Full Text Journal Articles by
Author Simonetta Filippi

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Breaking down calcium timing in heterogenous cells populations.

Alessandro Loppini, Christian Cherubini, Marta Bertolaso, Simonetta Filippi,

Calcium controls a large number of cellular processes at different scales. Decades of studies have pointed out the importance of calcium signaling in regulating differentiation, apoptosis, mitosis and functions such as secretion, muscle contraction and memory. The space-time structure of calcium signaling is central to this complex regulation. In particular, ... Read more >>

BioSystems (Bio Systems)
[2020, 191-192:104117]

Cited: 0 times

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Spatiotemporal correlation uncovers characteristic lengths in cardiac tissue.

Alessandro Loppini, Alessio Gizzi, Christian Cherubini, Elizabeth M Cherry, Flavio H Fenton, Simonetta Filippi,

Complex spatiotemporal patterns of action potential duration have been shown to occur in many mammalian hearts due to period-doubling bifurcations that develop with increasing frequency of stimulation. Here, through high-resolution optical mapping experiments and mathematical modeling, we introduce a characteristic spatial length of cardiac activity in canine ventricular wedges via ... Read more >>

Phys Rev E (Physical review. E)
[2019, 100(2-1):020201]

Cited: 0 times

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Biophysical modeling of C. elegans neurons: Single ion currents and whole-cell dynamics of AWCon and RMD.

Martina Nicoletti, Alessandro Loppini, Letizia Chiodo, Viola Folli, Giancarlo Ruocco, Simonetta Filippi,

C. elegans neuronal system constitutes the ideal framework for studying simple, yet realistic, neuronal activity, since the whole nervous system is fully characterized with respect to the exact number of neurons and the neuronal connections. Most recent efforts are devoted to investigate and clarify the signal processing and functional connectivity, ... Read more >>

PLoS One (PloS one)
[2019, 14(7):e0218738]

Cited: 2 times

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Critical transitions in heterogeneous networks: Loss of low-degree nodes as an early warning signal.

Alessandro Loppini, Simonetta Filippi, H Eugene Stanley,

A large number of real networks show abrupt phase transition phenomena in response to environmental changes. In this case, cascading phenomena can induce drastic and discontinuous changes in the system state and lead to collapse. Although complex network theory has been used to investigate these drastic events, we are still ... Read more >>

Phys Rev E (Physical review. E)
[2019, 99(4-1):040301]

Cited: 0 times

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Postbariatric Brachioplasty with Posteromedial Scar: Physical Model, Technical Refinements, and Clinical Outcomes.

Pierfranco Simone, Carlo Carusi, Francesco Segreto, Riccardo Iannuzzi, Silvia Buscaglione, Alessio Gizzi, Sara Giannitelli, Alberto Rainer, Simonetta Filippi, Paolo Persichetti,

Brachioplasty is an increasingly performed procedure following massive weight loss. A visible scar is the main hindrance to this surgery. The aims of the study were to develop a physical model to investigate the ideal location of the surgical incision and to present the authors' technical refinements with the posteromedial ... Read more >>

Plast. Reconstr. Surg. (Plastic and reconstructive surgery)
[2018, 141(2):344-353]

Cited: 0 times

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Systems Biology Modeling of Nonlinear Cancer Dynamics.

Christian Cherubini, Simonetta Filippi, Alessandro Loppini,

Systems Biology represents nowadays a promising standard framework for natural and human sciences to attack complicated problems involving Life. Here a particular application of such a program is discussed in the case of Cancer, by using a basic toy model for solid tumor spread for framing together two apparently different ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2018, 1702:203-213]

Cited: 1 time

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A note on stress-driven anisotropic diffusion and its role in active deformable media.

Christian Cherubini, Simonetta Filippi, Alessio Gizzi, Ricardo Ruiz-Baier,

We introduce a new model to describe diffusion processes within active deformable media. Our general theoretical framework is based on physical and mathematical considerations, and it suggests to employ diffusion tensors directly influenced by the coupling with mechanical stress. The proposed generalised reaction-diffusion-mechanics model reveals that initially isotropic and homogeneous ... Read more >>

J. Theor. Biol. (Journal of theoretical biology)
[2017, 430:221-228]

Cited: 3 times

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Computationally Informed Design of a Multi-Axial Actuated Microfluidic Chip Device.

Alessio Gizzi, Sara Maria Giannitelli, Marcella Trombetta, Christian Cherubini, Simonetta Filippi, Adele De Ninno, Luca Businaro, Annamaria Gerardino, Alberto Rainer,

This paper describes the computationally informed design and experimental validation of a microfluidic chip device with multi-axial stretching capabilities. The device, based on PDMS soft-lithography, consisted of a thin porous membrane, mounted between two fluidic compartments, and tensioned via a set of vacuum-driven actuators. A finite element analysis solver implementing ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):5489]

Cited: 3 times

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A FSI computational framework for vascular physiopathology: A novel flow-tissue multiscale strategy.

Daniele Bianchi, Elisabetta Monaldo, Alessio Gizzi, Michele Marino, Simonetta Filippi, Giuseppe Vairo,

A novel fluid-structure computational framework for vascular applications is herein presented. It is developed by combining the double multi-scale nature of vascular physiopathology in terms of both tissue properties and blood flow. Addressing arterial tissues, they are modelled via a nonlinear multiscale constitutive rationale, based only on parameters having a ... Read more >>

Med Eng Phys (Medical engineering & physics)
[2017, 47:25-37]

Cited: 3 times

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Mathematical modeling of gap junction coupling and electrical activity in human β-cells.

Alessandro Loppini, Matthias Braun, Simonetta Filippi, Morten Gram Pedersen,

Coordinated insulin secretion is controlled by electrical coupling of pancreatic β-cells due to connexin-36 gap junctions. Gap junction coupling not only synchronizes the heterogeneous β-cell population, but can also modify the electrical behavior of the cells. These phenomena have been widely studied with mathematical models based on data from mouse ... Read more >>

Phys Biol (Physical biology)
[2015, 12(6):066002]

Cited: 4 times

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Role of topology in complex functional networks of beta cells.

Christian Cherubini, Simonetta Filippi, Alessio Gizzi, Alessandro Loppini,

The activity of pancreatic β cells can be described by biological networks of coupled nonlinear oscillators that, via electrochemical synchronization, release insulin in response to augmented glucose levels. In this work, we analyze the emergent behavior of regular and percolated β-cells clusters through a stochastic mathematical model where "functional" networks ... Read more >>

Phys Rev E Stat Nonlin Soft Matter Phys (Physical review. E, Statistical, nonlinear, and soft matter physics)
[2015, 92(4):042702]

Cited: 1 time

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The role of coherence in emergent behavior of biological systems.

Marta Bertolaso, Antonio Capolupo, Christian Cherubini, Simonetta Filippi, Alessio Gizzi, Alessandro Loppini, Giuseppe Vitiello,

In his research activity, Emilio Del Giudice explored the possibility to move towards a unified view of some long-range dynamics in nature, ranging from quantum field theory in physics up to biology. Such a view is adopted in this contribution by discussing a mathematical model for synchronized electrical behavior of ... Read more >>

Electromagn Biol Med (Electromagnetic biology and medicine)
[2015, 34(2):138-140]

Cited: 2 times

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Why network approach can promote a new way of thinking in biology.

Alessandro Giuliani, Simonetta Filippi, Marta Bertolaso,

This work deals with the particular nature of network-based approach in biology. We will comment about the shift from the consideration of the molecular layer as the definitive place where causative process start to the elucidation of the among elements (at any level of biological organization they are located) interaction ... Read more >>

(Frontiers in genetics)
[2014, 5:83]

Cited: 11 times

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Assessment of type 1 diabetes risk conferred by HLA-DRB1, INS-VNTR and PTPN22 genes using the Bayesian network approach.

Rosalba Portuesi, Paolo Pozzilli, Bernhard Boehm, Raffaella Buzzetti, Simonetta Filippi,

BACKGROUND: Determining genetic risk is a fundamental prerequisite for the implementation of primary prevention trials for type 1 diabetes (T1D). The aim of this study was to assess the risk conferred by HLA-DRB1, INS-VNTR and PTPN22 single genes on the onset of T1D and the joint risk conferred by all ... Read more >>

PLoS One (PloS one)
[2013, 8(11):e79506]

Cited: 2 times

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Mathematical modelling of active contraction in isolated cardiomyocytes.

Ricardo Ruiz-Baier, Alessio Gizzi, Simone Rossi, Christian Cherubini, Aymen Laadhari, Simonetta Filippi, Alfio Quarteroni,

We investigate the interaction of intracellular calcium spatio-temporal variations with the self-sustained contractions in cardiac myocytes. A consistent mathematical model is presented considering a hyperelastic description of the passive mechanical properties of the cell, combined with an active-strain framework to explain the active shortening of myocytes and its coupling with ... Read more >>

Math Med Biol (Mathematical medicine and biology : a journal of the IMA)
[2014, 31(3):259-283]

Cited: 6 times

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Effects of pacing site and stimulation history on alternans dynamics and the development of complex spatiotemporal patterns in cardiac tissue.

Alessio Gizzi, Elizabeth M Cherry, Robert F Gilmour, Stefan Luther, Simonetta Filippi, Flavio H Fenton,

Alternans of action potential duration has been associated with T wave alternans and the development of arrhythmias because it produces large gradients of repolarization. However, little is known about alternans dynamics in large mammalian hearts. Using optical mapping to record electrical activations simultaneously from the epicardium and endocardium of 9 ... Read more >>

(Frontiers in physiology)
[2013, 4:71]

Cited: 33 times

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Role of temperature on nonlinear cardiac dynamics.

Flavio H Fenton, Alessio Gizzi, Christian Cherubini, Nicola Pomella, Simonetta Filippi,

Thermal effects affecting spatiotemporal behavior of cardiac tissue are discussed by relating temperature variations to proarrhythmic dynamics in the heart. By introducing a thermoelectric coupling in a minimal model of cardiac tissue, we are able to reproduce experimentally measured dynamics obtained simultaneously from epicardial and endocardial canine right ventricles at ... Read more >>

Phys Rev E Stat Nonlin Soft Matter Phys (Physical review. E, Statistical, nonlinear, and soft matter physics)
[2013, 87(4):042717]

Cited: 10 times

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Wave-train-induced termination of weakly anchored vortices in excitable media.

Alain Pumir, Sitabhra Sinha, S Sridhar, Médéric Argentina, Marcel Hörning, Simonetta Filippi, Christian Cherubini, Stefan Luther, Valentin Krinsky,

A free vortex in excitable media can be displaced and removed by a wave train. However, simple physical arguments suggest that vortices anchored to large inexcitable obstacles cannot be removed similarly. We show that unpinning of vortices attached to obstacles smaller than the core radius of the free vortex is ... Read more >>

Phys Rev E Stat Nonlin Soft Matter Phys (Physical review. E, Statistical, nonlinear, and soft matter physics)
[2010, 81(1 Pt 1):010901]

Cited: 10 times

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