates remain high among older adults. Thus, in this article, we describe older adults' self-reported awareness and use of community resources targeting fall prevention and physical activity. RESEARCH DESIGN AND METHODS:In-depth, semistructured interviews were conducted in Phase 1 with ... Read more >>

Gerontologist (The Gerontologist)
[2019, 59(3):436-446]

Cited: 2 times

View full text PDF listing >>



Protocol for serious fall injury adjudication in the Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) study.

David A Ganz, Albert L Siu, Jay Magaziner, Nancy K Latham, Thomas G Travison, Nancy P Lorenze, Charles Lu, Rixin Wang, Erich J Greene, Cynthia L Stowe, Lea N Harvin, Katy L B Araujo, Jerry H Gurwitz, Yuri Agrawal, Rosaly Correa-De-Araujo, Peter Peduzzi, Thomas M Gill, ,

<h4>Background</h4>This paper describes a protocol for determining the incidence of serious fall injuries for Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE), a large, multicenter pragmatic clinical trial with limited resources for event adjudication. We describe how administrative data (from participating health systems and Medicare claims) can be ... Read more >>

Inj Epidemiol (Injury epidemiology)
[2019, 6:14]

Cited: 4 times

View full text PDF listing >>



Differential Glycosylation Expression in Injured Rat Spinal Cord Treated with Immunosuppressive Drug Cyclosporin-A.

Michelle Kilcoyne, Vaibhav Patil, Claire O'Grady, Ciara Bradley, Siobhan S McMahon,

Glycosylation is ubiquitous throughout the central nervous system and altered following spinal cord injury (SCI). The glial scar that forms following SCI is composed of several chondroitin sulfate proteoglycans, which inhibit axonal regrowth. Cyclosporin-A (CsA), an immunosuppressive therapeutic, has been proposed as a potential treatment after SCI. We investigated CsA ... Read more >>

ACS Omega (ACS omega)
[2019, 4(2):3083-3097]

Cited: 2 times

View full text PDF listing >>



Cell viability in three ex vivo rat models of spinal cord injury.

Azim Patar, Peter Dockery, Linda Howard, Siobhan S McMahon,

Spinal cord injury (SCI) is a devastating disorder that has a poor prognosis of recovery. Animal models of SCI are useful to understand the pathophysiology of SCI and the potential use of therapeutic strategies for human SCI. Ex vivo models of central nervous system (CNS) trauma, particularly mechanical trauma, have ... Read more >>

J Anat (Journal of anatomy)
[2019, 234(2):244-251]

Cited: 3 times

View full text PDF listing >>



Analysis of reactive astrocytes and NG2 proteoglycan in ex vivo rat models of spinal cord injury.

Azim Patar, Peter Dockery, Linda Howard, Siobhan McMahon,

<h4>Background</h4>The use of animals to model spinal cord injury (SCI) requires extensive post-operative care and can be expensive, which makes an alternative model extremely attractive. The use ofex vivo slice cultures is an alternative way to study the pathophysiological changes that can mimic in vivo conditions and support the 3Rs ... Read more >>

J Neurosci Methods (Journal of neuroscience methods)
[2019, 311:418-425]

Cited: 2 times

View full text PDF listing >>



Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods.

Shalender Bhasin, Thomas M Gill, David B Reuben, Nancy K Latham, Jerry H Gurwitz, Patricia Dykes, Siobhan McMahon, Thomas W Storer, Pamela W Duncan, David A Ganz, Shehzad Basaria, Michael E Miller, Thomas G Travison, Erich J Greene, James Dziura, Denise Esserman, Heather Allore, Martha B Carnie, Maureen Fagan, Catherine Hanson, Dorothy Baker, Susan L Greenspan, Neil Alexander, Fred Ko, Albert L Siu, Elena Volpi, Albert W Wu, Jeremy Rich, Stephen C Waring, Robert Wallace, Carri Casteel, Jay Magaziner, Peter Charpentier, Charles Lu, Katy Araujo, Haseena Rajeevan, Scott Margolis, Richard Eder, Joanne M McGloin, Eleni Skokos, Jocelyn Wiggins, Lawrence Garber, Steven B Clauser, Rosaly Correa-De-Araujo, Peter Peduzzi,

Background:Fall injuries are a major cause of morbidity and mortality among older adults. We describe the design of a pragmatic trial to compare the effectiveness of an evidence-based, patient-centered multifactorial fall injury prevention strategy to an enhanced usual care. Methods:Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) is ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2018, 73(8):1053-1061]

Cited: 19 times

View full text PDF listing >>



The Strategies to Reduce Injuries and Develop Confidence in Elders Intervention: Falls Risk Factor Assessment and Management, Patient Engagement, and Nurse Co-management.

David B Reuben, Priscilla Gazarian, Neil Alexander, Katy Araujo, Dorothy Baker, Jonathan F Bean, Chad Boult, Peter Charpentier, Pamela Duncan, Nancy Latham, Rosanne M Leipzig, Lisa M Quintiliani, Thomas Storer, Siobhan McMahon,

In response to the epidemic of falls and serious falls-related injuries in older persons, in 2014, the Patient Centered Outcomes Research Institute (PCORI) and the National Institute on Aging funded a pragmatic trial, Strategies to Reduce Injuries and Develop confidence in Elders (STRIDE) to compare the effects of a multifactorial ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2017, 65(12):2733-2739]

Cited: 9 times

View full text PDF listing >>



Usability and clinical efficacy of diabetes mobile applications for adults with type 2 diabetes: A systematic review.

Helen Fu, Siobhan K McMahon, Cynthia R Gross, Terrence J Adam, Jean F Wyman,

<h4>Objectives</h4>To assess the usability and clinical effectiveness of diabetes mobile applications (diabetes apps) developed for adults with type 2 diabetes.<h4>Method</h4>A systematic review of the usability and effectiveness of diabetes apps was conducted. Searches were performed using MEDLINE, EMBASE, COMPENDEX, and IEEE XPLORE for articles published from January 1, 2011, to ... Read more >>

Diabetes Res Clin Pract (Diabetes research and clinical practice)
[2017, 131:70-81]

Cited: 37 times

View full text PDF listing >>



GDNF Schwann cells in hydrogel scaffolds promote regional axon regeneration, remyelination and functional improvement after spinal cord transection in rats.

Bingkun K Chen, Nicolas N Madigan, Jeffrey S Hakim, Mahrokh Dadsetan, Siobhan S McMahon, Michael J Yaszemski, Anthony J Windebank,

Positively-charged oligo[poly(ethylene glycol)fumarate] (OPF<sup>+</sup> ) is a biodegradable hydrogel used for spinal cord injury repair. We compared scaffolds containing primary Schwann cells (SCs) to scaffolds delivering SCs genetically modified to secrete high concentrations of glial cell-derived neurotrophic factor (GDNF). Multichannel OPF<sup>+</sup> scaffolds loaded with SCs or GDNF-SCs were implanted into ... Read more >>

J Tissue Eng Regen Med (Journal of tissue engineering and regenerative medicine)
[2018, 12(1):e398-e407]

Cited: 13 times

View full text PDF listing >>



Assessing the Effects of Interpersonal and Intrapersonal Behavior Change Strategies on Physical Activity in Older Adults: a Factorial Experiment.

Siobhan K McMahon, Beth Lewis, J Michael Oakes, Jean F Wyman, Weihua Guan, Alexander J Rothman,

<h4>Background</h4>Little is known about which behavior change strategies motivate older adults to increase their physical activity.<h4>Purpose</h4>The purpose of this study was to assess the relative effects of two sets of behavior change strategies to motivate increased physical activity among older adults: interpersonal and intrapersonal.<h4>Methods</h4>Community-dwelling older adults (N = 102, mean age = 79) were ... Read more >>

Ann Behav Med (Annals of behavioral medicine : a publication of the Society of Behavioral Medicine)
[2017, 51(3):376-390]

Cited: 18 times

View full text PDF listing >>



Non-viral xylosyltransferase-1 siRNA delivery as an effective alternative to chondroitinase in an in vitro model of reactive astrocytes.

Mohammad T Abu-Rub, Ben Newland, Michelle Naughton, Wenxin Wang, Siobhan McMahon, Abhay Pandit,

Reactive astrocytosis and the subsequent glial scar is ubiquitous to injuries of the central nervous system, especially spinal cord injury (SCI) and primarily serves to protect against further damage, but is also a prominent inhibitor of regeneration. Manipulating the glial scar by targeting chondroitin sulfate proteoglycans (CSPGs) has been the ... Read more >>

Neuroscience (Neuroscience)
[2016, 339:267-275]

Cited: 3 times

View full text PDF listing >>



Social Determinants Documentation in Electronic Health Records With and Without Standardized Terminologies.

Karen A Monsen, Nicole Kapinos, Joyce M Rudenick, Kathryn Warmbold, Siobhan K McMahon, Erica N Schorr,

West J Nurs Res (Western journal of nursing research)
[2016, 38(10):1399-1400]

Cited: 1 time

View full text PDF listing >>



Combining Motivational and Physical Intervention Components to Promote Fall-Reducing Physical Activity Among Community-Dwelling Older Adults: A Feasibility Study.

Siobhan Kathleen McMahon, Jean F Wyman, Michael J Belyea, Nelma Shearer, Eric B Hekler, Julie Fleury,

<h4>Purpose</h4>To assess the feasibility of a new intervention, Ready~Steady, in terms of demand, acceptability, implementation, and limited efficacy.<h4>Design</h4>Randomized controlled trial; repeated measures.<h4>Setting</h4>Two rural communities in Itasca County, Minnesota.<h4>Subjects</h4>Thirty participants were randomized to an intervention (n = 16) or attention-control (n = 14) group.<h4>Intervention</h4>Ready~Steady combined two components: (1) motivational (motivational support, ... Read more >>

Am J Health Promot (American journal of health promotion : AJHP)
[2016, 30(8):638-644]

Cited: 7 times

View full text PDF listing >>



Advertisement


Disclaimer

1.5057 s