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Author Simona Greco

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miR-210 hypoxamiR in angiogenesis and diabetes.

Germana Zaccagnini, Simona Greco, Christine Voellenkle, Carlo Gaetano, Fabio Martelli,

microRNA-210 (miR-210) is the master hypoxia-inducible miRNA (hypoxamiR) since it has been found significantly up-regulated under hypoxia in a wide range of cell types. Gene ontology analysis of its targets indicates that miR-210 modulates several aspects of cellular response to hypoxia. Due to its high pleiotropy, miR-210 not only plays ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2021, :]

Cited: 0 times

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Correction: Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia.

Germana Zaccagnini, Simona Greco, Marialucia Longo, Biagina Maimone, Christine Voellenkle, Paola Fuschi, Matteo Carrara, Pasquale Creo, Davide Maselli, Mario Tirone, Massimiliano Mazzone, Carlo Gaetano, Gaia Spinetti, Fabio Martelli,

Cell Death Dis (Cell death & disease)
[2021, 12(6):507]

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Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia.

Germana Zaccagnini, Simona Greco, Marialucia Longo, Biagina Maimone, Christine Voellenkle, Paola Fuschi, Matteo Carrara, Pasquale Creo, Davide Maselli, Mario Tirone, Massimiliano Mazzone, Carlo Gaetano, Gaia Spinetti, Fabio Martelli,

Hypoxia-induced miR-210 is a crucial component of the tissue response to ischemia, stimulating angiogenesis and improving tissue regeneration. Previous analysis of miR-210 impact on the transcriptome in a mouse model of hindlimb ischemia showed that miR-210 regulated not only vascular regeneration functions, but also inflammation. To investigate this event, doxycycline-inducible ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(5):435]

Cited: 0 times

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Long Noncoding Competing Endogenous RNA Networks in Age-Associated Cardiovascular Diseases.

Simona Greco, Carlo Gaetano, Fabio Martelli,

Cardiovascular diseases (CVDs) are the most serious health problem in the world, displaying high rates of morbidity and mortality. One of the main risk factors for CVDs is age. Indeed, several mechanisms are at play during aging, determining the functional decline of the cardiovascular system. Aging cells and tissues are ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(12):]

Cited: 16 times

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Circular RNAs in Muscle Function and Disease.

Simona Greco, Beatrice Cardinali, Germana Falcone, Fabio Martelli,

Circular RNAs (circRNAs) are a class of RNA produced during pre-mRNA splicing that are emerging as new members of the gene regulatory network. In addition to being spliced in a linear fashion, exons of pre-mRNAs can be circularized by use of the 3' acceptor splice site of upstream exons, leading ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(11):]

Cited: 22 times

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A Breath of Fresh Air(n) in Molecular Cardiology: Airn Long Noncoding RNA Regulates Cardiomyocyte Resistance to Stress and Igf2bp2 Translation.

Simona Greco, Fabio Martelli,

Circ Res (Circulation research)
[2018, 122(10):1321-1323]

Cited: 0 times

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Long Noncoding RNAs and Cardiac Disease.

Simona Greco, Antonio Salgado Somoza, Yvan Devaux, Fabio Martelli,

<h4>Significance</h4>To maintain homeostasis, gene expression has to be tightly regulated by complex and multiple mechanisms occurring at the epigenetic, transcriptional, and post-transcriptional levels. One crucial regulatory component is represented by long noncoding RNAs (lncRNAs), nonprotein-coding RNA species implicated in all of these levels. Thus, lncRNAs have been associated with any ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2018, 29(9):880-901]

Cited: 23 times

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The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy.

Gaia Spinetti, Elena Sangalli, Claudia Specchia, Francesco Villa, Chiara Spinelli, Rita Pipolo, Albino Carrizzo, Simona Greco, Christine Voellenkle, Carmine Vecchione, Paolo Madeddu, Fabio Martelli, Annibale Alessandro Puca,

The study of the health status in long-living individuals (LLIs) may help identifying health-span and life-span determinants. BPI-Fold-Containing-Family-B-Member-4 (BPIFB4) protein is higher in healthy vs. non-healthy (frail) LLIs serum and its longevity-associated variant forced expression improves cardiovascular outcomes in ischemia mice models. Thus, we tested the association of <i>BPIFB4</i> and ... Read more >>

Aging (Albany NY) (Aging)
[2017, 9(2):370-380]

Cited: 16 times

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Increased BACE1-AS long noncoding RNA and β-amyloid levels in heart failure.

Simona Greco, Germana Zaccagnini, Paola Fuschi, Christine Voellenkle, Matteo Carrara, Iman Sadeghi, Claudia Bearzi, Biagina Maimone, Serenella Castelvecchio, Konstantinos Stellos, Carlo Gaetano, Lorenzo Menicanti, Fabio Martelli,

<h4>Aims</h4>Antisense long noncoding RNAs (ncRNAs) are transcripts emerging from the opposite strand of a coding-RNA region and their role in heart failure (HF) is largely unknown. Additionally, HF and Alzheimer's disease (AD) share several non-genetic effectors and risk factors. We investigated the regulation of the β-secretase-1 (BACE1) gene and of ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2017, 113(5):453-463]

Cited: 30 times

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Long noncoding RNA dysregulation in ischemic heart failure.

Simona Greco, Germana Zaccagnini, Alessandra Perfetti, Paola Fuschi, Rea Valaperta, Christine Voellenkle, Serenella Castelvecchio, Carlo Gaetano, Nicoletta Finato, Antonio Paolo Beltrami, Lorenzo Menicanti, Fabio Martelli,

<h4>Background</h4>Long noncoding RNAs (lncRNAs) are non-protein coding transcripts regulating a variety of physiological and pathological functions. However, their implication in heart failure is still largely unknown. The aim of this study is to identify and characterize lncRNAs deregulated in patients affected by ischemic heart failure.<h4>Methods</h4>LncRNAs were profiled and validated in ... Read more >>

J Transl Med (Journal of translational medicine)
[2016, 14(1):183]

Cited: 75 times

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microRNAs in ischaemic cardiovascular diseases.

Simona Greco, Germana Zaccagnini, Christine Voellenkle, Fabio Martelli,

microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in ... Read more >>

Eur Heart J Suppl (European heart journal supplements : journal of the European Society of Cardiology)
[2016, 18(Suppl E):E31-E36]

Cited: 3 times

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Prognostic role of LDL cholesterol in non-dialysis chronic kidney disease: Multicenter prospective study in Italy.

Luca De Nicola, Michele Provenzano, Paolo Chiodini, Graziella D'Arrigo, Giovanni Tripepi, Lucia Del Vecchio, Giuseppe Conte, Francesco Locatelli, Carmine Zoccali, Roberto Minutolo, ,

The prognostic role of LDL in non-dialysis chronic kidney disease (CKD) is still undefined. We addressed this question in a multicenter prospective study including patients referred to nephrologist for management.1306 patients with CKD stage III-V were studied at basal visit in 79 Italian nephrology clinics in 2004-2006, and then followed ... Read more >>

Nutr Metab Cardiovasc Dis (Nutrition, metabolism, and cardiovascular diseases : NMCD)
[2015, 25(8):756-762]

Cited: 14 times

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Epigenetic mechanisms of hyperglycemic memory.

Chiara Cencioni, Francesco Spallotta, Simona Greco, Fabio Martelli, Andreas M Zeiher, Carlo Gaetano,

Recently the concept emerged that prolonged exposure to altered metabolic conditions, including hyperglycemia, may epigenetically imprint human cells permitting vertical or horizontal transfer to "descendants". Although mechanistically ill understood, the hyperglycemic/epigenetic memory may represent one of the major limitations for the application of cell therapy to treatment of chronic heart ... Read more >>

Int J Biochem Cell Biol (The international journal of biochemistry & cell biology)
[2014, 51:155-158]

Cited: 22 times

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Noncoding RNA in age-related cardiovascular diseases.

Simona Greco, Myriam Gorospe, Fabio Martelli,

Eukaryotic gene expression is tightly regulated transcriptionally and post-transcriptionally by a host of noncoding (nc)RNAs. The best-studied class of short ncRNAs, microRNAs, mainly repress gene expression post-transcriptionally. Long noncoding (lnc)RNAs, which comprise RNAs differing widely in length and function, can regulate gene transcription as well as post-transcriptional mRNA fate. Collectively, ... Read more >>

J Mol Cell Cardiol (Journal of molecular and cellular cardiology)
[2015, 83:142-155]

Cited: 58 times

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Plasma microRNAs as biomarkers for myotonic dystrophy type 1.

Alessandra Perfetti, Simona Greco, Enrico Bugiardini, Rosanna Cardani, Paola Gaia, Carlo Gaetano, Giovanni Meola, Fabio Martelli,

Myotonic dystrophy type 1 (DM1) lacks non-invasive and easy to measure biomarkers, still largely relying on semi-quantitative tests for diagnostic and prognostic purposes. Muscle biopsies provide valuable data, but their use is limited by their invasiveness. microRNA (miRNAs) are small non-coding RNAs regulating gene expression that are also present in ... Read more >>

Neuromuscul Disord (Neuromuscular disorders : NMD)
[2014, 24(6):509-515]

Cited: 33 times

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MicroRNAs in Hypoxia Response.

Simona Greco, Fabio Martelli,

Among the complex and articulated molecular mechanisms activated by hypoxia, microRNAs play a central role. Specifically, this Forum is dedicated to hypoxamiRs, defined as microRNAs that not only are directly regulated by hypoxia but also regulate cell responses to decreased oxygen tension. We assembled a collection of reviews and research ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2014, 21(8):1164-1166]

Cited: 16 times

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Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction.

Alessandra Magenta, Simona Greco, Maurizio C Capogrossi, Carlo Gaetano, Fabio Martelli,

Increased oxidative stress and reduced nitric oxide (NO) bioavailability play a causal role in endothelial cell dysfunction occurring in the vasculature of diabetic patients. In this review, we summarized the molecular mechanisms underpinning diabetic endothelial and vascular dysfunction. In particular, we focused our attention on the complex interplay existing among ... Read more >>

Biomed Res Int (BioMed research international)
[2014, 2014:193095]

Cited: 32 times

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Oxidative stress and microRNAs in vascular diseases.

Alessandra Magenta, Simona Greco, Carlo Gaetano, Fabio Martelli,

Oxidative stress has been demonstrated to play a causal role in different vascular diseases, such as hypertension, diabetic vasculopathy, hypercholesterolemia and atherosclerosis. Indeed, increased reactive oxygen species (ROS) production is known to impair endothelial and vascular smooth muscle cell functions, contributing to the development of cardiovascular diseases. MicroRNAs (miRNAs) are ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2013, 14(9):17319-17346]

Cited: 90 times

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Genome wide identification of aberrant alternative splicing events in myotonic dystrophy type 2.

Alessandra Perfetti, Simona Greco, Pasquale Fasanaro, Enrico Bugiardini, Rosanna Cardani, Jose M Garcia-Manteiga, Michela Riba, Michela Riba, Davide Cittaro, Elia Stupka, Giovanni Meola, Fabio Martelli,

Myotonic dystrophy type 2 (DM2) is a genetic, autosomal dominant disease due to expansion of tetraplet (CCTG) repetitions in the first intron of the ZNF9/CNBP gene. DM2 is a multisystemic disorder affecting the skeletal muscle, the heart, the eye and the endocrine system. According to the proposed pathological mechanism, the ... Read more >>

PLoS One (PloS one)
[2014, 9(4):e93983]

Cited: 11 times

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HypoxamiR regulation and function in ischemic cardiovascular diseases.

Simona Greco, Carlo Gaetano, Fabio Martelli,

<h4>Significance</h4>MicroRNAs (miRNAs) are deregulated and play a causal role in numerous cardiovascular diseases, including myocardial infarction, coronary artery disease, hypertension, heart failure, stroke, peripheral artery disease, kidney ischemia-reperfusion.<h4>Recent advances</h4>One crucial component of ischemic cardiovascular diseases is represented by hypoxia. Indeed, hypoxia is a powerful stimulus regulating the expression of a ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2014, 21(8):1202-1219]

Cited: 41 times

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Hypoxia-induced miR-210 modulates tissue response to acute peripheral ischemia.

Germana Zaccagnini, Biagina Maimone, Valeria Di Stefano, Pasquale Fasanaro, Simona Greco, Alessandra Perfetti, Maurizio C Capogrossi, Carlo Gaetano, Fabio Martelli,

<h4>Aims</h4>Peripheral artery disease is caused by the restriction or occlusion of arteries supplying the leg. Better understanding of the molecular mechanisms underpinning tissue response to ischemia is urgently needed to improve therapeutic options. The aim of this study is to investigate hypoxia-induced miR-210 regulation and its role in a mouse ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2014, 21(8):1177-1188]

Cited: 29 times

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Deregulated microRNAs in myotonic dystrophy type 2.

Simona Greco, Alessandra Perfetti, Pasquale Fasanaro, Rosanna Cardani, Maurizio C Capogrossi, Giovanni Meola, Fabio Martelli,

Myotonic Dystrophy Type-2 (DM2) is an autosomal dominant disease caused by the expansion of a CCTG tetraplet repeat. It is a multisystemic disorder, affecting skeletal muscles, the heart, the eye, the central nervous system and the endocrine system. Since microRNA (miRNA) expression is disrupted in Myotonic Dystrophy Type-1 and many ... Read more >>

PLoS One (PloS one)
[2012, 7(6):e39732]

Cited: 54 times

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miR-210: More than a silent player in hypoxia.

Cecilia Devlin, Simona Greco, Fabio Martelli, Mircea Ivan,

Multiple studies have consistently established that miR (microRNA)-210 induction is a feature of the hypoxic response in both normal and transformed cells. Here, we discuss the emerging biochemical functions of this miRNA and anticipate potential clinical applications. miR-210 is a robust target of hypoxia-inducible factor, and its overexpression has been ... Read more >>

IUBMB Life (IUBMB life)
[2011, 63(2):94-100]

Cited: 152 times

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MicroRNA dysregulation in diabetic ischemic heart failure patients.

Simona Greco, Pasquale Fasanaro, Serenella Castelvecchio, Yuri D'Alessandra, Diego Arcelli, Marisa Di Donato, Alexis Malavazos, Maurizio C Capogrossi, Lorenzo Menicanti, Fabio Martelli,

Increased morbidity and mortality associated with ischemic heart failure (HF) in type 2 diabetic patients requires a deeper understanding of the underpinning pathogenetic mechanisms. Given the implication of microRNAs (miRNAs) in HF, we investigated their regulation and potential role. miRNA expression profiles were measured in left ventricle biopsies from 10 ... Read more >>

Diabetes (Diabetes)
[2012, 61(6):1633-1641]

Cited: 123 times

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Dysregulation and cellular mislocalization of specific miRNAs in myotonic dystrophy type 1.

Riccardo Perbellini, Simona Greco, Gianluca Sarra-Ferraris, Rosanna Cardani, Maurizio C Capogrossi, Giovanni Meola, Fabio Martelli,

Myotonic Dystrophy Type-1 (DM1) is caused by the expansion of a CTG repeat with a peculiar pattern of multisystemic involvement affecting skeletal muscles, the heart, the eye, the central nervous system and the endocrine system. Since microRNA expression is disrupted in several myopathies, the expression of 24 candidate microRNAs was ... Read more >>

Neuromuscul Disord (Neuromuscular disorders : NMD)
[2011, 21(2):81-88]

Cited: 73 times

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