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Author Simone Scuderi

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Can Negative Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Avoid the Need for Pelvic Lymph Node Dissection in Newly Diagnosed Prostate Cancer Patients? A Systematic Review and Meta-analysis with Backup Histology as Reference Standard.

Armando Stabile, Antony Pellegrino, Elio Mazzone, Donato Cannoletta, Mario de Angelis, Francesco Barletta, Simone Scuderi, Vito Cucchiara, Giorgio Gandaglia, Daniele Raggi, Andrea Necchi, Pierre Karakiewicz, Francesco Montorsi, Alberto Briganti,

<h4>Context</h4>The role of positron emission tomography/computed tomography (PET/CT) with prostate-specific membrane antigen (PSMA) in the primary staging for patients with prostate cancer (PCa) is still debated.<h4>Objective</h4>To analyze published studies reporting the accuracy of PSMA PET/CT for detecting lymph node invasion (LNI) at pelvic lymph node dissection (PLND).<h4>Evidence acquisition</h4>A search of ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Multiparametric magnetic resonance imaging of the prostate underestimates tumour volume of small visible lesions.

Gabriele Sorce, Armando Stabile, Roberta Lucianò, Giovanni Motterle, Simone Scuderi, Francesco Barletta, Francesco Pellegrino, Vito Cucchiara, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Ilaria Guccini, Alberto Briganti,

<h4>Objective</h4>To assess the relationship between the volume of the index lesion (IL) measured at multiparametric magnetic resonance imaging (mpMRI; MRIvol) and at radical prostatectomy (RPvol), stratifying it according to Prostate Imaging-Reporting and Data System (PI-RADS) score.<h4>Patients and methods</h4>We identified 332 men with a positive mpMRI (single lesion with PI-RADS ≥3) ... Read more >>

BJU Int (BJU international)
[2021, :]

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A feasibility study of preoperative pembrolizumab before radical nephroureterectomy in patients with high-risk, upper tract urothelial carcinoma: PURE-02.

Andrea Necchi, Alberto Martini, Daniele Raggi, Vito Cucchiara, Maurizio Colecchia, Roberta Lucianò, Luca Villa, Elio Mazzone, Giuseppe Basile, Simone Scuderi, Filippo Pederzoli, Marco Bandini, Francesco Barletta, Alessandro Larcher, Umberto Capitanio, Andrea Salonia, Alberto Briganti, Jeffrey S Ross, Antonella Messina, Francesco Montorsi,

<h4>Introduction</h4>Advances in neoadjuvant therapy for patients with localized, nonmetastatic, upper tract urothelial carcinoma (UTUC) is needed.<h4>Patients and methods</h4>PURE-02 was a feasibility study enrolling individuals with UTUC, at clinical stage N0M0, with high-risk features according to the modified European Association of Urology definition, based on the presence of either: high-grade disease, ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Definition and Impact on Oncologic Outcomes of Persistently Elevated Prostate-specific Antigen After Salvage Lymph Node Dissection for Node-only Recurrent Prostate Cancer After Radical Prostatectomy: Clinical Implications for Multimodal Therapy.

Carlo A Bravi, Matteo Droghetti, Nicola Fossati, Giorgio Gandaglia, Nazareno Suardi, Elio Mazzone, Vito Cucchiara, Simone Scuderi, Francesco Barletta, Riccardo Schiavina, Daniar Osmonov, Klaus-Peter Juenemann, Luca Boeri, R Jeffrey Karnes, Alexander Kretschmer, Alexander Buchner, Christian Stief, Andreas Hiester, Alessandro Nini, Peter Albers, Gaëtan Devos, Steven Joniau, Hendrik Van Poppel, Bernhard Grubmüller, Shahrokh F Shariat, Axel Heidenreich, David Pfister, Derya Tilki, Markus Graefen, Inderbir S Gill, Alexandre Mottrie, Pierre I Karakiewicz, Francesco Montorsi, Alberto Briganti,

<h4>Background</h4>The optimal definition and prognostic significance of persistently elevated prostate-specific antigen (PSA) after salvage lymph node dissection (sLND) for node-only recurrent prostate cancer (PCa) remain unknown.<h4>Objective</h4>To assess the definition and clinical implications of persistently elevated PSA after sLND for node-only recurrent PCa after radical prostatectomy.<h4>Design, setting, and participants</h4>The study included ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Reducing the Risk of Postoperative Complications After Robot-assisted Radical Prostatectomy in Prostate Cancer Patients: Results of an Audit and Feedback Intervention Following the Implementation of Prospective Data Collection.

Giuseppe Rosiello, Giorgio Gandaglia, Simone Scuderi, Francesco Barletta, Nicola Fossati, Armando Stabile, Andrea Gallina, Elio Mazzone, Luca Maria Vitale, Antony Pellegrino, Carlo Bravi, Alberto Martini, Vito Cucchiara, Pierre I Karakiewicz, Alexandre Mottrie, Alberto Briganti, Francesco Montorsi,

<h4>Background</h4>Prospective data collection for perioperative outcomes might increase awareness of surgical results obtained for patients with prostate cancer (PCa) undergoing robot-assisted radical prostatectomy (RARP). This would prompt the implementation of measures aimed at reducing the risk of adverse outcomes.<h4>Objective</h4>To assess the efficacy of an audit and feedback process aimed at ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Age and gleason score upgrading between prostate biopsy and radical prostatectomy: Is this still true in the multiparametric resonance imaging era?

Elio Mazzone, Armando Stabile, Gabriele Sorce, Francesco Pellegrino, Francesco Barletta, Giovanni Motterle, Simone Scuderi, Giuseppe Ottone Cirulli, Vito Cucchiara, Giorgio Brembilla, Antonio Esposito, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Ilaria Guccini, Alberto Briganti,

<h4>Introduction</h4>Several studies have invariably shown that the risk of Grade Group (GG) upgrading between biopsy and radical prostatectomy (RP) is higher in elderly men. Whether this is due to a real biological effect or to a diagnostic bias is still unknown. We hypothesized that the introduction of multiparametric magnetic resonance ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Optimizing prostate-targeted biopsy schemes in men with multiple mpMRI visible lesions: should we target all suspicious areas? Results of a two institution series.

Armando Stabile, Francesco Barletta, Giovanni Motterle, Francesco Pellegrino, Gabriele Sorce, Elio Mazzone, Simone Scuderi, Giuseppe Ottone Cirulli, Vito Cucchiara, Antonio Esposito, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Alberto Briganti,

<h4>Background</h4>To assess the diagnostic added value of sampling secondary lesions at prostate mpMRI (SL) in addition to index lesion (IL) in detecting significant prostate cancer (csPCa) when also systematic biopsy (SBx) is performed.<h4>Methods</h4>We relied on a cohort of 312 men with two suspicious lesions at prostate mpMRI who underwent subsequent ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

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Diagnostic and prognostic factors in patients with prostate cancer: a systematic review protocol.

Katharina Beyer, Lisa Moris, Michael Lardas, Anna Haire, Francesco Barletta, Simone Scuderi, Eleni Vradi, Giorgio Gandaglia, Muhammad Imran Omar, Steven MacLennan, Jihong Zong, Bahman Farahmand, Sara J Maclennan, Zsuzsanna Devecseri, Alex Asiimwe, Laurence Collette, Anders Bjartell, James Ndow, Alberto Briganti, Mieke Van Hemelrijck, ,

<h4>Introduction</h4>As part of the PIONEER (Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe) Consortium, we will explore which diagnostic and prognostic factors (DPFs) are currently being researched to previously defined clinical and patient-reported outcomes for prostate cancer (PCa).<h4>Methods and analysis</h4>This research project will follow ... Read more >>

BMJ Open (BMJ open)
[2021, 11(2):e040531]

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Positive Predictive Value of Prostate Imaging Reporting and Data System Version 2 for the Detection of Clinically Significant Prostate Cancer: A Systematic Review and Meta-analysis.

Elio Mazzone, Armando Stabile, Francesco Pellegrino, Giuseppe Basile, Daniele Cignoli, Giuseppe Ottone Cirulli, Gabriele Sorce, Francesco Barletta, Simone Scuderi, Carlo Andrea Bravi, Vito Cucchiara, Nicola Fossati, Giorgio Gandaglia, Francesco Montorsi, Alberto Briganti,

<h4>Context</h4>The variability of the positive predictive value (PPV) represents a significant factor affecting the diagnostic performance of multiparametric magnetic resonance imaging (mpMRI).<h4>Objective</h4>To analyze published studies reporting mpMRI PPV and the reasons behind the variability of clinically significant prostate cancer (csPCa) detection rates on targeted biopsies (TBx) according to Prostate Imaging ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, :]

Cited: 3 times

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Prognostic Implications of Multiparametric Magnetic Resonance Imaging and Concomitant Systematic Biopsy in Predicting Biochemical Recurrence After Radical Prostatectomy in Prostate Cancer Patients Diagnosed with Magnetic Resonance Imaging-targeted Biopsy.

Giorgio Gandaglia, Guillaume Ploussard, Massimo Valerio, Giancarlo Marra, Marco Moschini, Alberto Martini, Mathieu Roumiguié, Nicola Fossati, Armando Stabile, Jean-Baptiste Beauval, Bernard Malavaud, Simone Scuderi, Francesco Barletta, Luca Afferi, Arnas Rakauskas, Paolo Gontero, Agostino Mattei, Francesco Montorsi, Alberto Briganti,

<h4>Background</h4>The prognostic role of multiparametric magnetic resonance imaging (mpMRI) and systematic biopsy in predicting biochemical recurrence (BCR) after radical prostatectomy (RP) in prostate cancer (PCa) patients has not been addressed yet.<h4>Objective</h4>To develop a risk tool predicting BCR after RP in patients diagnosed with magnetic resonance imaging (MRI)-targeted biopsy.<h4>Design, setting, and ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(6):739-747]

Cited: 1 time

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Surgical Safety of Radical Cystectomy and Pelvic Lymph Node Dissection Following Neoadjuvant Pembrolizumab in Patients with Bladder Cancer: Prospective Assessment of Perioperative Outcomes from the PURE-01 Trial.

Alberto Briganti, Giorgio Gandaglia, Simone Scuderi, Andrea Gallina, Renzo Colombo, Nicola Fossati, Francesco Barletta, Antony Pellegrino, Luigi Nocera, Francesco Montorsi, Andrea Necchi,

No data are available on the surgical safety of radical cystectomy (RC) and pelvic lymph node dissection (PLND) after the administration of checkpoint inhibitors. We aimed at reporting the first prospective rigorous assessment of perioperative outcomes after RC and extended PLND following neoadjuvant pembrolizumab in a contemporary cohort of patients ... Read more >>

Eur Urol (European urology)
[2020, 77(5):576-580]

Cited: 5 times

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Journal-of-Functional-Morphology-and-Kinesiology"-Journal-Club-Series:-Utility-and-Advantages-of-the-Eccentric-Training-through-the-Isoinertial-System.">The "Journal of Functional Morphology and Kinesiology" Journal Club Series: Utility and Advantages of the Eccentric Training through the Isoinertial System.

James P Fisher, Silvia Ravalli, Luke Carlson, Lee A Bridgeman, Federico Roggio, Simone Scuderi, Mario Maniaci, Cristina Cortis, Andrea Fusco, Giuseppe Musumeci,

We are glad to introduce the first Journal Club of volume five, the first issue. This edition is focused on relevant studies published in the last years in the field of eccentric training, chosen by our editorial board members and their colleagues. We hope to stimulate your curiosity in this ... Journal-of-Functional-Morphology-and-Kinesiology"-Journal-Club-Series:-Utility-and-Advantages-of-the-Eccentric-Training-through-the-Isoinertial-System.">Read more >>

J Funct Morphol Kinesiol (Journal of functional morphology and kinesiology)
[2020, 5(1):]

Cited: 2 times

Journal-of-Functional-Morphology-and-Kinesiology"-Journal-Club-Series:-Utility-and-Advantages-of-the-Eccentric-Training-through-the-Isoinertial-System.">View full text PDF listing >>



The Key Combined Value of Multiparametric Magnetic Resonance Imaging, and Magnetic Resonance Imaging-targeted and Concomitant Systematic Biopsies for the Prediction of Adverse Pathological Features in Prostate Cancer Patients Undergoing Radical Prostatectomy.

Giorgio Gandaglia, Guillaume Ploussard, Massimo Valerio, Agostino Mattei, Cristian Fiori, Mathieu Roumiguié, Nicola Fossati, Armando Stabile, Jean-Baptiste Beauval, Bernard Malavaud, Simone Scuderi, Francesco Barletta, Marco Moschini, Stefania Zamboni, Arnas Rakauskas, Zhe Tian, Pierre I Karakiewicz, Francesco De Cobelli, Francesco Porpiglia, Francesco Montorsi, Alberto Briganti,

<h4>Background</h4>The combined role of multiparametric magnetic resonance imaging (mp-MRI), and magnetic resonance imaging (MRI)-targeted and concomitant systematic biopsies in the identification of prostate cancer (PCa) patients at a higher risk of adverse pathology at radical prostatectomy (RP) is still unclear.<h4>Objective</h4>To develop novel models to predict extracapsular extension (ECE), seminal vesicle ... Read more >>

Eur Urol (European urology)
[2020, 77(6):733-741]

Cited: 7 times

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Defining Clinically Meaningful Positive Surgical Margins in Patients Undergoing Radical Prostatectomy for Localised Prostate Cancer.

Alberto Martini, Giorgio Gandaglia, Nicola Fossati, Simone Scuderi, Carlo Andrea Bravi, Elio Mazzone, Armando Stabile, Simone Scarcella, Daniele Robesti, Francesco Barletta, Vito Cucchiara, Vincenzo Mirone, Francesco Montorsi, Alberto Briganti,

<h4>Background</h4>The impact of positive surgical margins (PSMs) on the risk of metastases in prostate cancer (PCa) patients treated with radical prostatectomy (RP) is still debated.<h4>Objective</h4>To identify PSM features associated with recurrence in a stage-by-stage analysis.<h4>Design, setting, and participants</h4>A total of 1757 PCa patients treated with RP without neoadjuvant or adjuvant ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, 4(1):42-48]

Cited: 6 times

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Relative Contribution of Sampling and Grading to the Quality of Prostate Biopsy: Results from a Single High-volume Institution.

Carlo Andrea Bravi, Emily Vertosick, Amy Tin, Simone Scuderi, Giuseppe Fallara, Giuseppe Rosiello, Elio Mazzone, Marco Bandini, Giorgio Gandaglia, Nicola Fossati, Massimo Freschi, Rodolfo Montironi, Alberto Briganti, Francesco Montorsi, Andrew Vickers,

<h4>Background</h4>The quality of prostate biopsy is affected by sampling (does the urologist take cores from the right place?) and the histological evaluation (does the pathologist grade correctly?).<h4>Objective</h4>To evaluate the relative contribution of sampling and histological evaluation to the reliability of prostate biopsy in terms of concordance with grading of the ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(4):474-480]

Cited: 1 time

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The Impact of Implementation of the European Association of Urology Guidelines Panel Recommendations on Reporting and Grading Complications on Perioperative Outcomes after Robot-assisted Radical Prostatectomy.

Giorgio Gandaglia, Carlo Andrea Bravi, Paolo Dell'Oglio, Elio Mazzone, Nicola Fossati, Simone Scuderi, Daniele Robesti, Francesco Barletta, Luca Grillo, Steven Maclennan, James N'Dow, Francesco Montorsi, Alberto Briganti,

The rate of postoperative complications might vary according to the method used to collect perioperative data. We aimed at assessing the impact of the prospective implementation of the European Association of Urology (EAU) guidelines on reporting and grading of complications in prostate cancer patients undergoing robot-assisted radical prostatectomy (RARP). From ... Read more >>

Eur Urol (European urology)
[2018, 74(1):4-7]

Cited: 2 times

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